SEC16A Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description SEC16 homolog A (S. cerevisiae)|This gene encodes a protein that forms part of the Sec16 complex. This protein has a role in protein transport from the endoplasmic reticulum (ER) to the Golgi and mediates COPII vesicle formation at the transitional ER. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Feb 2013] (NCBI Entrez Gene Database, 9919)
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Genes

335 genes differentially expressed following the SEC16A gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
TMPRSS11A transmembrane protease, serine 11A 2.97598
DDN dendrin 2.97598
PCDHGB3 protocadherin gamma subfamily B, 3 2.97598
GJB1 gap junction protein, beta 1, 32kDa 2.97598
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3 2.97598
SIGLEC7 sialic acid binding Ig-like lectin 7 2.97598
GDNF glial cell derived neurotrophic factor 2.97598
SLC30A2 solute carrier family 30 (zinc transporter), member 2 2.97598
DIRAS3 DIRAS family, GTP-binding RAS-like 3 2.97598
MFAP5 microfibrillar associated protein 5 2.97598
SHCBP1L SHC SH2-domain binding protein 1-like 2.97598
CNTNAP4 contactin associated protein-like 4 2.97598
HES4 hes family bHLH transcription factor 4 2.97598
HRH4 histamine receptor H4 2.97598
ZACN zinc activated ligand-gated ion channel 2.97598
SELPLG selectin P ligand 2.97598
NPAP1 nuclear pore associated protein 1 2.97598
SLC46A2 solute carrier family 46, member 2 2.97598
ASPDH aspartate dehydrogenase domain containing 2.97598
NANOS2 nanos homolog 2 (Drosophila) 2.97598
TSGA13 testis specific, 13 2.97598
OR4K17 olfactory receptor, family 4, subfamily K, member 17 2.97598
PCDHB8 protocadherin beta 8 2.97598
GPR22 G protein-coupled receptor 22 2.97598
ARHGEF15 Rho guanine nucleotide exchange factor (GEF) 15 2.97598
CHD3 chromodomain helicase DNA binding protein 3 2.97598
JCHAIN joining chain of multimeric IgA and IgM 2.97598
GALR2 galanin receptor 2 2.97598
OIT3 oncoprotein induced transcript 3 2.97598
SLC22A7 solute carrier family 22 (organic anion transporter), member 7 2.97598
GPAT2 glycerol-3-phosphate acyltransferase 2, mitochondrial 2.97598
BOLA2 bolA family member 2 2.97598
NRSN1 neurensin 1 2.97598
TMEM184A transmembrane protein 184A 2.97598
PITX2 paired-like homeodomain 2 2.97598
ATOH1 atonal homolog 1 (Drosophila) 2.97598
MLN motilin 2.97598
GADL1 glutamate decarboxylase-like 1 2.97598
ABCG5 ATP-binding cassette, sub-family G (WHITE), member 5 2.97598
DEFB124 defensin, beta 124 2.97598
ZNF556 zinc finger protein 556 2.97598
MROH2B maestro heat-like repeat family member 2B 2.97598
KHDC3L KH domain containing 3-like, subcortical maternal complex member 2.97598
ACVRL1 activin A receptor type II-like 1 2.97598
GNRH2 gonadotropin-releasing hormone 2 2.97598
MISP mitotic spindle positioning 2.97598
NAA11 N(alpha)-acetyltransferase 11, NatA catalytic subunit 2.97598
NEUROD2 neuronal differentiation 2 2.97598
TMPRSS11D transmembrane protease, serine 11D 2.97598
TEX53 testis expressed 53 2.97598
GBP6 guanylate binding protein family, member 6 2.97598
ZNF726 zinc finger protein 726 2.97598
TAS2R60 taste receptor, type 2, member 60 2.97598
AANAT aralkylamine N-acetyltransferase 2.97598
PNLIPRP1 pancreatic lipase-related protein 1 2.97598
MYH6 myosin, heavy chain 6, cardiac muscle, alpha 2.97598
ELOVL3 ELOVL fatty acid elongase 3 2.97598
STMN4 stathmin-like 4 2.97598
FRG2C FSHD region gene 2 family, member C 2.97598
TBC1D3B TBC1 domain family, member 3B 2.97598
HAO2 hydroxyacid oxidase 2 (long chain) 2.97598
CCN6 cellular communication network factor 6 2.97598
WASL-DT WASL divergent transcript 2.97598
ANKRD42-DT ANKRD42 divergent transcript 2.97598
FOXL3 forkhead box L3 2.97598
C4ORF54 chromosome 4 open reading frame 54 2.97598
H4C12 H4 clustered histone 12 2.97598
SERTM2 serine rich and transmembrane domain containing 2 2.97598
CFAP107 cilia and flagella associated protein 107 2.97598
H2BW1 H2B.W histone 1 2.97598
TAFA3 TAFA chemokine like family member 3 2.97598
GPRASP3 G protein-coupled receptor associated sorting protein family member 3 2.97598
LMNTD1 lamin tail domain containing 1 2.97598
TMPRSS6 transmembrane protease, serine 6 2.97598
RERG RAS-like, estrogen-regulated, growth inhibitor 2.97598
CACNA1S calcium channel, voltage-dependent, L type, alpha 1S subunit 2.97598
UROC1 urocanate hydratase 1 2.97598
LIX1 Lix1 homolog (chicken) 2.97598
TNFRSF14 tumor necrosis factor receptor superfamily, member 14 2.97598
NXPE1 neurexophilin and PC-esterase domain family, member 1 2.97598
PCDHB12 protocadherin beta 12 2.97598
SPATA31F1 SPATA31 subfamily F member 1 2.97598
SLC22A16 solute carrier family 22 (organic cation/carnitine transporter), member 16 2.97598
SYCP1 synaptonemal complex protein 1 2.97598
OVOL3 ovo-like zinc finger 3 2.97598
KCNT1 potassium channel, sodium activated subfamily T, member 1 2.97598
SAG S-antigen; retina and pineal gland (arrestin) 2.97598
IMPG1 interphotoreceptor matrix proteoglycan 1 2.97598
GATA5 GATA binding protein 5 2.97598
SOAT2 sterol O-acyltransferase 2 2.97598
PCDHGC5 protocadherin gamma subfamily C, 5 2.97598
ZAR1L zygote arrest 1-like 2.97598
PGA5 pepsinogen 5, group I (pepsinogen A) 2.97598
SASH3 SAM and SH3 domain containing 3 2.97598
SPDYC speedy/RINGO cell cycle regulator family member C 2.97598
CREB3L3 cAMP responsive element binding protein 3-like 3 2.97598
GJA5 gap junction protein, alpha 5, 40kDa 2.97598
FAM209B family with sequence similarity 209, member B 2.97598
TREH trehalase (brush-border membrane glycoprotein) 2.97598
MUCL1 mucin-like 1 2.97598
CCL15 chemokine (C-C motif) ligand 15 2.97598
ISL2 ISL LIM homeobox 2 2.97598
TEX19 testis expressed 19 2.97598
HRCT1 histidine rich carboxyl terminus 1 2.97598
KLK15 kallikrein-related peptidase 15 2.97598
ZC3H11D zinc finger CCCH-type containing 11D 2.97598
UTS2R urotensin 2 receptor 2.97598
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1 2.97598
SULT2A1 sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 2.97598
PCDHGB1 protocadherin gamma subfamily B, 1 2.97598
ARHGAP20 Rho GTPase activating protein 20 2.97598
ZSCAN4 zinc finger and SCAN domain containing 4 2.97598
OR56A3 olfactory receptor, family 56, subfamily A, member 3 2.97598
OTC ornithine carbamoyltransferase 2.97598
DPRX divergent-paired related homeobox 2.97598
KLHL41 kelch-like family member 41 2.97598
IL21R interleukin 21 receptor 2.97598
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) 2.97598
UTS2B urotensin 2B 2.97598
RIPPLY2 ripply transcriptional repressor 2 2.97598
OPTC opticin 2.97598
C4B complement component 4B (Chido blood group) 2.97598
CASQ1 calsequestrin 1 (fast-twitch, skeletal muscle) 2.97598
ADAM18 ADAM metallopeptidase domain 18 2.97598
GBX2 gastrulation brain homeobox 2 2.97598
DKK1 dickkopf WNT signaling pathway inhibitor 1 2.97598
DRC7 dynein regulatory complex subunit 7 2.97598
VMO1 vitelline membrane outer layer 1 homolog (chicken) 2.97598
LRRC24 leucine rich repeat containing 24 2.97598
C11ORF42 chromosome 11 open reading frame 42 2.97598
ERVV-2 endogenous retrovirus group V, member 2 2.97598
TH tyrosine hydroxylase 2.97598
AGAP2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 2.97598
CTSS cathepsin S 2.97598
IGLL1 immunoglobulin lambda-like polypeptide 1 2.97598
CA5A carbonic anhydrase VA, mitochondrial 2.97598
CTRB1 chymotrypsinogen B1 2.97598
FLRT3 fibronectin leucine rich transmembrane protein 3 2.97598
DCN decorin 2.97598
CYTH4 cytohesin 4 2.97598
HCRT hypocretin (orexin) neuropeptide precursor 2.97598
AQP1 aquaporin 1 (Colton blood group) 2.97598
SLFN12L schlafen family member 12-like 2.97598
ASAH2 N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2 2.97598
SLCO1C1 solute carrier organic anion transporter family, member 1C1 2.97598
LBX2 ladybird homeobox 2 2.97598
NUTM2B NUT family member 2B 2.97598
IL10RA interleukin 10 receptor, alpha 2.97598
EPO erythropoietin 2.97598
POTEC POTE ankyrin domain family, member C 2.97598
DUOXA1 dual oxidase maturation factor 1 2.97598
FUT5 fucosyltransferase 5 (alpha (1,3) fucosyltransferase) 2.97598
ANKRD2 ankyrin repeat domain 2 (stretch responsive muscle) 2.97598
CLCA1 chloride channel accessory 1 2.97598
FOSB FBJ murine osteosarcoma viral oncogene homolog B 2.97598
XCR1 chemokine (C motif) receptor 1 2.97598
MAGEB17 melanoma antigen family B17 2.97598
MROH2A maestro heat-like repeat family member 2A 2.97598
SUN3 Sad1 and UNC84 domain containing 3 2.97598
GPRC5D G protein-coupled receptor, class C, group 5, member D 2.97598
SSX5 synovial sarcoma, X breakpoint 5 2.97598
OVOL1 ovo-like zinc finger 1 2.93725
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa 2.93725
SMG8 SMG8 nonsense mediated mRNA decay factor 2.93641
ADGRE2 adhesion G protein-coupled receptor E2 2.78517
MPZL3 myelin protein zero-like 3 2.74735
AOX1 aldehyde oxidase 1 2.64644
FRMD1 FERM domain containing 1 2.59441
AUP1 ancient ubiquitous protein 1 2.52095
METTL22 methyltransferase like 22 2.51674
SEC31A SEC31 homolog A (S. cerevisiae) 2.48951
ITGB1BP2 integrin beta 1 binding protein (melusin) 2 2.46333
SERPINI2 serpin peptidase inhibitor, clade I (pancpin), member 2 2.45321
ERFE erythroferrone 2.45321
ADIRF adipogenesis regulatory factor 2.45321
BMAL1 basic helix-loop-helix ARNT like 1 2.45321
LINC02560 long intergenic non-protein coding RNA 2560 2.44521
FAM114A1 family with sequence similarity 114, member A1 2.4396
TMED2 transmembrane emp24 domain trafficking protein 2 2.42894
SKAP2 src kinase associated phosphoprotein 2 2.42335
MANBAL mannosidase, beta A, lysosomal-like 2.42012
CDCA5 cell division cycle associated 5 2.40694
CTBP2 C-terminal binding protein 2 2.40055
MED8 mediator complex subunit 8 2.37931
NUTM1 NUT midline carcinoma, family member 1 2.37369
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled 2.37369
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) 2.3599
LTF lactotransferrin 2.34181
ETFA electron-transfer-flavoprotein, alpha polypeptide 2.32883
RNPEPL1 arginyl aminopeptidase (aminopeptidase B)-like 1 2.25854
LMCD1 LIM and cysteine-rich domains 1 2.21148
HILPDA hypoxia inducible lipid droplet-associated 2.19681
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 2.18865
MAP7D3 MAP7 domain containing 3 2.18358
LIPE lipase, hormone-sensitive 2.17537
APOBEC3C apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C 2.16846
ADAMTS20 ADAM metallopeptidase with thrombospondin type 1 motif, 20 2.16229
CNN1 calponin 1, basic, smooth muscle 2.16229
DCX doublecortin 2.1502
PTPN14 protein tyrosine phosphatase, non-receptor type 14 2.14773
GRIK1 glutamate receptor, ionotropic, kainate 1 2.11626
ZNF789 zinc finger protein 789 2.09668
PRDM10 PR domain containing 10 2.08973
ZBTB24 zinc finger and BTB domain containing 24 2.08973
PRCC papillary renal cell carcinoma (translocation-associated) 2.08178
TGFBI transforming growth factor, beta-induced, 68kDa 2.06625
CNGB3 cyclic nucleotide gated channel beta 3 2.06625
OTULINL OTU deubiquitinase with linear linkage specificity like 2.05521
CDK17 cyclin-dependent kinase 17 2.04055
ATP1B2 ATPase, Na+/K+ transporting, beta 2 polypeptide 2.04026
TM9SF2 transmembrane 9 superfamily member 2 2.03838
NEK2 NIMA-related kinase 2 2.03468
EPS15L1 epidermal growth factor receptor pathway substrate 15-like 1 2.02865
SLC30A6 solute carrier family 30 (zinc transporter), member 6 2.02855
ZNF883 zinc finger protein 883 2.01998
SCUBE2 signal peptide, CUB domain, EGF-like 2 2.00813
GAS1 growth arrest-specific 1 2.00131
ASB14 ankyrin repeat and SOCS box containing 14 2.00131
LAIR1 leukocyte-associated immunoglobulin-like receptor 1 2.00131
RGPD1 RANBP2-like and GRIP domain containing 1 2.00131
ODAD1 outer dynein arm docking complex subunit 1 2.00131
ABTB1 ankyrin repeat and BTB (POZ) domain containing 1 2.00131
PCNP PEST proteolytic signal containing nuclear protein 2.00131
MARCKS myristoylated alanine-rich protein kinase C substrate 2.00131
ABCG8 ATP-binding cassette, sub-family G (WHITE), member 8 2.00131
GET4 golgi to ER traffic protein 4 homolog (S. cerevisiae) 2.00131
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD) 2.00131
PEBP4 phosphatidylethanolamine-binding protein 4 2.00131
SIX1 SIX homeobox 1 2.00131

decreased expression

Symbol Name Standardized Value
LRFN5 leucine rich repeat and fibronectin type III domain containing 5 -2.97598
EPN3 epsin 3 -2.97598
ACKR3 atypical chemokine receptor 3 -2.97598
TNC tenascin C -2.97598
APOBEC4 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 4 (putative) -2.97598
GNG8 guanine nucleotide binding protein (G protein), gamma 8 -2.97598
BMP8A bone morphogenetic protein 8a -2.97598
DYNAP dynactin associated protein -2.97598
CCDC159 coiled-coil domain containing 159 -2.97598
CDKL4 cyclin-dependent kinase-like 4 -2.97598
CXCR5 chemokine (C-X-C motif) receptor 5 -2.97598
KCNH3 potassium channel, voltage gated eag related subfamily H, member 3 -2.97598
CA9 carbonic anhydrase IX -2.97598
C2ORF80 chromosome 2 open reading frame 80 -2.97598
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta -2.97598
SULT1A2 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2 -2.97598
SLC35D3 solute carrier family 35, member D3 -2.97598
STOML1 stomatin (EPB72)-like 1 -2.97598
ITIH6 inter-alpha-trypsin inhibitor heavy chain family, member 6 -2.97598
CXCL2 chemokine (C-X-C motif) ligand 2 -2.97598
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent) -2.97598
SEC16A SEC16 homolog A (S. cerevisiae) -2.97598
LURAP1L leucine rich adaptor protein 1-like -2.97598
PRKAB2 protein kinase, AMP-activated, beta 2 non-catalytic subunit -2.97598
LRRC55 leucine rich repeat containing 55 -2.97598
POM121L2 POM121 transmembrane nucleoporin-like 2 -2.97598
TTC29 tetratricopeptide repeat domain 29 -2.97598
UCN urocortin -2.97598
SERPINA10 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10 -2.97598
INCA1 inhibitor of CDK, cyclin A1 interacting protein 1 -2.97598
ALDOB aldolase B, fructose-bisphosphate -2.97598
CSDC2 cold shock domain containing C2, RNA binding -2.97598
PHF24 PHD finger protein 24 -2.97598
OR52P1 olfactory receptor family 52 subfamily P member 1 (gene/pseudogene) -2.97598
VXN vexin -2.97598
ODAPH odontogenesis associated phosphoprotein -2.97598
RASL10A RAS-like, family 10, member A -2.97598
NTF4 neurotrophin 4 -2.97598
MBLAC1 metallo-beta-lactamase domain containing 1 -2.97598
INHA inhibin, alpha -2.97598
C2CD4A C2 calcium-dependent domain containing 4A -2.97598
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) -2.97598
PCDHGA8 protocadherin gamma subfamily A, 8 -2.97598
TREX2 three prime repair exonuclease 2 -2.97598
SHISA8 shisa family member 8 -2.97598
STX11 syntaxin 11 -2.97598
PRIM2 primase, DNA, polypeptide 2 (58kDa) -2.97598
RRH retinal pigment epithelium-derived rhodopsin homolog -2.97598
GGPS1 geranylgeranyl diphosphate synthase 1 -2.80737
ZNF83 zinc finger protein 83 -2.73618
SDHAF2 succinate dehydrogenase complex assembly factor 2 -2.7342
SHPRH SNF2 histone linker PHD RING helicase, E3 ubiquitin protein ligase -2.66628
RNF187 ring finger protein 187 -2.62901
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) -2.61855
ZGRF1 zinc finger, GRF-type containing 1 -2.50427
EXOC5 exocyst complex component 5 -2.46333
DDX52 DEAD (Asp-Glu-Ala-Asp) box polypeptide 52 -2.45321
SDS serine dehydratase -2.42917
SYNPO2L synaptopodin 2-like -2.42917
PIRT phosphoinositide-interacting regulator of transient receptor potential channels -2.42917
TMEM170A transmembrane protein 170A -2.42335
IFI16 interferon, gamma-inducible protein 16 -2.39231
OTOA otoancorin -2.39231
AP5M1 adaptor-related protein complex 5, mu 1 subunit -2.39231
ACTN4 actinin, alpha 4 -2.39231
F11 coagulation factor XI -2.39231
HAP1 huntingtin-associated protein 1 -2.38495
TARBP1 TAR (HIV-1) RNA binding protein 1 -2.38444
EBAG9 estrogen receptor binding site associated, antigen, 9 -2.38411
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 -2.36262
FTH1 ferritin, heavy polypeptide 1 -2.35793
METTL1 methyltransferase like 1 -2.29476
TECPR2 tectonin beta-propeller repeat containing 2 -2.26241
EZR ezrin -2.26241
TMEM267 transmembrane protein 267 -2.25239
SPCS2 signal peptidase complex subunit 2 homolog (S. cerevisiae) -2.24564
RASGRP4 RAS guanyl releasing protein 4 -2.23248
ACOX2 acyl-CoA oxidase 2, branched chain -2.23248
HMGN4 high mobility group nucleosomal binding domain 4 -2.22825
BYSL bystin-like -2.18358
ADGRL1 adhesion G protein-coupled receptor L1 -2.17881
MRPS6 mitochondrial ribosomal protein S6 -2.17333
AQP11 aquaporin 11 -2.16799
IFFO1 intermediate filament family orphan 1 -2.1659
RPL39L ribosomal protein L39-like -2.16229
PIERCE2 piercer of microtubule wall 2 -2.13884
CNN3 calponin 3, acidic -2.13639
EPSTI1 epithelial stromal interaction 1 (breast) -2.12823
IER2 immediate early response 2 -2.12742
LAMC2 laminin, gamma 2 -2.12019
RGPD2 RANBP2-like and GRIP domain containing 2 -2.11288
KLF12 Kruppel-like factor 12 -2.10723
PDE4B phosphodiesterase 4B, cAMP-specific -2.1034
ZNF37A zinc finger protein 37A -2.08299
ZNF415 zinc finger protein 415 -2.06625
PDPK1 3-phosphoinositide dependent protein kinase 1 -2.06069
DYNLT5 dynein light chain Tctex-type family member 5 -2.05521
POLDIP2 polymerase (DNA-directed), delta interacting protein 2 -2.04372
NTF3 neurotrophin 3 -2.03685
PSMD12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 -2.01797
STK26 serine/threonine protein kinase 26 -2.00826
ANKZF1 ankyrin repeat and zinc finger domain containing 1 -2.00177
SH2D5 SH2 domain containing 5 -2.00131
SUPT16H suppressor of Ty 16 homolog (S. cerevisiae) -2.00131
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 -2.00131
PSMD7 proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 -2.00131