SEC63 Gene Set

Dataset Hub Proteins Protein-Protein Interactions
Category physical interactions
Type hub protein
Description SEC63 homolog (S. cerevisiae)|The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. The protein encoded by this gene and SEC62 protein are found to be associated with ribosome-free SEC61 complex. It is speculated that Sec61-Sec62-Sec63 may perform post-translational protein translocation into the ER. The Sec61-Sec62-Sec63 complex might also perform the backward transport of ER proteins that are subject to the ubiquitin-proteasome-dependent degradation pathway. The encoded protein is an integral membrane protein located in the rough ER. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 11231)
External Link http://www.ncbi.nlm.nih.gov/gene/11231
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Genes

98 interacting proteins for hub protein SEC63 from the curated Hub Proteins Protein-Protein Interactions dataset.

Symbol Name
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ATP6V1B1 ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1
ATP6V1E1 ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1
CBR1 carbonyl reductase 1
CCT6A chaperonin containing TCP1, subunit 6A (zeta 1)
CDC73 cell division cycle 73
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDIPT CDP-diacylglycerol--inositol 3-phosphatidyltransferase
CFDP1 craniofacial development protein 1
COG3 component of oligomeric golgi complex 3
CTH cystathionine gamma-lyase
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1
CYTH1 cytohesin 1
DIAPH3 diaphanous-related formin 3
DUS1L dihydrouridine synthase 1-like (S. cerevisiae)
DUS3L dihydrouridine synthase 3-like (S. cerevisiae)
EGLN2 egl-9 family hypoxia-inducible factor 2
EIF2AK4 eukaryotic translation initiation factor 2 alpha kinase 4
EIF3B eukaryotic translation initiation factor 3, subunit B
ELF1 E74-like factor 1 (ets domain transcription factor)
ENO1 enolase 1, (alpha)
ENO2 enolase 2 (gamma, neuronal)
ERN1 endoplasmic reticulum to nucleus signaling 1
ESRRA estrogen-related receptor alpha
EXOSC10 exosome component 10
FA2H fatty acid 2-hydroxylase
FAR1 fatty acyl CoA reductase 1
FAU Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed
FRS2 fibroblast growth factor receptor substrate 2
FURIN furin (paired basic amino acid cleaving enzyme)
GSTK1 glutathione S-transferase kappa 1
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
ISM1 isthmin 1, angiogenesis inhibitor
KIAA0368 KIAA0368
KIF23 kinesin family member 23
MAGEA6 melanoma antigen family A6
MCC mutated in colorectal cancers
MCM2 minichromosome maintenance complex component 2
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MMP3 matrix metallopeptidase 3
MON2 MON2 homolog (S. cerevisiae)
MSMO1 methylsterol monooxygenase 1
NAP1L3 nucleosome assembly protein 1-like 3
NR0B2 nuclear receptor subfamily 0, group B, member 2
ORM2 orosomucoid 2
PCSK2 proprotein convertase subtilisin/kexin type 2
PGK1 phosphoglycerate kinase 1
PHLDA3 pleckstrin homology-like domain, family A, member 3
PIF1 PIF1 5'-to-3' DNA helicase
PIGW phosphatidylinositol glycan anchor biosynthesis, class W
PPIP5K1 diphosphoinositol pentakisphosphate kinase 1
PRPF8 pre-mRNA processing factor 8
PSMD12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12
PSMD3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 3
PTK2B protein tyrosine kinase 2 beta
PTP4A3 protein tyrosine phosphatase type IVA, member 3
REEP5 receptor accessory protein 5
RIF1 replication timing regulatory factor 1
RNF20 ring finger protein 20, E3 ubiquitin protein ligase
RPN2 ribophorin II
RYBP RING1 and YY1 binding protein
SACM1L SAC1 suppressor of actin mutations 1-like (yeast)
SEC24B SEC24 family member B
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae)
SEC61B Sec61 beta subunit
SEC62 SEC62 homolog (S. cerevisiae)
SHFM1 split hand/foot malformation (ectrodactyly) type 1
SKIV2L2 superkiller viralicidic activity 2-like 2 (S. cerevisiae)
SLC1A2 solute carrier family 1 (glial high affinity glutamate transporter), member 2
SLC31A2 solute carrier family 31 (copper transporter), member 2
SLC39A1 solute carrier family 39 (zinc transporter), member 1
SMAD1 SMAD family member 1
SMC1A structural maintenance of chromosomes 1A
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1
SRCAP Snf2-related CREBBP activator protein
SRR serine racemase
SURF4 surfeit 4
SWI5 SWI5 recombination repair homolog (yeast)
TAZ tafazzin
TBCE tubulin folding cofactor E
TBL3 transducin (beta)-like 3
THOC2 THO complex 2
TRAF3IP2 TRAF3 interacting protein 2
TRIM21 tripartite motif containing 21
TROVE2 TROVE domain family, member 2
TYR tyrosinase
UBE2G2 ubiquitin-conjugating enzyme E2G 2
URB1 URB1 ribosome biogenesis 1 homolog (S. cerevisiae)
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
UTP23 UTP23, small subunit (SSU) processome component, homolog (yeast)
VPS35 vacuolar protein sorting 35 homolog (S. cerevisiae)
WBP1 WW domain binding protein 1
WDHD1 WD repeat and HMG-box DNA binding protein 1
WDR5 WD repeat domain 5
XPO1 exportin 1
YAP1 Yes-associated protein 1
ZMPSTE24 zinc metallopeptidase STE24