SE-81-RI20_0.1uM Gene Set

Dataset NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles
Category transcriptomics
Type drug perturbation
Description Dose=0.1uM (Novartis)
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Genes

321 genes differentially expressed following the SE-81-RI20_0.1uM drug perturbation from the NIBR DRUG-seq U2OS MoA Box dataset.

increased expression

Symbol Name Standardized Value
VTA1 vesicle (multivesicular body) trafficking 1 0.884568
PPDPF pancreatic progenitor cell differentiation and proliferation factor 0.813322
CD300A CD300a molecule 0.748981
RHOG ras homolog family member G 0.744911
PSMD12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 0.717073
CDC20 cell division cycle 20 0.717073
SNRPB small nuclear ribonucleoprotein polypeptides B and B1 0.652282
PHPT1 phosphohistidine phosphatase 1 0.618062
TRMT112 tRNA methyltransferase 11-2 homolog (S. cerevisiae) 0.610137
TRIM56 tripartite motif containing 56 0.603419
CST3 cystatin C 0.589939
HSD17B10 hydroxysteroid (17-beta) dehydrogenase 10 0.580063
HSPB1 heat shock 27kDa protein 1 0.563635
KRT81 keratin 81, type II 0.450466
CRYAB crystallin, alpha B 0.446663
PPP4C protein phosphatase 4, catalytic subunit 0.442386
DENND10 DENN domain containing 10 0.396196
COX8A cytochrome c oxidase subunit VIIIA (ubiquitous) 0.394593
MPV17 MpV17 mitochondrial inner membrane protein 0.393757
APRT adenine phosphoribosyltransferase 0.384251
AP2S1 adaptor-related protein complex 2, sigma 1 subunit 0.365039
FADS2 fatty acid desaturase 2 0.356224
MCM4 minichromosome maintenance complex component 4 0.346337
SSR4 signal sequence receptor, delta 0.34487
SF3B6 splicing factor 3b, subunit 6, 14kDa 0.339264
SSNA1 Sjogren syndrome nuclear autoantigen 1 0.329313
NOP10 NOP10 ribonucleoprotein 0.324907
OLFML3 olfactomedin-like 3 0.324158
COX6B1 cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous) 0.321435
CTSA cathepsin A 0.316943
KRT17 keratin 17, type I 0.316943
MYO1E myosin IE 0.316943
EIF5AL1 eukaryotic translation initiation factor 5A-like 1 0.312725
M6PR mannose-6-phosphate receptor (cation dependent) 0.299886
CPA2 carboxypeptidase A2 (pancreatic) 0.295356
TECR trans-2,3-enoyl-CoA reductase 0.286203
BCAR1 breast cancer anti-estrogen resistance 1 0.282764
BAG6 BCL2-associated athanogene 6 0.282443
CTSD cathepsin D 0.26974
SNRPA small nuclear ribonucleoprotein polypeptide A 0.269339
YIF1A Yip1 interacting factor homolog A (S. cerevisiae) 0.26591
MED25 mediator complex subunit 25 0.265474
ACTN4 actinin, alpha 4 0.263477
PLEC plectin 0.261734
C1ORF198 chromosome 1 open reading frame 198 0.261253
C1QL1 complement component 1, q subcomponent-like 1 0.260573
RPL37A ribosomal protein L37a 0.256464
SLC9A8 solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8 0.253261
TGFB1I1 transforming growth factor beta 1 induced transcript 1 0.251371
SCAND1 SCAN domain containing 1 0.250706
NDUFA11 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 11, 14.7kDa 0.236017
MLF2 myeloid leukemia factor 2 0.23234
RPS15 ribosomal protein S15 0.232164
MFAP2 microfibrillar-associated protein 2 0.226965
CAVIN1 caveolae associated protein 1 0.226965
EGFL7 EGF-like-domain, multiple 7 0.226526
AXL AXL receptor tyrosine kinase 0.225228
ARFRP1 ADP-ribosylation factor related protein 1 0.225228
LMF2 lipase maturation factor 2 0.224336
PRDX2 peroxiredoxin 2 0.223357
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa) 0.221973
GSK3A glycogen synthase kinase 3 alpha 0.221749
PFN1 profilin 1 0.220021
PTOV1 prostate tumor overexpressed 1 0.216704
FAM50A family with sequence similarity 50, member A 0.214528
NDUFB10 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 10, 22kDa 0.211581
IFITM3 interferon induced transmembrane protein 3 0.211164
MED16 mediator complex subunit 16 0.21095
RABAC1 Rab acceptor 1 (prenylated) 0.210498
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1 0.206886
PYCR1 pyrroline-5-carboxylate reductase 1 0.203717
PCOLCE procollagen C-endopeptidase enhancer 0.203029
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) 0.200719
DMAP1 DNA methyltransferase 1 associated protein 1 0.200042

decreased expression

Symbol Name Standardized Value
KCMF1 potassium channel modulatory factor 1 -0.748981
MAGEA1 melanoma antigen family A1 -0.744911
CNN3 calponin 3, acidic -0.726727
MRPL9 mitochondrial ribosomal protein L9 -0.704408
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 -0.704408
UBE2G2 ubiquitin-conjugating enzyme E2G 2 -0.655721
UBE2E1 ubiquitin-conjugating enzyme E2E 1 -0.653093
JPT1 Jupiter microtubule associated homolog 1 -0.653093
BRD7 bromodomain containing 7 -0.648536
FHL2 four and a half LIM domains 2 -0.645887
ATP5PF ATP synthase peripheral stalk subunit F6 -0.612231
RPS12 ribosomal protein S12 -0.606917
LSM2 LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae) -0.601819
EXO5 exonuclease 5 -0.595522
GNAS GNAS complex locus -0.595522
C1ORF122 chromosome 1 open reading frame 122 -0.589939
RPS4X ribosomal protein S4, X-linked -0.564422
SEC61B Sec61 beta subunit -0.553923
RNF7 ring finger protein 7 -0.549124
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 -0.549124
GPX1 glutathione peroxidase 1 -0.548228
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.537506
ISCA1 iron-sulfur cluster assembly 1 -0.537506
DYNLL1 dynein, light chain, LC8-type 1 -0.529461
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.529461
ATP6V1H ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H -0.502314
ZSWIM7 zinc finger, SWIM-type containing 7 -0.500745
YBX3 Y box binding protein 3 -0.500425
TXNL4A thioredoxin-like 4A -0.494874
ZPR1 ZPR1 zinc finger -0.487827
NME1-NME2 NME1-NME2 readthrough -0.484015
RPL11 ribosomal protein L11 -0.483442
FOXD1 forkhead box D1 -0.447284
RNF34 ring finger protein 34, E3 ubiquitin protein ligase -0.443239
NIPSNAP2 nipsnap homolog 2 -0.443239
LAMTOR5 late endosomal/lysosomal adaptor, MAPK and MTOR activator 5 -0.430456
RPS20 ribosomal protein S20 -0.425518
SUMO2 small ubiquitin-like modifier 2 -0.425518
TGM2 transglutaminase 2 -0.424476
FGF1 fibroblast growth factor 1 (acidic) -0.423615
SEPTIN2 septin 2 -0.423288
PIGH phosphatidylinositol glycan anchor biosynthesis, class H -0.419946
RPL12 ribosomal protein L12 -0.419223
MPHOSPH6 M-phase phosphoprotein 6 -0.41083
MESD mesoderm development LRP chaperone -0.407953
STMN1 stathmin 1 -0.407953
SIN3B SIN3 transcription regulator family member B -0.404545
PPP4R1 protein phosphatase 4, regulatory subunit 1 -0.403711
LEPROT leptin receptor overlapping transcript -0.402616
CFH complement factor H -0.399404
ERBIN erbb2 interacting protein -0.398231
CCDC142 coiled-coil domain containing 142 -0.396289
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.38582
METTL23 methyltransferase like 23 -0.379701
RPL27A ribosomal protein L27a -0.376594
ANXA5 annexin A5 -0.376594
UBE2K ubiquitin-conjugating enzyme E2K -0.376195
AGO1 argonaute RISC catalytic component 1 -0.375726
TFDP1 transcription factor Dp-1 -0.373521
CYCS cytochrome c, somatic -0.372604
RPL36AL ribosomal protein L36a-like -0.370702
BEX2 brain expressed X-linked 2 -0.369896
RAB5IF RAB5 interacting factor -0.368844
CDK4 cyclin-dependent kinase 4 -0.365039
HSPA1A heat shock 70kDa protein 1A -0.365039
PFDN1 prefoldin subunit 1 -0.365039
PRDX3 peroxiredoxin 3 -0.363066
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B -0.359652
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 -0.355265
MRPL48 mitochondrial ribosomal protein L48 -0.350336
TMA7 translation machinery associated 7 homolog (S. cerevisiae) -0.350336
RPS17 ribosomal protein S17 -0.350336
RPL34 ribosomal protein L34 -0.349345
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase) -0.349345
RAP1A RAP1A, member of RAS oncogene family -0.346337
MMS19 MMS19 nucleotide excision repair homolog (S. cerevisiae) -0.34487
NIPA1 non imprinted in Prader-Willi/Angelman syndrome 1 -0.34487
ACTL6A actin-like 6A -0.343972
HINT1 histidine triad nucleotide binding protein 1 -0.343115
SCAF4 SR-related CTD-associated factor 4 -0.342351
PRPSAP2 phosphoribosyl pyrophosphate synthetase-associated protein 2 -0.341603
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B -0.34056
VEZF1 vascular endothelial zinc finger 1 -0.34056
ATPAF1 ATP synthase mitochondrial F1 complex assembly factor 1 -0.338696
NEFL neurofilament, light polypeptide -0.338437
TAOK1 TAO kinase 1 -0.334779
SEC13 SEC13 homolog (S. cerevisiae) -0.330993
TUSC3 tumor suppressor candidate 3 -0.329996
RTKN rhotekin -0.329305
RPS23 ribosomal protein S23 -0.328743
PNRC2 proline-rich nuclear receptor coactivator 2 -0.324907
MYO1D myosin ID -0.324279
RPL23 ribosomal protein L23 -0.32379
SELENOK selenoprotein K -0.322575
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -0.318937
AMIGO2 adhesion molecule with Ig-like domain 2 -0.316943
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.316943
EME2 essential meiotic structure-specific endonuclease subunit 2 -0.316943
DDTL D-dopachrome tautomerase-like -0.312872
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 -0.311365
IER3IP1 immediate early response 3 interacting protein 1 -0.310329
BTN3A3 butyrophilin, subfamily 3, member A3 -0.305185
SBDS Shwachman-Bodian-Diamond syndrome -0.305185
ACTG1 actin gamma 1 -0.304984
JTB jumping translocation breakpoint -0.304689
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -0.303072
ARHGAP11A Rho GTPase activating protein 11A -0.302754
EFNB3 ephrin-B3 -0.30245
CHCHD1 coiled-coil-helix-coiled-coil-helix domain containing 1 -0.30245
SFPQ splicing factor proline/glutamine-rich -0.302297
CMTM3 CKLF-like MARVEL transmembrane domain containing 3 -0.298784
RPL32 ribosomal protein L32 -0.298784
NDUFAF8 NADH:ubiquinone oxidoreductase complex assembly factor 8 -0.298394
RPS16 ribosomal protein S16 -0.295942
RPL7A ribosomal protein L7a -0.295505
NBEAL1 neurobeachin-like 1 -0.292964
PSMG2 proteasome (prosome, macropain) assembly chaperone 2 -0.292135
RPL4 ribosomal protein L4 -0.290342
MOCS1 molybdenum cofactor synthesis 1 -0.290342
TCP11L1 t-complex 11, testis-specific-like 1 -0.290342
CNBP CCHC-type zinc finger, nucleic acid binding protein -0.288733
PPIF peptidylprolyl isomerase F -0.286998
PAGE2 P antigen family, member 2 (prostate associated) -0.286259
PHF10 PHD finger protein 10 -0.285389
LRRC37B leucine rich repeat containing 37B -0.283892
GHITM growth hormone inducible transmembrane protein -0.282475
ILF2 interleukin enhancer binding factor 2 -0.282443
BFAR bifunctional apoptosis regulator -0.282218
CERS6 ceramide synthase 6 -0.281248
ERH enhancer of rudimentary homolog (Drosophila) -0.280616
ARHGEF17 Rho guanine nucleotide exchange factor (GEF) 17 -0.280132
HRNR hornerin -0.279935
PBK PDZ binding kinase -0.278822
POFUT2 protein O-fucosyltransferase 2 -0.275705
ZBTB22 zinc finger and BTB domain containing 22 -0.270345
PCBP1 poly(rC) binding protein 1 -0.268949
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.268893
EIF3D eukaryotic translation initiation factor 3, subunit D -0.268261
MPC1 mitochondrial pyruvate carrier 1 -0.268261
SNX1 sorting nexin 1 -0.267397
PCLAF PCNA clamp associated factor -0.267101
UBLCP1 ubiquitin-like domain containing CTD phosphatase 1 -0.2669
RPL23A ribosomal protein L23a -0.265474
CREB1 cAMP responsive element binding protein 1 -0.265474
RPL8 ribosomal protein L8 -0.263675
PTCD3 pentatricopeptide repeat domain 3 -0.262501
NDN necdin, melanoma antigen (MAGE) family member -0.260466
MED10 mediator complex subunit 10 -0.26019
SRSF9 serine/arginine-rich splicing factor 9 -0.259173
KNSTRN kinetochore-localized astrin/SPAG5 binding protein -0.257169
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.256855
ACOT9 acyl-CoA thioesterase 9 -0.25588
ZWILCH zwilch kinetochore protein -0.255332
ATP6V0C ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c -0.25513
CDC42 cell division cycle 42 -0.254562
CAV1 caveolin 1, caveolae protein, 22kDa -0.254431
UBE2E3 ubiquitin-conjugating enzyme E2E 3 -0.254083
RPIA ribose 5-phosphate isomerase A -0.253749
INO80C INO80 complex subunit C -0.253375
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.253261
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.253261
CSTF3 cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa -0.253261
EEF1B2 eukaryotic translation elongation factor 1 beta 2 -0.251141
COX14 COX14 cytochrome c oxidase assembly factor -0.250328
NOL12 nucleolar protein 12 -0.250085
MAGEA12 melanoma antigen family A12 -0.246952
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase -0.246113
SH3BGRL SH3 domain binding glutamate-rich protein like -0.244523
CANX calnexin -0.24383
EXOC5 exocyst complex component 5 -0.241573
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B -0.241052
LAP3 leucine aminopeptidase 3 -0.240429
EIF1B eukaryotic translation initiation factor 1B -0.239382
COPS3 COP9 signalosome subunit 3 -0.239254
NPC2 Niemann-Pick disease, type C2 -0.239108
DZIP1 DAZ interacting zinc finger protein 1 -0.23846
VDAC3 voltage-dependent anion channel 3 -0.237402
NSUN2 NOP2/Sun RNA methyltransferase family, member 2 -0.236481
CMBL carboxymethylenebutenolidase homolog (Pseudomonas) -0.236313
PGK1 phosphoglycerate kinase 1 -0.235353
SLC25A21 solute carrier family 25 (mitochondrial oxoadipate carrier), member 21 -0.235263
MRPL13 mitochondrial ribosomal protein L13 -0.235263
EIF3L eukaryotic translation initiation factor 3, subunit L -0.232288
TRIAP1 TP53 regulated inhibitor of apoptosis 1 -0.230684
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 -0.230641
SIKE1 suppressor of IKBKE 1 -0.230382
NDUFAB1 NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1, 8kDa -0.229658
MPLKIP M-phase specific PLK1 interacting protein -0.229595
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4 -0.229329
PTAR1 protein prenyltransferase alpha subunit repeat containing 1 -0.228886
TAF7 TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDa -0.227446
TP53BP2 tumor protein p53 binding protein 2 -0.227304
CNIH4 cornichon family AMPA receptor auxiliary protein 4 -0.227304
SNRPC small nuclear ribonucleoprotein polypeptide C -0.226965
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.226965
CDC6 cell division cycle 6 -0.226965
RPL21 ribosomal protein L21 -0.226526
COX11 COX11 cytochrome c oxidase copper chaperone -0.225228
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.225228
NXT1 nuclear transport factor 2-like export factor 1 -0.225151
INTS3 integrator complex subunit 3 -0.224753
RAN RAN, member RAS oncogene family -0.224753
LIN7C lin-7 homolog C (C. elegans) -0.224336
TLNRD1 talin rod domain containing 1 -0.224336
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) -0.223656
ENOPH1 enolase-phosphatase 1 -0.223158
FAM47E-STBD1 FAM47E-STBD1 readthrough -0.221138
KTI12 KTI12 homolog, chromatin associated (S. cerevisiae) -0.220021
GMNN geminin, DNA replication inhibitor -0.220021
USP14 ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase) -0.220021
CATSPER1 cation channel, sperm associated 1 -0.219381
RPS3A ribosomal protein S3A -0.219341
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.21922
HAT1 histone acetyltransferase 1 -0.21922
RHOB ras homolog family member B -0.218834
ARPC5 actin related protein 2/3 complex, subunit 5, 16kDa -0.218834
BCCIP BRCA2 and CDKN1A interacting protein -0.217515
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.216976
FTSJ1 FtsJ RNA methyltransferase homolog 1 (E. coli) -0.216902
SSH2 slingshot protein phosphatase 2 -0.216846
TPT1 tumor protein, translationally-controlled 1 -0.216693
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase -0.214879
SIVA1 SIVA1, apoptosis-inducing factor -0.213739
RPL3 ribosomal protein L3 -0.211955
IFT52 intraflagellar transport 52 -0.211581
FAM32A family with sequence similarity 32, member A -0.211581
KPNA1 karyopherin alpha 1 (importin alpha 5) -0.211151
UQCRQ ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa -0.211151
RIC8B RIC8 guanine nucleotide exchange factor B -0.210498
SRSF3 serine/arginine-rich splicing factor 3 -0.210498
PEX13 peroxisomal biogenesis factor 13 -0.208196
TRRAP transformation/transcription domain-associated protein -0.208096
VMA12 vacuolar ATPase assembly factor VMA12 -0.207392
MAPRE1 microtubule-associated protein, RP/EB family, member 1 -0.207392
PIGC phosphatidylinositol glycan anchor biosynthesis, class C -0.207175
CNOT1 CCR4-NOT transcription complex, subunit 1 -0.205221
ADORA2B adenosine A2b receptor -0.2049
VAMP7 vesicle-associated membrane protein 7 -0.2049
C1ORF216 chromosome 1 open reading frame 216 -0.2049
PDCD5 programmed cell death 5 -0.202288
PUF60 poly-U binding splicing factor 60KDa -0.202077
ORC5 origin recognition complex, subunit 5 -0.201445
TMCC1 transmembrane and coiled-coil domain family 1 -0.201191
RPS27A ribosomal protein S27a -0.201009
STOML2 stomatin (EPB72)-like 2 -0.200355
RPLP0 ribosomal protein, large, P0 -0.200042
GTF3C6 general transcription factor IIIC, polypeptide 6, alpha 35kDa -0.200042