SEC61A1 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description Sec61 alpha 1 subunit (S. cerevisiae)|The protein encoded by this gene belongs to the SECY/SEC61- alpha family. It appears to play a crucial role in the insertion of secretory and membrane polypeptides into the endoplasmic reticulum. This protein found to be tightly associated with membrane-bound ribosomes, either directly or through adaptor proteins. This gene encodes an alpha subunit of the heteromeric SEC61 complex, which also contains beta and gamma subunits. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 29927)
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Genes

342 genes differentially expressed following the SEC61A1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2 2.66955
GNAT2 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2 2.66955
NHLRC4 NHL repeat containing 4 2.66955
NXPH4 neurexophilin 4 2.66955
ARHGEF15 Rho guanine nucleotide exchange factor (GEF) 15 2.66955
SCNN1D sodium channel, non voltage gated 1 delta subunit 2.66955
ADGRA1 adhesion G protein-coupled receptor A1 2.66955
TNNI1 troponin I type 1 (skeletal, slow) 2.66955
CIROZ ciliated left-right organizer protein containing ZP-N domains 2.66955
PABPC1L2B poly(A) binding protein, cytoplasmic 1-like 2B 2.66955
PNMA3 paraneoplastic Ma antigen 3 2.66955
AZGP1 alpha-2-glycoprotein 1, zinc-binding 2.66955
OR2A12 olfactory receptor, family 2, subfamily A, member 12 2.66955
OR6B1 olfactory receptor, family 6, subfamily B, member 1 2.66955
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2 2.66955
GMFG glia maturation factor, gamma 2.66955
IQCN IQ motif containing N 2.66955
EBLN1 endogenous Bornavirus-like nucleoprotein 1 2.66955
SHD Src homology 2 domain containing transforming protein D 2.66955
GALR3 galanin receptor 3 2.66955
GPR150 G protein-coupled receptor 150 2.66955
ABI3BP ABI family, member 3 (NESH) binding protein 2.66955
CPLX4 complexin 4 2.66955
CLEC19A C-type lectin domain family 19, member A 2.63642
PEAR1 platelet endothelial aggregation receptor 1 2.63642
GJB1 gap junction protein, beta 1, 32kDa 2.63642
HBA1 hemoglobin, alpha 1 2.63642
SCGN secretagogin, EF-hand calcium binding protein 2.63642
ADRB2 adrenoceptor beta 2, surface 2.63642
SLC26A9 solute carrier family 26 (anion exchanger), member 9 2.63642
BTK Bruton agammaglobulinemia tyrosine kinase 2.63642
DUXB double homeobox B 2.63642
IGFL3 IGF-like family member 3 2.63642
SLC16A11 solute carrier family 16, member 11 2.63642
LONRF3 LON peptidase N-terminal domain and ring finger 3 2.63642
DSG3 desmoglein 3 2.63642
RFPL3 ret finger protein-like 3 2.63642
RGL4 ral guanine nucleotide dissociation stimulator-like 4 2.63642
HAS1 hyaluronan synthase 1 2.63642
DCAF4L1 DDB1 and CUL4 associated factor 4-like 1 2.63642
CRYGB crystallin, gamma B 2.63642
MEIKIN meiotic kinetochore factor 2.63642
ANKK1 ankyrin repeat and kinase domain containing 1 2.63642
KYNU kynureninase 2.63642
ALPK2 alpha-kinase 2 2.63642
MYOM3 myomesin 3 2.63642
PTH2 parathyroid hormone 2 2.63642
PAX7 paired box 7 2.63642
EPHX4 epoxide hydrolase 4 2.63642
CEP295NL CEP295 N-terminal like 2.63642
OPRL1 opiate receptor-like 1 2.63642
DIRAS2 DIRAS family, GTP-binding RAS-like 2 2.63642
SHCBP1L SHC SH2-domain binding protein 1-like 2.63642
CORO1A coronin, actin binding protein, 1A 2.63642
EIF1 eukaryotic translation initiation factor 1 2.63642
USP26 ubiquitin specific peptidase 26 2.63642
CATSPER1 cation channel, sperm associated 1 2.63642
GPR35 G protein-coupled receptor 35 2.63642
SIM1 single-minded family bHLH transcription factor 1 2.63642
SLC2A2 solute carrier family 2 (facilitated glucose transporter), member 2 2.63642
TMPRSS6 transmembrane protease, serine 6 2.63642
WDR64 WD repeat domain 64 2.63642
TMEM40 transmembrane protein 40 2.63642
ARL14EPL ADP-ribosylation factor-like 14 effector protein-like 2.63642
GATA1 GATA binding protein 1 (globin transcription factor 1) 2.63642
CNTN6 contactin 6 2.63642
LTB4R2 leukotriene B4 receptor 2 2.63642
AVPR1A arginine vasopressin receptor 1A 2.63642
CPNE8-AS1 CPNE8 antisense RNA 1 2.63642
SMIM35 small integral membrane protein 35 2.63642
TAFA3 TAFA chemokine like family member 3 2.63642
KASH5 KASH domain containing 5 2.63642
MINAR1 membrane integral NOTCH2 associated receptor 1 2.63642
VEGFD vascular endothelial growth factor D 2.63642
CCN3 cellular communication network factor 3 2.63642
GNGT2 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2 2.63642
GBP4 guanylate binding protein 4 2.63642
LTF lactotransferrin 2.63642
LTB lymphotoxin beta (TNF superfamily, member 3) 2.63642
TAS1R1 taste receptor, type 1, member 1 2.63642
CATSPERD catsper channel auxiliary subunit delta 2.63642
CALCA calcitonin-related polypeptide alpha 2.63642
MAL mal, T-cell differentiation protein 2.63642
GAPDHS glyceraldehyde-3-phosphate dehydrogenase, spermatogenic 2.63642
PCDHA1 protocadherin alpha 1 2.63642
DPF3 D4, zinc and double PHD fingers, family 3 2.63642
ZNF99 zinc finger protein 99 2.63642
P2RY2 purinergic receptor P2Y, G-protein coupled, 2 2.63642
MS4A6E membrane-spanning 4-domains, subfamily A, member 6E 2.63642
NR1I3 nuclear receptor subfamily 1, group I, member 3 2.63642
CXCL14 chemokine (C-X-C motif) ligand 14 2.63642
SBSN suprabasin 2.63642
CLDN23 claudin 23 2.63642
CCDC121 coiled-coil domain containing 121 2.63642
SLC12A5 solute carrier family 12 (potassium/chloride transporter), member 5 2.63642
HSPB6 heat shock protein, alpha-crystallin-related, B6 2.63642
TFEC transcription factor EC 2.63642
IL5 interleukin 5 2.63642
HAPLN2 hyaluronan and proteoglycan link protein 2 2.63642
TACSTD2 tumor-associated calcium signal transducer 2 2.63642
MAP3K7CL MAP3K7 C-terminal like 2.63642
CMTM2 CKLF-like MARVEL transmembrane domain containing 2 2.63642
HSD17B13 hydroxysteroid (17-beta) dehydrogenase 13 2.63642
FTH1 ferritin, heavy polypeptide 1 2.63642
KLF4 Kruppel-like factor 4 (gut) 2.63642
CAMK2A calcium/calmodulin-dependent protein kinase II alpha 2.63642
TRADD TNFRSF1A-associated via death domain 2.63642
TMEM50A transmembrane protein 50A 2.63642
TREH trehalase (brush-border membrane glycoprotein) 2.63642
CDH10 cadherin 10, type 2 (T2-cadherin) 2.63642
PSMD1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 2.63642
DNAH12 dynein, axonemal, heavy chain 12 2.63642
KCNA6 potassium channel, voltage gated shaker related subfamily A, member 6 2.63642
HS3ST6 heparan sulfate (glucosamine) 3-O-sulfotransferase 6 2.63642
PCDHGB1 protocadherin gamma subfamily B, 1 2.63642
DACT2 dishevelled-binding antagonist of beta-catenin 2 2.63642
SEMG1 semenogelin I 2.63642
KRTAP5-11 keratin associated protein 5-11 2.63642
ABCG8 ATP-binding cassette, sub-family G (WHITE), member 8 2.63642
RSAD2 radical S-adenosyl methionine domain containing 2 2.63642
NIM1K NIM1 serine/threonine protein kinase 2.63642
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2 2.63642
FIBIN fin bud initiation factor homolog (zebrafish) 2.63642
C22ORF42 chromosome 22 open reading frame 42 2.63642
TRIM7 tripartite motif containing 7 2.63642
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 2.63642
OR13G1 olfactory receptor, family 13, subfamily G, member 1 2.63642
NKX6-2 NK6 homeobox 2 2.63642
PCDHAC1 protocadherin alpha subfamily C, 1 2.63642
GAS2L2 growth arrest-specific 2 like 2 2.63642
CLEC18B C-type lectin domain family 18, member B 2.63642
ADRA2B adrenoceptor alpha 2B 2.63642
GPR61 G protein-coupled receptor 61 2.63642
CRHBP corticotropin releasing hormone binding protein 2.63642
DYNLT1 dynein, light chain, Tctex-type 1 2.63642
CER1 cerberus 1, DAN family BMP antagonist 2.63642
EMILIN1 elastin microfibril interfacer 1 2.63642
SERPINI2 serpin peptidase inhibitor, clade I (pancpin), member 2 2.63642
KCNV1 potassium channel, voltage gated modifier subfamily V, member 1 2.63642
EPHA3 EPH receptor A3 2.63642
EPHA5 EPH receptor A5 2.63642
RASL11A RAS-like, family 11, member A 2.63642
GJC2 gap junction protein, gamma 2, 47kDa 2.63642
TMEM255A transmembrane protein 255A 2.63642
FGF4 fibroblast growth factor 4 2.63642
ATOH1 atonal homolog 1 (Drosophila) 2.63642
TMC3 transmembrane channel-like 3 2.63642
OR51Q1 olfactory receptor, family 51, subfamily Q, member 1 (gene/pseudogene) 2.63642
RNF148 ring finger protein 148 2.63642
TAS2R43 taste receptor, type 2, member 43 2.63642
ST18 suppression of tumorigenicity 18, zinc finger 2.63642
ADRA1B adrenoceptor alpha 1B 2.63642
NXF2 nuclear RNA export factor 2 2.63642
HES2 hes family bHLH transcription factor 2 2.63642
KCNK15 potassium channel, two pore domain subfamily K, member 15 2.63642
CYP4A22 cytochrome P450, family 4, subfamily A, polypeptide 22 2.63642
SOX30 SRY (sex determining region Y)-box 30 2.63642
AQP1 aquaporin 1 (Colton blood group) 2.63642
NRGN neurogranin (protein kinase C substrate, RC3) 2.63642
APOA1 apolipoprotein A-I 2.63642
WNK4 WNK lysine deficient protein kinase 4 2.63642
MMP3 matrix metallopeptidase 3 2.63642
ISLR2 immunoglobulin superfamily containing leucine-rich repeat 2 2.63642
ACTR3C ARP3 actin-related protein 3 homolog C (yeast) 2.63642
SLITRK1 SLIT and NTRK-like family, member 1 2.63642
DMTN dematin actin binding protein 2.63642
AOC3 amine oxidase, copper containing 3 2.63642
MMP28 matrix metallopeptidase 28 2.63642
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 2.61688
ESR2 estrogen receptor 2 (ER beta) 2.57259
POLR2F polymerase (RNA) II (DNA directed) polypeptide F 2.57259
RPL10A ribosomal protein L10a 2.56653
COX4I1 cytochrome c oxidase subunit IV isoform 1 2.54969
HAPLN4 hyaluronan and proteoglycan link protein 4 2.54969
CHRNA9 cholinergic receptor, nicotinic, alpha 9 (neuronal) 2.54768
ACSBG2 acyl-CoA synthetase bubblegum family member 2 2.54768
NSMF NMDA receptor synaptonuclear signaling and neuronal migration factor 2.52811
JTB jumping translocation breakpoint 2.52591
EFTUD2 elongation factor Tu GTP binding domain containing 2 2.52591
LEKR1 leucine, glutamate and lysine rich 1 2.49426
MFN2 mitofusin 2 2.49057
NT5DC2 5'-nucleotidase domain containing 2 2.48113
CCNI2 cyclin I family, member 2 2.44216
CDC25C cell division cycle 25C 2.43364
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma) 2.42998
HACD4 3-hydroxyacyl-CoA dehydratase 4 2.36068
SMIM26 small integral membrane protein 26 2.35923
RPS6 ribosomal protein S6 2.35923
PIGL phosphatidylinositol glycan anchor biosynthesis, class L 2.35307
DHX40 DEAH (Asp-Glu-Ala-His) box polypeptide 40 2.34325
ENTREP1 endosomal transmembrane epsin interactor 1 2.33385
NUP93 nucleoporin 93kDa 2.30919
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase 2.30578
RTKN rhotekin 2.2875
TTC21A tetratricopeptide repeat domain 21A 2.28036
LOC124906010 uncharacterized LOC124906010 2.28036
CCDC43 coiled-coil domain containing 43 2.27834
MIS12 MIS12 kinetochore complex component 2.27834
DAAM1 dishevelled associated activator of morphogenesis 1 2.27314
PARP6 poly (ADP-ribose) polymerase family, member 6 2.2711
SERINC1 serine incorporator 1 2.25705
MED29 mediator complex subunit 29 2.25619
FGFR1 fibroblast growth factor receptor 1 2.23973
LRCH2 leucine-rich repeats and calponin homology (CH) domain containing 2 2.23961
INSC inscuteable homolog (Drosophila) 2.23093
MTOR mechanistic target of rapamycin (serine/threonine kinase) 2.22945
RAD17 RAD17 homolog (S. pombe) 2.22775
PSMB3 proteasome (prosome, macropain) subunit, beta type, 3 2.21466
PTER phosphotriesterase related 2.20937
SMIM29 small integral membrane protein 29 2.20611
CRTC1 CREB regulated transcription coactivator 1 2.19982
DCC DCC netrin 1 receptor 2.19982
COA5 cytochrome c oxidase assembly factor 5 2.19901
SAMD4A sterile alpha motif domain containing 4A 2.1795
BORCS7 BLOC-1 related complex subunit 7 2.15923
JMJD6 jumonji domain containing 6 2.15685
ATL1 atlastin GTPase 1 2.13411
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5 2.13163
CRYBG1 crystallin beta-gamma domain containing 1 2.11596
BRD3OS BRD3 opposite strand 2.10222
KLF3 Kruppel-like factor 3 (basic) 2.10105
PRDX1 peroxiredoxin 1 2.07792
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2 2.06541
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1 2.05443
SH3BP2 SH3-domain binding protein 2 2.05443
UGCG UDP-glucose ceramide glucosyltransferase 2.02713
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 2.01077

decreased expression

Symbol Name Standardized Value
KCNH5 potassium channel, voltage gated eag related subfamily H, member 5 -2.66955
MELTF melanotransferrin -2.66955
RDM1 RAD52 motif containing 1 -2.66955
ABCC6 ATP-binding cassette, sub-family C (CFTR/MRP), member 6 -2.63642
PKLR pyruvate kinase, liver and RBC -2.63642
TRIM34 tripartite motif containing 34 -2.63642
MAP3K8 mitogen-activated protein kinase kinase kinase 8 -2.63642
TSGA10 testis specific, 10 -2.63642
MXRA8 matrix-remodelling associated 8 -2.63642
ALKBH6 alkB, alkylation repair homolog 6 (E. coli) -2.63642
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A -2.63642
IQSEC3 IQ motif and Sec7 domain 3 -2.63642
ARHGAP9 Rho GTPase activating protein 9 -2.63642
CPNE9 copine family member IX -2.63642
EFNA5 ephrin-A5 -2.63642
ANG angiogenin, ribonuclease, RNase A family, 5 -2.63642
CIMAP3 ciliary microtubule associated protein 3 -2.63642
NPSR1 neuropeptide S receptor 1 -2.63642
H2BC14 H2B clustered histone 14 -2.63642
STEEP1 STING1 ER exit protein 1 -2.63642
DNALI1 dynein, axonemal, light intermediate chain 1 -2.63642
NPRL2 nitrogen permease regulator-like 2 (S. cerevisiae) -2.63642
DCAF7 DDB1 and CUL4 associated factor 7 -2.63642
PRICKLE3 prickle homolog 3 (Drosophila) -2.61895
TCL1A T-cell leukemia/lymphoma 1A -2.60031
ZNF684 zinc finger protein 684 -2.56878
ZNF527 zinc finger protein 527 -2.56653
TRPM6 transient receptor potential cation channel, subfamily M, member 6 -2.56653
OVGP1 oviductal glycoprotein 1, 120kDa -2.54969
MTNR1B melatonin receptor 1B -2.54969
DNAI1 dynein, axonemal, intermediate chain 1 -2.54969
TRO trophinin -2.54969
SRL sarcalumenin -2.54969
SERF1B small EDRK-rich factor 1B (centromeric) -2.54969
CR1 complement component (3b/4b) receptor 1 (Knops blood group) -2.54969
ZNF597 zinc finger protein 597 -2.54969
ARHGDIG Rho GDP dissociation inhibitor (GDI) gamma -2.54969
FAM89B family with sequence similarity 89, member B -2.54969
HTR6 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled -2.54969
CELF3 CUGBP, Elav-like family member 3 -2.54969
ZNF566 zinc finger protein 566 -2.54969
TFAP2E transcription factor AP-2 epsilon (activating enhancer binding protein 2 epsilon) -2.54969
RIPK4 receptor-interacting serine-threonine kinase 4 -2.54969
HHAT hedgehog acyltransferase -2.54969
SEZ6L seizure related 6 homolog (mouse)-like -2.54969
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1 -2.54969
PGK1 phosphoglycerate kinase 1 -2.54969
H1-1 H1.1 linker histone, cluster member -2.54969
TF transferrin -2.54969
SLC17A6 solute carrier family 17 (vesicular glutamate transporter), member 6 -2.54969
DUSP28 dual specificity phosphatase 28 -2.54969
STAB2 stabilin 2 -2.54969
HSPB8 heat shock 22kDa protein 8 -2.54969
MASP2 mannan-binding lectin serine peptidase 2 -2.54969
ZBTB12 zinc finger and BTB domain containing 12 -2.54969
RASGRF1 Ras protein-specific guanine nucleotide-releasing factor 1 -2.54969
LDHAL6A lactate dehydrogenase A-like 6A -2.54969
IFITM10 interferon induced transmembrane protein 10 -2.54969
CACNG4 calcium channel, voltage-dependent, gamma subunit 4 -2.54969
COX8C cytochrome c oxidase subunit VIIIC -2.54969
BEST1 bestrophin 1 -2.54969
ZNF358 zinc finger protein 358 -2.54969
CFAP276 cilia and flagella associated protein 276 -2.54969
LOC107985101 uncharacterized LOC107985101 -2.5235
YIF1B Yip1 interacting factor homolog B (S. cerevisiae) -2.51975
SHTN1 shootin 1 -2.50568
GPR75-ASB3 GPR75-ASB3 readthrough -2.44853
SYT14 synaptotagmin XIV -2.42764
AP5Z1 adaptor-related protein complex 5, zeta 1 subunit -2.39222
C11ORF71 chromosome 11 open reading frame 71 -2.38881
SLC24A2 solute carrier family 24 (sodium/potassium/calcium exchanger), member 2 -2.38379
MBD3 methyl-CpG binding domain protein 3 -2.37614
USP53 ubiquitin specific peptidase 53 -2.34771
GLUD1 glutamate dehydrogenase 1 -2.34588
ELFN1 extracellular leucine-rich repeat and fibronectin type III domain containing 1 -2.34588
ERAL1 Era-like 12S mitochondrial rRNA chaperone 1 -2.34588
KCNH7 potassium channel, voltage gated eag related subfamily H, member 7 -2.33385
RYR2 ryanodine receptor 2 (cardiac) -2.30635
MMP25 matrix metallopeptidase 25 -2.28846
BRD2 bromodomain containing 2 -2.27363
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 -2.26289
NOM1 nucleolar protein with MIF4G domain 1 -2.26177
EPS15 epidermal growth factor receptor pathway substrate 15 -2.25705
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7 -2.25668
SLC19A3 solute carrier family 19 (thiamine transporter), member 3 -2.25668
TUBG2 tubulin, gamma 2 -2.2436
EVA1C eva-1 homolog C (C. elegans) -2.23616
RUMY2 RUMY family member 2 -2.23093
DENND6A DENN/MADD domain containing 6A -2.22775
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae) -2.2247
USP35 ubiquitin specific peptidase 35 -2.21466
BCO2 beta-carotene oxygenase 2 -2.21466
ASTE1 asteroid homolog 1 (Drosophila) -2.21466
PANX2 pannexin 2 -2.21466
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) -2.21248
ACIN1 apoptotic chromatin condensation inducer 1 -2.2016
DYNLT2 dynein light chain Tctex-type 2 -2.19982
CSRP1 cysteine and glycine-rich protein 1 -2.19901
C19ORF84 chromosome 19 open reading frame 84 -2.17777
RFK riboflavin kinase -2.15837
TANK TRAF family member-associated NFKB activator -2.15786
SOX15 SRY (sex determining region Y)-box 15 -2.13211
RNF26 ring finger protein 26 -2.13211
SMIM10L2B small integral membrane protein 10 like 2B -2.12224
ACOX3 acyl-CoA oxidase 3, pristanoyl -2.11085
MFAP1 microfibrillar-associated protein 1 -2.09914
CDK4 cyclin-dependent kinase 4 -2.09809
CXCL5 chemokine (C-X-C motif) ligand 5 -2.09067
SLC35B2 solute carrier family 35 (adenosine 3'-phospho 5'-phosphosulfate transporter), member B2 -2.08932
ZBTB5 zinc finger and BTB domain containing 5 -2.08915
OPN3 opsin 3 -2.08895
COMMD10 COMM domain containing 10 -2.06618
ARL5B ADP-ribosylation factor-like 5B -2.05576
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3 -2.04444
TDRKH tudor and KH domain containing -2.03521