SEKI Gene Set

Dataset DepMap CRISPR Gene Dependency
Category disease or phenotype associations
Type cell line
Description Melanoma cell line (Cancer Dependency Map)
External Link https://depmap.org/portal/cell_line/ACH-001645
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Genes

344 gene knockdowns changing fitness of SEKI relative to other cell lines from the DepMap CRISPR Gene Dependency Dataset.

Symbol Name Standardized Value
DMRT3 doublesex and mab-3 related transcription factor 3 25.1426
ADM2 adrenomedullin 2 17.2096
CHSY1 chondroitin sulfate synthase 1 10.3498
LIF leukemia inhibitory factor 10.0268
RESP18 regulated endocrine-specific protein 18 8.17676
SEPP1 selenoprotein P, plasma, 1 8.09722
FAM131B family with sequence similarity 131, member B 8.07591
SLC39A1 solute carrier family 39 (zinc transporter), member 1 7.6285
SOX5 SRY (sex determining region Y)-box 5 7.54822
SGPP2 sphingosine-1-phosphate phosphatase 2 6.76365
IFNA17 interferon, alpha 17 6.6495
CAVIN2 caveolae associated protein 2 6.53403
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3 6.30978
C2ORF50 chromosome 2 open reading frame 50 6.2417
EBAG9 estrogen receptor binding site associated, antigen, 9 6.03959
SIAH3 siah E3 ubiquitin protein ligase family member 3 5.97758
ZCCHC2 zinc finger, CCHC domain containing 2 5.69468
RBP1 retinol binding protein 1, cellular 5.66006
HLA-F major histocompatibility complex, class I, F 5.55172
ATP6V1E2 ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E2 5.51663
EPSTI1 epithelial stromal interaction 1 (breast) 5.4583
VIM vimentin 5.43357
PAQR9 progestin and adipoQ receptor family member IX 5.42334
H3-5 H3.5 histone 5.36795
CTIF CBP80/20-dependent translation initiation factor 5.30576
LYG1 lysozyme G-like 1 5.23493
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 5.20581
DCAF12L1 DDB1 and CUL4 associated factor 12-like 1 5.18754
ATP6V0A4 ATPase, H+ transporting, lysosomal V0 subunit a4 5.17068
CLEC4G C-type lectin domain family 4, member G 5.15609
UBE2F ubiquitin-conjugating enzyme E2F (putative) 5.09529
SLC5A1 solute carrier family 5 (sodium/glucose cotransporter), member 1 4.98844
ZNF24 zinc finger protein 24 4.97341
FRAT1 frequently rearranged in advanced T-cell lymphomas 1 4.97132
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha 4.89613
ARIH2 ariadne RBR E3 ubiquitin protein ligase 2 4.88317
TTC31 tetratricopeptide repeat domain 31 4.8757
TOM1 target of myb1 (chicken) 4.85585
TRIM21 tripartite motif containing 21 4.81644
EDA ectodysplasin A 4.80154
ITPRIP inositol 1,4,5-trisphosphate receptor interacting protein 4.79216
TRIM54 tripartite motif containing 54 4.75867
KRT15 keratin 15, type I 4.71745
CRYGC crystallin, gamma C 4.68715
IFNA1 interferon, alpha 1 4.66365
DUSP10 dual specificity phosphatase 10 4.54581
RAX retina and anterior neural fold homeobox 4.49797
YBX3 Y box binding protein 3 4.49682
H1-1 H1.1 linker histone, cluster member 4.48982
INSL3 insulin-like 3 (Leydig cell) 4.45924
PTF1A pancreas specific transcription factor, 1a 4.45169
TTLL1 tubulin tyrosine ligase-like family member 1 4.42734
PODXL podocalyxin-like 4.41546
CYTH2 cytohesin 2 4.39546
PHF21B PHD finger protein 21B 4.39299
EVX1 even-skipped homeobox 1 4.37979
MEGF11 multiple EGF-like-domains 11 4.37797
TSPO translocator protein (18kDa) 4.33704
HPS1 Hermansky-Pudlak syndrome 1 4.32549
TMEM64 transmembrane protein 64 4.31298
DMRT2 doublesex and mab-3 related transcription factor 2 4.29848
GAMT guanidinoacetate N-methyltransferase 4.29442
GNG13 guanine nucleotide binding protein (G protein), gamma 13 4.29176
GDPGP1 GDP-D-glucose phosphorylase 1 4.27798
PRAMEF4 PRAME family member 4 4.23818
CSNK2A1 casein kinase 2, alpha 1 polypeptide 4.22807
SIGLEC5 sialic acid binding Ig-like lectin 5 4.15451
FNDC3A fibronectin type III domain containing 3A 4.14328
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal) 4.13897
CDA cytidine deaminase 4.13635
TACR1 tachykinin receptor 1 4.1328
MAP2K1 mitogen-activated protein kinase kinase 1 4.12981
VIL1 villin 1 4.08603
SLC28A1 solute carrier family 28 (concentrative nucleoside transporter), member 1 4.08019
SH3YL1 SH3 and SYLF domain containing 1 4.07927
INHA inhibin, alpha 4.05054
ADGRG4 adhesion G protein-coupled receptor G4 4.02062
PPP6R2 protein phosphatase 6, regulatory subunit 2 3.99903
TMTC1 transmembrane and tetratricopeptide repeat containing 1 3.9865
PLSCR5 phospholipid scramblase family, member 5 3.97992
RAB40A RAB40A, member RAS oncogene family 3.90189
DRD4 dopamine receptor D4 3.88976
PSKH2 protein serine kinase H2 3.83936
BAIAP2L2 BAI1-associated protein 2-like 2 3.78861
DRD5 dopamine receptor D5 3.75795
NPPA natriuretic peptide A 3.75329
PIAS3 protein inhibitor of activated STAT, 3 3.73838
THEMIS2 thymocyte selection associated family member 2 3.69396
TMEM223 transmembrane protein 223 3.66662
MCEE methylmalonyl CoA epimerase 3.64848
CR1L complement component (3b/4b) receptor 1-like 3.60635
GRK7 G protein-coupled receptor kinase 7 3.57115
BRAF B-Raf proto-oncogene, serine/threonine kinase 3.5667
PDLIM2 PDZ and LIM domain 2 (mystique) 3.54534
KRTAP15-1 keratin associated protein 15-1 3.54118
CLEC2A C-type lectin domain family 2, member A 3.51988
RCAN1 regulator of calcineurin 1 3.51788
C8ORF46 chromosome 8 open reading frame 46 3.5154
GPRC5C G protein-coupled receptor, class C, group 5, member C 3.47601
ATP2A3 ATPase, Ca++ transporting, ubiquitous 3.47399
WWC1 WW and C2 domain containing 1 3.4665
CD1D CD1d molecule 3.46193
RXRG retinoid X receptor, gamma 3.46142
GYG1 glycogenin 1 3.4529
OR9A4 olfactory receptor, family 9, subfamily A, member 4 3.44752
SLC25A2 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 2 3.42799
PGM5 phosphoglucomutase 5 3.41479
AANAT aralkylamine N-acetyltransferase 3.39511
EPHX3 epoxide hydrolase 3 3.39079
TAS2R7 taste receptor, type 2, member 7 3.38197
KLF7 Kruppel-like factor 7 (ubiquitous) 3.37808
HRG histidine-rich glycoprotein 3.36282
CLCN4 chloride channel, voltage-sensitive 4 3.35704
KLF14 Kruppel-like factor 14 3.34994
PLEKHA7 pleckstrin homology domain containing, family A member 7 3.3482
KLHDC8A kelch domain containing 8A 3.3321
TMEM180 transmembrane protein 180 3.33122
FRMD1 FERM domain containing 1 3.32024
AKNA AT-hook transcription factor 3.3085
PDGFRL platelet-derived growth factor receptor-like 3.30468
PKP2 plakophilin 2 3.30105
MDC1 mediator of DNA-damage checkpoint 1 3.29856
FAM117A family with sequence similarity 117, member A 3.28957
P2RY11 purinergic receptor P2Y, G-protein coupled, 11 3.28834
GDF3 growth differentiation factor 3 3.28659
CFB complement factor B 3.26349
SOX30 SRY (sex determining region Y)-box 30 3.23948
LCE2D late cornified envelope 2D 3.23681
PSG6 pregnancy specific beta-1-glycoprotein 6 3.23203
SCN1B sodium channel, voltage gated, type I beta subunit 3.23166
AXIN1 axin 1 3.23095
FBN1 fibrillin 1 3.21495
OR5L2 olfactory receptor, family 5, subfamily L, member 2 3.20612
SOX10 SRY (sex determining region Y)-box 10 3.1935
PPM1K protein phosphatase, Mg2+/Mn2+ dependent, 1K 3.18305
MAGEC3 melanoma antigen family C3 3.16682
KHSRP KH-type splicing regulatory protein 3.16647
AGBL3 ATP/GTP binding protein-like 3 3.16583
DERA deoxyribose-phosphate aldolase (putative) 3.16421
KCNAB2 potassium channel, voltage gated subfamily A regulatory beta subunit 2 3.16233
STRA8 stimulated by retinoic acid 8 3.15964
RTKN rhotekin 3.15675
MIIP migration and invasion inhibitory protein 3.14511
CEP120 centrosomal protein 120kDa 3.12336
SLC22A11 solute carrier family 22 (organic anion/urate transporter), member 11 3.11897
MYADM myeloid-associated differentiation marker 3.11786
ALS2CR12 amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 12 3.1156
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit 3.11541
KRT23 keratin 23, type I 3.11372
CHST1 carbohydrate (keratan sulfate Gal-6) sulfotransferase 1 3.0913
MSL3 male-specific lethal 3 homolog (Drosophila) 3.08689
CD276 CD276 molecule 3.07441
CARF calcium responsive transcription factor 3.05691
CCDC142 coiled-coil domain containing 142 3.03548
SSTR2 somatostatin receptor 2 3.02753
EVI5L ecotropic viral integration site 5-like 3.023
FAM91A1 family with sequence similarity 91, member A1 3.01597
KRT86 keratin 86, type II 3.01409
GPR55 G protein-coupled receptor 55 3.01251
TSSC4 tumor suppressing subtransferable candidate 4 3.01081
SIX1 SIX homeobox 1 3.00992
MZB1 marginal zone B and B1 cell-specific protein 3.00807
PCDHGB2 protocadherin gamma subfamily B, 2 3.00336
GNB3 guanine nucleotide binding protein (G protein), beta polypeptide 3 2.99528
ESPN espin 2.99248
ADIPOQ adiponectin, C1Q and collagen domain containing 2.98178
MCM8 minichromosome maintenance complex component 8 2.98057
PRR30 proline rich 30 2.9749
YIF1B Yip1 interacting factor homolog B (S. cerevisiae) 2.92522
ADD1 adducin 1 (alpha) 2.92323
AHR aryl hydrocarbon receptor 2.91456
OR2L5 olfactory receptor, family 2, subfamily L, member 5 2.90374
MPPED1 metallophosphoesterase domain containing 1 2.89179
BEND7 BEN domain containing 7 2.88174
RPH3AL rabphilin 3A-like (without C2 domains) 2.87773
TM6SF1 transmembrane 6 superfamily member 1 2.86613
COL7A1 collagen, type VII, alpha 1 2.86234
SLC4A1 solute carrier family 4 (anion exchanger), member 1 (Diego blood group) 2.85926
CXORF40B chromosome X open reading frame 40B 2.84824
CORO2B coronin, actin binding protein, 2B 2.84248
CDH12 cadherin 12, type 2 (N-cadherin 2) 2.8417
ANKRD44 ankyrin repeat domain 44 2.8273
FAH fumarylacetoacetate hydrolase (fumarylacetoacetase) 2.82426
MATN1 matrilin 1, cartilage matrix protein 2.80555
SLK STE20-like kinase 2.7987
OR13C3 olfactory receptor, family 13, subfamily C, member 3 2.78335
C5ORF34 chromosome 5 open reading frame 34 2.77872
TPM2 tropomyosin 2 (beta) 2.77303
RBIS ribosomal biogenesis factor 2.76892
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 2.76858
CMKLR1 chemerin chemokine-like receptor 1 2.76611
SYT11 synaptotagmin XI 2.74848
ZDHHC19 zinc finger, DHHC-type containing 19 2.74429
ASAH2 N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2 2.74418
CSPG4 chondroitin sulfate proteoglycan 4 2.74382
FAM221A family with sequence similarity 221, member A 2.7318
ACTL9 actin-like 9 2.72715
BMPR1B bone morphogenetic protein receptor, type IB 2.70128
TRIM40 tripartite motif containing 40 2.69782
OR51B5 olfactory receptor, family 51, subfamily B, member 5 2.69111
SCNN1D sodium channel, non voltage gated 1 delta subunit 2.68801
SCG2 secretogranin II 2.67004
GBP1 guanylate binding protein 1, interferon-inducible 2.66958
ZFP30 ZFP30 zinc finger protein 2.65716
AMBP alpha-1-microglobulin/bikunin precursor 2.65218
EVA1A eva-1 homolog A (C. elegans) 2.646
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic) 2.63871
MCTS1 malignant T cell amplified sequence 1 2.6345
SH3PXD2A SH3 and PX domains 2A 2.60584
MLC1 megalencephalic leukoencephalopathy with subcortical cysts 1 2.5924
MFRP membrane frizzled-related protein 2.58841
EPHA8 EPH receptor A8 2.5698
PLA2G5 phospholipase A2, group V 2.56136
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B 2.5429
ODF3L1 outer dense fiber of sperm tails 3-like 1 2.53353
RBBP8NL RBBP8 N-terminal like 2.52972
KRTAP5-9 keratin associated protein 5-9 2.50624
SLC5A5 solute carrier family 5 (sodium/iodide cotransporter), member 5 2.49983
PSMF1 proteasome (prosome, macropain) inhibitor subunit 1 (PI31) 2.49186
OR8H3 olfactory receptor, family 8, subfamily H, member 3 2.46351
SNX21 sorting nexin family member 21 2.46275
KRT18 keratin 18, type I 2.45893
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled 2.45645
SH3RF2 SH3 domain containing ring finger 2 2.45386
ACOT12 acyl-CoA thioesterase 12 2.44442
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2 2.44372
RFPL3 ret finger protein-like 3 2.43314
MAGEA12 melanoma antigen family A12 2.43304
PPP1R1A protein phosphatase 1, regulatory (inhibitor) subunit 1A 2.42993
LYPD2 LY6/PLAUR domain containing 2 2.42388
CRYGD crystallin, gamma D 2.41679
KCNIP2 Kv channel interacting protein 2 2.41145
FAM207A family with sequence similarity 207, member A 2.4081
PHOSPHO1 phosphatase, orphan 1 2.40068
TNIP3 TNFAIP3 interacting protein 3 2.39879
DHRS3 dehydrogenase/reductase (SDR family) member 3 2.39274
GPBAR1 G protein-coupled bile acid receptor 1 2.39185
PLD2 phospholipase D2 2.3905
NMUR2 neuromedin U receptor 2 2.37815
ZNF71 zinc finger protein 71 2.37429
CIR1 corepressor interacting with RBPJ, 1 2.35871
DMKN dermokine 2.3582
ZNF3 zinc finger protein 3 2.35594
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 2.35472
XYLT1 xylosyltransferase I 2.35281
PCDHA7 protocadherin alpha 7 2.3457
FOXB1 forkhead box B1 2.32787
OR10H1 olfactory receptor, family 10, subfamily H, member 1 2.32284
BEND4 BEN domain containing 4 2.31874
TFE3 transcription factor binding to IGHM enhancer 3 2.31733
CSAD cysteine sulfinic acid decarboxylase 2.31728
ZNF862 zinc finger protein 862 2.30927
UGDH UDP-glucose 6-dehydrogenase 2.30787
MDM4 MDM4, p53 regulator 2.29614
LKAAEAR1 LKAAEAR motif containing 1 2.29281
PEF1 penta-EF-hand domain containing 1 2.29194
ROM1 retinal outer segment membrane protein 1 2.28543
ITSN1 intersectin 1 (SH3 domain protein) 2.28537
FMN2 formin 2 2.28362
OR5M8 olfactory receptor, family 5, subfamily M, member 8 2.27469
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble) 2.27204
NET1 neuroepithelial cell transforming 1 2.26822
ALG10B ALG10B, alpha-1,2-glucosyltransferase 2.25783
ACTRT2 actin-related protein T2 2.25482
H2BFWT H2B histone family, member W, testis-specific 2.25466
WIPI1 WD repeat domain, phosphoinositide interacting 1 2.24812
PEAR1 platelet endothelial aggregation receptor 1 2.24398
OR4D5 olfactory receptor, family 4, subfamily D, member 5 2.23624
MCF2L2 MCF.2 cell line derived transforming sequence-like 2 2.22767
IGFBP7 insulin-like growth factor binding protein 7 2.2267
TXNDC5 thioredoxin domain containing 5 (endoplasmic reticulum) 2.22428
SPATS2 spermatogenesis associated, serine-rich 2 2.22148
LOR loricrin 2.22051
STIP1 stress-induced phosphoprotein 1 2.2179
CD5L CD5 molecule-like 2.21664
TMEM235 transmembrane protein 235 2.20964
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 2.2074
ACAN aggrecan 2.20623
APBA1 amyloid beta (A4) precursor protein-binding, family A, member 1 2.19903
DENND11 DENN domain containing 11 2.1989
BICD1 bicaudal D homolog 1 (Drosophila) 2.19372
CALML3 calmodulin-like 3 2.18975
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2 2.18156
SPICE1 spindle and centriole associated protein 1 2.17904
MAF1 MAF1 homolog (S. cerevisiae) 2.17897
PKDREJ polycystin (PKD) family receptor for egg jelly 2.17252
GOLGA6D golgin A6 family, member D 2.17141
C1QTNF9 C1q and tumor necrosis factor related protein 9 2.17001
HMGN1 high mobility group nucleosome binding domain 1 2.16966
UGT2B7 UDP glucuronosyltransferase 2 family, polypeptide B7 2.16202
CMTM2 CKLF-like MARVEL transmembrane domain containing 2 2.16134
N4BP2L1 NEDD4 binding protein 2-like 1 2.16094
ZKSCAN3 zinc finger with KRAB and SCAN domains 3 2.15251
IFITM2 interferon induced transmembrane protein 2 2.15145
BHLHE41 basic helix-loop-helix family, member e41 2.15098
KRTAP13-4 keratin associated protein 13-4 2.15087
CHPF chondroitin polymerizing factor 2.14621
OR5K3 olfactory receptor, family 5, subfamily K, member 3 2.14212
UNG uracil-DNA glycosylase 2.13647
PTX4 pentraxin 4, long 2.12927
IBSP integrin-binding sialoprotein 2.12744
AOC3 amine oxidase, copper containing 3 2.12571
ANAPC7 anaphase promoting complex subunit 7 2.12492
TMEM127 transmembrane protein 127 2.12078
OPRK1 opioid receptor, kappa 1 2.11799
HOXC12 homeobox C12 2.1171
HECW2 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 2.11043
CCDC121 coiled-coil domain containing 121 2.10889
FAM124B family with sequence similarity 124B 2.10182
REG1A regenerating islet-derived 1 alpha 2.10158
OLIG3 oligodendrocyte transcription factor 3 2.09602
PAX2 paired box 2 2.09013
PRDM14 PR domain containing 14 2.08922
UCKL1 uridine-cytidine kinase 1-like 1 2.08874
CABP2 calcium binding protein 2 2.08859
MUC4 mucin 4, cell surface associated 2.08686
XCL2 chemokine (C motif) ligand 2 2.07328
CCL25 chemokine (C-C motif) ligand 25 2.07317
TCEAL5 transcription elongation factor A (SII)-like 5 2.07008
OR9A2 olfactory receptor, family 9, subfamily A, member 2 2.06077
PRAMEF20 PRAME family member 20 2.05403
CNOT12 CCR4-NOT transcription complex subunit 12 2.05223
METTL20 methyltransferase like 20 2.05016
ZBTB3 zinc finger and BTB domain containing 3 2.04674
ATAD3A ATPase family, AAA domain containing 3A 2.03818
KCNN2 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2 2.03237
OR5K4 olfactory receptor, family 5, subfamily K, member 4 2.03213
IGFBP5 insulin-like growth factor binding protein 5 2.03104
AMER2 APC membrane recruitment protein 2 2.03088
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 2.02702
SNX30 sorting nexin family member 30 2.02594
ERICH5 glutamate-rich 5 2.02457
B3GNT3 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3 2.02412
APOLD1 apolipoprotein L domain containing 1 2.02293
NXN nucleoredoxin 2.0227
PSG8 pregnancy specific beta-1-glycoprotein 8 2.02249
CD82 CD82 molecule 2.022
CD37 CD37 molecule 2.02176
MOGAT1 monoacylglycerol O-acyltransferase 1 2.01899
SYT10 synaptotagmin X 2.01314
IFNA21 interferon, alpha 21 2.00451
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) 2.0044
FCN2 ficolin (collagen/fibrinogen domain containing lectin) 2 2.00409
GTPBP1 GTP binding protein 1 2.00077