| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/176408 |
| Similar Terms | |
| Downloads & Tools |
198 proteins with high or low expression in SCH 58261 relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PPP1R26 | protein phosphatase 1, regulatory subunit 26 | 1.45 |
| FGA | fibrinogen alpha chain | 1.35 |
| DNAH14 | dynein, axonemal, heavy chain 14 | 1.23 |
| AAMDC | adipogenesis associated, Mth938 domain containing | 1.2 |
| DNAH2 | dynein, axonemal, heavy chain 2 | 1.15 |
| NPHP3 | nephronophthisis 3 (adolescent) | 1.1 |
| EPB41L1 | erythrocyte membrane protein band 4.1-like 1 | 1.07 |
| CSRNP1 | cysteine-serine-rich nuclear protein 1 | 1.04 |
| PTPN21 | protein tyrosine phosphatase, non-receptor type 21 | 0.91 |
| ATP8B3 | ATPase, aminophospholipid transporter, class I, type 8B, member 3 | 0.87 |
| NR1D2 | nuclear receptor subfamily 1, group D, member 2 | 0.85 |
| FBRSL1 | fibrosin-like 1 | 0.74 |
| SYN2 | synapsin II | 0.74 |
| KMT2B | lysine (K)-specific methyltransferase 2B | 0.71 |
| DNAL4 | dynein, axonemal, light chain 4 | 0.67 |
| GREB1 | growth regulation by estrogen in breast cancer 1 | 0.66 |
| LRRC58 | leucine rich repeat containing 58 | 0.64 |
| ALPK3 | alpha-kinase 3 | 0.63 |
| ANKRD20A4 | ankyrin repeat domain 20 family, member A4 | 0.57 |
| MYH6 | myosin, heavy chain 6, cardiac muscle, alpha | 0.55 |
| DOCK11 | dedicator of cytokinesis 11 | 0.52 |
| AZGP1 | alpha-2-glycoprotein 1, zinc-binding | 0.51 |
| DROSHA | drosha, ribonuclease type III | 0.51 |
| TXNL4B | thioredoxin-like 4B | 0.49 |
| SGSH | N-sulfoglucosamine sulfohydrolase | 0.48 |
| LENG9 | leukocyte receptor cluster (LRC) member 9 | 0.48 |
| CCDC112 | coiled-coil domain containing 112 | 0.48 |
| GALNT5 | polypeptide N-acetylgalactosaminyltransferase 5 | 0.47 |
| ZSCAN32 | zinc finger and SCAN domain containing 32 | 0.47 |
| FDFT1 | farnesyl-diphosphate farnesyltransferase 1 | 0.45 |
| USH2A | Usher syndrome 2A (autosomal recessive, mild) | 0.45 |
| CCNG1 | cyclin G1 | 0.44 |
| SH3RF2 | SH3 domain containing ring finger 2 | 0.44 |
| PAQR7 | progestin and adipoQ receptor family member VII | 0.43 |
| JUN | jun proto-oncogene | 0.43 |
| TTLL4 | tubulin tyrosine ligase-like family member 4 | 0.42 |
| FBXO46 | F-box protein 46 | 0.42 |
| AHR | aryl hydrocarbon receptor | 0.42 |
| FN1 | fibronectin 1 | 0.41 |
| ANAPC16 | anaphase promoting complex subunit 16 | 0.4 |
| TEX15 | testis expressed 15 | 0.4 |
| OGG1 | 8-oxoguanine DNA glycosylase | 0.39 |
| ISCA2 | iron-sulfur cluster assembly 2 | 0.39 |
| PRKRIP1 | PRKR interacting protein 1 (IL11 inducible) | 0.39 |
| MTUS2 | microtubule associated tumor suppressor candidate 2 | 0.38 |
| SP140 | SP140 nuclear body protein | 0.37 |
| DEPDC5 | DEP domain containing 5 | 0.37 |
| YAE1 | YAE1 maturation factor of ABCE1 | 0.37 |
| DUSP7 | dual specificity phosphatase 7 | 0.37 |
| DMD | dystrophin | 0.37 |
| IER5L | immediate early response 5-like | 0.36 |
| ENO1 | enolase 1, (alpha) | 0.36 |
| UBIAD1 | UbiA prenyltransferase domain containing 1 | 0.35 |
| C1ORF122 | chromosome 1 open reading frame 122 | 0.35 |
| PLAAT3 | phospholipase A and acyltransferase 3 | 0.35 |
| KLHL21 | kelch-like family member 21 | 0.35 |
| ZNF594 | zinc finger protein 594 | 0.34 |
| SMARCC2 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2 | 0.34 |
| MDM1 | Mdm1 nuclear protein homolog (mouse) | 0.34 |
| CCDC82 | coiled-coil domain containing 82 | 0.33 |
| ARHGEF35 | Rho guanine nucleotide exchange factor (GEF) 35 | 0.33 |
| SMAP1 | small ArfGAP 1 | 0.32 |
| NIN | ninein (GSK3B interacting protein) | 0.32 |
| SLC35A3 | solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 | 0.32 |
| CMC1 | C-x(9)-C motif containing 1 | 0.32 |
| UBAP1 | ubiquitin associated protein 1 | 0.31 |
| SCMH1 | sex comb on midleg homolog 1 (Drosophila) | 0.31 |
| ZNF124 | zinc finger protein 124 | 0.31 |
| CLIC6 | chloride intracellular channel 6 | 0.31 |
| ARHGAP23 | Rho GTPase activating protein 23 | 0.31 |
| PTMS | parathymosin | 0.3 |
| FBXL20 | F-box and leucine-rich repeat protein 20 | 0.3 |
| KIF27 | kinesin family member 27 | 0.3 |
| FGFR1 | fibroblast growth factor receptor 1 | 0.3 |
| TSPAN3 | tetraspanin 3 | 0.29 |
| P3H2 | prolyl 3-hydroxylase 2 | 0.29 |
| RBM20 | RNA binding motif protein 20 | 0.29 |
| B4GALNT1 | beta-1,4-N-acetyl-galactosaminyl transferase 1 | 0.29 |
| C1ORF226 | chromosome 1 open reading frame 226 | 0.29 |
| TACC3 | transforming, acidic coiled-coil containing protein 3 | 0.28 |
| STK17A | serine/threonine kinase 17a | 0.28 |
| MRFAP1 | Morf4 family associated protein 1 | 0.28 |
| SON | SON DNA binding protein | 0.28 |
| MXRA7 | matrix-remodelling associated 7 | 0.28 |
| C19ORF47 | chromosome 19 open reading frame 47 | 0.28 |
| ZNF776 | zinc finger protein 776 | 0.28 |
| ARFIP1 | ADP-ribosylation factor interacting protein 1 | 0.27 |
| RCAN3 | RCAN family member 3 | 0.27 |
| CHCHD4 | coiled-coil-helix-coiled-coil-helix domain containing 4 | 0.27 |
| SUPT7L | suppressor of Ty 7 (S. cerevisiae)-like | 0.27 |
| LPIN1 | lipin 1 | 0.27 |
| IRGQ | immunity-related GTPase family, Q | 0.27 |
| MED30 | mediator complex subunit 30 | 0.26 |
| CLASP2 | cytoplasmic linker associated protein 2 | 0.26 |
| HOXB9 | homeobox B9 | 0.26 |
| IGFBP6 | insulin-like growth factor binding protein 6 | 0.26 |
| NF1 | neurofibromin 1 | 0.26 |
| FAM177A1 | family with sequence similarity 177, member A1 | 0.26 |
| FAAP24 | FA core complex associated protein 24 | 0.26 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CYP1A1 | cytochrome P450, family 1, subfamily A, polypeptide 1 | -0.9 |
| CMTM4 | CKLF-like MARVEL transmembrane domain containing 4 | -0.72 |
| MYO3A | myosin IIIA | -0.72 |
| LRP11 | low density lipoprotein receptor-related protein 11 | -0.53 |
| ADCY9 | adenylate cyclase 9 | -0.49 |
| FAR2 | fatty acyl CoA reductase 2 | -0.49 |
| FAM126B | family with sequence similarity 126, member B | -0.48 |
| ZXDB | zinc finger, X-linked, duplicated B | -0.44 |
| FADS1 | fatty acid desaturase 1 | -0.43 |
| SNX25 | sorting nexin 25 | -0.42 |
| ADGRF1 | adhesion G protein-coupled receptor F1 | -0.39 |
| GTF2IRD1 | GTF2I repeat domain containing 1 | -0.39 |
| GRHL1 | grainyhead-like 1 (Drosophila) | -0.38 |
| EIF2B4 | eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa | -0.37 |
| TM2D3 | TM2 domain containing 3 | -0.37 |
| MMP14 | matrix metallopeptidase 14 (membrane-inserted) | -0.36 |
| TIMM8A | translocase of inner mitochondrial membrane 8 homolog A (yeast) | -0.34 |
| GSTM4 | glutathione S-transferase mu 4 | -0.33 |
| HIST2H2AA3 | histone cluster 2, H2aa3 | -0.33 |
| HMGCR | 3-hydroxy-3-methylglutaryl-CoA reductase | -0.31 |
| RNF13 | ring finger protein 13 | -0.3 |
| AKAP6 | A kinase (PRKA) anchor protein 6 | -0.3 |
| CERCAM | cerebral endothelial cell adhesion molecule | -0.3 |
| ALDH1A3 | aldehyde dehydrogenase 1 family, member A3 | -0.29 |
| GLI2 | GLI family zinc finger 2 | -0.29 |
| C17ORF53 | chromosome 17 open reading frame 53 | -0.29 |
| HIVEP1 | human immunodeficiency virus type I enhancer binding protein 1 | -0.29 |
| B4GALT2 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2 | -0.29 |
| FGFR2 | fibroblast growth factor receptor 2 | -0.29 |
| SETD5 | SET domain containing 5 | -0.28 |
| TBC1D32 | TBC1 domain family, member 32 | -0.28 |
| PHYH | phytanoyl-CoA 2-hydroxylase | -0.28 |
| ARNTL | aryl hydrocarbon receptor nuclear translocator-like | -0.28 |
| ELL3 | elongation factor RNA polymerase II-like 3 | -0.27 |
| C6ORF62 | chromosome 6 open reading frame 62 | -0.27 |
| ARHGAP28 | Rho GTPase activating protein 28 | -0.27 |
| ZSCAN25 | zinc finger and SCAN domain containing 25 | -0.26 |
| METAP2 | methionyl aminopeptidase 2 | -0.26 |
| ABHD3 | abhydrolase domain containing 3 | -0.25 |
| UGCG | UDP-glucose ceramide glucosyltransferase | -0.25 |
| MPND | MPN domain containing | -0.25 |
| SERINC5 | serine incorporator 5 | -0.25 |
| SHFL | shiftless antiviral inhibitor of ribosomal frameshifting | -0.25 |
| COL14A1 | collagen, type XIV, alpha 1 | -0.25 |
| CABLES1 | Cdk5 and Abl enzyme substrate 1 | -0.25 |
| ZBED9 | zinc finger, BED-type containing 9 | -0.25 |
| ZFP64 | ZFP64 zinc finger protein | -0.24 |
| MROH6 | maestro heat-like repeat family member 6 | -0.24 |
| USP46 | ubiquitin specific peptidase 46 | -0.24 |
| SF1 | splicing factor 1 | -0.24 |
| CYB5D2 | cytochrome b5 domain containing 2 | -0.24 |
| OPHN1 | oligophrenin 1 | -0.24 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.24 |
| CCN3 | cellular communication network factor 3 | -0.23 |
| UNC13D | unc-13 homolog D (C. elegans) | -0.23 |
| IRF3 | interferon regulatory factor 3 | -0.23 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | -0.23 |
| TTC33 | tetratricopeptide repeat domain 33 | -0.23 |
| TRAPPC2 | trafficking protein particle complex 2 | -0.23 |
| PDCD4 | programmed cell death 4 (neoplastic transformation inhibitor) | -0.23 |
| ZBTB8A | zinc finger and BTB domain containing 8A | -0.23 |
| SIGIRR | single immunoglobulin and toll-interleukin 1 receptor (TIR) domain | -0.23 |
| UBE2W | ubiquitin-conjugating enzyme E2W (putative) | -0.23 |
| LMF1 | lipase maturation factor 1 | -0.22 |
| TMEM135 | transmembrane protein 135 | -0.22 |
| SVIP | small VCP/p97-interacting protein | -0.22 |
| CREB3L2 | cAMP responsive element binding protein 3-like 2 | -0.22 |
| ULK1 | unc-51 like autophagy activating kinase 1 | -0.22 |
| SHC4 | SHC (Src homology 2 domain containing) family, member 4 | -0.22 |
| FAS | Fas cell surface death receptor | -0.22 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.22 |
| ZNF227 | zinc finger protein 227 | -0.22 |
| SYTL3 | synaptotagmin-like 3 | -0.22 |
| FABP6 | fatty acid binding protein 6, ileal | -0.22 |
| RMI2 | RecQ mediated genome instability 2 | -0.22 |
| CR2 | complement component (3d/Epstein Barr virus) receptor 2 | -0.22 |
| ZFHX4 | zinc finger homeobox 4 | -0.22 |
| MCFD2 | multiple coagulation factor deficiency 2 | -0.22 |
| ZNF526 | zinc finger protein 526 | -0.22 |
| ETV6 | ets variant 6 | -0.22 |
| MSH5 | mutS homolog 5 | -0.22 |
| TNFRSF12A | tumor necrosis factor receptor superfamily, member 12A | -0.21 |
| NEIL1 | nei endonuclease VIII-like 1 (E. coli) | -0.21 |
| CD58 | CD58 molecule | -0.21 |
| TIMM17B | translocase of inner mitochondrial membrane 17 homolog B (yeast) | -0.21 |
| VMA21 | VMA21 vacuolar H+-ATPase homolog (S. cerevisiae) | -0.21 |
| PKHD1L1 | polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1 | -0.21 |
| ARHGAP22 | Rho GTPase activating protein 22 | -0.21 |
| HAS3 | hyaluronan synthase 3 | -0.21 |
| PRAG1 | PEAK1 related, kinase-activating pseudokinase 1 | -0.21 |
| WDR60 | WD repeat domain 60 | -0.21 |
| FBXL8 | F-box and leucine-rich repeat protein 8 | -0.21 |
| ATMIN | ATM interactor | -0.2 |
| ALYREF | Aly/REF export factor | -0.2 |
| C1ORF50 | chromosome 1 open reading frame 50 | -0.2 |
| GDE1 | glycerophosphodiester phosphodiesterase 1 | -0.2 |
| DBI | diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein) | -0.2 |
| FAM53B | family with sequence similarity 53, member B | -0.2 |
| GATA2 | GATA binding protein 2 | -0.2 |
