SCH 530348 Gene Set

Dataset DeepCoverMOA Drug Mechanisms of Action
Category proteomics
Type drug perturbation
External Link https://pubchem.ncbi.nlm.nih.gov/compound/10077130
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Genes

199 proteins with high or low expression in SCH 530348 relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.

high expression

Symbol Name Standardized Value
APOB apolipoprotein B 2.25
PLEKHH2 pleckstrin homology domain containing, family H (with MyTH4 domain) member 2 2.18
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase 2.05
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 1.93
FDFT1 farnesyl-diphosphate farnesyltransferase 1 1.74
LMOD1 leiomodin 1 (smooth muscle) 1.57
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 1.55
SQLE squalene epoxidase 1.52
SCD stearoyl-CoA desaturase (delta-9-desaturase) 1.46
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 1.44
TMEM59 transmembrane protein 59 1.34
IDI1 isopentenyl-diphosphate delta isomerase 1 1.19
CAVIN2 caveolae associated protein 2 1.17
LPIN1 lipin 1 1.11
MSMO1 methylsterol monooxygenase 1 1.1
NCOA4 nuclear receptor coactivator 4 1.08
MVK mevalonate kinase 0.94
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 0.88
MCL1 myeloid cell leukemia 1 0.87
ABHD3 abhydrolase domain containing 3 0.86
NBR1 neighbor of BRCA1 gene 1 0.83
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) 0.82
NDFIP2 Nedd4 family interacting protein 2 0.81
HSD17B7 hydroxysteroid (17-beta) dehydrogenase 7 0.8
DHCR7 7-dehydrocholesterol reductase 0.78
ITM2B integral membrane protein 2B 0.77
ACSS2 acyl-CoA synthetase short-chain family member 2 0.76
SLC49A4 solute carrier family 49 member 4 0.75
LDLR low density lipoprotein receptor 0.75
DHCR24 24-dehydrocholesterol reductase 0.75
ALDOC aldolase C, fructose-bisphosphate 0.73
LIPA lipase A, lysosomal acid, cholesterol esterase 0.72
ITM2C integral membrane protein 2C 0.71
PLCB4 phospholipase C, beta 4 0.71
FADS1 fatty acid desaturase 1 0.7
ACAT2 acetyl-CoA acetyltransferase 2 0.7
SLC43A2 solute carrier family 43 (amino acid system L transporter), member 2 0.7
LRP10 low density lipoprotein receptor-related protein 10 0.69
GJC1 gap junction protein, gamma 1, 45kDa 0.69
RNF149 ring finger protein 149 0.68
KMT2B lysine (K)-specific methyltransferase 2B 0.68
SREBF2 sterol regulatory element binding transcription factor 2 0.65
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 0.65
ITGB8 integrin, beta 8 0.65
ERG28 ergosterol biosynthesis 28 homolog 0.64
SNX19 sorting nexin 19 0.64
SC5D sterol-C5-desaturase 0.64
SQSTM1 sequestosome 1 0.63
TRIM2 tripartite motif containing 2 0.63
DPP8 dipeptidyl-peptidase 8 0.62
MVD mevalonate (diphospho) decarboxylase 0.61
PCDHGA10 protocadherin gamma subfamily A, 10 0.58
RNF130 ring finger protein 130 0.58
CALCOCO2 calcium binding and coiled-coil domain 2 0.58
APOE apolipoprotein E 0.58
IFNGR1 interferon gamma receptor 1 0.57
UGCG UDP-glucose ceramide glucosyltransferase 0.57
DPH6 diphthamine biosynthesis 6 0.55
ADGRG1 adhesion G protein-coupled receptor G1 0.55
AHR aryl hydrocarbon receptor 0.55
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.55
FDPS farnesyl diphosphate synthase 0.54
ADIPOR1 adiponectin receptor 1 0.54
JAK3 Janus kinase 3 0.54
ZNF320 zinc finger protein 320 0.53
ACTBL2 actin, beta-like 2 0.53
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain 0.53
ACVR2A activin A receptor, type IIA 0.53
ADCY10 adenylate cyclase 10 (soluble) 0.52
SASH1 SAM and SH3 domain containing 1 0.52
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.52
GINM1 glycoprotein integral membrane 1 0.52
PITX2 paired-like homeodomain 2 0.51
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1 0.51
IL10RB interleukin 10 receptor, beta 0.51
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor) 0.5
ELOVL6 ELOVL fatty acid elongase 6 0.5
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase 0.5
DPY30 dpy-30 homolog (C. elegans) 0.49
TMEM41B transmembrane protein 41B 0.49
OAF OAF homolog (Drosophila) 0.49
C12ORF73 chromosome 12 open reading frame 73 0.48
RTN4R reticulon 4 receptor 0.46
PEG10 paternally expressed 10 0.46
FGFR1 fibroblast growth factor receptor 1 0.45
NPC1 Niemann-Pick disease, type C1 0.45
DNAJB5 DnaJ (Hsp40) homolog, subfamily B, member 5 0.45
SLFN5 schlafen family member 5 0.45
JAK1 Janus kinase 1 0.45
MYRF myelin regulatory factor 0.44
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1 0.44
PTPRS protein tyrosine phosphatase, receptor type, S 0.44
CCDC18 coiled-coil domain containing 18 0.44
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.44
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1 0.44
WRB tryptophan rich basic protein 0.43
PRELID3B PRELI domain containing 3B 0.43
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.43
TTYH2 tweety family member 2 0.43
FAM241B family with sequence similarity 241 member B 0.42

low expression

Symbol Name Standardized Value
SPTBN5 spectrin, beta, non-erythrocytic 5 -2.39
TMEM259 transmembrane protein 259 -1.01
EGR1 early growth response 1 -0.62
LYST lysosomal trafficking regulator -0.62
DIPK1B divergent protein kinase domain 1B -0.59
GBA glucosidase, beta, acid -0.58
EIF3C eukaryotic translation initiation factor 3, subunit C -0.58
FBXO31 F-box protein 31 -0.58
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 -0.57
RND3 Rho family GTPase 3 -0.57
FUNDC1 FUN14 domain containing 1 -0.56
PAQR7 progestin and adipoQ receptor family member VII -0.56
MAP3K5 mitogen-activated protein kinase kinase kinase 5 -0.52
PLIN2 perilipin 2 -0.51
ZNF544 zinc finger protein 544 -0.51
AEN apoptosis enhancing nuclease -0.49
SYK spleen tyrosine kinase -0.48
TMEM131L transmembrane 131 like -0.48
RNPEPL1 arginyl aminopeptidase (aminopeptidase B)-like 1 -0.48
PRR36 proline rich 36 -0.47
PIP prolactin-induced protein -0.47
TMEM168 transmembrane protein 168 -0.46
ZGRF1 zinc finger, GRF-type containing 1 -0.46
MCPH1 microcephalin 1 -0.46
E2F7 E2F transcription factor 7 -0.45
TENT5A terminal nucleotidyltransferase 5A -0.45
CECR2 cat eye syndrome chromosome region, candidate 2 -0.44
KLF4 Kruppel-like factor 4 (gut) -0.44
ARHGAP42 Rho GTPase activating protein 42 -0.44
ICOSLG inducible T-cell co-stimulator ligand -0.44
CCNB1 cyclin B1 -0.43
MARCHF7 membrane associated ring-CH-type finger 7 -0.42
HHEX hematopoietically expressed homeobox -0.42
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.42
PLD6 phospholipase D family, member 6 -0.41
LPIN2 lipin 2 -0.41
ITGB1BP1 integrin beta 1 binding protein 1 -0.4
SYDE1 synapse defective 1, Rho GTPase, homolog 1 (C. elegans) -0.4
GGACT gamma-glutamylamine cyclotransferase -0.4
ARHGAP19 Rho GTPase activating protein 19 -0.4
ZNF304 zinc finger protein 304 -0.4
KIF26A kinesin family member 26A -0.4
TOR4A torsin family 4, member A -0.39
GALNT5 polypeptide N-acetylgalactosaminyltransferase 5 -0.39
BIRC5 baculoviral IAP repeat containing 5 -0.39
SYBU syntabulin (syntaxin-interacting) -0.39
RAP1B RAP1B, member of RAS oncogene family -0.39
ADM adrenomedullin -0.39
CDK6 cyclin-dependent kinase 6 -0.39
SEMA7A semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group) -0.38
RUBCN rubicon autophagy regulator -0.38
CDC20 cell division cycle 20 -0.38
ANLN anillin, actin binding protein -0.37
DNAAF3 dynein, axonemal, assembly factor 3 -0.37
PTTG1 pituitary tumor-transforming 1 -0.37
PDK1 pyruvate dehydrogenase kinase, isozyme 1 -0.37
NFE2L3 nuclear factor, erythroid 2-like 3 -0.36
CDC6 cell division cycle 6 -0.36
TESC tescalcin -0.36
TOP2A topoisomerase (DNA) II alpha 170kDa -0.36
UBE2S ubiquitin-conjugating enzyme E2S -0.36
PKMYT1 protein kinase, membrane associated tyrosine/threonine 1 -0.35
RUNX2 runt-related transcription factor 2 -0.35
CPA4 carboxypeptidase A4 -0.35
MYO18B myosin XVIIIB -0.34
CDCA2 cell division cycle associated 2 -0.34
HIST2H2AA3 histone cluster 2, H2aa3 -0.34
PLK1 polo-like kinase 1 -0.34
ATP6V0A1 ATPase, H+ transporting, lysosomal V0 subunit a1 -0.34
KIF18B kinesin family member 18B -0.34
TRMO tRNA methyltransferase O -0.33
ZNF511 zinc finger protein 511 -0.33
ALDH1A3 aldehyde dehydrogenase 1 family, member A3 -0.33
PDSS1 prenyl (decaprenyl) diphosphate synthase, subunit 1 -0.33
BUB1 BUB1 mitotic checkpoint serine/threonine kinase -0.33
DXO decapping exoribonuclease -0.33
TNS4 tensin 4 -0.33
CLK1 CDC-like kinase 1 -0.32
IRAK2 interleukin-1 receptor-associated kinase 2 -0.32
SOCS2 suppressor of cytokine signaling 2 -0.32
COA4 cytochrome c oxidase assembly factor 4 homolog (S. cerevisiae) -0.32
EHF ets homologous factor -0.32
TADA2A transcriptional adaptor 2A -0.32
FKBPL FK506 binding protein like -0.31
PHLDA3 pleckstrin homology-like domain, family A, member 3 -0.31
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha -0.31
E2F8 E2F transcription factor 8 -0.31
BCDIN3D BCDIN3 domain containing -0.31
RAD51 RAD51 recombinase -0.31
STC2 stanniocalcin 2 -0.31
DESI2 desumoylating isopeptidase 2 -0.31
SPDL1 spindle apparatus coiled-coil protein 1 -0.31
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit -0.3
RLIM ring finger protein, LIM domain interacting -0.3
AURKA aurora kinase A -0.3
INCENP inner centromere protein antigens 135/155kDa -0.3
CLASP1 cytoplasmic linker associated protein 1 -0.3
MSX1 msh homeobox 1 -0.3
CCNA2 cyclin A2 -0.3