SE-81-RI20_1uM Gene Set

Dataset NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles
Category transcriptomics
Type drug perturbation
Description Dose=1uM (Novartis)
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Genes

92 genes differentially expressed following the SE-81-RI20_1uM drug perturbation from the NIBR DRUG-seq U2OS MoA Box dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 2.33036
RHOG ras homolog family member G 1.10295
CDC20 cell division cycle 20 0.877131
KRT81 keratin 81, type II 0.61577
TRMT112 tRNA methyltransferase 11-2 homolog (S. cerevisiae) 0.612772
VTA1 vesicle (multivesicular body) trafficking 1 0.601539
CST3 cystatin C 0.594288
TRIM56 tripartite motif containing 56 0.576983
PPDPF pancreatic progenitor cell differentiation and proliferation factor 0.526073
NOP10 NOP10 ribonucleoprotein 0.38568
SNRPB small nuclear ribonucleoprotein polypeptides B and B1 0.284996
TMEM258 transmembrane protein 258 0.281483
GADD45GIP1 growth arrest and DNA-damage-inducible, gamma interacting protein 1 0.279335
PSMD12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 0.273205
PQBP1 polyglutamine binding protein 1 0.249285
CARM1 coactivator-associated arginine methyltransferase 1 0.243735
APRT adenine phosphoribosyltransferase 0.225458
DENND10 DENN domain containing 10 0.221154
MEA1 male-enhanced antigen 1 0.221154
MCM4 minichromosome maintenance complex component 4 0.218028
BDKRB1 bradykinin receptor B1 0.214481
ENHO energy homeostasis associated 0.213043
APEH acylaminoacyl-peptide hydrolase 0.211052
SPANXN5 SPANX family, member N5 0.206787

decreased expression

Symbol Name Standardized Value
MAGEA1 melanoma antigen family A1 -0.612772
MAP1LC3B2 microtubule-associated protein 1 light chain 3 beta 2 -0.57891
DEDD death effector domain containing -0.493208
CBFB core-binding factor, beta subunit -0.449651
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.409493
AAGAB alpha- and gamma-adaptin binding protein -0.388695
NFIB nuclear factor I/B -0.373339
EIF3I eukaryotic translation initiation factor 3, subunit I -0.370366
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.365579
TOMM7 translocase of outer mitochondrial membrane 7 homolog (yeast) -0.364463
RPL27 ribosomal protein L27 -0.362129
ALKBH3 alkB, alkylation repair homolog 3 (E. coli) -0.358914
RPL34 ribosomal protein L34 -0.357093
RPS4X ribosomal protein S4, X-linked -0.349701
RPL9 ribosomal protein L9 -0.348854
RPS12 ribosomal protein S12 -0.335504
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 -0.334131
RPS23 ribosomal protein S23 -0.325245
COPS9 COP9 signalosome subunit 9 -0.316946
STMN1 stathmin 1 -0.316946
RPS27A ribosomal protein S27a -0.309112
JPT1 Jupiter microtubule associated homolog 1 -0.309112
TAF9 TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa -0.301906
THOC7 THO complex 7 -0.301049
OGFRL1 opioid growth factor receptor-like 1 -0.301028
RPS17 ribosomal protein S17 -0.298169
RPL32 ribosomal protein L32 -0.296984
ZKSCAN5 zinc finger with KRAB and SCAN domains 5 -0.294176
FN3KRP fructosamine 3 kinase related protein -0.293974
RPL11 ribosomal protein L11 -0.279335
RPS20 ribosomal protein S20 -0.279335
RPL27A ribosomal protein L27a -0.279335
PKNOX1 PBX/knotted 1 homeobox 1 -0.279335
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit -0.279335
RPL23 ribosomal protein L23 -0.27343
RSL24D1 ribosomal L24 domain containing 1 -0.27343
GNPTAB N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits -0.273205
CTSC cathepsin C -0.271587
RAN RAN, member RAS oncogene family -0.267721
NBEAL1 neurobeachin-like 1 -0.259345
ENDOD1 endonuclease domain containing 1 -0.255577
STOML2 stomatin (EPB72)-like 2 -0.25223
BRK1 BRICK1, SCAR/WAVE actin-nucleating complex subunit -0.25223
PPP4R3A protein phosphatase 4 regulatory subunit 3A -0.25223
RPL7A ribosomal protein L7a -0.243241
COMMD6 COMM domain containing 6 -0.242674
SEC22A SEC22 vesicle trafficking protein homolog A (S. cerevisiae) -0.242674
TNFAIP1 tumor necrosis factor, alpha-induced protein 1 (endothelial) -0.242674
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.2378
AURKA aurora kinase A -0.23775
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.23775
GNAS GNAS complex locus -0.235157
EGFLAM EGF-like, fibronectin type III and laminin G domains -0.231624
CISD2 CDGSH iron sulfur domain 2 -0.221979
UFSP2 UFM1-specific peptidase 2 -0.221154
YIPF1 Yip1 domain family, member 1 -0.221154
ZNF48 zinc finger protein 48 -0.221154
ZNF75A zinc finger protein 75a -0.221154
CCDC47 coiled-coil domain containing 47 -0.220628
PRAME preferentially expressed antigen in melanoma -0.214481
PFDN1 prefoldin subunit 1 -0.21251
RPS27L ribosomal protein S27-like -0.21251
SETDB1 SET domain, bifurcated 1 -0.210353
MAGEA12 melanoma antigen family A12 -0.204779
TMEM254 transmembrane protein 254 -0.203792
GTF2H5 general transcription factor IIH, polypeptide 5 -0.202998
TMEM94 transmembrane protein 94 -0.201856
CTR9 CTR9, Paf1/RNA polymerase II complex component -0.201198