SE-81-RI20_10uM Gene Set

Dataset NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles
Category transcriptomics
Type drug perturbation
Description Dose=10uM (Novartis)
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Genes

149 genes differentially expressed following the SE-81-RI20_10uM drug perturbation from the NIBR DRUG-seq U2OS MoA Box dataset.

increased expression

Symbol Name Standardized Value
RHOG ras homolog family member G 0.760801
VTA1 vesicle (multivesicular body) trafficking 1 0.634234
TRMT112 tRNA methyltransferase 11-2 homolog (S. cerevisiae) 0.503034
TMEM258 transmembrane protein 258 0.502205
SSR4 signal sequence receptor, delta 0.455409
CDC20 cell division cycle 20 0.454852
SNRPB small nuclear ribonucleoprotein polypeptides B and B1 0.446511
RPL37A ribosomal protein L37a 0.446511
ROMO1 reactive oxygen species modulator 1 0.42286
RPS27 ribosomal protein S27 0.422606
TRIM56 tripartite motif containing 56 0.391318
RPS15 ribosomal protein S15 0.378935
NOP10 NOP10 ribonucleoprotein 0.373482
RPL18A ribosomal protein L18a 0.357367
PPDPF pancreatic progenitor cell differentiation and proliferation factor 0.344738
PSMD12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 0.325965
RABAC1 Rab acceptor 1 (prenylated) 0.323576
PHPT1 phosphohistidine phosphatase 1 0.32325
PRAF2 PRA1 domain family, member 2 0.297447
CST3 cystatin C 0.296136
EIF5AL1 eukaryotic translation initiation factor 5A-like 1 0.290797
MNS1 meiosis-specific nuclear structural 1 0.2731
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa) 0.252404
NDUFA13 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13 0.242515
GNA12 guanine nucleotide binding protein (G protein) alpha 12 0.240307
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2 0.240307
PFN1 profilin 1 0.237642
NDUFA3 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa 0.234729
UBTF upstream binding transcription factor, RNA polymerase I 0.234559
NDUFA11 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 11, 14.7kDa 0.23385
AP2S1 adaptor-related protein complex 2, sigma 1 subunit 0.230174
COX8A cytochrome c oxidase subunit VIIIA (ubiquitous) 0.226865
PAQR5 progestin and adipoQ receptor family member V 0.217694
YIF1A Yip1 interacting factor homolog A (S. cerevisiae) 0.214196
CST2 cystatin SA 0.210133
NDUFB10 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 10, 22kDa 0.20654
RPS5 ribosomal protein S5 0.205516
RBM38 RNA binding motif protein 38 0.204597
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) 0.204597
PLK5 polo-like kinase 5 0.204115
SF3B6 splicing factor 3b, subunit 6, 14kDa 0.201137

decreased expression

Symbol Name Standardized Value
RPS17 ribosomal protein S17 -0.611051
POFUT2 protein O-fucosyltransferase 2 -0.503034
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -0.502205
INHBA inhibin, beta A -0.49153
KIF3C kinesin family member 3C -0.468687
PIGH phosphatidylinositol glycan anchor biosynthesis, class H -0.455409
PCBP1 poly(rC) binding protein 1 -0.454852
FN1 fibronectin 1 -0.454852
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 -0.417198
TMEM268 transmembrane protein 268 -0.407442
TBCC tubulin folding cofactor C -0.403587
RAN RAN, member RAS oncogene family -0.389779
NPC2 Niemann-Pick disease, type C2 -0.373482
RPS12 ribosomal protein S12 -0.373482
ACTG1 actin gamma 1 -0.362823
CCDC51 coiled-coil domain containing 51 -0.362503
POGK pogo transposable element with KRAB domain -0.359729
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -0.356558
NOL7 nucleolar protein 7, 27kDa -0.35309
LAYN layilin -0.35309
PLEKHA8 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 8 -0.352154
C1ORF122 chromosome 1 open reading frame 122 -0.348411
FOXD1 forkhead box D1 -0.344622
LAPTM4B lysosomal protein transmembrane 4 beta -0.344622
CFH complement factor H -0.33889
KNSTRN kinetochore-localized astrin/SPAG5 binding protein -0.33889
SEC23B Sec23 homolog B (S. cerevisiae) -0.33889
TECPR1 tectonin beta-propeller repeat containing 1 -0.334922
SELENOS selenoprotein S -0.334922
FAM229B family with sequence similarity 229, member B -0.32789
RPL34 ribosomal protein L34 -0.324903
EEF1E1 eukaryotic translation elongation factor 1 epsilon 1 -0.32325
NDN necdin, melanoma antigen (MAGE) family member -0.32325
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 -0.32325
SNX2 sorting nexin 2 -0.32325
NOL9 nucleolar protein 9 -0.311413
TARDBP TAR DNA binding protein -0.30903
BNIP2 BCL2/adenovirus E1B 19kDa interacting protein 2 -0.306735
CALCOCO2 calcium binding and coiled-coil domain 2 -0.302338
JPT1 Jupiter microtubule associated homolog 1 -0.299743
RPS27A ribosomal protein S27a -0.299743
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.299743
KIF4A kinesin family member 4A -0.299686
MAGEA3 melanoma antigen family A3 -0.297193
EED embryonic ectoderm development -0.297069
UQCC1 ubiquinol-cytochrome c reductase complex assembly factor 1 -0.292586
SH3BGRL SH3 domain binding glutamate-rich protein like -0.289981
MRM3 mitochondrial rRNA methyltransferase 3 -0.285564
RPS23 ribosomal protein S23 -0.285477
LAMTOR5 late endosomal/lysosomal adaptor, MAPK and MTOR activator 5 -0.284356
DPM1 dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit -0.283353
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.277009
RPL27 ribosomal protein L27 -0.276173
AMMECR1L AMMECR1-like -0.270439
PLK2 polo-like kinase 2 -0.270439
PPCDC phosphopantothenoylcysteine decarboxylase -0.270439
TRIP13 thyroid hormone receptor interactor 13 -0.268923
ACTR5 ARP5 actin-related protein 5 homolog (yeast) -0.267958
TBL2 transducin (beta)-like 2 -0.267958
GGCX gamma-glutamyl carboxylase -0.258272
PLCE1 phospholipase C, epsilon 1 -0.258223
RPL27A ribosomal protein L27a -0.256486
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3 -0.256138
CHCHD1 coiled-coil-helix-coiled-coil-helix domain containing 1 -0.255945
ZNF90 zinc finger protein 90 -0.252404
DUSP14 dual specificity phosphatase 14 -0.251696
RETREG3 reticulophagy regulator family member 3 -0.248382
COTL1 coactosin-like F-actin binding protein 1 -0.247641
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3 -0.246061
B2M beta-2-microglobulin -0.245935
TSPAN6 tetraspanin 6 -0.244658
TMED3 transmembrane emp24 protein transport domain containing 3 -0.242515
COMMD7 COMM domain containing 7 -0.242515
IDH3A isocitrate dehydrogenase 3 (NAD+) alpha -0.242274
COX7A2 cytochrome c oxidase subunit VIIa polypeptide 2 (liver) -0.242229
SNRPC small nuclear ribonucleoprotein polypeptide C -0.2404
RPS8 ribosomal protein S8 -0.240307
PRAME preferentially expressed antigen in melanoma -0.240307
SRSF9 serine/arginine-rich splicing factor 9 -0.234943
PSMD8 proteasome (prosome, macropain) 26S subunit, non-ATPase, 8 -0.234275
CNBP CCHC-type zinc finger, nucleic acid binding protein -0.23195
EIF3I eukaryotic translation initiation factor 3, subunit I -0.231653
RPL11 ribosomal protein L11 -0.230174
DDX56 DEAD (Asp-Glu-Ala-Asp) box helicase 56 -0.230174
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.230174
ZSCAN29 zinc finger and SCAN domain containing 29 -0.229631
RPS20 ribosomal protein S20 -0.226865
XPO1 exportin 1 -0.22633
HDAC1 histone deacetylase 1 -0.224075
RHOB ras homolog family member B -0.223378
YIPF1 Yip1 domain family, member 1 -0.223223
RBM4B RNA binding motif protein 4B -0.219993
TUBB6 tubulin, beta 6 class V -0.219873
ZDHHC2 zinc finger, DHHC-type containing 2 -0.218408
COPA coatomer protein complex, subunit alpha -0.208552
RAB5IF RAB5 interacting factor -0.207108
KTN1 kinectin 1 (kinesin receptor) -0.207108
DPP3 dipeptidyl-peptidase 3 -0.207108
RSL24D1 ribosomal L24 domain containing 1 -0.20654
KLHDC4 kelch domain containing 4 -0.206344
ADAM9 ADAM metallopeptidase domain 9 -0.206344
PGK1 phosphoglycerate kinase 1 -0.206344
ARMC10 armadillo repeat containing 10 -0.204938
KHNYN KH and NYN domain containing -0.203884
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.203099
COX6C cytochrome c oxidase subunit VIc -0.201562
ZNF133 zinc finger protein 133 -0.201161
TOMM7 translocase of outer mitochondrial membrane 7 homolog (yeast) -0.20045