SEC61A2 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description Sec61 alpha 2 subunit (S. cerevisiae)|The protein encoded by this gene has similarity to a mouse protein which suggests a role in the insertion of secretory and membrane polypeptides into the endoplasmic reticulum. It may also be required for the assembly of membrane and secretory proteins. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2008] (NCBI Entrez Gene Database, 55176)
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Genes

306 genes differentially expressed following the SEC61A2 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
MYL3 myosin, light chain 3, alkali; ventricular, skeletal, slow 2.85181
FOXI2 forkhead box I2 2.85181
UBQLNL ubiquilin-like 2.85181
KLRF1 killer cell lectin-like receptor subfamily F, member 1 2.85181
TRIM55 tripartite motif containing 55 2.85181
TNFRSF19 tumor necrosis factor receptor superfamily, member 19 2.85181
KRT86 keratin 86, type II 2.85181
CAMK2B calcium/calmodulin-dependent protein kinase II beta 2.85181
NR4A3 nuclear receptor subfamily 4, group A, member 3 2.85181
ABCC9 ATP-binding cassette, sub-family C (CFTR/MRP), member 9 2.85181
NRAP nebulin-related anchoring protein 2.85181
PSORS1C1 psoriasis susceptibility 1 candidate 1 2.85181
RAB3A RAB3A, member RAS oncogene family 2.85181
MYOM3 myomesin 3 2.85181
OR56B1 olfactory receptor, family 56, subfamily B, member 1 2.85181
BCAS1 breast carcinoma amplified sequence 1 2.85181
TWIST1 twist family bHLH transcription factor 1 2.85181
TCERG1L transcription elongation regulator 1-like 2.85181
TRPC7 transient receptor potential cation channel, subfamily C, member 7 2.85181
GPR149 G protein-coupled receptor 149 2.85181
PTPN20 protein tyrosine phosphatase, non-receptor type 20 2.85181
TMDD1 transmembrane and death domain 1 2.81406
IRF2-DT IRF2 divergent transcript 2.81406
CCL3L3 chemokine (C-C motif) ligand 3-like 3 2.81406
SLC28A2 solute carrier family 28 (concentrative nucleoside transporter), member 2 2.81406
EXOC1L exocyst complex component 1 like 2.81406
SPATA31F1 SPATA31 subfamily F member 1 2.81406
HCRTR2 hypocretin (orexin) receptor 2 2.81406
CEP295NL CEP295 N-terminal like 2.81406
DMRTC1B DMRT-like family C1B 2.81406
CSTL1 cystatin-like 1 2.81406
UCP1 uncoupling protein 1 (mitochondrial, proton carrier) 2.81406
MUC5B mucin 5B, oligomeric mucus/gel-forming 2.81406
GSTM2 glutathione S-transferase mu 2 (muscle) 2.81406
TMA7B translation machinery associated 7 homolog B 2.81406
SIRPB1 signal-regulatory protein beta 1 2.81406
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15 2.81406
FAM90A11 family with sequence similarity 90 member A11 2.81406
GFI1 growth factor independent 1 transcription repressor 2.81406
IL18R1 interleukin 18 receptor 1 2.81406
KCNU1 potassium channel, subfamily U, member 1 2.81406
GSTT2 glutathione S-transferase theta 2 (gene/pseudogene) 2.81406
SLC39A12 solute carrier family 39 (zinc transporter), member 12 2.81406
BFSP2 beaded filament structural protein 2, phakinin 2.81406
SLC35D4 solute carrier family 35 member D4 2.81406
PTK6 protein tyrosine kinase 6 2.81406
CRYGA crystallin, gamma A 2.81406
CRYGC crystallin, gamma C 2.81406
OR2L2 olfactory receptor, family 2, subfamily L, member 2 2.81406
PARP10 poly (ADP-ribose) polymerase family, member 10 2.81406
MOGAT3 monoacylglycerol O-acyltransferase 3 2.81406
OR1L8 olfactory receptor, family 1, subfamily L, member 8 2.81406
TPSD1 tryptase delta 1 2.81406
HAS3 hyaluronan synthase 3 2.81406
BIRC3 baculoviral IAP repeat containing 3 2.81406
PCDHB6 protocadherin beta 6 2.81406
MAGEA2 melanoma antigen family A2 2.81406
H1-6 H1.6 linker histone, cluster member 2.81406
GBP6 guanylate binding protein family, member 6 2.81406
CCR8 chemokine (C-C motif) receptor 8 2.81406
CLDN22 claudin 22 2.81406
SBSN suprabasin 2.81406
SAA1 serum amyloid A1 2.81406
C9 complement component 9 2.81406
LRRC71 leucine rich repeat containing 71 2.81406
GATA5 GATA binding protein 5 2.81406
FAM228A family with sequence similarity 228, member A 2.81406
GCSAM germinal center-associated, signaling and motility 2.81406
LMNTD1 lamin tail domain containing 1 2.81406
MLN motilin 2.81406
IL36G interleukin 36, gamma 2.81406
RD3 retinal degeneration 3 2.81406
ST6GALNAC1 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 2.81406
CREB3L3 cAMP responsive element binding protein 3-like 3 2.81406
H3-5 H3.5 histone 2.81406
IGFL2 IGF-like family member 2 2.81406
CDH5 cadherin 5, type 2 (vascular endothelium) 2.81406
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3 2.81406
LILRA4 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 4 2.81406
H3C13 H3 clustered histone 13 2.81406
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 2.81406
SLC6A18 solute carrier family 6 (neutral amino acid transporter), member 18 2.81406
PLVAP plasmalemma vesicle associated protein 2.81406
H2AC19 H2A clustered histone 19 2.81406
GPR4 G protein-coupled receptor 4 2.81406
TEX55 testis expressed 55 2.81406
HBA2 hemoglobin, alpha 2 2.81406
TRIM63 tripartite motif containing 63, E3 ubiquitin protein ligase 2.81406
CCN6 cellular communication network factor 6 2.81406
DSG1 desmoglein 1 2.81406
ALPG alkaline phosphatase, germ cell 2.81406
HOXC13 homeobox C13 2.81406
AGXT2 alanine--glyoxylate aminotransferase 2 2.81406
ZNF366 zinc finger protein 366 2.81406
BCL2A1 BCL2-related protein A1 2.81406
APOH apolipoprotein H (beta-2-glycoprotein I) 2.81406
LY6G6C lymphocyte antigen 6 complex, locus G6C 2.81406
CRHBP corticotropin releasing hormone binding protein 2.81406
BARHL2 BarH-like homeobox 2 2.81406
DLX3 distal-less homeobox 3 2.81406
OTOP2 otopetrin 2 2.81406
RUFY4 RUN and FYVE domain containing 4 2.81406
NT5C1A 5'-nucleotidase, cytosolic IA 2.81406
OR4D2 olfactory receptor, family 4, subfamily D, member 2 2.81406
OR13A1 olfactory receptor, family 13, subfamily A, member 1 2.81406
MAPK11 mitogen-activated protein kinase 11 2.81406
TCEA3 transcription elongation factor A (SII), 3 2.81406
SST somatostatin 2.81406
CCL17 chemokine (C-C motif) ligand 17 2.81406
CLEC4E C-type lectin domain family 4, member E 2.81406
C11ORF16 chromosome 11 open reading frame 16 2.81406
TRADD TNFRSF1A-associated via death domain 2.81406
ADAM7 ADAM metallopeptidase domain 7 2.81406
VWA3B von Willebrand factor A domain containing 3B 2.81406
UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17 2.81406
AQP8 aquaporin 8 2.81406
VWA7 von Willebrand factor A domain containing 7 2.81406
MS4A7 membrane-spanning 4-domains, subfamily A, member 7 2.81406
C8ORF89 chromosome 8 open reading frame 89 2.81406
EPGN epithelial mitogen 2.81406
CDRT15L2 CMT1A duplicated region transcript 15-like 2 2.81406
LHX5 LIM homeobox 5 2.81406
NAT2 N-acetyltransferase 2 (arylamine N-acetyltransferase) 2.81406
RAB6C RAB6C, member RAS oncogene family 2.81406
ATP6V0D2 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2 2.81406
ADAM18 ADAM metallopeptidase domain 18 2.81406
OR51I1 olfactory receptor, family 51, subfamily I, member 1 2.81406
OR51I2 olfactory receptor, family 51, subfamily I, member 2 2.81406
CEACAM20 carcinoembryonic antigen-related cell adhesion molecule 20 2.81406
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 2.81406
SCIN scinderin 2.81406
TPRX1 tetra-peptide repeat homeobox 1 2.81406
GJC2 gap junction protein, gamma 2, 47kDa 2.81406
IL23R interleukin 23 receptor 2.81406
CCDC83 coiled-coil domain containing 83 2.81406
BTG4 B-cell translocation gene 4 2.81406
MSLN mesothelin 2.81406
DDI1 DNA-damage inducible 1 homolog 1 (S. cerevisiae) 2.81406
DMRTC1 DMRT-like family C1 2.81406
C5AR2 complement component 5a receptor 2 2.81406
DCAF8L2 DDB1 and CUL4 associated factor 8-like 2 2.81406
POU4F1 POU class 4 homeobox 1 2.81406
REG1A regenerating islet-derived 1 alpha 2.81406
CIDEC cell death-inducing DFFA-like effector c 2.81406
RNF222 ring finger protein 222 2.81406
GCM2 glial cells missing homolog 2 (Drosophila) 2.81406
ANK3 ankyrin 3, node of Ranvier (ankyrin G) 2.81406
SLC51B solute carrier family 51, beta subunit 2.81406
KCNA1 potassium channel, voltage gated shaker related subfamily A, member 1 2.81406
ADH1A alcohol dehydrogenase 1A (class I), alpha polypeptide 2.79162
OSTF1 osteoclast stimulating factor 1 2.77374
MID2 midline 2 2.73608
SHB Src homology 2 domain containing adaptor protein B 2.66259
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) 2.66259
SEC13 SEC13 homolog (S. cerevisiae) 2.64339
CHRNA3 cholinergic receptor, nicotinic, alpha 3 (neuronal) 2.54482
SPINK6 serine peptidase inhibitor, Kazal type 6 2.52839
FMO1 flavin containing monooxygenase 1 2.49999
BTG2 BTG family, member 2 2.49694
VSTM2L V-set and transmembrane domain containing 2 like 2.48746
MTARC1 mitochondrial amidoxime reducing component 1 2.45177
DPF1 D4, zinc and double PHD fingers family 1 2.34555
XRN1 5'-3' exoribonuclease 1 2.33138
BTC betacellulin 2.32734
PRKG1 protein kinase, cGMP-dependent, type I 2.31933
SLC38A4 solute carrier family 38, member 4 2.31933
UBAP1L ubiquitin associated protein 1-like 2.31933
GPLD1 glycosylphosphatidylinositol specific phospholipase D1 2.29252
CHP2 calcineurin-like EF-hand protein 2 2.29252
BCKDK branched chain ketoacid dehydrogenase kinase 2.29252
LPAR2 lysophosphatidic acid receptor 2 2.28207
TMEM74B transmembrane protein 74B 2.27895
TSPYL1 TSPY-like 1 2.26976
PURB purine-rich element binding protein B 2.26212
ATP5F1E ATP synthase F1 subunit epsilon 2.25798
PGR progesterone receptor 2.23824
COBL cordon-bleu WH2 repeat protein 2.23283
CTPS2 CTP synthase 2 2.23283
MUC12 mucin 12, cell surface associated 2.21172
UBA1 ubiquitin-like modifier activating enzyme 1 2.20079
IER5L immediate early response 5-like 2.172
DGUOK deoxyguanosine kinase 2.16954
BCL6 B-cell CLL/lymphoma 6 2.16401
LMO1 LIM domain only 1 (rhombotin 1) 2.12201
LMOD3 leiomodin 3 (fetal) 2.11607
SPATA13 spermatogenesis associated 13 2.11607
TMEM250 transmembrane protein 250 2.11236
CCL26 chemokine (C-C motif) ligand 26 2.09323
PIGB phosphatidylinositol glycan anchor biosynthesis, class B 2.08362
POLR2E polymerase (RNA) II (DNA directed) polypeptide E, 25kDa 2.08108
GLMP glycosylated lysosomal membrane protein 2.08066
KNSTRN kinetochore-localized astrin/SPAG5 binding protein 2.07544
FLAD1 flavin adenine dinucleotide synthetase 1 2.06131
SATL1 spermidine/spermine N1-acetyl transferase-like 1 2.05172
AGAP5 ArfGAP with GTPase domain, ankyrin repeat and PH domain 5 2.04103
HDAC5 histone deacetylase 5 2.03691
DCUN1D2 DCN1, defective in cullin neddylation 1, domain containing 2 2.02703
ABCC8 ATP-binding cassette, sub-family C (CFTR/MRP), member 8 2.02701
PLPP3 phospholipid phosphatase 3 2.02625
SYN1 synapsin I 2.02264
L3MBTL4 l(3)mbt-like 4 (Drosophila) 2.0014

decreased expression

Symbol Name Standardized Value
CCDC159 coiled-coil domain containing 159 -2.85181
LINC02798 long intergenic non-protein coding RNA 2798 -2.85181
MPZL2 myelin protein zero-like 2 -2.85181
ANKRD63 ankyrin repeat domain 63 -2.85181
OR2AJ1 olfactory receptor, family 2, subfamily AJ, member 1 -2.81406
LCN12 lipocalin 12 -2.81406
SLC71A2 solute carrier family 71 member 2 -2.81406
PRDM16 PR domain containing 16 -2.81406
SLC22A9 solute carrier family 22 (organic anion transporter), member 9 -2.81406
BLOC1S3 biogenesis of lysosomal organelles complex-1, subunit 3 -2.81406
POTEI POTE ankyrin domain family, member I -2.81406
ZMYND15 zinc finger, MYND-type containing 15 -2.81406
TTBK1 tau tubulin kinase 1 -2.81406
FAM221B family with sequence similarity 221, member B -2.81406
PKD1L1 polycystic kidney disease 1 like 1 -2.81406
CCN5 cellular communication network factor 5 -2.81406
SLC1A6 solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6 -2.81406
PRDM6 PR domain containing 6 -2.81406
FAM133A family with sequence similarity 133, member A -2.81406
STARD8 StAR-related lipid transfer (START) domain containing 8 -2.81406
PCDHA1 protocadherin alpha 1 -2.81406
OR2A1 olfactory receptor, family 2, subfamily A, member 1 -2.81406
ISCA1 iron-sulfur cluster assembly 1 -2.81406
LURAP1L leucine rich adaptor protein 1-like -2.81406
EGFL6 EGF-like-domain, multiple 6 -2.81406
HES3 hes family bHLH transcription factor 3 -2.81406
LRTM3 leucine rich repeat transmembrane protein 3 -2.81406
RGS11 regulator of G-protein signaling 11 -2.81406
RARB retinoic acid receptor, beta -2.81406
SLC22A24 solute carrier family 22, member 24 -2.81406
CCDC154 coiled-coil domain containing 154 -2.81406
CLRN1 clarin 1 -2.81406
TTC13 tetratricopeptide repeat domain 13 -2.81406
ADGRD1 adhesion G protein-coupled receptor D1 -2.81406
SEMG1 semenogelin I -2.81406
C10ORF105 chromosome 10 open reading frame 105 -2.81406
MEIS1 Meis homeobox 1 -2.81406
KCNA2 potassium channel, voltage gated shaker related subfamily A, member 2 -2.81406
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) -2.81406
TBXA2R thromboxane A2 receptor -2.73305
MAPK15 mitogen-activated protein kinase 15 -2.73305
RAP1GDS1 RAP1, GTP-GDP dissociation stimulator 1 -2.70542
KIF9 kinesin family member 9 -2.68095
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 -2.65779
TRAPPC3 trafficking protein particle complex 3 -2.57455
PCDHB9 protocadherin beta 9 -2.52376
RHOC ras homolog family member C -2.50727
TINCR tissue differentiation-inducing non-protein coding RNA -2.50202
ZNF221 zinc finger protein 221 -2.47433
LYG2 lysozyme G-like 2 -2.42991
ZNF165 zinc finger protein 165 -2.41125
PDE4C phosphodiesterase 4C, cAMP-specific -2.34555
TMEM121 transmembrane protein 121 -2.32734
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7 -2.32734
SLC37A2 solute carrier family 37 (glucose-6-phosphate transporter), member 2 -2.32734
PCDHGB7 protocadherin gamma subfamily B, 7 -2.31933
IPP intracisternal A particle-promoted polypeptide -2.31933
C17ORF113 chromosome 17 open reading frame 113 -2.31933
ACVR1C activin A receptor, type IC -2.31933
AK4 adenylate kinase 4 -2.28207
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -2.26976
DSTYK dual serine/threonine and tyrosine protein kinase -2.26424
C20ORF203 chromosome 20 open reading frame 203 -2.25996
ABI3 ABI family, member 3 -2.24855
SERF1B small EDRK-rich factor 1B (centromeric) -2.24855
RSPH1 radial spoke head 1 homolog (Chlamydomonas) -2.23824
TRPA1 transient receptor potential cation channel, subfamily A, member 1 -2.23824
RGPD6 RANBP2-like and GRIP domain containing 6 -2.23824
SYCE3 synaptonemal complex central element protein 3 -2.23824
NCOA2 nuclear receptor coactivator 2 -2.22016
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.22016
RPF1 ribosome production factor 1 homolog (S. cerevisiae) -2.20878
FREM3 FRAS1 related extracellular matrix 3 -2.18942
LAMB2 laminin, beta 2 (laminin S) -2.18249
SNTG2 syntrophin, gamma 2 -2.17448
TRAM1L1 translocation associated membrane protein 1-like 1 -2.16955
ATG3 autophagy related 3 -2.16889
ITSN1 intersectin 1 (SH3 domain protein) -2.16889
NAPB N-ethylmaleimide-sensitive factor attachment protein, beta -2.16848
UMPS uridine monophosphate synthetase -2.14999
ABCD3 ATP-binding cassette, sub-family D (ALD), member 3 -2.14837
LRRC47 leucine rich repeat containing 47 -2.12511
BGN biglycan -2.12505
ZBTB42 zinc finger and BTB domain containing 42 -2.11607
SMIM47 small integral membrane protein 47 -2.11607
KCNH4 potassium channel, voltage gated eag related subfamily H, member 4 -2.11607
EAPP E2F-associated phosphoprotein -2.11607
KCNA3 potassium channel, voltage gated shaker related subfamily A, member 3 -2.11607
FKBP7 FK506 binding protein 7 -2.09383
ZNF136 zinc finger protein 136 -2.09294
ARPC3 actin related protein 2/3 complex, subunit 3, 21kDa -2.08362
TMEM106A transmembrane protein 106A -2.08108
FOXO3 forkhead box O3 -2.07544
MPST mercaptopyruvate sulfurtransferase -2.07465
NR1H2 nuclear receptor subfamily 1, group H, member 2 -2.06591
DNAJC8 DnaJ (Hsp40) homolog, subfamily C, member 8 -2.06591
GATD3 glutamine amidotransferase class 1 domain containing 3 -2.06591
NDUFA1 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1, 7.5kDa -2.05267
KLHDC9 kelch domain containing 9 -2.05172
RNF121 ring finger protein 121 -2.05137
DLC1 DLC1 Rho GTPase activating protein -2.04849
SPSB4 splA/ryanodine receptor domain and SOCS box containing 4 -2.04103
MRPS36 mitochondrial ribosomal protein S36 -2.02312
DDX11 DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11 -2.01043
CEACAM19 carcinoembryonic antigen-related cell adhesion molecule 19 -2.0014