SEC11A Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description SEC11 homolog A (S. cerevisiae)|This gene encodes a member of the peptidase S26B family. The encoded protein is an 18kDa subunit of the signal peptidase complex and has been linked to cell migration and invasion, gastric cancer and lymph node metastasis. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 8. [provided by RefSeq, Dec 2012] (NCBI Entrez Gene Database, 23478)
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Genes

346 genes differentially expressed following the SEC11A gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4 4.11401
KRT20 keratin 20, type I 4.11401
CASP4 caspase 4, apoptosis-related cysteine peptidase 4.11401
GJA10 gap junction protein, alpha 10, 62kDa 4.11401
OR2AG1 olfactory receptor, family 2, subfamily AG, member 1 (gene/pseudogene) 4.11401
LRRC52 leucine rich repeat containing 52 4.11401
MUC5B mucin 5B, oligomeric mucus/gel-forming 4.11401
KCNJ9 potassium channel, inwardly rectifying subfamily J, member 9 4.11401
PAX7 paired box 7 4.11401
GFAP glial fibrillary acidic protein 4.11401
TUBB1 tubulin, beta 1 class VI 4.11401
PNMA5 paraneoplastic Ma antigen family member 5 4.11401
GLYAT glycine-N-acyltransferase 4.11401
SLC5A7 solute carrier family 5 (sodium/choline cotransporter), member 7 4.11401
USP29 ubiquitin specific peptidase 29 4.11401
FAM24A family with sequence similarity 24, member A 4.11401
SPAM1 sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding) 4.11401
CELF6 CUGBP, Elav-like family member 6 4.11401
PLIN1 perilipin 1 4.11401
TMEM176B transmembrane protein 176B 4.11401
DNASE1L3 deoxyribonuclease I-like 3 4.11401
PON1 paraoxonase 1 4.11401
TMEM244 transmembrane protein 244 4.11401
TAL2 T-cell acute lymphocytic leukemia 2 4.11401
C11ORF87 chromosome 11 open reading frame 87 4.11401
ATOH7 atonal homolog 7 (Drosophila) 4.11401
OR5AN1 olfactory receptor, family 5, subfamily AN, member 1 4.11401
GYS2 glycogen synthase 2 (liver) 4.11401
NMUR2 neuromedin U receptor 2 4.11401
SPAG6 sperm associated antigen 6 4.11401
CYP4A22 cytochrome P450, family 4, subfamily A, polypeptide 22 4.11401
LOC102724877 uncharacterized LOC102724877 4.11401
METTL21C methyltransferase like 21C 4.11401
NR2F2 nuclear receptor subfamily 2, group F, member 2 4.11401
MEIG1 meiosis/spermiogenesis associated 1 4.11401
B3GNT8 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8 4.11401
TBATA thymus, brain and testes associated 4.11401
F7 coagulation factor VII (serum prothrombin conversion accelerator) 4.11401
TDRD9 tudor domain containing 9 4.11401
C9ORF152 chromosome 9 open reading frame 152 4.11401
EDDM3B epididymal protein 3B 4.11401
SPP2 secreted phosphoprotein 2, 24kDa 4.11401
KCNE1 potassium channel, voltage gated subfamily E regulatory beta subunit 1 4.11401
F2 coagulation factor II (thrombin) 4.11401
DPPA3 developmental pluripotency associated 3 4.11401
SOWAHB sosondowah ankyrin repeat domain family member B 4.11401
LRRC61 leucine rich repeat containing 61 4.11401
TSSK1B testis-specific serine kinase 1B 4.11401
SPATA31G1 SPATA31 subfamily G member 1 4.11401
H3-5 H3.5 histone 4.11401
VSIR V-set immunoregulatory receptor 4.11401
SLC7A13 solute carrier family 7 (anionic amino acid transporter), member 13 4.11401
RHCG Rh family, C glycoprotein 4.11401
C20ORF202 chromosome 20 open reading frame 202 4.11401
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5 4.11401
ADRB1 adrenoceptor beta 1 4.11401
FCMR Fc fragment of IgM receptor 4.11401
RASD1 RAS, dexamethasone-induced 1 4.11401
ZNF705G zinc finger protein 705G 4.11401
DERPC DERPC proline and glycine rich nuclear protein 4.11401
ATP5MGL ATP synthase membrane subunit g like 4.11401
CIMIP4 ciliary microtubule inner protein 4 4.11401
H3-7 H3.7 histone (putative) 4.11401
OR52P1 olfactory receptor family 52 subfamily P member 1 (gene/pseudogene) 4.11401
LY6L lymphocyte antigen 6 family member L 4.11401
EZHIP EZH inhibitory protein 4.11401
DEFB131A defensin beta 131A 4.11401
ACP4 acid phosphatase 4 4.11401
CFAP107 cilia and flagella associated protein 107 4.11401
H2BW2 H2B.W histone 2 4.11401
H1-8 H1.8 linker histone 4.11401
HTR3C 5-hydroxytryptamine (serotonin) receptor 3C, ionotropic 4.11401
TAF1L TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa-like 4.11401
ARL5C ADP-ribosylation factor-like 5C 4.11401
CAPN11 calpain 11 4.11401
ACTL10 actin-like 10 4.11401
COX7A1 cytochrome c oxidase subunit VIIa polypeptide 1 (muscle) 4.11401
LOX lysyl oxidase 4.11401
SIX3 SIX homeobox 3 4.11401
FAM90A26 family with sequence similarity 90, member A26, pseudogene 4.11401
PLEKHG7 pleckstrin homology domain containing, family G (with RhoGef domain) member 7 4.11401
UPK3B uroplakin 3B 4.11401
CD274 CD274 molecule 4.11401
C1ORF87 chromosome 1 open reading frame 87 4.11401
IRF5 interferon regulatory factor 5 4.11401
LTF lactotransferrin 4.11401
ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 4.11401
GSC goosecoid homeobox 4.11401
NPFF neuropeptide FF-amide peptide precursor 4.11401
TFEC transcription factor EC 4.11401
OVOL3 ovo-like zinc finger 3 4.11401
OR11A1 olfactory receptor, family 11, subfamily A, member 1 4.11401
C3ORF80 chromosome 3 open reading frame 80 4.11401
IL31RA interleukin 31 receptor A 4.11401
PANX3 pannexin 3 4.11401
FGF21 fibroblast growth factor 21 4.11401
GPD1 glycerol-3-phosphate dehydrogenase 1 (soluble) 4.11401
RORC RAR-related orphan receptor C 4.11401
TNR tenascin R 4.11401
SYNE3 spectrin repeat containing, nuclear envelope family member 3 4.11401
PSG9 pregnancy specific beta-1-glycoprotein 9 4.11401
CAMK2A calcium/calmodulin-dependent protein kinase II alpha 4.11401
WFDC9 WAP four-disulfide core domain 9 4.11401
PAGE4 P antigen family, member 4 (prostate associated) 4.11401
APOC2 apolipoprotein C-II 4.11401
HUS1B HUS1 checkpoint homolog b (S. pombe) 4.11401
MAB21L2 mab-21-like 2 (C. elegans) 4.11401
CST7 cystatin F (leukocystatin) 4.11401
NXNL1 nucleoredoxin-like 1 4.11401
CMTM5 CKLF-like MARVEL transmembrane domain containing 5 4.11401
PYHIN1 pyrin and HIN domain family, member 1 4.11401
A3GALT2 alpha 1,3-galactosyltransferase 2 4.11401
EBF2 early B-cell factor 2 4.11401
IL17REL interleukin 17 receptor E-like 4.11401
GAL3ST2 galactose-3-O-sulfotransferase 2 4.11401
FNDC9 fibronectin type III domain containing 9 4.11401
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 4.11401
HAMP hepcidin antimicrobial peptide 4.11401
MUCL1 mucin-like 1 4.11401
RASGRP3 RAS guanyl releasing protein 3 (calcium and DAG-regulated) 4.11401
MUC13 mucin 13, cell surface associated 4.11401
CRHBP corticotropin releasing hormone binding protein 4.11401
TAGAP T-cell activation RhoGTPase activating protein 4.11401
SLC38A8 solute carrier family 38, member 8 4.11401
PSG8 pregnancy specific beta-1-glycoprotein 8 4.11401
SH2D1A SH2 domain containing 1A 4.11401
SLC25A31 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 31 4.11401
IGIP IgA-inducing protein 4.11401
ACSS1 acyl-CoA synthetase short-chain family member 1 4.11401
NPY2R neuropeptide Y receptor Y2 4.11401
FCRL3 Fc receptor-like 3 4.11401
UTS2R urotensin 2 receptor 4.11401
SMPX small muscle protein, X-linked 4.11401
VWA3B von Willebrand factor A domain containing 3B 4.11401
ISL1 ISL LIM homeobox 1 4.11401
TEKT1 tektin 1 4.11401
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39) 4.11401
RGCC regulator of cell cycle 4.11401
P2RX2 purinergic receptor P2X, ligand gated ion channel, 2 4.11401
CFH complement factor H 4.11401
SAMD5 sterile alpha motif domain containing 5 4.11401
CFB complement factor B 4.11401
FCN1 ficolin (collagen/fibrinogen domain containing) 1 4.11401
MMP10 matrix metallopeptidase 10 4.11401
TBC1D26 TBC1 domain family, member 26 4.11401
DMRTC1 DMRT-like family C1 4.11401
MAGEC3 melanoma antigen family C3 4.11401
GALNT15 polypeptide N-acetylgalactosaminyltransferase 15 4.11401
PRRX1 paired related homeobox 1 4.11401
TRPM8 transient receptor potential cation channel, subfamily M, member 8 4.11401
GLT6D1 glycosyltransferase 6 domain containing 1 4.11401
FOXG1 forkhead box G1 4.11401
EPO erythropoietin 4.11401
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16 4.11401
AMER2 APC membrane recruitment protein 2 4.11401
TGM7 transglutaminase 7 4.11401
CALML6 calmodulin-like 6 4.11401
TEX35 testis expressed 35 4.11401
SDSL serine dehydratase-like 4.11401
C9ORF50 chromosome 9 open reading frame 50 4.11401
TSPAN32 tetraspanin 32 4.11401
NEUROD2 neuronal differentiation 2 4.11401
DBX2 developing brain homeobox 2 4.11401
ANGPTL3 angiopoietin-like 3 4.11401
KIF4B kinesin family member 4B 4.11401
RNMT RNA (guanine-7-) methyltransferase 4.06709
SPACA9 sperm acrosome associated 9 4.06513
RNF222 ring finger protein 222 4.06513
SMIM45 small integral membrane protein 45 4.06513
TRIM47 tripartite motif containing 47 3.49677
SET SET nuclear proto-oncogene 3.28455
CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4 3.10125
DRD4 dopamine receptor D4 3.01477
SERBP1 SERPINE1 mRNA binding protein 1 3.01477
SLC1A2 solute carrier family 1 (glial high affinity glutamate transporter), member 2 3.01477
FGF23 fibroblast growth factor 23 3.01477
CFAP119 cilia and flagella associated protein 119 3.01477
AQP7 aquaporin 7 3.01477
AOC3 amine oxidase, copper containing 3 3.01477
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9 3.01169
HPSE2 heparanase 2 (inactive) 2.9715
EFHD2 EF-hand domain family, member D2 2.96675
RRAGC Ras-related GTP binding C 2.91718
EDNRB endothelin receptor type B 2.83996
CCNI2 cyclin I family, member 2 2.80266
IKZF5 IKAROS family zinc finger 5 (Pegasus) 2.6945
TAF6 TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa 2.6754
BTN2A1 butyrophilin, subfamily 2, member A1 2.63505
TMEM184B transmembrane protein 184B 2.57768
DNAH3 dynein, axonemal, heavy chain 3 2.57006
BCORL1 BCL6 corepressor-like 1 2.56927
TRPA1 transient receptor potential cation channel, subfamily A, member 1 2.5618
MRPS2 mitochondrial ribosomal protein S2 2.49254
PRPF4B pre-mRNA processing factor 4B 2.49254
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 2.45741
TMCO6 transmembrane and coiled-coil domains 6 2.45741
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class) 2.45741
DDX56 DEAD (Asp-Glu-Ala-Asp) box helicase 56 2.45154
DLL3 delta-like 3 (Drosophila) 2.44912
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2 2.40114
DNPH1 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 2.40114
FBXL4 F-box and leucine-rich repeat protein 4 2.39975
TPRG1L tumor protein p63 regulated 1-like 2.39975
FBXO42 F-box protein 42 2.38296
TJP1 tight junction protein 1 2.37728
HINT1 histidine triad nucleotide binding protein 1 2.37646
ELF4 E74-like factor 4 (ets domain transcription factor) 2.37646
ZNF680 zinc finger protein 680 2.33624
AGAP6 ArfGAP with GTPase domain, ankyrin repeat and PH domain 6 2.30059
SLCO3A1 solute carrier organic anion transporter family, member 3A1 2.29953
CSRNP2 cysteine-serine-rich nuclear protein 2 2.29762
STARD7 StAR-related lipid transfer (START) domain containing 7 2.29519
AP3S2 adaptor-related protein complex 3, sigma 2 subunit 2.28637
MRPL23 mitochondrial ribosomal protein L23 2.27757
TMC4 transmembrane channel-like 4 2.27622
COLGALT2 collagen beta(1-O)galactosyltransferase 2 2.26654
FBXO21 F-box protein 21 2.26203
XNDC1N XRCC1 N-terminal domain containing 1, N-terminal like 2.23926
RPA4 replication protein A4, 30kDa 2.23348
UGCG UDP-glucose ceramide glucosyltransferase 2.21149
CKAP2 cytoskeleton associated protein 2 2.20086
KMT5A lysine methyltransferase 5A 2.19035
EFNA4 ephrin-A4 2.18025
WFIKKN1 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1 2.16524
CAMK2N2 calcium/calmodulin-dependent protein kinase II inhibitor 2 2.16524
MAN2C1 mannosidase, alpha, class 2C, member 1 2.15657
MCF2 MCF.2 cell line derived transforming sequence 2.11142
TWNK twinkle mtDNA helicase 2.10794
SOHLH2 spermatogenesis and oogenesis specific basic helix-loop-helix 2 2.09382
EIPR1 EARP complex and GARP complex interacting protein 1 2.0734
CCDC57 coiled-coil domain containing 57 2.07119
RPS11 ribosomal protein S11 2.07119
ALKBH6 alkB, alkylation repair homolog 6 (E. coli) 2.07119
MRPL17 mitochondrial ribosomal protein L17 2.05953
LSG1 large 60S subunit nuclear export GTPase 1 2.05947
PLS1 plastin 1 2.0519
FKBP2 FK506 binding protein 2, 13kDa 2.03176
PEX11B peroxisomal biogenesis factor 11 beta 2.02129
PLCXD3 phosphatidylinositol-specific phospholipase C, X domain containing 3 2.01902
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 2.01596

decreased expression

Symbol Name Standardized Value
LHX6 LIM homeobox 6 -4.11401
CGB7 chorionic gonadotropin, beta polypeptide 7 -4.11401
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32) -4.11401
RAB44 RAB44, member RAS oncogene family -4.11401
AQP4 aquaporin 4 -4.11401
BTNL9 butyrophilin-like 9 -4.11401
STKLD1 serine/threonine kinase-like domain containing 1 -4.11401
MBLAC1 metallo-beta-lactamase domain containing 1 -4.11401
ADTRP androgen-dependent TFPI-regulating protein -4.11401
SGPP2 sphingosine-1-phosphate phosphatase 2 -4.11401
SERPIND1 serpin peptidase inhibitor, clade D (heparin cofactor), member 1 -4.11401
FCN3 ficolin (collagen/fibrinogen domain containing) 3 -4.11401
DNAJC22 DnaJ (Hsp40) homolog, subfamily C, member 22 -4.11401
CSTL1 cystatin-like 1 -4.11401
MEIKIN meiotic kinetochore factor -4.11401
IL33 interleukin 33 -4.11401
RSPH14 radial spoke head 14 homolog (Chlamydomonas) -4.11401
C6ORF118 chromosome 6 open reading frame 118 -4.11401
PSG3 pregnancy specific beta-1-glycoprotein 3 -4.11401
PFN4 profilin family, member 4 -4.11401
PPP1R3G protein phosphatase 1, regulatory subunit 3G -4.11401
RASA4 RAS p21 protein activator 4 -4.11401
HPGDS hematopoietic prostaglandin D synthase -4.11401
ADAM12 ADAM metallopeptidase domain 12 -4.11401
CTXND1 cortexin domain containing 1 -4.11401
RPS21-DT RPS21 divergent transcript -4.11401
STING1 stimulator of interferon response cGAMP interactor 1 -4.11401
LSMEM2 leucine-rich single-pass membrane protein 2 -4.11401
CATSPERT catsper channel auxiliary subunit tau -4.11401
ZNF723 zinc finger protein 723 -3.74585
KCNH6 potassium channel, voltage gated eag related subfamily H, member 6 -3.69805
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae) -3.36145
SEC11A SEC11 homolog A (S. cerevisiae) -3.35025
MKRN2 makorin ring finger protein 2 -3.2606
SLC35A2 solute carrier family 35 (UDP-galactose transporter), member A2 -3.25369
GNB5 guanine nucleotide binding protein (G protein), beta 5 -3.20368
TMEM86B transmembrane protein 86B -3.00902
TMC3 transmembrane channel-like 3 -3.00902
KCTD11 potassium channel tetramerization domain containing 11 -3.00902
GPR171 G protein-coupled receptor 171 -2.99708
SFRP5 secreted frizzled-related protein 5 -2.88803
ART5 ADP-ribosyltransferase 5 -2.81918
ATAD5 ATPase family, AAA domain containing 5 -2.73083
ITGB4 integrin, beta 4 -2.6945
TMEM51 transmembrane protein 51 -2.69106
COQ6 coenzyme Q6 monooxygenase -2.66325
ENOPH1 enolase-phosphatase 1 -2.64511
SOCS3 suppressor of cytokine signaling 3 -2.63164
ANKRD16 ankyrin repeat domain 16 -2.57907
BIN1 bridging integrator 1 -2.5711
ZNF593 zinc finger protein 593 -2.54537
PTCD1 pentatricopeptide repeat domain 1 -2.50909
SNX4 sorting nexin 4 -2.49254
BCL2L11 BCL2-like 11 (apoptosis facilitator) -2.48565
FOXP2 forkhead box P2 -2.45966
TM2D1 TM2 domain containing 1 -2.45741
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast) -2.45741
ZCCHC7 zinc finger, CCHC domain containing 7 -2.45668
TRABD TraB domain containing -2.44912
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -2.44912
KHSRP KH-type splicing regulatory protein -2.41038
GMPS guanine monphosphate synthase -2.40114
REPIN1 replication initiator 1 -2.40114
HMGN2 high mobility group nucleosomal binding domain 2 -2.3376
SEZ6L2 seizure related 6 homolog (mouse)-like 2 -2.302
CBFA2T3 core-binding factor, runt domain, alpha subunit 2; translocated to, 3 -2.29699
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9 -2.28423
MLPH melanophilin -2.27626
ZNF79 zinc finger protein 79 -2.27626
ELL2 elongation factor, RNA polymerase II, 2 -2.25508
ALKBH8 alkB, alkylation repair homolog 8 (E. coli) -2.24608
PLA2G10 phospholipase A2, group X -2.24608
FSCN3 fascin actin-bundling protein 3, testicular -2.24608
MUC20 mucin 20, cell surface associated -2.24608
RTBDN retbindin -2.23926
EOLA1 endothelium and lymphocyte associated ASCH domain 1 -2.23926
CCER2 coiled-coil glutamate-rich protein 2 -2.23926
SOX8 SRY (sex determining region Y)-box 8 -2.23926
NPAT nuclear protein, ataxia-telangiectasia locus -2.23285
GAS6 growth arrest-specific 6 -2.20419
NHSL3 NHS like 3 -2.19035
RDH5 retinol dehydrogenase 5 (11-cis/9-cis) -2.18072
APC adenomatous polyposis coli -2.14564
KANK1 KN motif and ankyrin repeat domains 1 -2.12451
TMED9 transmembrane emp24 protein transport domain containing 9 -2.11908
TXNL1 thioredoxin-like 1 -2.11908
ABLIM1 actin binding LIM protein 1 -2.1156
TDGF1 teratocarcinoma-derived growth factor 1 -2.09345
FOXN2 forkhead box N2 -2.07944
RSPH3 radial spoke 3 homolog (Chlamydomonas) -2.07922
CDX4 caudal type homeobox 4 -2.07922
CGRRF1 cell growth regulator with ring finger domain 1 -2.07871
ZNF860 zinc finger protein 860 -2.07871
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 -2.07119
GKAP1 G kinase anchoring protein 1 -2.05953
MICOS10 mitochondrial contact site and cristae organizing system subunit 10 -2.05953
FOXK2 forkhead box K2 -2.05382
AFF1 AF4/FMR2 family, member 1 -2.05382
KIAA1614 KIAA1614 -2.04787
NFASC neurofascin -2.03426
PRCP prolylcarboxypeptidase (angiotensinase C) -2.03426
RASSF3 Ras association (RalGDS/AF-6) domain family member 3 -2.02559
SNX8 sorting nexin 8 -2.01944
ZNF580 zinc finger protein 580 -2.009
RPL37 ribosomal protein L37 -2.00546
ABHD6 abhydrolase domain containing 6 -2.00228