SCRIB Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description scribbled planar cell polarity protein|This gene encodes a protein that was identified as being similar to the Drosophila scribble protein. The mammalian protein is involved in tumor suppression pathways. As a scaffold protein involved in cell polarization processes, this protein binds to many other proteins. The encoded protein binds to papillomavirus E6 protein via its PDZ domain and the C-terminus of E6. Two alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. [provided by RefSeq, Nov 2011] (NCBI Entrez Gene Database, 23513)
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Genes

308 genes differentially expressed following the SCRIB gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
LY86 lymphocyte antigen 86 2.82621
TSPAN8 tetraspanin 8 2.82621
LRRN4CL LRRN4 C-terminal like 2.82621
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) 2.82621
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 2.82621
KHDC3L KH domain containing 3-like, subcortical maternal complex member 2.82621
FZD1 frizzled class receptor 1 2.82621
GYS2 glycogen synthase 2 (liver) 2.82621
KLK11 kallikrein-related peptidase 11 2.82621
TMEM207 transmembrane protein 207 2.82621
ALKBH3 alkB, alkylation repair homolog 3 (E. coli) 2.82621
TRIM60 tripartite motif containing 60 2.82621
CPA2 carboxypeptidase A2 (pancreatic) 2.82621
CAMK2B calcium/calmodulin-dependent protein kinase II beta 2.82621
OR56A4 olfactory receptor, family 56, subfamily A, member 4 2.82621
SCEL sciellin 2.82621
OCM oncomodulin 2.82621
LRRC24 leucine rich repeat containing 24 2.82621
FAM151A family with sequence similarity 151, member A 2.82621
RHOJ ras homolog family member J 2.82621
SOST sclerostin 2.82621
CFAP54 cilia and flagella associated 54 2.82621
PADI1 peptidyl arginine deiminase, type I 2.82621
TSPAN19 tetraspanin 19 2.82621
SCRT2 scratch family zinc finger 2 2.75543
SPDYE11 speedy/RINGO cell cycle regulator family member E11 2.65989
CXORF65 chromosome X open reading frame 65 2.65989
ANXA2R annexin A2 receptor 2.65989
NCF1 neutrophil cytosolic factor 1 2.65989
NBPF19 neuroblastoma breakpoint family, member 19 2.65989
MILR1 mast cell immunoglobulin-like receptor 1 2.65989
ACY3 aminoacylase 3 2.65989
PRODH2 proline dehydrogenase (oxidase) 2 2.65989
ABRA actin binding Rho activating protein 2.65989
PDYN prodynorphin 2.65989
CELA3A chymotrypsin-like elastase family, member 3A 2.65989
CARD18 caspase recruitment domain family, member 18 2.65989
BFSP2 beaded filament structural protein 2, phakinin 2.65989
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4 2.65989
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) 2.65989
DSG3 desmoglein 3 2.65989
SPP2 secreted phosphoprotein 2, 24kDa 2.65989
KRTAP12-1 keratin associated protein 12-1 2.65989
TPSD1 tryptase delta 1 2.65989
TRAT1 T cell receptor associated transmembrane adaptor 1 2.65989
METTL21C methyltransferase like 21C 2.65989
TAS2R1 taste receptor, type 2, member 1 2.65989
SLC30A4 solute carrier family 30 (zinc transporter), member 4 2.65989
TNFRSF9 tumor necrosis factor receptor superfamily, member 9 2.65989
HRG histidine-rich glycoprotein 2.65989
S100A5 S100 calcium binding protein A5 2.65989
MPP4 membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4) 2.65989
B3GNT6 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6 2.65989
TYRP1 tyrosinase-related protein 1 2.65989
UNC45B unc-45 homolog B (C. elegans) 2.65989
CD5 CD5 molecule 2.65989
AVPR1A arginine vasopressin receptor 1A 2.65989
FOXC1 forkhead box C1 2.65989
UGT2B4 UDP glucuronosyltransferase 2 family, polypeptide B4 2.65989
MOV10L1 Mov10 RISC complex RNA helicase like 1 2.65989
OR2D3 olfactory receptor, family 2, subfamily D, member 3 2.65989
PGA3 pepsinogen 3, group I (pepsinogen A) 2.65989
GSC goosecoid homeobox 2.65989
S100B S100 calcium binding protein B 2.65989
ZAR1 zygote arrest 1 2.65989
MT3 metallothionein 3 2.65989
TBC1D3I TBC1 domain family member 3I 2.65989
FAM237A family with sequence similarity 237 member A 2.65989
NHERF4 NHERF family PDZ scaffold protein 4 2.65989
H4C15 H4 clustered histone 15 2.65989
SMIM35 small integral membrane protein 35 2.65989
CCDC198 coiled-coil domain containing 198 2.65989
PLAAT4 phospholipase A and acyltransferase 4 2.65989
SLC7A13 solute carrier family 7 (anionic amino acid transporter), member 13 2.65989
S100P S100 calcium binding protein P 2.65989
CCR4 chemokine (C-C motif) receptor 4 2.65989
ZNF280A zinc finger protein 280A 2.65989
P2RY4 pyrimidinergic receptor P2Y, G-protein coupled, 4 2.65989
OR2AT4 olfactory receptor, family 2, subfamily AT, member 4 2.65989
NTRK1 neurotrophic tyrosine kinase, receptor, type 1 2.65989
SF3B3 splicing factor 3b, subunit 3, 130kDa 2.65989
TSSK4 testis-specific serine kinase 4 2.65989
RNF17 ring finger protein 17 2.65989
CST11 cystatin 11 2.65989
TEX101 testis expressed 101 2.65989
TNFRSF19 tumor necrosis factor receptor superfamily, member 19 2.65989
PRR4 proline rich 4 (lacrimal) 2.65989
MYOG myogenin (myogenic factor 4) 2.65989
KLRF1 killer cell lectin-like receptor subfamily F, member 1 2.65989
TBX3 T-box 3 2.65989
B4GALT6 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6 2.65989
LIX1 Lix1 homolog (chicken) 2.65989
OR51B5 olfactory receptor, family 51, subfamily B, member 5 2.65989
TMEM276-ZFTRAF1 TMEM276-ZFTRAF1 readthrough 2.65989
CSNK2A2IP casein kinase 2 subunit alpha' interacting protein 2.65989
ZNF80 zinc finger protein 80 2.65989
ZNF596 zinc finger protein 596 2.65989
LRRC15 leucine rich repeat containing 15 2.65989
NIM1K NIM1 serine/threonine protein kinase 2.65989
ITGAX integrin, alpha X (complement component 3 receptor 4 subunit) 2.65989
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) 2.65989
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 2.65989
LRRC46 leucine rich repeat containing 46 2.65989
APOD apolipoprotein D 2.65989
WFIKKN2 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 2.65989
CRHBP corticotropin releasing hormone binding protein 2.65989
OR8H1 olfactory receptor, family 8, subfamily H, member 1 2.65989
OTOP2 otopetrin 2 2.65989
TCF21 transcription factor 21 2.65989
CDRT15L2 CMT1A duplicated region transcript 15-like 2 2.65989
OR5AU1 olfactory receptor, family 5, subfamily AU, member 1 2.65989
SEC14L3 SEC14-like 3 (S. cerevisiae) 2.65989
MUC13 mucin 13, cell surface associated 2.65989
MCCD1 mitochondrial coiled-coil domain 1 2.65989
COL6A5 collagen, type VI, alpha 5 2.65989
TRIM55 tripartite motif containing 55 2.65989
TRIM50 tripartite motif containing 50 2.65989
TTC16 tetratricopeptide repeat domain 16 2.65989
HUS1B HUS1 checkpoint homolog b (S. pombe) 2.65989
RNASE10 ribonuclease, RNase A family, 10 (non-active) 2.65989
KLHL41 kelch-like family member 41 2.65989
KLF2 Kruppel-like factor 2 2.65989
CLRN1 clarin 1 2.65989
BTNL2 butyrophilin-like 2 2.65989
NT5C1B 5'-nucleotidase, cytosolic IB 2.65989
OPALIN oligodendrocytic myelin paranodal and inner loop protein 2.65989
GRAP2 GRB2-related adaptor protein 2 2.65989
PHGR1 proline/histidine/glycine-rich 1 2.65989
GPR149 G protein-coupled receptor 149 2.65989
CCDC166 coiled-coil domain containing 166 2.65989
TMPRSS12 transmembrane (C-terminal) protease, serine 12 2.65989
LHB luteinizing hormone beta polypeptide 2.65989
NXF2 nuclear RNA export factor 2 2.65989
MMP13 matrix metallopeptidase 13 2.65989
FOXG1 forkhead box G1 2.65989
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3 2.65989
WNT10B wingless-type MMTV integration site family, member 10B 2.65989
OR14A2 olfactory receptor, family 14, subfamily A, member 2 2.65989
C5ORF46 chromosome 5 open reading frame 46 2.65989
RIPK3 receptor-interacting serine-threonine kinase 3 2.65989
RHAG Rh-associated glycoprotein 2.65989
KRTAP10-5 keratin associated protein 10-5 2.65989
PSG3 pregnancy specific beta-1-glycoprotein 3 2.65989
GLT6D1 glycosyltransferase 6 domain containing 1 2.65989
SLN sarcolipin 2.65989
ALOX5AP arachidonate 5-lipoxygenase-activating protein 2.65989
SOSTDC1 sclerostin domain containing 1 2.65989
LRRC74A leucine rich repeat containing 74A 2.65989
GPR65 G protein-coupled receptor 65 2.65989
USP17L2 ubiquitin specific peptidase 17-like family member 2 2.65989
TMEM237 transmembrane protein 237 2.65884
KCTD13 potassium channel tetramerization domain containing 13 2.61985
HPCAL4 hippocalcin like 4 2.60371
GPS1 G protein pathway suppressor 1 2.56492
HLA-G major histocompatibility complex, class I, G 2.54183
TMEM39B transmembrane protein 39B 2.53768
NAP1L4 nucleosome assembly protein 1-like 4 2.52029
ISG20 interferon stimulated exonuclease gene 20kDa 2.4653
ARHGAP4 Rho GTPase activating protein 4 2.46191
VMA21 VMA21 vacuolar H+-ATPase homolog (S. cerevisiae) 2.45757
ZNF213 zinc finger protein 213 2.408
CUZD1 CUB and zona pellucida-like domains 1 2.40525
UBAC2 UBA domain containing 2 2.40091
RNF113B ring finger protein 113B 2.39649
OR2A1 olfactory receptor, family 2, subfamily A, member 1 2.39649
NME7 NME/NM23 family member 7 2.35042
CRYGD crystallin, gamma D 2.34222
IFIT1B interferon-induced protein with tetratricopeptide repeats 1B 2.3208
VTCN1 V-set domain containing T cell activation inhibitor 1 2.3208
LRRC38 leucine rich repeat containing 38 2.3208
TSPAN6 tetraspanin 6 2.31621
AQP5 aquaporin 5 2.30468
MAPK1IP1L mitogen-activated protein kinase 1 interacting protein 1-like 2.30468
PARP12 poly (ADP-ribose) polymerase family, member 12 2.28318
TAMM41 TAM41, mitochondrial translocator assembly and maintenance protein, homolog (S. cerevisiae) 2.27309
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta 2.26092
RWDD1 RWD domain containing 1 2.20466
PSMG2 proteasome (prosome, macropain) assembly chaperone 2 2.19652
ZNF608 zinc finger protein 608 2.17771
CA5B carbonic anhydrase VB, mitochondrial 2.16341
B9D2 B9 protein domain 2 2.16213
TMIGD2 transmembrane and immunoglobulin domain containing 2 2.15481
DMAC2L distal membrane arm assembly component 2 like 2.13717
BCL7A B-cell CLL/lymphoma 7A 2.13651
TCN2 transcobalamin II 2.13622
ATXN10 ataxin 10 2.13461
TCF7 transcription factor 7 (T-cell specific, HMG-box) 2.12779
SCAMP4 secretory carrier membrane protein 4 2.12079
TM7SF2 transmembrane 7 superfamily member 2 2.11246
NDFIP1 Nedd4 family interacting protein 1 2.11104
GLT8D1 glycosyltransferase 8 domain containing 1 2.10474
SUCLA2 succinate-CoA ligase, ADP-forming, beta subunit 2.08967
ACAP1 ArfGAP with coiled-coil, ankyrin repeat and PH domains 1 2.08778
SHISAL1 shisa like 1 2.06761
DYNLT5 dynein light chain Tctex-type family member 5 2.0663
HSBP1 heat shock factor binding protein 1 2.06277
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 2.0468
GALNT16 polypeptide N-acetylgalactosaminyltransferase 16 2.0468
HIGD1A HIG1 hypoxia inducible domain family, member 1A 2.0468
CCDC66 coiled-coil domain containing 66 2.04021
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5 2.03534
ATP6V1H ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H 2.03255
DPEP3 dipeptidase 3 2.03255
MTG1 mitochondrial ribosome-associated GTPase 1 2.02342
POLH polymerase (DNA directed), eta 2.02342
FAM124B family with sequence similarity 124B 2.01519
CRBN cereblon 2.00839

decreased expression

Symbol Name Standardized Value
GPR179 G protein-coupled receptor 179 -2.82621
CLIC5 chloride intracellular channel 5 -2.82621
TPPP3 tubulin polymerization-promoting protein family member 3 -2.82621
CD86 CD86 molecule -2.82621
PAX6 paired box 6 -2.82621
MSC musculin -2.82621
MT1M metallothionein 1M -2.82621
HRH1 histamine receptor H1 -2.82621
LOC114841035 uncharacterized LOC114841035 -2.65989
MLC1 megalencephalic leukoencephalopathy with subcortical cysts 1 -2.65989
TPBGL trophoblast glycoprotein-like -2.65989
SULT1C4 sulfotransferase family, cytosolic, 1C, member 4 -2.65989
PCDHGB4 protocadherin gamma subfamily B, 4 -2.65989
SIX2 SIX homeobox 2 -2.65989
UBTD2 ubiquitin domain containing 2 -2.65989
HMX2 H6 family homeobox 2 -2.65989
NWD2 NACHT and WD repeat domain containing 2 -2.65989
SGCZ sarcoglycan, zeta -2.65989
C11ORF87 chromosome 11 open reading frame 87 -2.65989
SDC2 syndecan 2 -2.65989
CD34 CD34 molecule -2.65989
SLC25A24 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24 -2.65989
SQSTM1 sequestosome 1 -2.65989
POPDC2 popeye domain containing 2 -2.65989
SPINK1 serine peptidase inhibitor, Kazal type 1 -2.65989
TAS2R5 taste receptor, type 2, member 5 -2.65989
USH1G Usher syndrome 1G (autosomal recessive) -2.65989
CIMAP1D CIMAP1 family member D -2.65989
MGP matrix Gla protein -2.65989
H3-7 H3.7 histone (putative) -2.65989
ANKRD40CL ANKRD40 C-terminal like -2.65989
GYPB glycophorin B (MNS blood group) -2.65989
DERPC DERPC proline and glycine rich nuclear protein -2.65989
MUCL1 mucin-like 1 -2.65989
IDI2 isopentenyl-diphosphate delta isomerase 2 -2.65989
PCDHGB5 protocadherin gamma subfamily B, 5 -2.65989
MAPK11 mitogen-activated protein kinase 11 -2.65989
ACOT1 acyl-CoA thioesterase 1 -2.65989
TBX6 T-box 6 -2.65989
COL23A1 collagen, type XXIII, alpha 1 -2.65989
CFAP99 cilia and flagella associated protein 99 -2.65989
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -2.63877
SLC35E1 solute carrier family 35, member E1 -2.60249
ZNF740 zinc finger protein 740 -2.59432
FAM219A family with sequence similarity 219, member A -2.57757
QPRT quinolinate phosphoribosyltransferase -2.57757
CRYBB1 crystallin, beta B1 -2.49503
HHEX hematopoietically expressed homeobox -2.45595
LOC122526780 uncharacterized LOC122526780 -2.45595
PTGER3 prostaglandin E receptor 3 (subtype EP3) -2.45595
ZNF473 zinc finger protein 473 -2.41665
SYN2 synapsin II -2.39649
CMAS cytidine monophosphate N-acetylneuraminic acid synthetase -2.37151
EXOSC6 exosome component 6 -2.34775
GRM6 glutamate receptor, metabotropic 6 -2.32388
ADRA2A adrenoceptor alpha 2A -2.32388
SOS1 son of sevenless homolog 1 (Drosophila) -2.31621
CCDC74A coiled-coil domain containing 74A -2.30909
BBS12 Bardet-Biedl syndrome 12 -2.29727
PPP4R2 protein phosphatase 4, regulatory subunit 2 -2.29727
ADAM10 ADAM metallopeptidase domain 10 -2.28237
JSRP1 junctional sarcoplasmic reticulum protein 1 -2.25843
CSP2 CS pseudogene 2 -2.25843
NCOR1 nuclear receptor corepressor 1 -2.24377
INSIG1 insulin induced gene 1 -2.22405
SLC13A4 solute carrier family 13 (sodium/sulfate symporter), member 4 -2.21231
PMM2 phosphomannomutase 2 -2.16191
RASL12 RAS-like, family 12 -2.15261
POU2F1 POU class 2 homeobox 1 -2.14633
HHIPL1 HHIP-like 1 -2.14502
PRPF31 pre-mRNA processing factor 31 -2.13995
SYPL2 synaptophysin-like 2 -2.13622
ZSWIM3 zinc finger, SWIM-type containing 3 -2.13461
PHKG2 phosphorylase kinase, gamma 2 (testis) -2.13461
WDR55 WD repeat domain 55 -2.12981
WARS2 tryptophanyl tRNA synthetase 2, mitochondrial -2.12779
ZIM3 zinc finger, imprinted 3 -2.12779
SFXN5 sideroflexin 5 -2.12089
PDZD11 PDZ domain containing 11 -2.11571
CACNG7 calcium channel, voltage-dependent, gamma subunit 7 -2.10228
SIRAL1 SIR2 antiphage like 1 -2.08756
ZMAT1 zinc finger, matrin-type 1 -2.07839
SDC3 syndecan 3 -2.07675
TOP2B topoisomerase (DNA) II beta 180kDa -2.05741
CENPQ centromere protein Q -2.05105
SEC24A SEC24 family member A -2.0468
CEP170 centrosomal protein 170kDa -2.04532
TNFSF12 tumor necrosis factor (ligand) superfamily, member 12 -2.04532
GALNT18 polypeptide N-acetylgalactosaminyltransferase 18 -2.04021
SLC35F2 solute carrier family 35, member F2 -2.04021
TXNL4B thioredoxin-like 4B -2.04021
HNRNPUL2 heterogeneous nuclear ribonucleoprotein U-like 2 -2.04021
ZDHHC17 zinc finger, DHHC-type containing 17 -2.03133
TMEM51 transmembrane protein 51 -2.01157
PRR5 proline rich 5 (renal) -2.00839
NAA10 N(alpha)-acetyltransferase 10, NatA catalytic subunit -2.00839
RNF150 ring finger protein 150 -2.00689
CMYA5 cardiomyopathy associated 5 -2.00689
TTLL13 tubulin tyrosine ligase like 13 -2.00689
SPRED1 sprouty-related, EVH1 domain containing 1 -2.00388
PELP1 proline, glutamate and leucine rich protein 1 -2.00388