SCG3 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description secretogranin III|The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. Granins may serve as precursors for biologically active peptides. Some granins have been shown to function as helper proteins in sorting and proteolytic processing of prohormones; however, the function of this protein is unknown. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009] (NCBI Entrez Gene Database, 29106)
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Genes

312 genes differentially expressed following the SCG3 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
CLDN4 claudin 4 2.09765
SERPINA10 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10 2.09765
SLC46A3 solute carrier family 46, member 3 2.09765
MUC1 mucin 1, cell surface associated 2.09765
ZNF467 zinc finger protein 467 2.09765
NCF1 neutrophil cytosolic factor 1 2.09765
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha 2.09765
PEAR1 platelet endothelial aggregation receptor 1 2.09765
SLC25A46 solute carrier family 25, member 46 2.09765
GJB5 gap junction protein, beta 5, 31.1kDa 2.09765
RABL2B RAB, member of RAS oncogene family-like 2B 2.09765
IYD iodotyrosine deiodinase 2.09765
FAM167A family with sequence similarity 167, member A 2.09765
UCN urocortin 2.09765
CYP26C1 cytochrome P450, family 26, subfamily C, polypeptide 1 2.09765
SLC22A11 solute carrier family 22 (organic anion/urate transporter), member 11 2.09765
NTRK2 neurotrophic tyrosine kinase, receptor, type 2 2.09765
NTRK1 neurotrophic tyrosine kinase, receptor, type 1 2.09765
ZNF580 zinc finger protein 580 2.09765
ABCC9 ATP-binding cassette, sub-family C (CFTR/MRP), member 9 2.09765
CD274 CD274 molecule 2.09765
INHBB inhibin, beta B 2.09765
LILRA5 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 5 2.09765
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2 2.09765
GPR22 G protein-coupled receptor 22 2.09765
C19ORF38 chromosome 19 open reading frame 38 2.09765
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 2.09765
NPIPA3 nuclear pore complex interacting protein family, member A3 2.09765
NPIPA8 nuclear pore complex interacting protein family, member A8 2.09765
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone) 2.09765
SPINK14 serine peptidase inhibitor, Kazal type 14 (putative) 2.09765
HEPHL1 hephaestin-like 1 2.09765
IL2RA interleukin 2 receptor, alpha 2.09765
PRDM13 PR domain containing 13 2.09765
MYO16 myosin XVI 2.09765
LGALS2 lectin, galactoside-binding, soluble, 2 2.09765
S100A5 S100 calcium binding protein A5 2.09765
LRRIQ1 leucine-rich repeats and IQ motif containing 1 2.09765
CLEC5A C-type lectin domain family 5, member A 2.09765
KCNRG potassium channel regulator 2.09765
FAM221B family with sequence similarity 221, member B 2.09765
SUSD2 sushi domain containing 2 2.09765
GCKR glucokinase (hexokinase 4) regulator 2.09765
POSTN periostin, osteoblast specific factor 2.09765
CA9 carbonic anhydrase IX 2.09765
ZNF556 zinc finger protein 556 2.09765
HCST hematopoietic cell signal transducer 2.09765
KCNE4 potassium channel, voltage gated subfamily E regulatory beta subunit 4 2.09765
CD69 CD69 molecule 2.09765
SULT6B1 sulfotransferase family, cytosolic, 6B, member 1 2.09765
MAGEB2 melanoma antigen family B2 2.09765
CIMAP1D CIMAP1 family member D 2.09765
KRT81 keratin 81, type II 2.09765
PLCZ1 phospholipase C, zeta 1 2.09765
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 2.09765
RSPH4A radial spoke head 4 homolog A (Chlamydomonas) 2.09765
PROX2 prospero homeobox 2 2.09765
ACSL5 acyl-CoA synthetase long-chain family member 5 2.09765
WDR64 WD repeat domain 64 2.09765
LITAFD LITAF domain containing 2.09765
FOXC1 forkhead box C1 2.09765
MYL10 myosin, light chain 10, regulatory 2.09765
RBL1 retinoblastoma-like 1 2.09765
HOXC13 homeobox C13 2.09765
ZAR1 zygote arrest 1 2.09765
CIMAP1B ciliary microtubule associated protein 1B 2.09765
AKR1C8 aldo-keto reductase family 1 member C8 2.09765
CFAP276 cilia and flagella associated protein 276 2.09765
DEFB131B defensin beta 131B 2.09765
SLC49A3 solute carrier family 49 member 3 2.09765
CARMIL3 capping protein regulator and myosin 1 linker 3 2.09765
DNAAF8 dynein axonemal assembly factor 8 2.09765
ENTREP1 endosomal transmembrane epsin interactor 1 2.09765
CCN3 cellular communication network factor 3 2.09765
NIBAN3 niban apoptosis regulator 3 2.09765
RASD1 RAS, dexamethasone-induced 1 2.09765
SELL selectin L 2.09765
CFAP45 cilia and flagella associated protein 45 2.09765
CGNL1 cingulin-like 1 2.09765
IFRD2 interferon-related developmental regulator 2 2.09765
TLR1 toll-like receptor 1 2.09765
SCRT1 scratch family zinc finger 1 2.09765
SIM2 single-minded family bHLH transcription factor 2 2.09765
LRIT3 leucine-rich repeat, immunoglobulin-like and transmembrane domains 3 2.09765
TMEM235 transmembrane protein 235 2.09765
CD79A CD79a molecule, immunoglobulin-associated alpha 2.09765
ANXA13 annexin A13 2.09765
OR2L2 olfactory receptor, family 2, subfamily L, member 2 2.09765
C6ORF118 chromosome 6 open reading frame 118 2.09765
GJD4 gap junction protein, delta 4, 40.1kDa 2.09765
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific) 2.09765
LTF lactotransferrin 2.09765
HAL histidine ammonia-lyase 2.09765
ARPC5 actin related protein 2/3 complex, subunit 5, 16kDa 2.09765
BARX2 BARX homeobox 2 2.09765
TACR2 tachykinin receptor 2 2.09765
POLD3 polymerase (DNA-directed), delta 3, accessory subunit 2.09765
S100B S100 calcium binding protein B 2.09765
EXOC3L4 exocyst complex component 3-like 4 2.09765
GJD2 gap junction protein, delta 2, 36kDa 2.09765
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 2.09765
CCL25 chemokine (C-C motif) ligand 25 2.09765
TAF4B TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa 2.09765
CXCR2 chemokine (C-X-C motif) receptor 2 2.09765
DUOX2 dual oxidase 2 2.09765
RARB retinoic acid receptor, beta 2.09765
C2ORF66 chromosome 2 open reading frame 66 2.09765
KLHL41 kelch-like family member 41 2.09765
EMX2 empty spiracles homeobox 2 2.09765
CLEC4D C-type lectin domain family 4, member D 2.09765
TMPPE transmembrane protein with metallophosphoesterase domain 2.09765
CXCR6 chemokine (C-X-C motif) receptor 6 2.09765
HMGB4 high mobility group box 4 2.09765
GSC2 goosecoid homeobox 2 2.09765
TMEM132D transmembrane protein 132D 2.09765
KCNK9 potassium channel, two pore domain subfamily K, member 9 2.09765
TMEM258 transmembrane protein 258 2.09765
TCEA3 transcription elongation factor A (SII), 3 2.09765
CERKL ceramide kinase-like 2.09765
GFY golgi-associated, olfactory signaling regulator 2.09765
HCRT hypocretin (orexin) neuropeptide precursor 2.09765
TSLP thymic stromal lymphopoietin 2.09765
HHATL hedgehog acyltransferase-like 2.09765
PEBP4 phosphatidylethanolamine-binding protein 4 2.09765
IRGC immunity-related GTPase family, cinema 2.09765
POU2AF1 POU class 2 associating factor 1 2.09765
PCDHA13 protocadherin alpha 13 2.09765
SLC31A2 solute carrier family 31 (copper transporter), member 2 2.09765
SST somatostatin 2.09765
TBX1 T-box 1 2.09765
IL9R interleukin 9 receptor 2.09765
TPPP3 tubulin polymerization-promoting protein family member 3 2.09765
FCRLB Fc receptor-like B 2.09765
TP63 tumor protein p63 2.09765
LYZ lysozyme 2.09765
PLA1A phospholipase A1 member A 2.09765
EMILIN1 elastin microfibril interfacer 1 2.09765
ANKS4B ankyrin repeat and sterile alpha motif domain containing 4B 2.09765
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1 2.09765
C22ORF42 chromosome 22 open reading frame 42 2.09765
PCDHGA3 protocadherin gamma subfamily A, 3 2.09765
P2RY13 purinergic receptor P2Y, G-protein coupled, 13 2.09765
IFITM5 interferon induced transmembrane protein 5 2.09765
MUC17 mucin 17, cell surface associated 2.09765
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1 2.09765
PPP1R14C protein phosphatase 1, regulatory (inhibitor) subunit 14C 2.09765
UBXN10 UBX domain protein 10 2.09765
SOSTDC1 sclerostin domain containing 1 2.09765
LRRC46 leucine rich repeat containing 46 2.09765
MYO1G myosin IG 2.09765
EVI2A ecotropic viral integration site 2A 2.09765
CSNK2B casein kinase 2, beta polypeptide 2.09765
ABRA actin binding Rho activating protein 2.09765
STOML3 stomatin (EPB72)-like 3 2.09765
TMEM215 transmembrane protein 215 2.09765
ZNF831 zinc finger protein 831 2.09765
AHSG alpha-2-HS-glycoprotein 2.09765
MMP12 matrix metallopeptidase 12 2.09765
SLC17A6 solute carrier family 17 (vesicular glutamate transporter), member 6 2.09765
METTL21C methyltransferase like 21C 2.09765
NTMT1 N-terminal Xaa-Pro-Lys N-methyltransferase 1 2.09765
ACRBP acrosin binding protein 2.09765
KCNU1 potassium channel, subfamily U, member 1 2.09765
LVRN laeverin 2.09765
ABCA4 ATP-binding cassette, sub-family A (ABC1), member 4 2.09765
EVPL envoplakin 2.09765
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) 2.09765
SLC10A5 solute carrier family 10, member 5 2.09765
CFI complement factor I 2.09765
CNTN2 contactin 2 (axonal) 2.09765
OLFML2B olfactomedin-like 2B 2.09765
KCTD3 potassium channel tetramerization domain containing 3 2.09765
TTC36 tetratricopeptide repeat domain 36 2.09765
ADRA1A adrenoceptor alpha 1A 2.09765
ZNF474 zinc finger protein 474 2.09765
NDUFA11 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 11, 14.7kDa 2.09765
KRT17 keratin 17, type I 2.09765
DYTN dystrotelin 2.09765
PMP2 peripheral myelin protein 2 2.09765
MBOAT4 membrane bound O-acyltransferase domain containing 4 2.09765
APOD apolipoprotein D 2.09765
GP1BB glycoprotein Ib (platelet), beta polypeptide 2.09765
DPRX divergent-paired related homeobox 2.09765
PCF11 PCF11 cleavage and polyadenylation factor subunit 2.09765
C4ORF51 chromosome 4 open reading frame 51 2.09765
ACSM4 acyl-CoA synthetase medium-chain family member 4 2.09765
FKBP15 FK506 binding protein 15, 133kDa 2.09765
PIK3R6 phosphoinositide-3-kinase, regulatory subunit 6 2.09765
MGP matrix Gla protein 2.09765
GCM1 glial cells missing homolog 1 (Drosophila) 2.09765
APOL3 apolipoprotein L, 3 2.09765
KCNA7 potassium channel, voltage gated shaker related subfamily A, member 7 2.09765
MT1A metallothionein 1A 2.09765
FUT3 fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group) 2.09765
KANK2 KN motif and ankyrin repeat domains 2 2.09765
GPR149 G protein-coupled receptor 149 2.09765
ATP5PF ATP synthase peripheral stalk subunit F6 2.09202
SYCE3 synaptonemal complex central element protein 3 2.09122
ZNF226 zinc finger protein 226 2.09122
RNF43 ring finger protein 43 2.09037
SAV1 salvador family WW domain containing protein 1 2.08755
SMAGP small cell adhesion glycoprotein 2.06655
RNF157 ring finger protein 157 2.06533
E2F5 E2F transcription factor 5, p130-binding 2.06533
RAB11FIP4 RAB11 family interacting protein 4 (class II) 2.06533
CLDN11 claudin 11 2.06533
PAPOLA poly(A) polymerase alpha 2.06533
SLC12A5 solute carrier family 12 (potassium/chloride transporter), member 5 2.06145
RSKR ribosomal protein S6 kinase related 2.05855
NANP N-acetylneuraminic acid phosphatase 2.05855
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 2.05855
C6ORF89 chromosome 6 open reading frame 89 2.05185
RAVER1 ribonucleoprotein, PTB-binding 1 2.03526
CCR5AS CCR5 antisense RNA 2.02714
GP1BA glycoprotein Ib (platelet), alpha polypeptide 2.02714
TMEM213 transmembrane protein 213 2.02714
SERF1A small EDRK-rich factor 1A (telomeric) 2.02714
ADAL adenosine deaminase-like 2.02304
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae) 2.0221

decreased expression

Symbol Name Standardized Value
CRIPTO3 cripto, EGF-CFC family member 3 -2.09765
ZNF501 zinc finger protein 501 -2.09765
SCG3 secretogranin III -2.09765
ACCS 1-aminocyclopropane-1-carboxylate synthase homolog (Arabidopsis)(non-functional) -2.09765
DCUN1D2 DCN1, defective in cullin neddylation 1, domain containing 2 -2.09765
ZNF100 zinc finger protein 100 -2.09765
GRIA1 glutamate receptor, ionotropic, AMPA 1 -2.09765
CORO1A coronin, actin binding protein, 1A -2.09765
CCDC85A coiled-coil domain containing 85A -2.09765
FBXO27 F-box protein 27 -2.09765
KCNE5 potassium channel, voltage gated subfamily E regulatory beta subunit 5 -2.09765
YIF1B Yip1 interacting factor homolog B (S. cerevisiae) -2.09765
QRSL1 glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1 -2.09765
GPA33 glycoprotein A33 (transmembrane) -2.09765
ZNF791 zinc finger protein 791 -2.09765
NYAP1 neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 1 -2.09765
SLC25A18 solute carrier family 25 (glutamate carrier), member 18 -2.09765
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B -2.09765
HROB homologous recombination factor with OB-fold -2.09765
CFAP77 cilia and flagella associated protein 77 -2.09765
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -2.09765
CNIH2 cornichon family AMPA receptor auxiliary protein 2 -2.09765
KIF5A kinesin family member 5A -2.09765
PRPF40B PRP40 pre-mRNA processing factor 40 homolog B (S. cerevisiae) -2.09765
MCMDC2 minichromosome maintenance domain containing 2 -2.09765
ATP2B2 ATPase, Ca++ transporting, plasma membrane 2 -2.09765
BMI1 BMI1 proto-oncogene, polycomb ring finger -2.09765
TMEM233 transmembrane protein 233 -2.09765
MEOX2 mesenchyme homeobox 2 -2.09765
SMARCA5 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 -2.09765
PRADC1 protease-associated domain containing 1 -2.09765
ZSWIM8 zinc finger, SWIM-type containing 8 -2.09765
DYRK4 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4 -2.09765
SLC25A25 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25 -2.09765
MANSC1 MANSC domain containing 1 -2.09765
NRBP1 nuclear receptor binding protein 1 -2.09765
TMEM132B transmembrane protein 132B -2.09765
SNX33 sorting nexin 33 -2.09765
ABCB4 ATP-binding cassette, sub-family B (MDR/TAP), member 4 -2.09765
FAM114A1 family with sequence similarity 114, member A1 -2.09765
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -2.09765
ADGRV1 adhesion G protein-coupled receptor V1 -2.09765
KLHDC8A kelch domain containing 8A -2.09765
OPA1 optic atrophy 1 (autosomal dominant) -2.09765
DEXI Dexi homolog (mouse) -2.09765
ZNF619 zinc finger protein 619 -2.09765
CDC37 cell division cycle 37 -2.09765
PATL2 protein associated with topoisomerase II homolog 2 (yeast) -2.09765
JMJD7 jumonji domain containing 7 -2.09765
MARK1 MAP/microtubule affinity-regulating kinase 1 -2.09037
MAFA v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog A -2.08755
FRS3 fibroblast growth factor receptor substrate 3 -2.08755
IDE insulin-degrading enzyme -2.06533
ZNF765 zinc finger protein 765 -2.06533
NWD2 NACHT and WD repeat domain containing 2 -2.06533
RPH3A rabphilin 3A -2.06533
LECT2 leukocyte cell-derived chemotaxin 2 -2.06533
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled -2.06533
PLK5 polo-like kinase 5 -2.06533
NR1I3 nuclear receptor subfamily 1, group I, member 3 -2.06533
XKRX XK, Kell blood group complex subunit-related, X-linked -2.06533
CISH cytokine inducible SH2-containing protein -2.06533
CCDC171 coiled-coil domain containing 171 -2.06533
KLHL33 kelch-like family member 33 -2.06533
SLA Src-like-adaptor -2.06533
SPATS1 spermatogenesis associated, serine-rich 1 -2.06533
ACADL acyl-CoA dehydrogenase, long chain -2.06533
H4C2 H4 clustered histone 2 -2.06533
NDUFAF8 NADH:ubiquinone oxidoreductase complex assembly factor 8 -2.06533
ZNF324 zinc finger protein 324 -2.06533
C6ORF52 chromosome 6 open reading frame 52 -2.06533
UBE2D4 ubiquitin-conjugating enzyme E2D 4 (putative) -2.06533
LYST lysosomal trafficking regulator -2.06533
KLK5 kallikrein-related peptidase 5 -2.06533
SPAM1 sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding) -2.06533
KCNH1 potassium channel, voltage gated eag related subfamily H, member 1 -2.06533
JSRP1 junctional sarcoplasmic reticulum protein 1 -2.06533
F2RL2 coagulation factor II (thrombin) receptor-like 2 -2.06533
GBE1 glucan (1,4-alpha-), branching enzyme 1 -2.06533
PARP15 poly (ADP-ribose) polymerase family, member 15 -2.06533
SHISA8 shisa family member 8 -2.06533
ERVFRD-1 endogenous retrovirus group FRD, member 1 -2.06533
ARF5 ADP-ribosylation factor 5 -2.06533
PODNL1 podocan-like 1 -2.06533
CA7 carbonic anhydrase VII -2.06533
EGR2 early growth response 2 -2.06533
CEP44 centrosomal protein 44kDa -2.06416
XDH xanthine dehydrogenase -2.05427
ZNF500 zinc finger protein 500 -2.03526
TP53I11 tumor protein p53 inducible protein 11 -2.02588
HACD1 3-hydroxyacyl-CoA dehydratase 1 -2.01558
UTP15 UTP15, U3 small nucleolar ribonucleoprotein, homolog (S. cerevisiae) -2.0122
CCDC88C coiled-coil domain containing 88C -2.0108