SEC63 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description SEC63 homolog (S. cerevisiae)|The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. The protein encoded by this gene and SEC62 protein are found to be associated with ribosome-free SEC61 complex. It is speculated that Sec61-Sec62-Sec63 may perform post-translational protein translocation into the ER. The Sec61-Sec62-Sec63 complex might also perform the backward transport of ER proteins that are subject to the ubiquitin-proteasome-dependent degradation pathway. The encoded protein is an integral membrane protein located in the rough ER. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 11231)
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Genes

693 genes differentially expressed following the SEC63 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
SIX3 SIX homeobox 3 3.16924
VPS37D vacuolar protein sorting 37 homolog D (S. cerevisiae) 3.03807
ADAM32 ADAM metallopeptidase domain 32 3.03807
LYG2 lysozyme G-like 2 3.03807
C4ORF33 chromosome 4 open reading frame 33 3.03807
BTNL9 butyrophilin-like 9 3.03807
NOX4 NADPH oxidase 4 3.03807
NRL neural retina leucine zipper 3.03807
SLC26A5 solute carrier family 26 (anion exchanger), member 5 3.03807
CALB2 calbindin 2 3.03807
BAIAP2 BAI1-associated protein 2 3.03807
ACP2 acid phosphatase 2, lysosomal 3.03807
HAPLN1 hyaluronan and proteoglycan link protein 1 3.03807
DNASE1L1 deoxyribonuclease I-like 1 3.03807
SCN7A sodium channel, voltage gated, type VII alpha subunit 3.03807
PLIN5 perilipin 5 3.03807
GSTM2 glutathione S-transferase mu 2 (muscle) 3.03807
IL17RC interleukin 17 receptor C 3.03807
OTX1 orthodenticle homeobox 1 3.03807
AMPD2 adenosine monophosphate deaminase 2 3.03807
FGF17 fibroblast growth factor 17 3.03807
ABI3BP ABI family, member 3 (NESH) binding protein 3.03807
RAB26 RAB26, member RAS oncogene family 3.03807
KIAA0319 KIAA0319 3.03807
CA3 carbonic anhydrase III 3.03807
CA4 carbonic anhydrase IV 3.03807
ALDH1L1 aldehyde dehydrogenase 1 family, member L1 3.03807
NGFR nerve growth factor receptor 3.03807
CYP46A1 cytochrome P450, family 46, subfamily A, polypeptide 1 3.03807
CASS4 Cas scaffolding protein family member 4 3.03807
IL17RD interleukin 17 receptor D 3.03807
VAX1 ventral anterior homeobox 1 3.03807
ZNF512B zinc finger protein 512B 3.03807
POU2F3 POU class 2 homeobox 3 3.03807
DISP3 dispatched RND transporter family member 3 3.03807
PRDM6 PR domain containing 6 3.03807
CALCOCO1 calcium binding and coiled-coil domain 1 3.03807
HTRA3 HtrA serine peptidase 3 3.03807
TMEM269 transmembrane protein 269 3.03807
ADAP2 ArfGAP with dual PH domains 2 3.03807
GRIN3B glutamate receptor, ionotropic, N-methyl-D-aspartate 3B 3.03807
GABRA4 gamma-aminobutyric acid (GABA) A receptor, alpha 4 2.94623
FAM86B1 family with sequence similarity 86, member B1 2.94623
NECAP1 NECAP endocytosis associated 1 2.94623
SIRT2 sirtuin 2 2.94623
ZNF180 zinc finger protein 180 2.94623
MEIKIN meiotic kinetochore factor 2.94623
ARHGEF15 Rho guanine nucleotide exchange factor (GEF) 15 2.94623
FGFR3 fibroblast growth factor receptor 3 2.94623
TBC1D8B TBC1 domain family, member 8B (with GRAM domain) 2.94623
INSYN2B inhibitory synaptic factor family member 2B 2.94623
JHY junctional cadherin complex regulator 2.94623
TUBB8B tubulin beta 8B 2.94623
MOGAT1 monoacylglycerol O-acyltransferase 1 2.94623
AADACL3 arylacetamide deacetylase-like 3 2.94623
LRRC52 leucine rich repeat containing 52 2.94623
PPP2R5B protein phosphatase 2, regulatory subunit B', beta 2.94623
VSIR V-set immunoregulatory receptor 2.94623
WASHC2A WASH complex subunit 2A 2.94623
NIBAN3 niban apoptosis regulator 3 2.94623
TMEM198 transmembrane protein 198 2.94623
PAX7 paired box 7 2.94623
SLC22A13 solute carrier family 22 (organic anion/urate transporter), member 13 2.94623
TTN titin 2.94623
CSMD3 CUB and Sushi multiple domains 3 2.94623
GPRASP3 G protein-coupled receptor associated sorting protein family member 3 2.94623
ETFBKMT electron transfer flavoprotein subunit beta lysine methyltransferase 2.94623
COL16A1 collagen, type XVI, alpha 1 2.94623
FHIP2A FHF complex subunit HOOK interacting protein 2A 2.94623
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3 2.94623
MUSK muscle, skeletal, receptor tyrosine kinase 2.94623
LOC124903233 uncharacterized LOC124903233 2.94623
MUC20 mucin 20, cell surface associated 2.94623
STOML1 stomatin (EPB72)-like 1 2.94623
FGF8 fibroblast growth factor 8 (androgen-induced) 2.94623
CYSRT1 cysteine-rich tail protein 1 2.94623
NABP1 nucleic acid binding protein 1 2.94623
NOXRED1 NADP-dependent oxidoreductase domain containing 1 2.94623
NR2F1 nuclear receptor subfamily 2, group F, member 1 2.94623
CYGB cytoglobin 2.94623
CSP2 CS pseudogene 2 2.94623
ASTE1 asteroid homolog 1 (Drosophila) 2.94623
GHRH growth hormone releasing hormone 2.94623
IRX3 iroquois homeobox 3 2.94623
PNMA6F PNMA family member 6F 2.94623
ICAM4 intercellular adhesion molecule 4 (Landsteiner-Wiener blood group) 2.94623
NLRP7 NLR family, pyrin domain containing 7 2.94623
GALNT9 polypeptide N-acetylgalactosaminyltransferase 9 2.94623
FOXG1 forkhead box G1 2.94623
FGF4 fibroblast growth factor 4 2.94623
SGCZ sarcoglycan, zeta 2.94623
NPB neuropeptide B 2.94623
HYPK huntingtin interacting protein K 2.94623
MMP26 matrix metallopeptidase 26 2.94623
ADH4 alcohol dehydrogenase 4 (class II), pi polypeptide 2.94623
BMP5 bone morphogenetic protein 5 2.94623
PTCHD4 patched domain containing 4 2.94623
SPHK1 sphingosine kinase 1 2.94623
ASNS asparagine synthetase (glutamine-hydrolyzing) 2.94623
RTP1 receptor (chemosensory) transporter protein 1 2.94623
DRC3 dynein regulatory complex subunit 3 2.94623
SLC22A9 solute carrier family 22 (organic anion transporter), member 9 2.94623
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4 2.94623
TENM3 teneurin transmembrane protein 3 2.94623
SEMA6A sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A 2.94623
ZNF804A zinc finger protein 804A 2.94623
ATAD3C ATPase family, AAA domain containing 3C 2.94623
RP1 retinitis pigmentosa 1 (autosomal dominant) 2.94623
NME8 NME/NM23 family member 8 2.94623
CDKL4 cyclin-dependent kinase-like 4 2.94623
KCNAB1 potassium channel, voltage gated subfamily A regulatory beta subunit 1 2.94623
ZNF578 zinc finger protein 578 2.94623
ZNF572 zinc finger protein 572 2.94623
S1PR1 sphingosine-1-phosphate receptor 1 2.94623
STYK1 serine/threonine/tyrosine kinase 1 2.94623
ARMC5 armadillo repeat containing 5 2.94623
CXCL16 chemokine (C-X-C motif) ligand 16 2.94623
TMEM233 transmembrane protein 233 2.94623
CBLN1 cerebellin 1 precursor 2.94623
COL6A3 collagen, type VI, alpha 3 2.94623
THPO thrombopoietin 2.94623
AMBP alpha-1-microglobulin/bikunin precursor 2.94623
GTF2IRD2 GTF2I repeat domain containing 2 2.94623
ZNF845 zinc finger protein 845 2.94623
SPMIP1 sperm microtubule inner protein 1 2.94623
TLR2 toll-like receptor 2 2.94623
PLEKHA7 pleckstrin homology domain containing, family A member 7 2.94623
CSAG3 CSAG family, member 3 2.94623
BEST2 bestrophin 2 2.94623
BEST3 bestrophin 3 2.94623
NOXA1 NADPH oxidase activator 1 2.94623
GPR83 G protein-coupled receptor 83 2.94623
LRRC71 leucine rich repeat containing 71 2.94623
GPR139 G protein-coupled receptor 139 2.94623
DNAL4 dynein, axonemal, light chain 4 2.94623
SAMD11 sterile alpha motif domain containing 11 2.94623
ALKBH6 alkB, alkylation repair homolog 6 (E. coli) 2.94623
CNTFR ciliary neurotrophic factor receptor 2.94623
MROH5 maestro heat-like repeat family member 5 2.94623
CCDC121 coiled-coil domain containing 121 2.94623
TBX6 T-box 6 2.94623
SNCA synuclein, alpha (non A4 component of amyloid precursor) 2.94623
IAPP islet amyloid polypeptide 2.94623
IQUB IQ motif and ubiquitin domain containing 2.94623
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 2.94623
SPAM1 sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding) 2.94623
CNNM1 cyclin and CBS domain divalent metal cation transport mediator 1 2.94623
PTGES prostaglandin E synthase 2.94623
SOHLH1 spermatogenesis and oogenesis specific basic helix-loop-helix 1 2.94623
SYBU syntabulin (syntaxin-interacting) 2.94623
SNX9 sorting nexin 9 2.94623
DGAT2L6 diacylglycerol O-acyltransferase 2-like 6 2.94623
PKP3 plakophilin 3 2.94623
DPEP1 dipeptidase 1 (renal) 2.94623
RUNDC3B RUN domain containing 3B 2.94623
CASP7 caspase 7, apoptosis-related cysteine peptidase 2.94623
ECEL1 endothelin converting enzyme-like 1 2.94623
SPESP1 sperm equatorial segment protein 1 2.94623
ZBTB42 zinc finger and BTB domain containing 42 2.94623
PNMA8B PNMA family member 8B 2.94623
SDR9C7 short chain dehydrogenase/reductase family 9C, member 7 2.94623
LDB3 LIM domain binding 3 2.94623
SIM1 single-minded family bHLH transcription factor 1 2.94623
INHBE inhibin, beta E 2.94623
SELPLG selectin P ligand 2.94623
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 2.94623
FMO2 flavin containing monooxygenase 2 (non-functional) 2.94623
EQTN equatorin, sperm acrosome associated 2.94623
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5 2.94623
NPR1 natriuretic peptide receptor 1 2.94623
AKAP14 A kinase (PRKA) anchor protein 14 2.94623
KRT80 keratin 80, type II 2.94623
DUSP1 dual specificity phosphatase 1 2.94623
RXFP2 relaxin/insulin-like family peptide receptor 2 2.94623
LIPH lipase, member H 2.94623
ADGRE3 adhesion G protein-coupled receptor E3 2.94623
SIK1 salt-inducible kinase 1 2.94623
ADCK5 aarF domain containing kinase 5 2.94623
VSTM2L V-set and transmembrane domain containing 2 like 2.94623
GH2 growth hormone 2 2.94623
FBXO43 F-box protein 43 2.94623
CST1 cystatin SN 2.94623
DACT3 dishevelled-binding antagonist of beta-catenin 3 2.94623
SCX scleraxis basic helix-loop-helix transcription factor 2.94623
MAN2A2 mannosidase, alpha, class 2A, member 2 2.94623
PRRX1 paired related homeobox 1 2.94623
FBXL22 F-box and leucine-rich repeat protein 22 2.94623
IFI16 interferon, gamma-inducible protein 16 2.94623
RIBC2 RIB43A domain with coiled-coils 2 2.94623
ZNF658 zinc finger protein 658 2.94623
MSMP microseminoprotein, prostate associated 2.94623
DCDC2B doublecortin domain containing 2B 2.94623
TSPAN16 tetraspanin 16 2.94623
ANKS4B ankyrin repeat and sterile alpha motif domain containing 4B 2.94623
SLC30A10 solute carrier family 30, member 10 2.94623
SLITRK1 SLIT and NTRK-like family, member 1 2.94623
C11ORF91 chromosome 11 open reading frame 91 2.94623
GRK1 G protein-coupled receptor kinase 1 2.94623
WIF1 WNT inhibitory factor 1 2.94623
SCN3A sodium channel, voltage gated, type III alpha subunit 2.94623
CDRT4 CMT1A duplicated region transcript 4 2.94623
OCA2 oculocutaneous albinism II 2.94623
PRAM1 PML-RARA regulated adaptor molecule 1 2.94623
SCUBE2 signal peptide, CUB domain, EGF-like 2 2.94623
OR3A3 olfactory receptor, family 3, subfamily A, member 3 2.94623
GABRQ gamma-aminobutyric acid (GABA) A receptor, theta 2.94623
FEZF2 FEZ family zinc finger 2 2.94623
LRRC43 leucine rich repeat containing 43 2.94623
LRRC45 leucine rich repeat containing 45 2.94623
MANSC1 MANSC domain containing 1 2.94623
SV2B synaptic vesicle glycoprotein 2B 2.94623
FOXP2 forkhead box P2 2.94623
CEL carboxyl ester lipase 2.94623
BEAN1 brain expressed, associated with NEDD4, 1 2.94623
CMTM1 CKLF-like MARVEL transmembrane domain containing 1 2.94623
SMKR1 small lysine-rich protein 1 2.94623
PRSS53 protease, serine, 53 2.94623
MR1 major histocompatibility complex, class I-related 2.94623
PLAC1 placenta-specific 1 2.94623
ELANE elastase, neutrophil expressed 2.94623
ILDR2 immunoglobulin-like domain containing receptor 2 2.94623
DLX5 distal-less homeobox 5 2.94623
CSPG5 chondroitin sulfate proteoglycan 5 (neuroglycan C) 2.94623
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1 2.94623
USP35 ubiquitin specific peptidase 35 2.94623
MT1M metallothionein 1M 2.94623
TBXA2R thromboxane A2 receptor 2.94623
CCNO cyclin O 2.94623
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7 2.94623
CEND1 cell cycle exit and neuronal differentiation 1 2.94623
MAPK8IP2 mitogen-activated protein kinase 8 interacting protein 2 2.94623
GRAP2 GRB2-related adaptor protein 2 2.94623
FES FES proto-oncogene, tyrosine kinase 2.94623
CACNA2D4 calcium channel, voltage-dependent, alpha 2/delta subunit 4 2.94623
PRAP1 proline-rich acidic protein 1 2.94623
TRPM8 transient receptor potential cation channel, subfamily M, member 8 2.94623
RGPD5 RANBP2-like and GRIP domain containing 5 2.94623
C19ORF44 chromosome 19 open reading frame 44 2.94623
MB myoglobin 2.94623
KCTD21 potassium channel tetramerization domain containing 21 2.94623
MMP19 matrix metallopeptidase 19 2.94623
LPAR6 lysophosphatidic acid receptor 6 2.94623
CLEC4G C-type lectin domain family 4, member G 2.94623
GREM2 gremlin 2, DAN family BMP antagonist 2.94623
TGM1 transglutaminase 1 2.94623
MLKL mixed lineage kinase domain-like 2.94623
FRMPD2 FERM and PDZ domain containing 2 2.94623
FRMPD4 FERM and PDZ domain containing 4 2.94623
ATAD2 ATPase family, AAA domain containing 2 2.94623
ZNF536 zinc finger protein 536 2.94623
ARHGAP40 Rho GTPase activating protein 40 2.94623
ZNF416 zinc finger protein 416 2.94623
LCP1 lymphocyte cytosolic protein 1 (L-plastin) 2.94623
WFDC10B WAP four-disulfide core domain 10B 2.94623
UFSP1 UFM1-specific peptidase 1 (non-functional) 2.94623
OLFML1 olfactomedin-like 1 2.94623
TMEM61 transmembrane protein 61 2.94623
SEC14L4 SEC14-like 4 (S. cerevisiae) 2.94623
LCN2 lipocalin 2 2.94623
PCSK2 proprotein convertase subtilisin/kexin type 2 2.94623
TAT tyrosine aminotransferase 2.94623
SDR42E1 short chain dehydrogenase/reductase family 42E, member 1 2.94623
ADM5 adrenomedullin 5 (putative) 2.94623
WNT2 wingless-type MMTV integration site family member 2 2.94623
RASGRP4 RAS guanyl releasing protein 4 2.94623
DPRX divergent-paired related homeobox 2.94623
TESK1 testis-specific kinase 1 2.94623
CMC1 C-x(9)-C motif containing 1 2.93818
EDNRB endothelin receptor type B 2.92638
MXI1 MAX interactor 1, dimerization protein 2.92166
SCUBE1 signal peptide, CUB domain, EGF-like 1 2.91493
MAP1LC3A microtubule-associated protein 1 light chain 3 alpha 2.91493
DLK1 delta-like 1 homolog (Drosophila) 2.91062
KCNK10 potassium channel, two pore domain subfamily K, member 10 2.85888
AIFM2 apoptosis-inducing factor, mitochondrion-associated, 2 2.85888
ZNF846 zinc finger protein 846 2.85241
HAUS3 HAUS augmin-like complex, subunit 3 2.83778
B9D2 B9 protein domain 2 2.8254
KPNA7 karyopherin alpha 7 (importin alpha 8) 2.8254
ACVR1C activin A receptor, type IC 2.8254
ARL10 ADP-ribosylation factor-like 10 2.82265
MTERF2 mitochondrial transcription termination factor 2 2.82265
HOMEZ homeobox and leucine zipper encoding 2.82265
NAGA N-acetylgalactosaminidase, alpha- 2.82265
CYP4Z1 cytochrome P450, family 4, subfamily Z, polypeptide 1 2.82265
AFF1 AF4/FMR2 family, member 1 2.81648
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 2.81041
FNDC3B fibronectin type III domain containing 3B 2.81041
MPHOSPH9 M-phase phosphoprotein 9 2.73599
ACCS 1-aminocyclopropane-1-carboxylate synthase homolog (Arabidopsis)(non-functional) 2.72737
TCF19 transcription factor 19 2.72737
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 2.70241
CYRIB CYFIP related Rac1 interactor B 2.67457
SIX6 SIX homeobox 6 2.653
BAZ2B bromodomain adjacent to zinc finger domain, 2B 2.63934
TRIO trio Rho guanine nucleotide exchange factor 2.59441
PLEKHM3 pleckstrin homology domain containing, family M, member 3 2.58322
MECOM MDS1 and EVI1 complex locus 2.568
TMSB4X thymosin beta 4, X-linked 2.54822
MRTFB myocardin related transcription factor B 2.54387
FLVCR1 feline leukemia virus subgroup C cellular receptor 1 2.5349
PLEKHG1 pleckstrin homology domain containing, family G (with RhoGef domain) member 1 2.5349
ZNF33A zinc finger protein 33A 2.52093
FAM199X family with sequence similarity 199, X-linked 2.50404
PHACTR2 phosphatase and actin regulator 2 2.49252
ZRANB3 zinc finger, RAN-binding domain containing 3 2.49252
MACF1 microtubule-actin crosslinking factor 1 2.4912
E2F1 E2F transcription factor 1 2.48988
ABTB3 ankyrin repeat and BTB domain containing 3 2.48816
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 2.46706
NKAP NFKB activating protein 2.46547
CHODL chondrolectin 2.464
WDR19 WD repeat domain 19 2.45988
PCMTD2 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2 2.45947
PCDH11X protocadherin 11 X-linked 2.43929
FGFR2 fibroblast growth factor receptor 2 2.43929
KLHL15 kelch-like family member 15 2.43111
ZEB2 zinc finger E-box binding homeobox 2 2.42416
GRID2IP glutamate receptor, ionotropic, delta 2 (Grid2) interacting protein 2.41498
SHROOM4 shroom family member 4 2.4113
PTDSS1 phosphatidylserine synthase 1 2.4113
ALDH3A2 aldehyde dehydrogenase 3 family, member A2 2.38987
GREB1L growth regulation by estrogen in breast cancer-like 2.38218
DENND5B DENN/MADD domain containing 5B 2.34608
NDUFS7 NADH dehydrogenase (ubiquinone) Fe-S protein 7, 20kDa (NADH-coenzyme Q reductase) 2.34155
CENPQ centromere protein Q 2.33226
PPP1R3B protein phosphatase 1, regulatory subunit 3B 2.33226
TMEM260 transmembrane protein 260 2.32661
LRRN1 leucine rich repeat neuronal 1 2.32661
CNTNAP3 contactin associated protein-like 3 2.32661
BRD4 bromodomain containing 4 2.32661
ADK adenosine kinase 2.32661
EPHA7 EPH receptor A7 2.32661
NUBP1 nucleotide binding protein 1 2.32661
ACAD11 acyl-CoA dehydrogenase family, member 11 2.31308
PDS5B PDS5 cohesin associated factor B 2.30573
PRDM4 PR domain containing 4 2.29745
PARP16 poly (ADP-ribose) polymerase family, member 16 2.27642
SMOC1 SPARC related modular calcium binding 1 2.27642
ACTR10 actin-related protein 10 homolog (S. cerevisiae) 2.2757
RRP36 ribosomal RNA processing 36 homolog (S. cerevisiae) 2.27538
CLMN calmin (calponin-like, transmembrane) 2.25386
KLHL10 kelch-like family member 10 2.24644
RAPGEF3 Rap guanine nucleotide exchange factor (GEF) 3 2.24644
FOXP4 forkhead box P4 2.24644
IGSF22 immunoglobulin superfamily, member 22 2.24644
GARIN1B golgi associated RAB2 interactor 1B 2.24644
SMIM10L2A small integral membrane protein 10 like 2A 2.24644
SLC36A4 solute carrier family 36 (proton/amino acid symporter), member 4 2.24644
ATF1 activating transcription factor 1 2.24644
ANKRD44 ankyrin repeat domain 44 2.24644
CNTNAP2 contactin associated protein-like 2 2.24644
PRSS3 protease, serine, 3 2.24644
PNCK pregnancy up-regulated nonubiquitous CaM kinase 2.24644
ZNF671 zinc finger protein 671 2.24644
FOXP1 forkhead box P1 2.24644
SERPINA10 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10 2.24644
NDST4 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4 2.24644
WFIKKN1 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1 2.24644
QPCTL glutaminyl-peptide cyclotransferase-like 2.24403
TMEM107 transmembrane protein 107 2.24403
TMEM220 transmembrane protein 220 2.24403
DUSP4 dual specificity phosphatase 4 2.24403
VIPR2 vasoactive intestinal peptide receptor 2 2.24403
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 2.23113
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 2.21737
POM121C POM121 transmembrane nucleoporin C 2.19672
STEAP2 STEAP family member 2, metalloreductase 2.19456
NARF nuclear prelamin A recognition factor 2.19379
TMEM161B transmembrane protein 161B 2.1898
NLGN1 neuroligin 1 2.18944
TCN2 transcobalamin II 2.18864
FBN2 fibrillin 2 2.18393
RPRD2 regulation of nuclear pre-mRNA domain containing 2 2.18342
MED13L mediator complex subunit 13-like 2.17856
STAT5B signal transducer and activator of transcription 5B 2.17856
CHML choroideremia-like (Rab escort protein 2) 2.15435
CLCN3 chloride channel, voltage-sensitive 3 2.15244
LRRC14 leucine rich repeat containing 14 2.14649
C12ORF42 chromosome 12 open reading frame 42 2.13978
BCDIN3D BCDIN3 domain containing 2.13978
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9 2.13978
ADIRF adipogenesis regulatory factor 2.13978
DIO1 deiodinase, iodothyronine, type I 2.13978
TEPSIN TEPSIN adaptor related protein complex 4 accessory protein 2.13978
PITPNM2 phosphatidylinositol transfer protein, membrane-associated 2 2.13978
AMOT angiomotin 2.13978
LRRC66 leucine rich repeat containing 66 2.13978
TSSK6 testis-specific serine kinase 6 2.13978
BORCS6 BLOC-1 related complex subunit 6 2.13978
NPIPB15 nuclear pore complex interacting protein family, member B15 2.13978
PLPP1 phospholipid phosphatase 1 2.13399
RAB38 RAB38, member RAS oncogene family 2.13286
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 2.13286
GPC3 glypican 3 2.12835
ADGRL2 adhesion G protein-coupled receptor L2 2.12596
TENT5C terminal nucleotidyltransferase 5C 2.12596
LGALS9 lectin, galactoside-binding, soluble, 9 2.12596
CUBN cubilin (intrinsic factor-cobalamin receptor) 2.12596
MATCAP2 microtubule associated tyrosine carboxypeptidase 2 2.12596
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 2.12596
LOC107985101 uncharacterized LOC107985101 2.12596
C6ORF47 chromosome 6 open reading frame 47 2.12596
GTPBP2 GTP binding protein 2 2.12596
FBXO24 F-box protein 24 2.12596
TSPAN17 tetraspanin 17 2.12596
HDAC11 histone deacetylase 11 2.12596
IBA57 IBA57, iron-sulfur cluster assembly homolog (S. cerevisiae) 2.12596
VWF von Willebrand factor 2.12596
KREMEN2 kringle containing transmembrane protein 2 2.12596
CCDC40 coiled-coil domain containing 40 2.12596
TM6SF2 transmembrane 6 superfamily member 2 2.12596
ZNF766 zinc finger protein 766 2.12471
AUTS2 autism susceptibility candidate 2 2.12335
PMEL premelanosome protein 2.12335
FBH1 F-box DNA helicase 1 2.11293
ATG4B autophagy related 4B, cysteine peptidase 2.11293
PFDN1 prefoldin subunit 1 2.11293
RDH13 retinol dehydrogenase 13 (all-trans/9-cis) 2.11076
TNC tenascin C 2.10632
GJA1 gap junction protein, alpha 1, 43kDa 2.09584
MTDH metadherin 2.09584
RILPL1 Rab interacting lysosomal protein-like 1 2.09523
NSUN5 NOP2/Sun domain family, member 5 2.09515
LOC124906010 uncharacterized LOC124906010 2.09201
PSORS1C1 psoriasis susceptibility 1 candidate 1 2.09201
MORC2 MORC family CW-type zinc finger 2 2.08452
RSBN1L round spermatid basic protein 1-like 2.08433
LONP2 lon peptidase 2, peroxisomal 2.08433
ZMAT3 zinc finger, matrin-type 3 2.08306
ABHD12B abhydrolase domain containing 12B 2.07753
HM13 histocompatibility (minor) 13 2.0762
FAM53A family with sequence similarity 53, member A 2.06861
PTH2 parathyroid hormone 2 2.06861
PLEKHA5 pleckstrin homology domain containing, family A member 5 2.06833
ZC3H14 zinc finger CCCH-type containing 14 2.06776
SSTR2 somatostatin receptor 2 2.06691
TGFB1 transforming growth factor, beta 1 2.06156
ZNF66 zinc finger protein 66 2.06131
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 2.0579
ANKRD17 ankyrin repeat domain 17 2.05466
RPS29 ribosomal protein S29 2.04865
DPP10 dipeptidyl-peptidase 10 (non-functional) 2.04865
CD63 CD63 molecule 2.04865
SOD2 superoxide dismutase 2, mitochondrial 2.04865
PRTG protogenin 2.04589
PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta 2.04189
SEC14L1 SEC14-like 1 (S. cerevisiae) 2.04189
MGAT1 mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase 2.03642
TLE4 transducin-like enhancer of split 4 2.03548
DPYSL3 dihydropyrimidinase-like 3 2.03046
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 2.03046
THAP8 THAP domain containing 8 2.03043
ADAM17 ADAM metallopeptidase domain 17 2.03043
SERINC5 serine incorporator 5 2.02958
USP40 ubiquitin specific peptidase 40 2.02617

decreased expression

Symbol Name Standardized Value
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae) -3.03807
PANX1 pannexin 1 -3.03807
HEATR3 HEAT repeat containing 3 -3.03807
DRC9 dynein regulatory complex subunit 9 -2.9582
PRPSAP1 phosphoribosyl pyrophosphate synthetase-associated protein 1 -2.9582
FAM131B family with sequence similarity 131, member B -2.94623
NEIL2 nei endonuclease VIII-like 2 (E. coli) -2.94623
ZNF548 zinc finger protein 548 -2.94623
CA5B carbonic anhydrase VB, mitochondrial -2.94623
NUDT5 nudix (nucleoside diphosphate linked moiety X)-type motif 5 -2.94623
NDOR1 NADPH dependent diflavin oxidoreductase 1 -2.94623
SGCD sarcoglycan, delta (35kDa dystrophin-associated glycoprotein) -2.94623
ZNF33B zinc finger protein 33B -2.94623
NUDT6 nudix (nucleoside diphosphate linked moiety X)-type motif 6 -2.94623
FDFT1 farnesyl-diphosphate farnesyltransferase 1 -2.94623
SYNDIG1L synapse differentiation inducing 1-like -2.94623
TMCO4 transmembrane and coiled-coil domains 4 -2.94623
CKS1B CDC28 protein kinase regulatory subunit 1B -2.94623
TMEM53 transmembrane protein 53 -2.94623
CENPVL3 centromere protein V like 3 -2.94623
TAOK2 TAO kinase 2 -2.94623
MARCHF9 membrane associated ring-CH-type finger 9 -2.94623
ZFYVE28 zinc finger, FYVE domain containing 28 -2.94623
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma) -2.94623
DNAJC7 DnaJ (Hsp40) homolog, subfamily C, member 7 -2.94623
IRAK4 interleukin-1 receptor-associated kinase 4 -2.94623
COX5A cytochrome c oxidase subunit Va -2.94623
SPRED3 sprouty-related, EVH1 domain containing 3 -2.94623
ABCB10 ATP-binding cassette, sub-family B (MDR/TAP), member 10 -2.94244
PPIC peptidylprolyl isomerase C (cyclophilin C) -2.92357
ARFIP2 ADP-ribosylation factor interacting protein 2 -2.88285
IRF1 interferon regulatory factor 1 -2.84185
LNPEP leucyl/cystinyl aminopeptidase -2.8254
ZNF775 zinc finger protein 775 -2.82265
ILF3 interleukin enhancer binding factor 3, 90kDa -2.82265
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like -2.81648
PRX periaxin -2.73292
MICOS10 mitochondrial contact site and cristae organizing system subunit 10 -2.72548
EIF4E2 eukaryotic translation initiation factor 4E family member 2 -2.71257
RCC1 regulator of chromosome condensation 1 -2.70246
DNPH1 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 -2.69278
GDI1 GDP dissociation inhibitor 1 -2.67547
RTL4 retrotransposon Gag like 4 -2.67457
RPS26 ribosomal protein S26 -2.66978
TRAK2 trafficking protein, kinesin binding 2 -2.64416
EGLN1 egl-9 family hypoxia-inducible factor 1 -2.64416
DIDO1 death inducer-obliterator 1 -2.62692
GRAMD4 GRAM domain containing 4 -2.6132
CCT8 chaperonin containing TCP1, subunit 8 (theta) -2.60098
EIF1AX eukaryotic translation initiation factor 1A, X-linked -2.60063
METAP1 methionyl aminopeptidase 1 -2.58135
MED28 mediator complex subunit 28 -2.55261
PLAUR plasminogen activator, urokinase receptor -2.54848
LYRM4 LYR motif containing 4 -2.54387
SF3B6 splicing factor 3b, subunit 6, 14kDa -2.53774
GDI2 GDP dissociation inhibitor 2 -2.53734
PAPOLA poly(A) polymerase alpha -2.53734
NEK6 NIMA-related kinase 6 -2.51291
PRMT9 protein arginine methyltransferase 9 -2.49725
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta -2.49252
LAMTOR2 late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 -2.48816
EID2 EP300 interacting inhibitor of differentiation 2 -2.47835
ANK3 ankyrin 3, node of Ranvier (ankyrin G) -2.47835
PSME2 proteasome (prosome, macropain) activator subunit 2 (PA28 beta) -2.47364
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -2.47271
PNRC2 proline-rich nuclear receptor coactivator 2 -2.45807
IVNS1ABP influenza virus NS1A binding protein -2.43929
RSPO4 R-spondin 4 -2.43641
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) -2.43641
ESPN espin -2.43641
GIPC2 GIPC PDZ domain containing family, member 2 -2.43641
POU5F1 POU class 5 homeobox 1 -2.42169
DCAF15 DDB1 and CUL4 associated factor 15 -2.42169
SRI sorcin -2.40132
UBE2V2 ubiquitin-conjugating enzyme E2 variant 2 -2.39041
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase -2.37756
CUX2 cut-like homeobox 2 -2.36586
KCNJ6 potassium channel, inwardly rectifying subfamily J, member 6 -2.36586
C8ORF34 chromosome 8 open reading frame 34 -2.36586
VCPKMT valosin containing protein lysine (K) methyltransferase -2.36586
SENP8 SUMO/sentrin specific peptidase family member 8 -2.36586
SEC63 SEC63 homolog (S. cerevisiae) -2.34656
DFFA DNA fragmentation factor, 45kDa, alpha polypeptide -2.33608
ZBTB22 zinc finger and BTB domain containing 22 -2.32661
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11 -2.32661
H2BC18 H2B clustered histone 18 -2.32661
OXTR oxytocin receptor -2.32661
C7ORF25 chromosome 7 open reading frame 25 -2.32661
CADM3 cell adhesion molecule 3 -2.32661
UCKL1 uridine-cytidine kinase 1-like 1 -2.32661
PNMA8A PNMA family member 8A -2.32661
SPACA9 sperm acrosome associated 9 -2.32661
GCC1 GRIP and coiled-coil domain containing 1 -2.32661
METTL27 methyltransferase like 27 -2.32661
WASHC1 WASH complex subunit 1 -2.32661
CASP10 caspase 10, apoptosis-related cysteine peptidase -2.32661
FOXI3 forkhead box I3 -2.32661
SLC12A1 solute carrier family 12 (sodium/potassium/chloride transporter), member 1 -2.32661
ALG1L2 ALG1, chitobiosyldiphosphodolichol beta-mannosyltransferase-like 2 -2.32661
EXO5 exonuclease 5 -2.32661
RELL2 RELT-like 2 -2.32661
EIF4A1 eukaryotic translation initiation factor 4A1 -2.32661
DPF1 D4, zinc and double PHD fingers family 1 -2.32661
CELF1 CUGBP, Elav-like family member 1 -2.32661
CAPN13 calpain 13 -2.32661
LACC1 laccase (multicopper oxidoreductase) domain containing 1 -2.32661
WSCD2 WSC domain containing 2 -2.32661
S1PR5 sphingosine-1-phosphate receptor 5 -2.32661
CGREF1 cell growth regulator with EF-hand domain 1 -2.32661
CACNA1I calcium channel, voltage-dependent, T type, alpha 1I subunit -2.32661
L1CAM L1 cell adhesion molecule -2.32661
ZNF26 zinc finger protein 26 -2.32661
PLK3 polo-like kinase 3 -2.32661
DACT1 dishevelled-binding antagonist of beta-catenin 1 -2.32661
SLC38A5 solute carrier family 38, member 5 -2.32661
KBTBD3 kelch repeat and BTB (POZ) domain containing 3 -2.32661
SCTR secretin receptor -2.32661
EFEMP2 EGF containing fibulin-like extracellular matrix protein 2 -2.32661
FASTKD3 FAST kinase domains 3 -2.32661
GRSF1 G-rich RNA sequence binding factor 1 -2.32661
HNRNPA0 heterogeneous nuclear ribonucleoprotein A0 -2.32661
ITLN2 intelectin 2 -2.32661
HSD17B3 hydroxysteroid (17-beta) dehydrogenase 3 -2.32661
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -2.32661
AJAP1 adherens junctions associated protein 1 -2.32661
ZKSCAN4 zinc finger with KRAB and SCAN domains 4 -2.32661
RPL7 ribosomal protein L7 -2.32661
CCDC7 coiled-coil domain containing 7 -2.32661
C11ORF98 chromosome 11 open reading frame 98 -2.32661
GNMT glycine N-methyltransferase -2.32661
PLCD1 phospholipase C, delta 1 -2.32661
FAM110A family with sequence similarity 110, member A -2.32661
PHYHIP phytanoyl-CoA 2-hydroxylase interacting protein -2.32661
STK36 serine/threonine kinase 36 -2.32661
ZNF304 zinc finger protein 304 -2.32661
CACYBP calcyclin binding protein -2.32661
MRPL24 mitochondrial ribosomal protein L24 -2.32661
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -2.32661
CCDC172 coiled-coil domain containing 172 -2.32661
SPAG1 sperm associated antigen 1 -2.32661
CHST3 carbohydrate (chondroitin 6) sulfotransferase 3 -2.32661
ANKRD45 ankyrin repeat domain 45 -2.32661
PCSK4 proprotein convertase subtilisin/kexin type 4 -2.32661
UQCRFS1 ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 -2.32431
GLTP glycolipid transfer protein -2.31701
CCT5 chaperonin containing TCP1, subunit 5 (epsilon) -2.29145
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -2.28142
NIFK nucleolar protein interacting with the FHA domain of MKI67 -2.27642
ZNF250 zinc finger protein 250 -2.2757
C3ORF52 chromosome 3 open reading frame 52 -2.26401
TASP1 taspase, threonine aspartase, 1 -2.2638
ACBD6 acyl-CoA binding domain containing 6 -2.2589
HMGB1 high mobility group box 1 -2.24644
ALDH4A1 aldehyde dehydrogenase 4 family, member A1 -2.24403
C18ORF54 chromosome 18 open reading frame 54 -2.24403
PPIA peptidylprolyl isomerase A (cyclophilin A) -2.24403
SYVN1 synovial apoptosis inhibitor 1, synoviolin -2.24403
GLIS2 GLIS family zinc finger 2 -2.24403
ATXN7L1 ataxin 7-like 1 -2.24389
CADM2 cell adhesion molecule 2 -2.24308
GLO1 glyoxalase I -2.23647
ZP3 zona pellucida glycoprotein 3 (sperm receptor) -2.23113
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1 -2.23113
PRMT8 protein arginine methyltransferase 8 -2.23113
CD109 CD109 molecule -2.23113
MEF2C myocyte enhancer factor 2C -2.23113
EPM2A epilepsy, progressive myoclonus type 2A, Lafora disease (laforin) -2.22575
MET MET proto-oncogene, receptor tyrosine kinase -2.2237
ATF3 activating transcription factor 3 -2.2237
EPHB1 EPH receptor B1 -2.21648
OCIAD2 OCIA domain containing 2 -2.21549
CLYBL citrate lyase beta like -2.21467
NOL10 nucleolar protein 10 -2.20955
SPATA2 spermatogenesis associated 2 -2.20314
MYPOP Myb-related transcription factor, partner of profilin -2.20314
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -2.20314
PPIP5K1 diphosphoinositol pentakisphosphate kinase 1 -2.20314
KANK2 KN motif and ankyrin repeat domains 2 -2.20314
FER fer (fps/fes related) tyrosine kinase -2.20314
WWC1 WW and C2 domain containing 1 -2.20296
PA2G4 proliferation-associated 2G4, 38kDa -2.20164
STXBP4 syntaxin binding protein 4 -2.19547
NASP nuclear autoantigenic sperm protein (histone-binding) -2.19456
HDGF hepatoma-derived growth factor -2.1938
LIN7C lin-7 homolog C (C. elegans) -2.19379
IRS2 insulin receptor substrate 2 -2.19379
ABRACL ABRA C-terminal like -2.18925
MORN4 MORN repeat containing 4 -2.17856
ZNF362 zinc finger protein 362 -2.17856
TWSG1 twisted gastrulation BMP signaling modulator 1 -2.17856
MTF2 metal response element binding transcription factor 2 -2.17659
PEX26 peroxisomal biogenesis factor 26 -2.17659
DOT1L DOT1-like histone H3K79 methyltransferase -2.16641
MLX MLX, MAX dimerization protein -2.15761
MRAP2 melanocortin 2 receptor accessory protein 2 -2.15761
FAM20C family with sequence similarity 20, member C -2.15761
RPS2 ribosomal protein S2 -2.15761
TRIM32 tripartite motif containing 32 -2.15761
NDUFAF8 NADH:ubiquinone oxidoreductase complex assembly factor 8 -2.13978
MPV17 MpV17 mitochondrial inner membrane protein -2.13978
PPM1K protein phosphatase, Mg2+/Mn2+ dependent, 1K -2.13399
COTL1 coactosin-like F-actin binding protein 1 -2.12765
PHKA1 phosphorylase kinase, alpha 1 (muscle) -2.1273
IRF6 interferon regulatory factor 6 -2.12596
TRMT1 tRNA methyltransferase 1 homolog (S. cerevisiae) -2.12596
AKAP6 A kinase (PRKA) anchor protein 6 -2.12596
CAMKK2 calcium/calmodulin-dependent protein kinase kinase 2, beta -2.1257
DR1 down-regulator of transcription 1, TBP-binding (negative cofactor 2) -2.12262
RTRAF RNA transcription, translation and transport factor -2.11745
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3 -2.11376
CD24 CD24 molecule -2.11293
CDK5 cyclin-dependent kinase 5 -2.10928
ATP6V0D1 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1 -2.10928
FAHD2B fumarylacetoacetate hydrolase domain containing 2B -2.10928
NAT10 N-acetyltransferase 10 (GCN5-related) -2.10746
WDR86 WD repeat domain 86 -2.09974
MPHOSPH10 M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein) -2.09584
ARMC9 armadillo repeat containing 9 -2.09156
NOAZFP nucleolar atypical zinc finger -2.08816
CCDC85B coiled-coil domain containing 85B -2.07334
GPX1 glutathione peroxidase 1 -2.06156
FHL2 four and a half LIM domains 2 -2.06131
FEM1C fem-1 homolog c (C. elegans) -2.05808
PKD1 polycystic kidney disease 1 (autosomal dominant) -2.05808
HINT1 histidine triad nucleotide binding protein 1 -2.0576
GRID2 glutamate receptor, ionotropic, delta 2 -2.0576
DMKN dermokine -2.04923
IMP3 IMP3, U3 small nucleolar ribonucleoprotein -2.04865
PARK7 parkinson protein 7 -2.04865
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -2.04737
DHX36 DEAH (Asp-Glu-Ala-His) box polypeptide 36 -2.0368
PARP1 poly (ADP-ribose) polymerase 1 -2.03043
RPL21 ribosomal protein L21 -2.02635
NXPH1 neurexophilin 1 -2.02293
MRPL4 mitochondrial ribosomal protein L4 -2.01459
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.01265
PSD3 pleckstrin and Sec7 domain containing 3 -2.00189