SEC23A Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description Sec23 homolog A (S. cerevisiae)|The protein encoded by this gene is a member of the SEC23 subfamily of the SEC23/SEC24 family. It is part of a protein complex and found in the ribosome-free transitional face of the endoplasmic reticulum (ER) and associated vesicles. This protein has similarity to yeast Sec23p component of COPII. COPII is the coat protein complex responsible for vesicle budding from the ER. The encoded protein is suggested to play a role in the ER-Golgi protein trafficking. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 10484)
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Genes

341 genes differentially expressed following the SEC23A gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
TMEM119 transmembrane protein 119 2.39361
FRG2C FSHD region gene 2 family, member C 2.39361
IL18R1 interleukin 18 receptor 1 2.39361
SCNN1D sodium channel, non voltage gated 1 delta subunit 2.39361
TPTE transmembrane phosphatase with tensin homology 2.39361
MYH13 myosin, heavy chain 13, skeletal muscle 2.39361
CBX2 chromobox homolog 2 2.39361
CACNG2 calcium channel, voltage-dependent, gamma subunit 2 2.39361
HIGD1B HIG1 hypoxia inducible domain family, member 1B 2.39361
EPPIN epididymal peptidase inhibitor 2.39361
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5 2.39361
NLRP3 NLR family, pyrin domain containing 3 2.39361
OR2AT4 olfactory receptor, family 2, subfamily AT, member 4 2.39361
MSX2 msh homeobox 2 2.39361
MAEL maelstrom spermatogenic transposon silencer 2.39361
GABRD gamma-aminobutyric acid (GABA) A receptor, delta 2.39361
OTP orthopedia homeobox 2.39361
PRDM12 PR domain containing 12 2.39361
PLVAP plasmalemma vesicle associated protein 2.34995
MYBPC3 myosin binding protein C, cardiac 2.34995
OR1I1 olfactory receptor, family 1, subfamily I, member 1 2.34995
NDRG1 N-myc downstream regulated 1 2.34995
P2RY2 purinergic receptor P2Y, G-protein coupled, 2 2.34995
MS4A4A membrane-spanning 4-domains, subfamily A, member 4A 2.34995
WDR87 WD repeat domain 87 2.34995
CDH3 cadherin 3, type 1, P-cadherin (placental) 2.34995
TMEM212 transmembrane protein 212 2.34995
IRF5 interferon regulatory factor 5 2.34995
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3 2.34995
SLC2A4RG SLC2A4 regulator 2.34995
MYBPHL myosin binding protein H-like 2.34995
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B 2.34995
CLEC12A C-type lectin domain family 12, member A 2.34995
ISM2 isthmin 2 2.34995
CD14 CD14 molecule 2.34995
ADA adenosine deaminase 2.34995
BATF basic leucine zipper transcription factor, ATF-like 2.34995
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 2.34995
PECAM1 platelet/endothelial cell adhesion molecule 1 2.34995
ADGB androglobin 2.34995
TRAT1 T cell receptor associated transmembrane adaptor 1 2.34995
PTGFR prostaglandin F receptor (FP) 2.34995
WSB1 WD repeat and SOCS box containing 1 2.34995
UMODL1 uromodulin-like 1 2.34995
KCNE4 potassium channel, voltage gated subfamily E regulatory beta subunit 4 2.34995
OLIG3 oligodendrocyte transcription factor 3 2.34995
MUC5B mucin 5B, oligomeric mucus/gel-forming 2.34995
SKOR2 SKI family transcriptional corepressor 2 2.34995
NANOS3 nanos homolog 3 (Drosophila) 2.34995
CAMP cathelicidin antimicrobial peptide 2.34995
PRELP proline/arginine-rich end leucine-rich repeat protein 2.34995
SLC35G5 solute carrier family 35, member G5 2.34995
TNNT3 troponin T type 3 (skeletal, fast) 2.34995
CASP4 caspase 4, apoptosis-related cysteine peptidase 2.34995
CLEC19A C-type lectin domain family 19, member A 2.34995
LRRC14B leucine rich repeat containing 14B 2.34995
GSTM5 glutathione S-transferase mu 5 2.34995
CPB2 carboxypeptidase B2 (plasma) 2.34995
SPMIP1 sperm microtubule inner protein 1 2.34995
MYH8 myosin, heavy chain 8, skeletal muscle, perinatal 2.34995
HTRA4 HtrA serine peptidase 4 2.34995
SRGN serglycin 2.34995
LMNTD1 lamin tail domain containing 1 2.34995
ABCC12 ATP-binding cassette, sub-family C (CFTR/MRP), member 12 2.34995
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 2.34995
SHROOM2 shroom family member 2 2.34995
FOXC2 forkhead box C2 2.34995
C10ORF53 chromosome 10 open reading frame 53 2.34995
PNLIPRP1 pancreatic lipase-related protein 1 2.34995
OTOS otospiralin 2.34995
SPDYE8 speedy/RINGO cell cycle regulator family member E8 2.34995
FAM240A family with sequence similarity 240 member A 2.34995
TMA7B translation machinery associated 7 homolog B 2.34995
SMIM31 small integral membrane protein 31 2.34995
H2BC3 H2B clustered histone 3 2.34995
CABCOCO1 ciliary associated calcium binding coiled-coil 1 2.34995
LBHD2 LBH domain containing 2 2.34995
GMCL2 germ cell-less 2, spermatogenesis associated 2.34995
ERVW-1 endogenous retrovirus group W, member 1 2.34995
LRTM3 leucine rich repeat transmembrane protein 3 2.34995
TSPAN8 tetraspanin 8 2.34995
OR51M1 olfactory receptor, family 51, subfamily M, member 1 2.34995
NHLRC1 NHL repeat containing E3 ubiquitin protein ligase 1 2.34995
LDHAL6B lactate dehydrogenase A-like 6B 2.34995
MEOX1 mesenchyme homeobox 1 2.34995
SCN10A sodium channel, voltage gated, type X alpha subunit 2.34995
TRAPPC3L trafficking protein particle complex 3-like 2.34995
MBD1 methyl-CpG binding domain protein 1 2.34995
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa 2.34995
NKX2-6 NK2 homeobox 6 2.34995
OR2A2 olfactory receptor, family 2, subfamily A, member 2 2.34995
GZMM granzyme M (lymphocyte met-ase 1) 2.34995
TBX5 T-box 5 2.34995
LAMA2 laminin, alpha 2 2.34995
GATA5 GATA binding protein 5 2.34995
GATA4 GATA binding protein 4 2.34995
MSGN1 mesogenin 1 2.34995
CNTN6 contactin 6 2.34995
LRRN4CL LRRN4 C-terminal like 2.34995
GDF9 growth differentiation factor 9 2.34995
VCX3B variable charge, X-linked 3B 2.34995
S100B S100 calcium binding protein B 2.34995
OR2A1 olfactory receptor, family 2, subfamily A, member 1 2.34995
ANKRD33 ankyrin repeat domain 33 2.34995
LRTM2 leucine-rich repeats and transmembrane domains 2 2.34995
EXTL1 exostosin-like glycosyltransferase 1 2.34995
EFCAB3 EF-hand calcium binding domain 3 2.34995
AQP9 aquaporin 9 2.34995
PRM2 protamine 2 2.34995
NIPAL4 NIPA-like domain containing 4 2.34995
MAB21L2 mab-21-like 2 (C. elegans) 2.34995
MAB21L1 mab-21-like 1 (C. elegans) 2.34995
CCDC185 coiled-coil domain containing 185 2.34995
CNTF ciliary neurotrophic factor 2.34995
TXNIP thioredoxin interacting protein 2.34995
CSF3R colony stimulating factor 3 receptor (granulocyte) 2.34995
ECM1 extracellular matrix protein 1 2.34995
CMTM5 CKLF-like MARVEL transmembrane domain containing 5 2.34995
PLA2G4D phospholipase A2, group IVD (cytosolic) 2.34995
MORC1 MORC family CW-type zinc finger 1 2.34995
VAX2 ventral anterior homeobox 2 2.34995
DAPL1 death associated protein-like 1 2.34995
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) 2.34995
MOGS mannosyl-oligosaccharide glucosidase 2.34995
MUC13 mucin 13, cell surface associated 2.34995
VWA3B von Willebrand factor A domain containing 3B 2.34995
ZCCHC12 zinc finger, CCHC domain containing 12 2.34995
HIGD2B HIG1 hypoxia inducible domain family, member 2B 2.34995
SLC38A8 solute carrier family 38, member 8 2.34995
MOK MOK protein kinase 2.34995
ROS1 ROS proto-oncogene 1 , receptor tyrosine kinase 2.34995
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3 2.34995
SERPINB8 serpin peptidase inhibitor, clade B (ovalbumin), member 8 2.34995
SLC17A3 solute carrier family 17 (organic anion transporter), member 3 2.34995
SLC17A4 solute carrier family 17, member 4 2.34995
DLGAP5 discs, large (Drosophila) homolog-associated protein 5 2.34995
PWP2 PWP2 periodic tryptophan protein homolog (yeast) 2.34995
INPP1 inositol polyphosphate-1-phosphatase 2.34995
TWSG1 twisted gastrulation BMP signaling modulator 1 2.34995
IGF2 insulin-like growth factor 2 2.34995
TBX2 T-box 2 2.34995
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) 2.34995
SPEF1 sperm flagellar 1 2.34995
ALDH5A1 aldehyde dehydrogenase 5 family, member A1 2.34995
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) 2.34995
TPPP2 tubulin polymerization-promoting protein family member 2 2.34995
PLA2G12B phospholipase A2, group XIIB 2.34995
BCL2A1 BCL2-related protein A1 2.34995
NNMT nicotinamide N-methyltransferase 2.34995
LBX2 ladybird homeobox 2 2.34995
CHD4 chromodomain helicase DNA binding protein 4 2.34995
NLRP9 NLR family, pyrin domain containing 9 2.34995
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa 2.34995
IRX5 iroquois homeobox 5 2.34995
HMX3 H6 family homeobox 3 2.34995
RTP3 receptor (chemosensory) transporter protein 3 2.34995
LYPLA1 lysophospholipase I 2.34995
HMX1 H6 family homeobox 1 2.34995
FAM9B family with sequence similarity 9, member B 2.34995
SGCA sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein) 2.34995
CCDC89 coiled-coil domain containing 89 2.34995
METTL21C methyltransferase like 21C 2.34995
ABRA actin binding Rho activating protein 2.34995
WNT8B wingless-type MMTV integration site family, member 8B 2.34995
NAA11 N(alpha)-acetyltransferase 11, NatA catalytic subunit 2.34995
GHRH growth hormone releasing hormone 2.34995
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19 2.34995
NOX1 NADPH oxidase 1 2.34995
HEPACAM2 HEPACAM family member 2 2.34995
S100A7 S100 calcium binding protein A7 2.34995
DUOXA1 dual oxidase maturation factor 1 2.34995
EN1 engrailed homeobox 1 2.34995
TMEM223 transmembrane protein 223 2.34995
OR5V1 olfactory receptor, family 5, subfamily V, member 1 2.34995
CEACAM21 carcinoembryonic antigen-related cell adhesion molecule 21 2.34995
KCNK16 potassium channel, two pore domain subfamily K, member 16 2.34995
ANGPTL3 angiopoietin-like 3 2.34995
PADI1 peptidyl arginine deiminase, type I 2.34995
ST18 suppression of tumorigenicity 18, zinc finger 2.34995
DXO decapping exoribonuclease 2.34434
GPD1L glycerol-3-phosphate dehydrogenase 1-like 2.33039
SUN3 Sad1 and UNC84 domain containing 3 2.31939
DCAF4L1 DDB1 and CUL4 associated factor 4-like 1 2.31939
ALAD aminolevulinate dehydratase 2.31408
ZNF10 zinc finger protein 10 2.31023
LRRC4 leucine rich repeat containing 4 2.2526
TBX15 T-box 15 2.24743
IDUA iduronidase, alpha-L- 2.24743
RASD1 RAS, dexamethasone-induced 1 2.24743
ZNF671 zinc finger protein 671 2.19796
IQANK1 IQ motif and ankyrin repeat containing 1 2.183
ZNRF1 zinc and ring finger 1, E3 ubiquitin protein ligase 2.17974
GIN1 gypsy retrotransposon integrase 1 2.17816
PRRT4 proline-rich transmembrane protein 4 2.16372
GAL3ST4 galactose-3-O-sulfotransferase 4 2.12621
SUSD1 sushi domain containing 1 2.11307
C1GALT1 core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 2.08911
ABCB8 ATP-binding cassette, sub-family B (MDR/TAP), member 8 2.08911
TGFB1 transforming growth factor, beta 1 2.08911
GDPD2 glycerophosphodiester phosphodiesterase domain containing 2 2.0652
ERGIC1 endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1 2.05923
PSKH1 protein serine kinase H1 2.05923
ADAT2 adenosine deaminase, tRNA-specific 2 2.05137
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 2.05137
LIN28B lin-28 homolog B (C. elegans) 2.04847
NEURL1B neuralized E3 ubiquitin protein ligase 1B 2.0357
WNT2B wingless-type MMTV integration site family, member 2B 2.0329
STPG2 sperm-tail PG-rich repeat containing 2 2.0294
ANO1 anoctamin 1, calcium activated chloride channel 2.02681
LMAN1 lectin, mannose-binding, 1 2.02455
ZNF646 zinc finger protein 646 2.01282
XRN1 5'-3' exoribonuclease 1 2.01168
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 2.01089
A2M alpha-2-macroglobulin 2.00881
SACK1B scaffolding CK1 anchoring protein B 2.00633
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase) 2.00258

decreased expression

Symbol Name Standardized Value
IQCN IQ motif containing N -2.39361
ANKRD65 ankyrin repeat domain 65 -2.39361
EMILIN1 elastin microfibril interfacer 1 -2.39361
H4C1 H4 clustered histone 1 -2.39361
GJA4 gap junction protein, alpha 4, 37kDa -2.39361
LGSN lengsin, lens protein with glutamine synthetase domain -2.39361
SCART1 scavenger receptor protein family member -2.39361
EFCC1 EF-hand and coiled-coil domain containing 1 -2.39361
AADACL3 arylacetamide deacetylase-like 3 -2.39361
SPDL1 spindle apparatus coiled-coil protein 1 -2.36996
TLR7 toll-like receptor 7 -2.34995
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -2.34995
CLDN2 claudin 2 -2.34995
SEMA3G sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G -2.34995
CDCP2 CUB domain containing protein 2 -2.34995
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 -2.34995
MRPL2 mitochondrial ribosomal protein L2 -2.34995
CBLN1 cerebellin 1 precursor -2.34995
EP400 E1A binding protein p400 -2.34995
ARL6IP6 ADP-ribosylation factor-like 6 interacting protein 6 -2.34995
DPP9 dipeptidyl-peptidase 9 -2.34995
SLC22A5 solute carrier family 22 (organic cation/carnitine transporter), member 5 -2.34995
LPA lipoprotein, Lp(a) -2.34995
FBXO9 F-box protein 9 -2.34995
CA7 carbonic anhydrase VII -2.34995
SEC23A Sec23 homolog A (S. cerevisiae) -2.34995
PTCD2 pentatricopeptide repeat domain 2 -2.34995
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1 -2.34995
CHD7 chromodomain helicase DNA binding protein 7 -2.34995
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide -2.34995
NDST4 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4 -2.34995
C1ORF116 chromosome 1 open reading frame 116 -2.34995
LDHC lactate dehydrogenase C -2.34995
ZNF804A zinc finger protein 804A -2.34995
SLC10A4 solute carrier family 10, member 4 -2.34995
CD34 CD34 molecule -2.34995
PPIP5K1 diphosphoinositol pentakisphosphate kinase 1 -2.34995
LOXL4 lysyl oxidase-like 4 -2.34995
RGN regucalcin -2.34995
LIMS3 LIM and senescent cell antigen-like domains 3 -2.34995
CCER2 coiled-coil glutamate-rich protein 2 -2.34995
GBP4 guanylate binding protein 4 -2.34995
COL17A1 collagen, type XVII, alpha 1 -2.34995
PNN pinin, desmosome associated protein -2.34995
VEGFD vascular endothelial growth factor D -2.34995
CLEC20A C-type lectin domain containing 20A -2.34995
ZNF835 zinc finger protein 835 -2.34995
WWP1 WW domain containing E3 ubiquitin protein ligase 1 -2.34995
CCDC92B coiled-coil domain containing 92B -2.34995
LRAT lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase) -2.34995
MEPE matrix extracellular phosphoglycoprotein -2.34995
DRD2 dopamine receptor D2 -2.34995
LOC124904542 uncharacterized LOC124904542 -2.34995
BATF2 basic leucine zipper transcription factor, ATF-like 2 -2.34995
MTMR11 myotubularin related protein 11 -2.34995
RAB3IL1 RAB3A interacting protein (rabin3)-like 1 -2.34995
TSPAN18 tetraspanin 18 -2.34995
TRPA1 transient receptor potential cation channel, subfamily A, member 1 -2.34995
REP15 RAB15 effector protein -2.34995
TM7SF2 transmembrane 7 superfamily member 2 -2.34995
DHDDS dehydrodolichyl diphosphate synthase -2.34995
RPN1 ribophorin I -2.34995
CXCR5 chemokine (C-X-C motif) receptor 5 -2.34995
PLEKHA3 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 3 -2.32791
RLN1 relaxin 1 -2.32165
FBP1 fructose-1,6-bisphosphatase 1 -2.32165
GRID1 glutamate receptor, ionotropic, delta 1 -2.32165
WRN Werner syndrome, RecQ helicase-like -2.31939
NUB1 negative regulator of ubiquitin-like proteins 1 -2.30343
ATG16L1 autophagy related 16-like 1 (S. cerevisiae) -2.29646
ATAD2 ATPase family, AAA domain containing 2 -2.27659
BROX BRO1 domain and CAAX motif containing -2.24956
KIDINS220 kinase D-interacting substrate, 220kDa -2.22946
PIP4P1 phosphatidylinositol-4,5-bisphosphate 4-phosphatase 1 -2.21566
CYP3A7 cytochrome P450, family 3, subfamily A, polypeptide 7 -2.20987
CALCA calcitonin-related polypeptide alpha -2.19796
RPS5 ribosomal protein S5 -2.19796
DLX4 distal-less homeobox 4 -2.19796
LIAT1 ligand of ATE1 -2.19796
CHRNA9 cholinergic receptor, nicotinic, alpha 9 (neuronal) -2.19796
MID2 midline 2 -2.19796
PRRG2 proline rich Gla (G-carboxyglutamic acid) 2 -2.19796
URGCP upregulator of cell proliferation -2.19223
TNXB tenascin XB -2.19223
ZNF672 zinc finger protein 672 -2.18571
CNNM1 cyclin and CBS domain divalent metal cation transport mediator 1 -2.17816
SHBG sex hormone-binding globulin -2.17816
FBLN7 fibulin 7 -2.17816
BCOR BCL6 corepressor -2.17383
RUBCNL rubicon like autophagy enhancer -2.17207
HMX2 H6 family homeobox 2 -2.16372
FOXL2 forkhead box L2 -2.16372
CHMP2B charged multivesicular body protein 2B -2.16372
MESP1 mesoderm posterior basic helix-loop-helix transcription factor 1 -2.16349
SPDYE3 speedy/RINGO cell cycle regulator family member E3 -2.16349
ASS1 argininosuccinate synthase 1 -2.15367
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa -2.14256
DEPTOR DEP domain containing MTOR-interacting protein -2.14173
ZNF394 zinc finger protein 394 -2.13268
TMEM33 transmembrane protein 33 -2.12621
DDX41 DEAD (Asp-Glu-Ala-Asp) box polypeptide 41 -2.12621
SS18L2 synovial sarcoma translocation gene on chromosome 18-like 2 -2.11612
EVL Enah/Vasp-like -2.11307
ANXA6 annexin A6 -2.08911
C3ORF38 chromosome 3 open reading frame 38 -2.08911
AURKB aurora kinase B -2.06301
ADGRF3 adhesion G protein-coupled receptor F3 -2.05137
KCTD20 potassium channel tetramerization domain containing 20 -2.05137
SORCS3 sortilin-related VPS10 domain containing receptor 3 -2.04941
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7 -2.04941
SLC35E4 solute carrier family 35, member E4 -2.04941
ERAP1 endoplasmic reticulum aminopeptidase 1 -2.04941
UBAP2L ubiquitin associated protein 2-like -2.04941
C2CD5 C2 calcium-dependent domain containing 5 -2.04847
KIFC3 kinesin family member C3 -2.03675
TPCN1 two pore segment channel 1 -2.0329
ABHD3 abhydrolase domain containing 3 -2.02578
IL3RA interleukin 3 receptor, alpha (low affinity) -2.02104
SH3PXD2B SH3 and PX domains 2B -2.01991
SCAND1 SCAN domain containing 1 -2.01991
DGCR2 DiGeorge syndrome critical region gene 2 -2.01891
TMOD1 tropomodulin 1 -2.01089
NCAPH non-SMC condensin I complex, subunit H -2.00713
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans) -2.00486
PANK4 pantothenate kinase 4 -2.00258