SD-208 Gene Set

Dataset DeepCoverMOA Drug Mechanisms of Action
Category proteomics
Type drug perturbation
External Link https://pubchem.ncbi.nlm.nih.gov/compound/10316032
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Genes

200 proteins with high or low expression in SD-208 relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.

high expression

Symbol Name Standardized Value
TTLL4 tubulin tyrosine ligase-like family member 4 2.3
DCHS2 dachsous cadherin-related 2 2.13
ALPK3 alpha-kinase 3 1.99
ARHGAP44 Rho GTPase activating protein 44 1.97
SETD9 SET domain containing 9 1.95
MCOLN2 mucolipin 2 1.16
CPN1 carboxypeptidase N, polypeptide 1 1.14
ALAS1 5'-aminolevulinate synthase 1 0.95
ADAM22 ADAM metallopeptidase domain 22 0.79
SDCCAG8 serologically defined colon cancer antigen 8 0.79
JUN jun proto-oncogene 0.69
TP73 tumor protein p73 0.65
TACSTD2 tumor-associated calcium signal transducer 2 0.64
AHR aryl hydrocarbon receptor 0.61
PLPP2 phospholipid phosphatase 2 0.6
DES desmin 0.59
HSH2D hematopoietic SH2 domain containing 0.57
SKI SKI proto-oncogene 0.57
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase 0.55
ZNF483 zinc finger protein 483 0.52
PMF1 polyamine-modulated factor 1 0.51
AAMDC adipogenesis associated, Mth938 domain containing 0.5
TNK2 tyrosine kinase, non-receptor, 2 0.5
DGCR8 DGCR8 microprocessor complex subunit 0.48
GLRX glutaredoxin (thioltransferase) 0.46
TGFBR3 transforming growth factor, beta receptor III 0.45
HSBP1 heat shock factor binding protein 1 0.45
BLZF1 basic leucine zipper nuclear factor 1 0.44
ADIRF adipogenesis regulatory factor 0.43
S100A14 S100 calcium binding protein A14 0.41
MYH13 myosin, heavy chain 13, skeletal muscle 0.41
ARHGAP22 Rho GTPase activating protein 22 0.4
GM2A GM2 ganglioside activator 0.4
TNS4 tensin 4 0.39
HBA1 hemoglobin, alpha 1 0.39
DPY30 dpy-30 homolog (C. elegans) 0.39
DMTF1 cyclin D binding myb-like transcription factor 1 0.39
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13 0.38
ZSWIM7 zinc finger, SWIM-type containing 7 0.38
SBSN suprabasin 0.38
LZTS1 leucine zipper, putative tumor suppressor 1 0.38
MED10 mediator complex subunit 10 0.37
RPL36AL ribosomal protein L36a-like 0.37
USP19 ubiquitin specific peptidase 19 0.37
GID8 GID complex subunit 8 0.35
PDE7A phosphodiesterase 7A 0.35
EPC2 enhancer of polycomb homolog 2 (Drosophila) 0.35
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B 0.34
SBNO2 strawberry notch homolog 2 (Drosophila) 0.34
S100A5 S100 calcium binding protein A5 0.34
SYNE3 spectrin repeat containing, nuclear envelope family member 3 0.34
OBSL1 obscurin-like 1 0.34
FAM136A family with sequence similarity 136, member A 0.33
PLEKHA6 pleckstrin homology domain containing, family A member 6 0.33
EXPH5 exophilin 5 0.33
SH3RF2 SH3 domain containing ring finger 2 0.33
H2AZ1 H2A.Z variant histone 1 0.32
TMOD2 tropomodulin 2 (neuronal) 0.32
ANO8 anoctamin 8 0.31
PLAUR plasminogen activator, urokinase receptor 0.31
NDFIP2 Nedd4 family interacting protein 2 0.31
ATG2B autophagy related 2B 0.31
MSX1 msh homeobox 1 0.31
HNRNPK heterogeneous nuclear ribonucleoprotein K 0.31
EIF4EBP2 eukaryotic translation initiation factor 4E binding protein 2 0.31
NT5E 5'-nucleotidase, ecto (CD73) 0.31
CHST3 carbohydrate (chondroitin 6) sulfotransferase 3 0.3
TMEM200A transmembrane protein 200A 0.3
DUSP6 dual specificity phosphatase 6 0.3
N6AMT1 N-6 adenine-specific DNA methyltransferase 1 (putative) 0.3
LAMA1 laminin, alpha 1 0.3
ZNF185 zinc finger protein 185 (LIM domain) 0.3
BANF1 barrier to autointegration factor 1 0.29
PGRMC1 progesterone receptor membrane component 1 0.29
TMUB2 transmembrane and ubiquitin-like domain containing 2 0.29
TRIAP1 TP53 regulated inhibitor of apoptosis 1 0.29
TRIB3 tribbles pseudokinase 3 0.29
DUSP4 dual specificity phosphatase 4 0.29
PKN3 protein kinase N3 0.29
LGALS1 lectin, galactoside-binding, soluble, 1 0.29
VSNL1 visinin-like 1 0.29
NEIL3 nei endonuclease VIII-like 3 (E. coli) 0.29
CDON cell adhesion associated, oncogene regulated 0.29
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.29
ACAD10 acyl-CoA dehydrogenase family, member 10 0.29
NF1 neurofibromin 1 0.29
GGACT gamma-glutamylamine cyclotransferase 0.28
OASL 2'-5'-oligoadenylate synthetase-like 0.28
ITGB4 integrin, beta 4 0.28
TRIM32 tripartite motif containing 32 0.28
XTBD1 XRN2 binding domain containing 1 0.27
CORO2B coronin, actin binding protein, 2B 0.27
MACC1 metastasis associated in colon cancer 1 0.27
ACVR1B activin A receptor, type IB 0.27
PXMP4 peroxisomal membrane protein 4, 24kDa 0.27
COL1A1 collagen, type I, alpha 1 0.27
IFI30 interferon, gamma-inducible protein 30 0.27
UQCRH ubiquinol-cytochrome c reductase hinge protein 0.27
S100A6 S100 calcium binding protein A6 0.27
RREB1 ras responsive element binding protein 1 0.27

low expression

Symbol Name Standardized Value
AZGP1 alpha-2-glycoprotein 1, zinc-binding -2.7
PIP prolactin-induced protein -1.23
CCDC15 coiled-coil domain containing 15 -1.09
FBXO31 F-box protein 31 -0.81
ADGRF1 adhesion G protein-coupled receptor F1 -0.75
C12ORF66 chromosome 12 open reading frame 66 -0.7
DHRS3 dehydrogenase/reductase (SDR family) member 3 -0.66
TRIML2 tripartite motif family-like 2 -0.57
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 -0.57
B3GALNT2 beta-1,3-N-acetylgalactosaminyltransferase 2 -0.57
DNAH9 dynein, axonemal, heavy chain 9 -0.55
CDC14A cell division cycle 14A -0.53
SMAD3 SMAD family member 3 -0.51
CROCC2 ciliary rootlet coiled-coil, rootletin family member 2 -0.5
ZNF136 zinc finger protein 136 -0.49
KPTN kaptin (actin binding protein) -0.48
LYST lysosomal trafficking regulator -0.48
STC2 stanniocalcin 2 -0.46
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -0.46
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -0.46
PPP1R11 protein phosphatase 1, regulatory (inhibitor) subunit 11 -0.45
C19ORF54 chromosome 19 open reading frame 54 -0.44
RPP21 ribonuclease P/MRP 21kDa subunit -0.43
NBPF20 neuroblastoma breakpoint family, member 20 -0.41
NDST1 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1 -0.4
B3GNTL1 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like 1 -0.39
GDF15 growth differentiation factor 15 -0.39
CCNI cyclin I -0.39
AMACR alpha-methylacyl-CoA racemase -0.39
ZNF28 zinc finger protein 28 -0.38
TBC1D31 TBC1 domain family, member 31 -0.38
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1 -0.37
C4ORF33 chromosome 4 open reading frame 33 -0.37
CR2 complement component (3d/Epstein Barr virus) receptor 2 -0.37
AFG1L AFG1 like ATPase -0.37
ALDH1A3 aldehyde dehydrogenase 1 family, member A3 -0.36
F8A1 coagulation factor VIII-associated 1 -0.36
DNAAF3 dynein, axonemal, assembly factor 3 -0.36
PIEZO1 piezo-type mechanosensitive ion channel component 1 -0.35
MKNK2 MAP kinase interacting serine/threonine kinase 2 -0.35
ZC3H6 zinc finger CCCH-type containing 6 -0.34
SCARA3 scavenger receptor class A, member 3 -0.34
BET1 Bet1 golgi vesicular membrane trafficking protein -0.34
COL14A1 collagen, type XIV, alpha 1 -0.34
ODC1 ornithine decarboxylase 1 -0.33
NRIP1 nuclear receptor interacting protein 1 -0.33
SLC19A2 solute carrier family 19 (thiamine transporter), member 2 -0.33
MRAS muscle RAS oncogene homolog -0.33
ENDOV endonuclease V -0.32
CALHM2 calcium homeostasis modulator 2 -0.32
SERINC1 serine incorporator 1 -0.32
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit -0.32
ARFGEF3 ARFGEF family member 3 -0.32
ZFP36L1 ZFP36 ring finger protein-like 1 -0.32
DDA1 DET1 and DDB1 associated 1 -0.32
APOBEC3D apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D -0.32
DECR2 2,4-dienoyl CoA reductase 2, peroxisomal -0.31
WDTC1 WD and tetratricopeptide repeats 1 -0.31
RHBDF1 rhomboid 5 homolog 1 (Drosophila) -0.31
BCORL1 BCL6 corepressor-like 1 -0.31
FASTK Fas-activated serine/threonine kinase -0.31
PDE4B phosphodiesterase 4B, cAMP-specific -0.3
ZNF724 zinc finger protein 724 -0.3
ILRUN inflammation and lipid regulator with UBA-like and NBR1-like domains -0.3
RNF141 ring finger protein 141 -0.3
NCKAP1L NCK-associated protein 1-like -0.3
ARL6IP6 ADP-ribosylation factor-like 6 interacting protein 6 -0.3
ZNF142 zinc finger protein 142 -0.3
CLDND1 claudin domain containing 1 -0.3
DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1) -0.29
REXO1 REX1, RNA exonuclease 1 homolog (S. cerevisiae) -0.29
MRPL18 mitochondrial ribosomal protein L18 -0.29
HMGN4 high mobility group nucleosomal binding domain 4 -0.29
ADCY6 adenylate cyclase 6 -0.29
B3GALT6 UDP-Gal:betaGal beta 1,3-galactosyltransferase polypeptide 6 -0.29
ZBTB20 zinc finger and BTB domain containing 20 -0.29
CDK6 cyclin-dependent kinase 6 -0.28
STARD9 StAR-related lipid transfer (START) domain containing 9 -0.28
HGFAC HGF activator -0.28
ZNF721 zinc finger protein 721 -0.28
KLC3 kinesin light chain 3 -0.28
TNIP2 TNFAIP3 interacting protein 2 -0.28
SEZ6L2 seizure related 6 homolog (mouse)-like 2 -0.28
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.28
RAB19 RAB19, member RAS oncogene family -0.28
ZNF264 zinc finger protein 264 -0.28
PDIA4 protein disulfide isomerase family A, member 4 -0.28
THAP9 THAP domain containing 9 -0.28
TRIM13 tripartite motif containing 13 -0.28
SLC16A10 solute carrier family 16 (aromatic amino acid transporter), member 10 -0.28
TXNDC15 thioredoxin domain containing 15 -0.27
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -0.27
SP6 Sp6 transcription factor -0.27
ARL5A ADP-ribosylation factor-like 5A -0.27
SPRTN SprT-like N-terminal domain -0.27
TMEM259 transmembrane protein 259 -0.27
GCH1 GTP cyclohydrolase 1 -0.27
OGFRL1 opioid growth factor receptor-like 1 -0.27
RNF26 ring finger protein 26 -0.27
ABITRAM actin binding transcription modulator -0.27