SDHA Gene Set

Dataset LINCS L1000 CMAP CRISPR Knockout Consensus Signatures
Category transcriptomics
Type gene perturbation
Description succinate dehydrogenase complex, subunit A, flavoprotein (Fp)|This gene encodes a major catalytic subunit of succinate-ubiquinone oxidoreductase, a complex of the mitochondrial respiratory chain. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. Mutations in this gene have been associated with a form of mitochondrial respiratory chain deficiency known as Leigh Syndrome. A pseudogene has been identified on chromosome 3q29. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2014] (NCBI Entrez Gene Database, 6389)
External Link https://ncbi.nlm.nih.gov/gene/6389
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Genes

497 genes differentially expressed following the SDHA gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.

increased expression

Symbol Name Standardized Value
LAMB1 laminin, beta 1 0.0147219
CXCL14 chemokine (C-X-C motif) ligand 14 0.0138158
MGLL monoglyceride lipase 0.0130782
ADGRG2 adhesion G protein-coupled receptor G2 0.0124247
RTN2 reticulon 2 0.0121522
JMJD6 jumonji domain containing 6 0.0115926
PDGFD platelet derived growth factor D 0.0115914
CASP10 caspase 10, apoptosis-related cysteine peptidase 0.0113675
VCL vinculin 0.011022
CD40 CD40 molecule, TNF receptor superfamily member 5 0.0110121
PROM1 prominin 1 0.0110089
LOXL2 lysyl oxidase-like 2 0.0106503
NPTX2 neuronal pentraxin II 0.0103797
ASS1 argininosuccinate synthase 1 0.010222
DLK1 delta-like 1 homolog (Drosophila) 0.0100276
LY75 lymphocyte antigen 75 0.00988102
RHOBTB3 Rho-related BTB domain containing 3 0.0097533
L1CAM L1 cell adhesion molecule 0.00967428
NRCAM neuronal cell adhesion molecule 0.00964322
PBX3 pre-B-cell leukemia homeobox 3 0.00956669
ADGRG6 adhesion G protein-coupled receptor G6 0.0095166
RHOF ras homolog family member F (in filopodia) 0.00945906
TFPI2 tissue factor pathway inhibitor 2 0.00944795
IER5 immediate early response 5 0.00928829
QPRT quinolinate phosphoribosyltransferase 0.00927503
ECM1 extracellular matrix protein 1 0.00912489
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein 0.00907783
FN1 fibronectin 1 0.00899145
RND3 Rho family GTPase 3 0.00891292
PLXNB2 plexin B2 0.00889769
SCUBE2 signal peptide, CUB domain, EGF-like 2 0.00884354
EEF1A2 eukaryotic translation elongation factor 1 alpha 2 0.00879757
FCGBP Fc fragment of IgG binding protein 0.00870195
DHRS2 dehydrogenase/reductase (SDR family) member 2 0.0086766
OLFML2A olfactomedin-like 2A 0.00865528
NEFH neurofilament, heavy polypeptide 0.00859586
MBD1 methyl-CpG binding domain protein 1 0.0085061
NID2 nidogen 2 (osteonidogen) 0.00847058
NLRP2 NLR family, pyrin domain containing 2 0.00845942
SAMD4A sterile alpha motif domain containing 4A 0.00845533
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein 0.00844746
SIK1 salt-inducible kinase 1 0.00833641
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2 0.00833398
GAL galanin/GMAP prepropeptide 0.00832839
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.00830502
RBM34 RNA binding motif protein 34 0.00824016
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.00822174
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0081901
TFF1 trefoil factor 1 0.0081822
ACKR3 atypical chemokine receptor 3 0.00816207
HILPDA hypoxia inducible lipid droplet-associated 0.00813212
SMAD3 SMAD family member 3 0.00809502
RBPMS RNA binding protein with multiple splicing 0.00793831
ADCY9 adenylate cyclase 9 0.00784046
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7 0.00780931
PLIN2 perilipin 2 0.00780329
COL9A3 collagen, type IX, alpha 3 0.0077703
SIDT2 SID1 transmembrane family, member 2 0.00776569
ITPRID2 ITPR interacting domain containing 2 0.00770568
RET ret proto-oncogene 0.00769597
PTGER4 prostaglandin E receptor 4 (subtype EP4) 0.00766101
KRT20 keratin 20, type I 0.00764379
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.00762481
AMOTL2 angiomotin like 2 0.00760467
L1TD1 LINE-1 type transposase domain containing 1 0.00752846
MAN1C1 mannosidase, alpha, class 1C, member 1 0.00750923
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 0.00750891
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8 0.00748549
GOLGA8H golgin A8 family, member H 0.00748542
LITAF lipopolysaccharide-induced TNF factor 0.00748318
IGFBP4 insulin-like growth factor binding protein 4 0.00744213
SYNGR3 synaptogyrin 3 0.00744148
TSPAN13 tetraspanin 13 0.00743013
CDA cytidine deaminase 0.00737985
PBX1 pre-B-cell leukemia homeobox 1 0.00735544
TPBG trophoblast glycoprotein 0.00735375
TCTA T-cell leukemia translocation altered 0.00734703
CFH complement factor H 0.00729209
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor) 0.00728669
CARD10 caspase recruitment domain family, member 10 0.00728319
NPY1R neuropeptide Y receptor Y1 0.00727809
FSTL1 follistatin-like 1 0.00727476
TSC22D2 TSC22 domain family, member 2 0.00723054
MVP major vault protein 0.0072267
ZBTB20 zinc finger and BTB domain containing 20 0.00722452
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5 0.00719322
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2 0.0071759
MAGEA3 melanoma antigen family A3 0.0071452
LRP4 low density lipoprotein receptor-related protein 4 0.00713075
HEATR1 HEAT repeat containing 1 0.00706632
LPCAT1 lysophosphatidylcholine acyltransferase 1 0.00706074
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 0.00701363
NOTCH1 notch 1 0.00699275
EHD3 EH-domain containing 3 0.00693558
NANOG Nanog homeobox 0.00692915
SYNPO synaptopodin 0.00686604
CAV1 caveolin 1, caveolae protein, 22kDa 0.00684879
MATN2 matrilin 2 0.00684443
DCHS1 dachsous cadherin-related 1 0.00678268
PIM1 Pim-1 proto-oncogene, serine/threonine kinase 0.00671995
DYNLL1 dynein, light chain, LC8-type 1 0.006716
ITIH5 inter-alpha-trypsin inhibitor heavy chain family, member 5 0.00667959
RGS5 regulator of G-protein signaling 5 0.00665163
GBP2 guanylate binding protein 2, interferon-inducible 0.00665061
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 0.00664446
NOTCH2NL notch 2 N-terminal like 0.00660682
STS steroid sulfatase (microsomal), isozyme S 0.00654199
PIP prolactin-induced protein 0.00652743
LXN latexin 0.00650981
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1 0.00649507
ECPAS Ecm29 proteasome adaptor and scaffold 0.00646487
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans) 0.0064558
TNS3 tensin 3 0.00645366
CALCA calcitonin-related polypeptide alpha 0.00640328
PLEKHA5 pleckstrin homology domain containing, family A member 5 0.00636868
DENND3 DENN/MADD domain containing 3 0.00634502
FGFR1 fibroblast growth factor receptor 1 0.00631196
RHBDF1 rhomboid 5 homolog 1 (Drosophila) 0.00630972
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.00629442
RABAC1 Rab acceptor 1 (prenylated) 0.00628171
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9 0.00626199
FKBP11 FK506 binding protein 11, 19 kDa 0.00625817
EPB41L3 erythrocyte membrane protein band 4.1-like 3 0.00624643
APOD apolipoprotein D 0.00621575
TSPAN12 tetraspanin 12 0.00621448
CYBA cytochrome b-245, alpha polypeptide 0.00621174
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa 0.00620255
MTUS1 microtubule associated tumor suppressor 1 0.00619792
COL4A5 collagen, type IV, alpha 5 0.00617832
SOWAHC sosondowah ankyrin repeat domain family member C 0.00617328
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) 0.00616671
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1) 0.00616554
LEPROTL1 leptin receptor overlapping transcript-like 1 0.00616254
GAS1 growth arrest-specific 1 0.00613802
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1 0.0061139
SEZ6L2 seizure related 6 homolog (mouse)-like 2 0.00610997
LIN28A lin-28 homolog A (C. elegans) 0.00609106
RABEP2 rabaptin, RAB GTPase binding effector protein 2 0.0060886
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) 0.00608059
MICAL1 microtubule associated monooxygenase, calponin and LIM domain containing 1 0.00608026
TUBB2B tubulin, beta 2B class IIb 0.00607162
CLIC3 chloride intracellular channel 3 0.00605292
NID1 nidogen 1 0.00595162
CGA glycoprotein hormones, alpha polypeptide 0.00594199
AMIGO2 adhesion molecule with Ig-like domain 2 0.00588944
PTK2 protein tyrosine kinase 2 0.00588172
BIRC3 baculoviral IAP repeat containing 3 0.0058784
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) 0.0058766
ELF4 E74-like factor 4 (ets domain transcription factor) 0.00584257
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.00583563
ZG16 zymogen granule protein 16 0.0058321
PHLDA3 pleckstrin homology-like domain, family A, member 3 0.00583096
HSPB8 heat shock 22kDa protein 8 0.00580313
ANO10 anoctamin 10 0.00579088
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase 0.00578107
SPRY4 sprouty homolog 4 (Drosophila) 0.00577753
MAST4 microtubule associated serine/threonine kinase family member 4 0.00577471
CX3CR1 chemokine (C-X3-C motif) receptor 1 0.00577314
DUSP5 dual specificity phosphatase 5 0.005761
CTSA cathepsin A 0.00575917
GPX3 glutathione peroxidase 3 0.00575626
TGFBR3 transforming growth factor, beta receptor III 0.00575127
NPIPB3 nuclear pore complex interacting protein family, member B3 0.00574798
HSPA1A heat shock 70kDa protein 1A 0.00574727
SEC14L1 SEC14-like 1 (S. cerevisiae) 0.00573607
HERC1 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 0.00573473
TES testin LIM domain protein 0.00571877
RCAN2 regulator of calcineurin 2 0.00571833
ADIRF adipogenesis regulatory factor 0.00570509
BMP2 bone morphogenetic protein 2 0.00568743
MFSD10 major facilitator superfamily domain containing 10 0.00567708
SNX11 sorting nexin 11 0.00567275
KLC1 kinesin light chain 1 0.00566454
CRABP1 cellular retinoic acid binding protein 1 0.00565994
GADD45A growth arrest and DNA-damage-inducible, alpha 0.00565916
PELI1 pellino E3 ubiquitin protein ligase 1 0.00564092
RFTN1 raftlin, lipid raft linker 1 0.00563485
LIMA1 LIM domain and actin binding 1 0.00562809
RGS16 regulator of G-protein signaling 16 0.00562532
TRIM14 tripartite motif containing 14 0.00558097
GPRC5B G protein-coupled receptor, class C, group 5, member B 0.00557192
POU5F1P3 POU class 5 homeobox 1 pseudogene 3 0.00555041
KIF13B kinesin family member 13B 0.00554276
TENT5A terminal nucleotidyltransferase 5A 0.00553056
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) 0.00552809
ISYNA1 inositol-3-phosphate synthase 1 0.00552639
NR2F2 nuclear receptor subfamily 2, group F, member 2 0.00552524
MRPS16 mitochondrial ribosomal protein S16 0.00549485
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16 0.00548511
NVL nuclear VCP-like 0.00548351
ADD3 adducin 3 (gamma) 0.00545437
CLTB clathrin, light chain B 0.00544628
SASH1 SAM and SH3 domain containing 1 0.00543501
SLC30A1 solute carrier family 30 (zinc transporter), member 1 0.0054181
USP9X ubiquitin specific peptidase 9, X-linked 0.00541074
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 0.00540918
PLOD3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 0.00539351
LMO2 LIM domain only 2 (rhombotin-like 1) 0.0053878
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 0.00538267
EPS8L2 EPS8-like 2 0.00534238
ARHGEF40 Rho guanine nucleotide exchange factor (GEF) 40 0.00532826
HMOX1 heme oxygenase 1 0.0053246
TTC39A tetratricopeptide repeat domain 39A 0.00531637
CHMP2A charged multivesicular body protein 2A 0.00531412
ISG15 ISG15 ubiquitin-like modifier 0.00530417
TBC1D2B TBC1 domain family, member 2B 0.00530012
NSF N-ethylmaleimide-sensitive factor 0.00529036
FSCN1 fascin actin-bundling protein 1 0.00528853
HEPH hephaestin 0.00527636
IL18 interleukin 18 0.00526607
CYB5R3 cytochrome b5 reductase 3 0.00526516
LECT1 leukocyte cell derived chemotaxin 1 0.0052278
ENTPD4 ectonucleoside triphosphate diphosphohydrolase 4 0.00522589
CAVIN1 caveolae associated protein 1 0.00522483
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1 0.0052109
REEP1 receptor accessory protein 1 0.0052068
IGSF3 immunoglobulin superfamily, member 3 0.00520318
ZNF160 zinc finger protein 160 0.0051977
FBP1 fructose-1,6-bisphosphatase 1 0.00519215
VNN1 vanin 1 0.0051907
SYNM synemin, intermediate filament protein 0.0051877
PGAM1 phosphoglycerate mutase 1 (brain) 0.00518683
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.00516132
JPT1 Jupiter microtubule associated homolog 1 0.00515782
ITM2C integral membrane protein 2C 0.00515343
SDC1 syndecan 1 0.00512635
SPINK1 serine peptidase inhibitor, Kazal type 1 0.00512591
NES nestin 0.0051202
INAVA innate immunity activator 0.005115
NEFM neurofilament, medium polypeptide 0.00511206
POU5F1B POU class 5 homeobox 1B 0.00510793
LEFTY1 left-right determination factor 1 0.00510433
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1 0.00508938
PLLP plasmolipin 0.00508399
CRHBP corticotropin releasing hormone binding protein 0.0050738
EXOC7 exocyst complex component 7 0.00506051
IPW imprinted in Prader-Willi syndrome (non-protein coding) 0.00505676
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase) 0.00505675
ACTA1 actin, alpha 1, skeletal muscle 0.00505253
PLAGL1 pleiomorphic adenoma gene-like 1 0.00505196
FZD10 frizzled class receptor 10 0.00505085
ZDHHC7 zinc finger, DHHC-type containing 7 0.00505
TFF3 trefoil factor 3 (intestinal) 0.00504904
POLR3G polymerase (RNA) III (DNA directed) polypeptide G (32kD) 0.00504789
ARHGAP17 Rho GTPase activating protein 17 0.00504142
PLCE1 phospholipase C, epsilon 1 0.00503494
RAB29 RAB29, member RAS oncogene family 0.00502605
QSOX1 quiescin Q6 sulfhydryl oxidase 1 0.00500869

decreased expression

Symbol Name Standardized Value
LTF lactotransferrin -0.0217175
CSTA cystatin A (stefin A) -0.01345
H1-0 H1.0 linker histone -0.0117232
STEAP1 six transmembrane epithelial antigen of the prostate 1 -0.0112425
AMDHD2 amidohydrolase domain containing 2 -0.0107264
MLF1 myeloid leukemia factor 1 -0.0102914
IGFBP2 insulin-like growth factor binding protein 2, 36kDa -0.0101801
CETN2 centrin, EF-hand protein, 2 -0.01012
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -0.00972431
WFDC2 WAP four-disulfide core domain 2 -0.00952257
CSRP3 cysteine and glycine-rich protein 3 (cardiac LIM protein) -0.00934408
SFTPA2 surfactant protein A2 -0.00929057
NQO1 NAD(P)H dehydrogenase, quinone 1 -0.00913092
HP haptoglobin -0.00912051
CIAO3 cytosolic iron-sulfur assembly component 3 -0.00904368
CPA3 carboxypeptidase A3 (mast cell) -0.0088754
TACSTD2 tumor-associated calcium signal transducer 2 -0.00878063
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.00875969
RAD23B RAD23 homolog B (S. cerevisiae) -0.00864772
KRT15 keratin 15, type I -0.00839716
SPTSSA serine palmitoyltransferase, small subunit A -0.00839661
PHYH phytanoyl-CoA 2-hydroxylase -0.00837276
ALOX5 arachidonate 5-lipoxygenase -0.00824591
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14 -0.00820258
GLUL glutamate-ammonia ligase -0.00815695
IQCG IQ motif containing G -0.00809533
TPSAB1 tryptase alpha/beta 1 -0.00807761
S100A9 S100 calcium binding protein A9 -0.00780893
GARS1 glycyl-tRNA synthetase 1 -0.0077839
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3 -0.00771244
CST3 cystatin C -0.00744429
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -0.00739289
NUSAP1 nucleolar and spindle associated protein 1 -0.00739013
GLOD4 glyoxalase domain containing 4 -0.00738562
SFTPB surfactant protein B -0.00732919
ATP6V0E2 ATPase, H+ transporting V0 subunit e2 -0.00729716
THAP12 THAP domain containing 12 -0.00727988
BANF1 barrier to autointegration factor 1 -0.0071933
PDP1 pyruvate dehyrogenase phosphatase catalytic subunit 1 -0.00706539
FZD6 frizzled class receptor 6 -0.00701229
ASNS asparagine synthetase (glutamine-hydrolyzing) -0.00699217
S100A2 S100 calcium binding protein A2 -0.00692526
NIPSNAP2 nipsnap homolog 2 -0.0069142
ERH enhancer of rudimentary homolog (Drosophila) -0.00690238
LYZ lysozyme -0.0068927
SULF1 sulfatase 1 -0.00686209
NKX3-1 NK3 homeobox 1 -0.00680534
UBE2E3 ubiquitin-conjugating enzyme E2E 3 -0.00676782
TMEM231 transmembrane protein 231 -0.00674917
SPON1 spondin 1, extracellular matrix protein -0.00673501
SSBP2 single-stranded DNA binding protein 2 -0.00672495
CEMIP cell migration inducing protein, hyaluronan binding -0.00668504
MNDA myeloid cell nuclear differentiation antigen -0.00666969
IFRD2 interferon-related developmental regulator 2 -0.00660806
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide -0.00659135
DAZAP2 DAZ associated protein 2 -0.00653184
ARHGAP26 Rho GTPase activating protein 26 -0.00647849
CD2 CD2 molecule -0.00645739
ZDHHC6 zinc finger, DHHC-type containing 6 -0.00640604
CHPT1 choline phosphotransferase 1 -0.00636206
EFHC2 EF-hand domain (C-terminal) containing 2 -0.00632962
MPP1 membrane protein, palmitoylated 1, 55kDa -0.00629835
TSPYL5 TSPY-like 5 -0.00628913
NUPR1 nuclear protein, transcriptional regulator, 1 -0.00628678
CEP55 centrosomal protein 55kDa -0.00627228
SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3 -0.00626427
F5 coagulation factor V (proaccelerin, labile factor) -0.00624673
NPC2 Niemann-Pick disease, type C2 -0.00623667
VTCN1 V-set domain containing T cell activation inhibitor 1 -0.00619256
CDH3 cadherin 3, type 1, P-cadherin (placental) -0.00616469
PCP4 Purkinje cell protein 4 -0.00615751
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase -0.00614046
SIAH2 siah E3 ubiquitin protein ligase 2 -0.00608497
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) -0.00607935
CGRRF1 cell growth regulator with ring finger domain 1 -0.00607748
ERBB4 erb-b2 receptor tyrosine kinase 4 -0.00602134
ABI1 abl-interactor 1 -0.00601982
TAGLN2 transgelin 2 -0.00599497
IFT57 intraflagellar transport 57 -0.00599023
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast) -0.00593573
GPNMB glycoprotein (transmembrane) nmb -0.00592244
DHCR7 7-dehydrocholesterol reductase -0.00591635
RPRD1A regulation of nuclear pre-mRNA domain containing 1A -0.00588526
SOX9 SRY (sex determining region Y)-box 9 -0.00587669
CSF3R colony stimulating factor 3 receptor (granulocyte) -0.0058743
PEA15 phosphoprotein enriched in astrocytes 15 -0.00587291
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39) -0.00587222
FCN1 ficolin (collagen/fibrinogen domain containing) 1 -0.00587094
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin) -0.00587016
STK38L serine/threonine kinase 38 like -0.00586143
EXOC5 exocyst complex component 5 -0.00585786
PCLO piccolo presynaptic cytomatrix protein -0.00584057
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1 -0.00578054
NMT2 N-myristoyltransferase 2 -0.0057781
RNF41 ring finger protein 41, E3 ubiquitin protein ligase -0.005764
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 -0.00575948
KIAA0226L KIAA0226-like -0.00575137
CD1E CD1e molecule -0.00574201
RFC4 replication factor C (activator 1) 4, 37kDa -0.00573309
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 -0.00570864
SERP1 stress-associated endoplasmic reticulum protein 1 -0.00570854
HMGB2 high mobility group box 2 -0.00570295
RSL24D1 ribosomal L24 domain containing 1 -0.00568072
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1 -0.00566717
OAT ornithine aminotransferase -0.00563349
SRP9 signal recognition particle 9kDa -0.00561442
ZNF410 zinc finger protein 410 -0.00561334
MPO myeloperoxidase -0.00561188
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma -0.00560301
GSAP gamma-secretase activating protein -0.00560209
C5ORF28 chromosome 5 open reading frame 28 -0.00558345
YME1L1 YME1-like 1 ATPase -0.00557889
GABRP gamma-aminobutyric acid (GABA) A receptor, pi -0.00557138
ORC4 origin recognition complex, subunit 4 -0.00556401
SNRPB small nuclear ribonucleoprotein polypeptides B and B1 -0.00556297
IFI16 interferon, gamma-inducible protein 16 -0.00555051
NRN1 neuritin 1 -0.00552149
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 -0.00551315
CRLF1 cytokine receptor-like factor 1 -0.00548627
RCN2 reticulocalbin 2, EF-hand calcium binding domain -0.00547415
ALDH3A2 aldehyde dehydrogenase 3 family, member A2 -0.00545634
LTB lymphotoxin beta (TNF superfamily, member 3) -0.00545086
RAG1 recombination activating gene 1 -0.00544124
SGMS1 sphingomyelin synthase 1 -0.0054379
KRT5 keratin 5, type II -0.00543473
SH3GLB2 SH3-domain GRB2-like endophilin B2 -0.00543041
KRCC1 lysine-rich coiled-coil 1 -0.00541137
ELANE elastase, neutrophil expressed -0.00540853
PRPF18 pre-mRNA processing factor 18 -0.00540153
TMC5 transmembrane channel-like 5 -0.00538696
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) -0.00538344
MRPL13 mitochondrial ribosomal protein L13 -0.00536724
RAPSN receptor-associated protein of the synapse -0.0053661
HBB hemoglobin, beta -0.00535814
ZBTB18 zinc finger and BTB domain containing 18 -0.00535566
S100A12 S100 calcium binding protein A12 -0.00532719
IL1R1 interleukin 1 receptor, type I -0.00530984
HSPA14 heat shock 70kDa protein 14 -0.00530096
CDC45 cell division cycle 45 -0.00529105
NOTCH3 notch 3 -0.00527033
SDHAF3 succinate dehydrogenase complex assembly factor 3 -0.00526069
FAM171A1 family with sequence similarity 171, member A1 -0.00523905
NEDD8 neural precursor cell expressed, developmentally down-regulated 8 -0.00523255
CDS1 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1 -0.00523197
RPS5 ribosomal protein S5 -0.0052287
GCA grancalcin, EF-hand calcium binding protein -0.00522308
AQP9 aquaporin 9 -0.00521077
NIBAN1 niban apoptosis regulator 1 -0.00521018
EMP1 epithelial membrane protein 1 -0.00520762
IDI1 isopentenyl-diphosphate delta isomerase 1 -0.00519821
APOM apolipoprotein M -0.00519217
PLGRKT plasminogen receptor, C-terminal lysine transmembrane protein -0.00518713
TPD52L1 tumor protein D52-like 1 -0.0051728
GRK2 G protein-coupled receptor kinase 2 -0.00517097
RNF141 ring finger protein 141 -0.00516887
MREG melanoregulin -0.00516665
GAB2 GRB2-associated binding protein 2 -0.00515965
GSTA4 glutathione S-transferase alpha 4 -0.00515871
CCDC176 coiled-coil domain containing 176 -0.00512916
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase) -0.00512041
EMX2 empty spiracles homeobox 2 -0.00511851
GYPC glycophorin C (Gerbich blood group) -0.00511715
FZD7 frizzled class receptor 7 -0.00511065
NME5 NME/NM23 family member 5 -0.00510964
SLC44A4 solute carrier family 44, member 4 -0.00509934
MNS1 meiosis-specific nuclear structural 1 -0.00509309
LZTFL1 leucine zipper transcription factor-like 1 -0.00509011
MLF2 myeloid leukemia factor 2 -0.00508318
EHF ets homologous factor -0.0050729
MRPS28 mitochondrial ribosomal protein S28 -0.00506745
ILF2 interleukin enhancer binding factor 2 -0.00504534
DAD1 defender against cell death 1 -0.00503331
PTGES prostaglandin E synthase -0.00503025
CRYL1 crystallin, lambda 1 -0.00502119
EAPP E2F-associated phosphoprotein -0.00501214
TNC tenascin C -0.00501175
ORC5 origin recognition complex, subunit 5 -0.00500782
ACYP2 acylphosphatase 2, muscle type -0.00499433
CYP4F3 cytochrome P450, family 4, subfamily F, polypeptide 3 -0.00497585
TREM1 triggering receptor expressed on myeloid cells 1 -0.00497219
CD59 CD59 molecule, complement regulatory protein -0.00495681
VBP1 von Hippel-Lindau binding protein 1 -0.00495042
RAB25 RAB25, member RAS oncogene family -0.00494501
SQLE squalene epoxidase -0.00493742
S100A8 S100 calcium binding protein A8 -0.0049312
SFTPC surfactant protein C -0.00490791
TMEM14B transmembrane protein 14B -0.00490562
CPVL carboxypeptidase, vitellogenic-like -0.00489569
HS3ST1 heparan sulfate (glucosamine) 3-O-sulfotransferase 1 -0.00486967
TMEM106B transmembrane protein 106B -0.0048606
ZDHHC4 zinc finger, DHHC-type containing 4 -0.004848
PUF60 poly-U binding splicing factor 60KDa -0.0048458
LSM2 LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae) -0.00484332
RPL26L1 ribosomal protein L26-like 1 -0.00484143
NUDT6 nudix (nucleoside diphosphate linked moiety X)-type motif 6 -0.00483674
MARCHF6 membrane associated ring-CH-type finger 6 -0.00483671
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -0.0048334
FGF13 fibroblast growth factor 13 -0.00482978
SPA17 sperm autoantigenic protein 17 -0.00482673
RLN1 relaxin 1 -0.00482577
SLC27A5 solute carrier family 27 (fatty acid transporter), member 5 -0.00481783
SINHCAF SIN3-HDAC complex associated factor -0.0048151
MYL12B myosin, light chain 12B, regulatory -0.00481337
SPRR1B small proline-rich protein 1B -0.00480943
MYB v-myb avian myeloblastosis viral oncogene homolog -0.00480587
ASPH aspartate beta-hydroxylase -0.00480349
CTSH cathepsin H -0.00480164
CALD1 caldesmon 1 -0.00478409
CD48 CD48 molecule -0.0047784
MAOA monoamine oxidase A -0.00477251
PFDN5 prefoldin subunit 5 -0.00477219
PRRX1 paired related homeobox 1 -0.00475177
EYA2 EYA transcriptional coactivator and phosphatase 2 -0.00474989
PAGE4 P antigen family, member 4 (prostate associated) -0.00474824
KRT6B keratin 6B, type II -0.00474627
RAB23 RAB23, member RAS oncogene family -0.00473545
SMAD4 SMAD family member 4 -0.00473418
PLSCR1 phospholipid scramblase 1 -0.00472671
CYP46A1 cytochrome P450, family 46, subfamily A, polypeptide 1 -0.00470317
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated) -0.00469094
HPN hepsin -0.00468292
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit -0.00467343
DNALI1 dynein, axonemal, light intermediate chain 1 -0.00467303
TSEN2 TSEN2 tRNA splicing endonuclease subunit -0.00466262
YAP1 Yes-associated protein 1 -0.00465967
PSMA6 proteasome (prosome, macropain) subunit, alpha type, 6 -0.00465237
PIK3C3 phosphatidylinositol 3-kinase, catalytic subunit type 3 -0.00465071
RAMP1 receptor (G protein-coupled) activity modifying protein 1 -0.00464371
IL1RN interleukin 1 receptor antagonist -0.00464028
DYRK4 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4 -0.00463681
CCNA2 cyclin A2 -0.00462841
SLC25A46 solute carrier family 25, member 46 -0.00462543
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.00462514
C10ORF10 chromosome 10 open reading frame 10 -0.00462504
SCN3A sodium channel, voltage gated, type III alpha subunit -0.00462423
ETNPPL ethanolamine-phosphate phospho-lyase -0.00462111
CDC42 cell division cycle 42 -0.00461707
MAPK1 mitogen-activated protein kinase 1 -0.00461428
COX7A2L cytochrome c oxidase subunit VIIa polypeptide 2 like -0.00461171
PERP PERP, TP53 apoptosis effector -0.00461047
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.00460839
LAMP3 lysosomal-associated membrane protein 3 -0.00460511
ESD esterase D -0.00460343
MUC5AC mucin 5AC, oligomeric mucus/gel-forming -0.00458729
CYBRD1 cytochrome b reductase 1 -0.00457602
PGC progastricsin (pepsinogen C) -0.00455985
GTF2A2 general transcription factor IIA, 2, 12kDa -0.00455902
LOX lysyl oxidase -0.00455324
CMPK1 cytidine monophosphate (UMP-CMP) kinase 1, cytosolic -0.00455162