SEC31A Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description SEC31 homolog A (S. cerevisiae)|The protein encoded by this gene is similar to yeast Sec31 protein. Yeast Sec31 protein is known to be a component of the COPII protein complex which is responsible for vesicle budding from endoplasmic reticulum (ER). This protein was found to colocalize with SEC13, one of the other components of COPII , in the subcellular structures corresponding to the vesicle transport function. An immunodepletion experiment confirmed that this protein is required for ER-Golgi transport. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 22872)
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Genes

325 genes differentially expressed following the SEC31A gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
ZNF436 zinc finger protein 436 3.33999
NEIL1 nei endonuclease VIII-like 1 (E. coli) 3.33999
ABCA10 ATP-binding cassette, sub-family A (ABC1), member 10 3.33999
TAL2 T-cell acute lymphocytic leukemia 2 3.33999
STARD6 StAR-related lipid transfer (START) domain containing 6 3.33999
COL17A1 collagen, type XVII, alpha 1 3.33999
LRRC73 leucine rich repeat containing 73 3.33999
MUC17 mucin 17, cell surface associated 3.33999
HAL histidine ammonia-lyase 3.33999
MUCL1 mucin-like 1 3.33999
CXCR2 chemokine (C-X-C motif) receptor 2 3.33999
MSX1 msh homeobox 1 3.33999
OLFML1 olfactomedin-like 1 3.33999
CBLN3 cerebellin 3 precursor 3.33999
CD48 CD48 molecule 3.33999
OR52A5 olfactory receptor, family 52, subfamily A, member 5 3.33999
PCDHGB4 protocadherin gamma subfamily B, 4 3.33999
OR52E5 olfactory receptor, family 52, subfamily E, member 5 3.33999
RTN4RL1 reticulon 4 receptor-like 1 3.33999
LY96 lymphocyte antigen 96 3.33999
PGM5 phosphoglucomutase 5 3.33999
BCL2L15 BCL2-like 15 3.33999
CCNI2 cyclin I family, member 2 3.33999
NMUR1 neuromedin U receptor 1 3.33999
TXNDC15 thioredoxin domain containing 15 3.23351
CACNG1 calcium channel, voltage-dependent, gamma subunit 1 3.23271
LDHC lactate dehydrogenase C 3.23271
CELF6 CUGBP, Elav-like family member 6 3.23271
R3HDML R3H domain containing-like 3.23271
ENTHD1 ENTH domain containing 1 3.23271
SCN2B sodium channel, voltage gated, type II beta subunit 3.23271
CD33 CD33 molecule 3.23271
MAP3K7CL MAP3K7 C-terminal like 3.23271
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4 3.23271
NR1H4 nuclear receptor subfamily 1, group H, member 4 3.23271
HTR6 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled 3.23271
INHBB inhibin, beta B 3.23271
SPINK6 serine peptidase inhibitor, Kazal type 6 3.23271
ZEB2 zinc finger E-box binding homeobox 2 3.23271
UNC45B unc-45 homolog B (C. elegans) 3.23271
MS4A14 membrane-spanning 4-domains, subfamily A, member 14 3.23271
HCRTR2 hypocretin (orexin) receptor 2 3.23271
OCM2 oncomodulin 2 3.23271
MAGED4 melanoma antigen family D4 3.23271
LGI1 leucine-rich, glioma inactivated 1 3.23271
RSPO3 R-spondin 3 3.23271
PAX9 paired box 9 3.23271
CLEC14A C-type lectin domain family 14, member A 3.23271
GNG13 guanine nucleotide binding protein (G protein), gamma 13 3.23271
NPIPA8 nuclear pore complex interacting protein family, member A8 3.23271
GDNF glial cell derived neurotrophic factor 3.23271
CRYGB crystallin, gamma B 3.23271
OR2J2 olfactory receptor, family 2, subfamily J, member 2 3.23271
TRPC5OS TRPC5 opposite strand 3.23271
FOXL1 forkhead box L1 3.23271
SBK3 SH3 domain binding kinase family, member 3 3.23271
NDRG1 N-myc downstream regulated 1 3.23271
TSPAN1 tetraspanin 1 3.23271
WNT16 wingless-type MMTV integration site family, member 16 3.23271
MIOX myo-inositol oxygenase 3.23271
TMPRSS4 transmembrane protease, serine 4 3.23271
ABCC11 ATP-binding cassette, sub-family C (CFTR/MRP), member 11 3.23271
TBC1D3B TBC1 domain family, member 3B 3.23271
PDC phosducin 3.23271
CXCL13 chemokine (C-X-C motif) ligand 13 3.23271
OTOS otospiralin 3.23271
DEPP1 DEPP autophagy regulator 1 3.23271
LORICRIN loricrin cornified envelope precursor protein 3.23271
MPIG6B megakaryocyte and platelet inhibitory receptor G6b 3.23271
SOFU1 sperm-oocyte fusion factor 1 3.23271
DUSP29 dual specificity phosphatase 29 3.23271
TEX13C TEX13 family member C 3.23271
IHO1 interactor of HORMAD1 1 3.23271
C20ORF204 chromosome 20 open reading frame 204 3.23271
SPMIP11 sperm microtubule inner protein 11 3.23271
OR51M1 olfactory receptor, family 51, subfamily M, member 1 3.23271
RNF151 ring finger protein 151 3.23271
SLC22A16 solute carrier family 22 (organic cation/carnitine transporter), member 16 3.23271
PVRIG poliovirus receptor related immunoglobulin domain containing 3.23271
RS1 retinoschisin 1 3.23271
OR5H2 olfactory receptor, family 5, subfamily H, member 2 3.23271
OPN5 opsin 5 3.23271
OASL 2'-5'-oligoadenylate synthetase-like 3.23271
GGT5 gamma-glutamyltransferase 5 3.23271
GHSR growth hormone secretagogue receptor 3.23271
PDE1B phosphodiesterase 1B, calmodulin-dependent 3.23271
MIA melanoma inhibitory activity 3.23271
NPFF neuropeptide FF-amide peptide precursor 3.23271
SAMD15 sterile alpha motif domain containing 15 3.23271
PNPLA1 patatin-like phospholipase domain containing 1 3.23271
GDF9 growth differentiation factor 9 3.23271
GDF7 growth differentiation factor 7 3.23271
ZNF705G zinc finger protein 705G 3.23271
SPMIP10 sperm microtubule inner protein 10 3.23271
PRSS55 protease, serine, 55 3.23271
CTAGE9 CTAGE family, member 9 3.23271
CPSF4L cleavage and polyadenylation specific factor 4-like 3.23271
PCP2 Purkinje cell protein 2 3.23271
KLF2 Kruppel-like factor 2 3.23271
ADAM7 ADAM metallopeptidase domain 7 3.23271
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) 3.23271
TREH trehalase (brush-border membrane glycoprotein) 3.23271
MAMLD1 mastermind-like domain containing 1 3.23271
DEFB107A defensin, beta 107A 3.23271
HHLA2 HERV-H LTR-associating 2 3.23271
S100A12 S100 calcium binding protein A12 3.23271
GBA3 glucosidase, beta, acid 3 (gene/pseudogene) 3.23271
OR2T12 olfactory receptor, family 2, subfamily T, member 12 3.23271
TP53AIP1 tumor protein p53 regulated apoptosis inducing protein 1 3.23271
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) 3.23271
FNDC9 fibronectin type III domain containing 9 3.23271
KCNK3 potassium channel, two pore domain subfamily K, member 3 3.23271
GP2 glycoprotein 2 (zymogen granule membrane) 3.23271
CSTA cystatin A (stefin A) 3.23271
RANBP3L RAN binding protein 3-like 3.23271
CCDC27 coiled-coil domain containing 27 3.23271
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled 3.23271
SLC6A20 solute carrier family 6 (proline IMINO transporter), member 20 3.23271
MYH7B myosin, heavy chain 7B, cardiac muscle, beta 3.23271
CFP complement factor properdin 3.23271
RBBP8NL RBBP8 N-terminal like 3.23271
TYR tyrosinase 3.23271
TSPAN19 tetraspanin 19 3.23271
NPM2 nucleophosmin/nucleoplasmin 2 3.23271
TPPP3 tubulin polymerization-promoting protein family member 3 3.23271
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 3.23271
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) 3.23271
MUC13 mucin 13, cell surface associated 3.23271
VWA3B von Willebrand factor A domain containing 3B 3.23271
PPP1R14D protein phosphatase 1, regulatory (inhibitor) subunit 14D 3.23271
SIAH3 siah E3 ubiquitin protein ligase family member 3 3.23271
CHRNA1 cholinergic receptor, nicotinic, alpha 1 (muscle) 3.23271
ZC3H11D zinc finger CCCH-type containing 11D 3.23271
KCNV1 potassium channel, voltage gated modifier subfamily V, member 1 3.23271
FGR FGR proto-oncogene, Src family tyrosine kinase 3.23271
GOLGA8R golgin A8 family, member R 3.23271
AQP1 aquaporin 1 (Colton blood group) 3.23271
NLRP9 NLR family, pyrin domain containing 9 3.23271
CYP2W1 cytochrome P450, family 2, subfamily W, polypeptide 1 3.23271
POPDC2 popeye domain containing 2 3.23271
IHH indian hedgehog 3.23271
NPAS4 neuronal PAS domain protein 4 3.23271
PRR15L proline rich 15-like 3.23271
MMP12 matrix metallopeptidase 12 3.23271
THEM5 thioesterase superfamily member 5 3.23271
ALLC allantoicase 3.23271
ASCL4 achaete-scute family bHLH transcription factor 4 3.23271
DNAH8 dynein, axonemal, heavy chain 8 3.23271
SNTN sentan, cilia apical structure protein 3.23271
WNK4 WNK lysine deficient protein kinase 4 3.23271
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent) 3.16361
GET4 golgi to ER traffic protein 4 homolog (S. cerevisiae) 3.16361
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 3.16361
CTDSP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1 3.05685
ZNF837 zinc finger protein 837 3.03251
SPDYE17 speedy/RINGO cell cycle regulator family member E17 3.02042
RUFY1 RUN and FYVE domain containing 1 2.9524
MIOS missing oocyte, meiosis regulator, homolog (Drosophila) 2.90292
ASS1 argininosuccinate synthase 1 2.87875
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 2.81779
INPP4A inositol polyphosphate-4-phosphatase, type I, 107kDa 2.75319
QPRT quinolinate phosphoribosyltransferase 2.70735
LRRC4B leucine rich repeat containing 4B 2.6827
SF3A1 splicing factor 3a, subunit 1, 120kDa 2.64749
DNAH1 dynein, axonemal, heavy chain 1 2.61877
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein) 2.61877
POLE4 polymerase (DNA-directed), epsilon 4, accessory subunit 2.59694
ERGIC2 ERGIC and golgi 2 2.58891
ZNF8 zinc finger protein 8 2.54293
NUDT14 nudix (nucleoside diphosphate linked moiety X)-type motif 14 2.50783
INPP5B inositol polyphosphate-5-phosphatase, 75kDa 2.41752
ANKRD42-DT ANKRD42 divergent transcript 2.41696
EBNA1BP2 EBNA1 binding protein 2 2.4037
FLVCR2 feline leukemia virus subgroup C cellular receptor family, member 2 2.40223
TNIP3 TNFAIP3 interacting protein 3 2.39636
CRB3 crumbs family member 3 2.3955
SLC17A8 solute carrier family 17 (vesicular glutamate transporter), member 8 2.35154
TNS4 tensin 4 2.35154
NAALADL1 N-acetylated alpha-linked acidic dipeptidase-like 1 2.35126
JMJD6 jumonji domain containing 6 2.35047
CABIN1 calcineurin binding protein 1 2.32379
KBTBD2 kelch repeat and BTB (POZ) domain containing 2 2.29248
EBF3 early B-cell factor 3 2.27831
TMC3 transmembrane channel-like 3 2.27831
SAXO5 stabilizer of axonemal microtubules 5 2.27831
RASGRP3 RAS guanyl releasing protein 3 (calcium and DAG-regulated) 2.27831
PRSS51 protease, serine, 51 2.27831
VARS1 valyl-tRNA synthetase 1 2.24863
LIMD2 LIM domain containing 2 2.22382
TRIM22 tripartite motif containing 22 2.2087
WRNIP1 Werner helicase interacting protein 1 2.18814
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase) 2.18814
KANK2 KN motif and ankyrin repeat domains 2 2.18814
SLC38A10 solute carrier family 38, member 10 2.17476
CDKL5 cyclin-dependent kinase-like 5 2.17169
BBX bobby sox homolog (Drosophila) 2.14388
SHFL shiftless antiviral inhibitor of ribosomal frameshifting 2.14302
LEO1 Leo1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) 2.09989
SGSM1 small G protein signaling modulator 1 2.09802
NDUFB3 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3, 12kDa 2.09214
UBA3 ubiquitin-like modifier activating enzyme 3 2.0875
USP1 ubiquitin specific peptidase 1 2.07602
TBL3 transducin (beta)-like 3 2.06781
GAK cyclin G associated kinase 2.06291
CHRNG cholinergic receptor, nicotinic, gamma (muscle) 2.05821
CYP2S1 cytochrome P450, family 2, subfamily S, polypeptide 1 2.05003
YIPF5 Yip1 domain family, member 5 2.04927
DIO2 deiodinase, iodothyronine, type II 2.0432
SLC25A40 solute carrier family 25, member 40 2.00778
ZNF100 zinc finger protein 100 2.00225
AP3D1 adaptor-related protein complex 3, delta 1 subunit 2.00225

decreased expression

Symbol Name Standardized Value
HDAC10 histone deacetylase 10 -3.33999
NICN1 nicolin 1 -3.33999
SHISAL2A shisa like 2A -3.23351
CD36 CD36 molecule (thrombospondin receptor) -3.23351
NECAB3 N-terminal EF-hand calcium binding protein 3 -3.23271
SEC31A SEC31 homolog A (S. cerevisiae) -3.23271
TENM1 teneurin transmembrane protein 1 -3.23271
PPP1R1B protein phosphatase 1, regulatory (inhibitor) subunit 1B -3.16943
PRSS22 protease, serine, 22 -3.16361
PCDHGB5 protocadherin gamma subfamily B, 5 -3.16361
A3GALT2 alpha 1,3-galactosyltransferase 2 -3.16361
GYPB glycophorin B (MNS blood group) -3.16361
DYDC1 DPY30 domain containing 1 -3.16361
KY kyphoscoliosis peptidase -3.16361
NAT16 N-acetyltransferase 16 (GCN5-related, putative) -3.16361
GNG8 guanine nucleotide binding protein (G protein), gamma 8 -3.16361
KRT86 keratin 86, type II -3.16361
OR2A5 olfactory receptor, family 2, subfamily A, member 5 -3.16361
ITPK1 inositol-tetrakisphosphate 1-kinase -3.16361
RDH12 retinol dehydrogenase 12 (all-trans/9-cis/11-cis) -3.16361
TGM1 transglutaminase 1 -3.16361
NEU4 sialidase 4 -3.16361
EVPL envoplakin -3.16361
IRX1 iroquois homeobox 1 -3.16361
WFDC1 WAP four-disulfide core domain 1 -3.16361
LRRC24 leucine rich repeat containing 24 -3.16361
SEZ6L seizure related 6 homolog (mouse)-like -3.16361
ZNF320 zinc finger protein 320 -3.16361
MORN5 MORN repeat containing 5 -3.16361
SOSTDC1 sclerostin domain containing 1 -3.16361
DRD3 dopamine receptor D3 -3.16361
NFIX nuclear factor I/X (CCAAT-binding transcription factor) -3.16361
CBLIF cobalamin binding intrinsic factor -3.16361
CFAP157 cilia and flagella associated protein 157 -3.16361
PTPN20 protein tyrosine phosphatase, non-receptor type 20 -3.16361
EGR2 early growth response 2 -3.16361
PCDHA13 protocadherin alpha 13 -3.16361
SCT secretin -3.16361
MAB21L1 mab-21-like 1 (C. elegans) -3.16361
LRRC26 leucine rich repeat containing 26 -3.02858
HPSE heparanase -3.02858
VAMP5 vesicle-associated membrane protein 5 -3.02858
FBXO2 F-box protein 2 -2.99378
EGLN3 egl-9 family hypoxia-inducible factor 3 -2.84223
PSMG3 proteasome (prosome, macropain) assembly chaperone 3 -2.80971
STAT2 signal transducer and activator of transcription 2, 113kDa -2.7789
TOMM40L translocase of outer mitochondrial membrane 40 homolog (yeast)-like -2.7525
TFCP2L1 transcription factor CP2-like 1 -2.73487
INSC inscuteable homolog (Drosophila) -2.73487
GGT7 gamma-glutamyltransferase 7 -2.70746
LRRC28 leucine rich repeat containing 28 -2.66052
RAB22A RAB22A, member RAS oncogene family -2.59694
HECTD2 HECT domain containing E3 ubiquitin protein ligase 2 -2.57809
CCDC30 coiled-coil domain containing 30 -2.54456
WNT3 wingless-type MMTV integration site family, member 3 -2.51968
PP2D1 protein phosphatase 2C-like domain containing 1 -2.50811
NIPA2 non imprinted in Prader-Willi/Angelman syndrome 2 -2.50783
TAC1 tachykinin, precursor 1 -2.46811
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -2.46811
BCAS4 breast carcinoma amplified sequence 4 -2.44111
AK1 adenylate kinase 1 -2.41752
SCAMP5 secretory carrier membrane protein 5 -2.40726
PLAUR plasminogen activator, urokinase receptor -2.4037
LPCAT4 lysophosphatidylcholine acyltransferase 4 -2.40223
BROX BRO1 domain and CAAX motif containing -2.3986
ASIC1 acid sensing (proton gated) ion channel 1 -2.38868
ZNF282 zinc finger protein 282 -2.38868
CHRAC1 chromatin accessibility complex 1 -2.3794
KIAA1671 KIAA1671 -2.36848
FBXO33 F-box protein 33 -2.36277
CXCL17 chemokine (C-X-C motif) ligand 17 -2.35818
PAGR1 PAXIP1 associated glutamate-rich protein 1 -2.34577
ATRN attractin -2.30857
ZYG11B zyg-11 family member B, cell cycle regulator -2.3039
AK4 adenylate kinase 4 -2.27831
UBE2T ubiquitin-conjugating enzyme E2T -2.27303
HECTD4 HECT domain containing E3 ubiquitin protein ligase 4 -2.25565
CCPG1 cell cycle progression 1 -2.25331
EFEMP2 EGF containing fibulin-like extracellular matrix protein 2 -2.23384
HSPA2 heat shock 70kDa protein 2 -2.23197
SLU7 SLU7 splicing factor homolog (S. cerevisiae) -2.23197
SFXN2 sideroflexin 2 -2.23197
INTS6L integrator complex subunit 6 like -2.19076
PARL presenilin associated, rhomboid-like -2.18814
PDK2 pyruvate dehydrogenase kinase, isozyme 2 -2.1782
MAU2 MAU2 sister chromatid cohesion factor -2.16347
ANKRD28 ankyrin repeat domain 28 -2.15466
TUBG1 tubulin, gamma 1 -2.14595
IL15RA interleukin 15 receptor, alpha -2.14388
DPH6 diphthamine biosynthesis 6 -2.14388
FBLN7 fibulin 7 -2.14388
TBX19 T-box 19 -2.14302
ZSCAN21 zinc finger and SCAN domain containing 21 -2.13777
NACC1 nucleus accumbens associated 1, BEN and BTB (POZ) domain containing -2.13777
TMEM177 transmembrane protein 177 -2.11993
NSD3 nuclear receptor binding SET domain protein 3 -2.11588
CCM2L cerebral cavernous malformation 2-like -2.09111
NDUFC1 NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 1, 6kDa -2.06337
TBRG4 transforming growth factor beta regulator 4 -2.06291
TSPAN11 tetraspanin 11 -2.06291
H2AC8 H2A clustered histone 8 -2.06154
KLHL31 kelch-like family member 31 -2.05944
MRAP2 melanocortin 2 receptor accessory protein 2 -2.05821
C6ORF120 chromosome 6 open reading frame 120 -2.05821
MIA2 melanoma inhibitory activity 2 -2.05684
TGDS TDP-glucose 4,6-dehydratase -2.05617
VASN vasorin -2.0479
PAWR PRKC, apoptosis, WT1, regulator -2.04136
ISYNA1 inositol-3-phosphate synthase 1 -2.03633
ASPHD1 aspartate beta-hydroxylase domain containing 1 -2.01989
NHSL2 NHS-like 2 -2.01436
ZNF426 zinc finger protein 426 -2.01127
JCAD junctional cadherin 5 associated -2.00386
TMEM186 transmembrane protein 186 -2.00225