SET Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description SET nuclear proto-oncogene|The protein encoded by this gene inhibits acetylation of nucleosomes, especially histone H4, by histone acetylases (HAT). This inhibition is most likely accomplished by masking histone lysines from being acetylated, and the consequence is to silence HAT-dependent transcription. The encoded protein is part of a complex localized to the endoplasmic reticulum but is found in the nucleus and inhibits apoptosis following attack by cytotoxic T lymphocytes. This protein can also enhance DNA replication of the adenovirus genome. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011] (NCBI Entrez Gene Database, 6418)
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Genes

337 genes differentially expressed following the SET gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
ACTL10 actin-like 10 2.8673
ROBO4 roundabout, axon guidance receptor, homolog 4 (Drosophila) 2.8673
ADGRE3 adhesion G protein-coupled receptor E3 2.8673
NPPB natriuretic peptide B 2.8673
SLC46A2 solute carrier family 46, member 2 2.8673
PLIN1 perilipin 1 2.8673
PON1 paraoxonase 1 2.8673
TM4SF1 transmembrane 4 L six family member 1 2.8673
PCDHGB3 protocadherin gamma subfamily B, 3 2.8673
NOD2 nucleotide-binding oligomerization domain containing 2 2.8673
CSTL1 cystatin-like 1 2.8673
GPR52 G protein-coupled receptor 52 2.8673
OR1I1 olfactory receptor, family 1, subfamily I, member 1 2.8673
ZNF492 zinc finger protein 492 2.8673
ATP13A5 ATPase type 13A5 2.8673
SPDYE6 speedy/RINGO cell cycle regulator family member E6 2.8673
FPR2 formyl peptide receptor 2 2.8673
HBA2 hemoglobin, alpha 2 2.8673
P2RY8 purinergic receptor P2Y, G-protein coupled, 8 2.8673
TAS2R3 taste receptor, type 2, member 3 2.8673
TPBGL trophoblast glycoprotein-like 2.8673
SIX2 SIX homeobox 2 2.8673
SLC6A18 solute carrier family 6 (neutral amino acid transporter), member 18 2.8673
AKR7L aldo-keto reductase family 7-like (gene/pseudogene) 2.8673
SLC22A13 solute carrier family 22 (organic anion/urate transporter), member 13 2.8673
SSMEM1 serine-rich single-pass membrane protein 1 2.8673
ASB10 ankyrin repeat and SOCS box containing 10 2.8673
TTLL8 tubulin tyrosine ligase-like family member 8 2.8673
MAGED4 melanoma antigen family D4 2.8673
TMEM121 transmembrane protein 121 2.8673
GNRH2 gonadotropin-releasing hormone 2 2.8673
SPINK13 serine peptidase inhibitor, Kazal type 13 (putative) 2.8673
GNRHR gonadotropin-releasing hormone receptor 2.8673
MUC20 mucin 20, cell surface associated 2.8673
ATOH8 atonal homolog 8 (Drosophila) 2.8673
GRIN2C glutamate receptor, ionotropic, N-methyl D-aspartate 2C 2.8673
OR4D9 olfactory receptor, family 4, subfamily D, member 9 2.8673
LOC124906892 uncharacterized LOC124906892 2.8673
LCN10 lipocalin 10 2.8673
MS4A18 membrane-spanning 4-domains, subfamily A, member 18 2.8673
RSPO3 R-spondin 3 2.8673
TAS2R1 taste receptor, type 2, member 1 2.8673
TNFSF18 tumor necrosis factor (ligand) superfamily, member 18 2.8673
KCNMB1 potassium channel subfamily M regulatory beta subunit 1 2.8673
MYOM2 myomesin 2 2.8673
GIMAP4 GTPase, IMAP family member 4 2.8673
LYZL6 lysozyme-like 6 2.8673
SLC39A2 solute carrier family 39 (zinc transporter), member 2 2.8673
CYP4F12 cytochrome P450, family 4, subfamily F, polypeptide 12 2.8673
PTGER1 prostaglandin E receptor 1 (subtype EP1), 42kDa 2.8673
RPEL1 ribulose-5-phosphate-3-epimerase-like 1 2.8673
FOXD1 forkhead box D1 2.8673
SPMIP2 sperm microtubule inner protein 2 2.8673
GPX5 glutathione peroxidase 5 2.8673
DUSP8 dual specificity phosphatase 8 2.8673
STX11 syntaxin 11 2.8673
KRT80 keratin 80, type II 2.8673
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9 2.8673
ANO1 anoctamin 1, calcium activated chloride channel 2.8673
ADRB1 adrenoceptor beta 1 2.8673
TREX2 three prime repair exonuclease 2 2.8673
ASB9 ankyrin repeat and SOCS box containing 9 2.8673
LY6H lymphocyte antigen 6 complex, locus H 2.8673
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 2.8673
ST6GALNAC1 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 2.8673
YIPF7 Yip1 domain family, member 7 2.8673
LINC02268 long intergenic non-protein coding RNA 2268 2.8673
CTXND1 cortexin domain containing 1 2.8673
ARMH2 armadillo like helical domain containing 2 2.8673
H2BW1 H2B.W histone 1 2.8673
MPIG6B megakaryocyte and platelet inhibitory receptor G6b 2.8673
ANKRD40CL ANKRD40 C-terminal like 2.8673
CCN6 cellular communication network factor 6 2.8673
H2BC1 H2B clustered histone 1 2.8673
NECTIN4 nectin cell adhesion molecule 4 2.8673
ELFN2 extracellular leucine-rich repeat and fibronectin type III domain containing 2 2.8673
KCND3 potassium channel, voltage gated Shal related subfamily D, member 3 2.8673
TBX10 T-box 10 2.8673
C15ORF62 chromosome 15 open reading frame 62 2.8673
DMBX1 diencephalon/mesencephalon homeobox 1 2.8673
OR2A12 olfactory receptor, family 2, subfamily A, member 12 2.8673
UROC1 urocanate hydratase 1 2.8673
CALCA calcitonin-related polypeptide alpha 2.8673
OR2J1 olfactory receptor, family 2, subfamily J, member 1 (gene/pseudogene) 2.8673
HPR haptoglobin-related protein 2.8673
AMBP alpha-1-microglobulin/bikunin precursor 2.8673
PTGDR2 prostaglandin D2 receptor 2 2.8673
ZBTB11 zinc finger and BTB domain containing 11 2.8673
RHOXF2 Rhox homeobox family, member 2 2.8673
IL6 interleukin 6 2.8673
IL4 interleukin 4 2.8673
BARHL1 BarH-like homeobox 1 2.8673
GATA2 GATA binding protein 2 2.8673
LRRN4CL LRRN4 C-terminal like 2.8673
GDF9 growth differentiation factor 9 2.8673
LRRC72 leucine rich repeat containing 72 2.8673
OOSP1 oocyte secreted protein 1, pseudogene 2.8673
PGA5 pepsinogen 5, group I (pepsinogen A) 2.8673
PLD4 phospholipase D family, member 4 2.8673
CLDN22 claudin 22 2.8673
S100G S100 calcium binding protein G 2.8673
SLC12A3 solute carrier family 12 (sodium/chloride transporter), member 3 2.8673
CAPN11 calpain 11 2.8673
HMX3 H6 family homeobox 3 2.8673
FGF10 fibroblast growth factor 10 2.8673
GLYATL3 glycine-N-acyltransferase-like 3 2.8673
AKR1B15 aldo-keto reductase family 1, member B15 2.8673
ERICH3 glutamate-rich 3 2.8673
CLDN34 claudin 34 2.8673
CSTA cystatin A (stefin A) 2.8673
GPR12 G protein-coupled receptor 12 2.8673
S100A14 S100 calcium binding protein A14 2.8673
C11ORF91 chromosome 11 open reading frame 91 2.8673
HHATL hedgehog acyltransferase-like 2.8673
C9ORF64 chromosome 9 open reading frame 64 2.8673
LRRC43 leucine rich repeat containing 43 2.8673
PALMD palmdelphin 2.8673
LRCOL1 leucine rich colipase-like 1 2.8673
CHRM4 cholinergic receptor, muscarinic 4 2.8673
TBC1D28 TBC1 domain family, member 28 2.8673
CSF3R colony stimulating factor 3 receptor (granulocyte) 2.8673
PRSS50 protease, serine, 50 2.8673
PRSS57 protease, serine, 57 2.8673
SPRN shadow of prion protein homolog (zebrafish) 2.8673
CMTM2 CKLF-like MARVEL transmembrane domain containing 2 2.8673
MORC1 MORC family CW-type zinc finger 1 2.8673
CABP7 calcium binding protein 7 2.8673
GP1BB glycoprotein Ib (platelet), beta polypeptide 2.8673
CPSF4L cleavage and polyadenylation specific factor 4-like 2.8673
ADAMDEC1 ADAM-like, decysin 1 2.8673
TAS2R50 taste receptor, type 2, member 50 2.8673
PRSS37 protease, serine, 37 2.8673
OTOP2 otopetrin 2 2.8673
SEL1L2 sel-1 suppressor of lin-12-like 2 (C. elegans) 2.8673
LGALS12 lectin, galactoside-binding, soluble, 12 2.8673
POU4F2 POU class 4 homeobox 2 2.8673
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 2.8673
STRC stereocilin 2.8673
CCDC170 coiled-coil domain containing 170 2.8673
OR52N1 olfactory receptor, family 52, subfamily N, member 1 2.8673
CFP complement factor properdin 2.8673
NT5DC4 5'-nucleotidase domain containing 4 2.8673
MESP1 mesoderm posterior basic helix-loop-helix transcription factor 1 2.8673
CHIT1 chitinase 1 (chitotriosidase) 2.8673
RNASE11 ribonuclease, RNase A family, 11 (non-active) 2.8673
UGT2B11 UDP glucuronosyltransferase 2 family, polypeptide B11 2.8673
CALHM1 calcium homeostasis modulator 1 2.8673
TREH trehalase (brush-border membrane glycoprotein) 2.8673
POU2AF1 POU class 2 associating factor 1 2.8673
FIBIN fin bud initiation factor homolog (zebrafish) 2.8673
C22ORF42 chromosome 22 open reading frame 42 2.8673
PCDHGA2 protocadherin gamma subfamily A, 2 2.8673
FBXO40 F-box protein 40 2.8673
FSHR follicle stimulating hormone receptor 2.8673
ACSM5 acyl-CoA synthetase medium-chain family member 5 2.8673
OR14A16 olfactory receptor, family 14, subfamily A, member 16 2.8673
GPD1 glycerol-3-phosphate dehydrogenase 1 (soluble) 2.8673
FGF4 fibroblast growth factor 4 2.8673
SYTL4 synaptotagmin-like 4 2.8673
PCDHGA11 protocadherin gamma subfamily A, 11 2.8673
ST8SIA4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 2.8673
CYP3A43 cytochrome P450, family 3, subfamily A, polypeptide 43 2.8673
PGM5 phosphoglucomutase 5 2.8673
ADRA1B adrenoceptor alpha 1B 2.8673
OR5A1 olfactory receptor, family 5, subfamily A, member 1 2.8673
RBP4 retinol binding protein 4, plasma 2.8673
PPP1R3G protein phosphatase 1, regulatory subunit 3G 2.8673
FXYD7 FXYD domain containing ion transport regulator 7 2.8673
SLC38A11 solute carrier family 38, member 11 2.8673
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family) 2.8673
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1 2.8673
IL17B interleukin 17B 2.8673
LOC102724877 uncharacterized LOC102724877 2.8673
GPAT2 glycerol-3-phosphate acyltransferase 2, mitochondrial 2.8673
CHAD chondroadherin 2.8673
PRDM1 PR domain containing 1, with ZNF domain 2.8673
STAP1 signal transducing adaptor family member 1 2.8673
IRX1 iroquois homeobox 1 2.8673
ARSH arylsulfatase family, member H 2.8673
PIK3R6 phosphoinositide-3-kinase, regulatory subunit 6 2.8673
RHAG Rh-associated glycoprotein 2.8673
NMUR2 neuromedin U receptor 2 2.8673
TECTB tectorin beta 2.8673
RBPJ recombination signal binding protein for immunoglobulin kappa J region 2.84964
XKR8 XK, Kell blood group complex subunit-related family, member 8 2.84293
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 2.79796
ZZEF1 zinc finger, ZZ-type with EF-hand domain 1 2.78529
HIPK4 homeodomain interacting protein kinase 4 2.76254
LRRTM2 leucine rich repeat transmembrane neuronal 2 2.76254
KIAA0825 KIAA0825 2.67121
RDH12 retinol dehydrogenase 12 (all-trans/9-cis/11-cis) 2.52593
MTX1 metaxin 1 2.50002
FLT3 fms-related tyrosine kinase 3 2.47511
ZNF443 zinc finger protein 443 2.35453
TMEM132C transmembrane protein 132C 2.32261
TBC1D4 TBC1 domain family, member 4 2.31958
UQCRC2 ubiquinol-cytochrome c reductase core protein II 2.31073
EPHA3 EPH receptor A3 2.30146
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 2.30146
GALNT11 polypeptide N-acetylgalactosaminyltransferase 11 2.29289
FAM78A family with sequence similarity 78, member A 2.28472
ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif, 12 2.27748
METTL4 methyltransferase like 4 2.25041
SCYL3 SCY1-like 3 (S. cerevisiae) 2.24225
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 2.20828
FAAP100 FA core complex associated protein 100 2.20568
CAMKV CaM kinase-like vesicle-associated 2.19983
CCDC3 coiled-coil domain containing 3 2.19281
ARL15 ADP-ribosylation factor-like 15 2.1782
ADCY8 adenylate cyclase 8 (brain) 2.16479
TUBA8 tubulin, alpha 8 2.11741
NUP37 nucleoporin 37kDa 2.10097
KCNH8 potassium channel, voltage gated eag related subfamily H, member 8 2.09563
ITGA6 integrin, alpha 6 2.09261
NDUFB11 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 11, 17.3kDa 2.08358
ZFR2 zinc finger RNA binding protein 2 2.08358
PPIL1 peptidylprolyl isomerase (cyclophilin)-like 1 2.08186
SNX10 sorting nexin 10 2.07567
SMIM3 small integral membrane protein 3 2.07472
AKAP12 A kinase (PRKA) anchor protein 12 2.07397
IL15 interleukin 15 2.07016
GLMN glomulin, FKBP associated protein 2.06118
USP22 ubiquitin specific peptidase 22 2.05586
CCNH cyclin H 2.0518
TXNDC9 thioredoxin domain containing 9 2.03948
DGKA diacylglycerol kinase, alpha 80kDa 2.03739
KIFBP kinesin family binding protein 2.03673
EML4 echinoderm microtubule associated protein like 4 2.02421
LMBRD2 LMBR1 domain containing 2 2.01182
TMEM51 transmembrane protein 51 2.01088
NDC80 NDC80 kinetochore complex component 2.01022
FRA10AC1 fragile site, folic acid type, rare, fra(10)(q23.3) or fra(10)(q24.2) candidate 1 2.00636
XXYLT1 xyloside xylosyltransferase 1 2.00572
TAGLN transgelin 2.00572
ZDHHC8 zinc finger, DHHC-type containing 8 2.00572
SGCZ sarcoglycan, zeta 2.00572

decreased expression

Symbol Name Standardized Value
B3GAT1 beta-1,3-glucuronyltransferase 1 -2.8673
TEKT3 tektin 3 -2.8673
TEKT2 tektin 2 (testicular) -2.8673
UCP3 uncoupling protein 3 (mitochondrial, proton carrier) -2.8673
KCNJ9 potassium channel, inwardly rectifying subfamily J, member 9 -2.8673
PAX7 paired box 7 -2.8673
BRICD5 BRICHOS domain containing 5 -2.8673
PRR22 proline rich 22 -2.8673
NWD2 NACHT and WD repeat domain containing 2 -2.8673
SET SET nuclear proto-oncogene -2.8673
XPO7 exportin 7 -2.8673
ABCG8 ATP-binding cassette, sub-family G (WHITE), member 8 -2.8673
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related) -2.8673
CDK20 cyclin-dependent kinase 20 -2.8673
RUNDC3A RUN domain containing 3A -2.8673
PCDHB4 protocadherin beta 4 -2.8673
SERTM2 serine rich and transmembrane domain containing 2 -2.8673
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 -2.8673
FAM186A family with sequence similarity 186, member A -2.8673
GPC6 glypican 6 -2.8673
HEMK1 HemK methyltransferase family member 1 -2.8673
PTPRQ protein tyrosine phosphatase, receptor type, Q -2.8673
APOA1 apolipoprotein A-I -2.8673
PENK proenkephalin -2.8673
PLEK2 pleckstrin 2 -2.8673
GPR162 G protein-coupled receptor 162 -2.8673
SLC26A7 solute carrier family 26 (anion exchanger), member 7 -2.8673
GLYR1 glyoxylate reductase 1 homolog (Arabidopsis) -2.8673
GDAP1 ganglioside induced differentiation associated protein 1 -2.84964
SLC67A1 solute carrier family 67 member 1 -2.76254
SUGT1 SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae) -2.74953
NKX3-1 NK3 homeobox 1 -2.71839
ADRA1D adrenoceptor alpha 1D -2.71839
SLC5A8 solute carrier family 5 (sodium/monocarboxylate cotransporter), member 8 -2.71839
FANCE Fanconi anemia, complementation group E -2.70681
HS3ST4 heparan sulfate (glucosamine) 3-O-sulfotransferase 4 -2.62138
CHD9NB CHD9 neighbor -2.53512
NR2C1 nuclear receptor subfamily 2, group C, member 1 -2.53512
MTERF4 mitochondrial transcription termination factor 4 -2.53064
NHLRC3 NHL repeat containing 3 -2.52593
GREB1L growth regulation by estrogen in breast cancer-like -2.51673
KCNJ11 potassium channel, inwardly rectifying subfamily J, member 11 -2.50977
SAMD10 sterile alpha motif domain containing 10 -2.50977
ANGEL1 angel homolog 1 (Drosophila) -2.50048
PDE2A phosphodiesterase 2A, cGMP-stimulated -2.47943
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) -2.47511
LDHB lactate dehydrogenase B -2.43122
TFB2M transcription factor B2, mitochondrial -2.40214
SMIM20 small integral membrane protein 20 -2.39764
SNX18 sorting nexin 18 -2.39437
ANKRD18B ankyrin repeat domain 18B -2.38541
RAMACL RNA guanine-7 methyltransferase activating subunit like -2.3746
IDO2 indoleamine 2,3-dioxygenase 2 -2.3746
FBXL22 F-box and leucine-rich repeat protein 22 -2.3746
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1 -2.37188
MAP2K6 mitogen-activated protein kinase kinase 6 -2.35301
EXOSC4 exosome component 4 -2.33645
MYO9B myosin IXB -2.33301
UBN2 ubinuclein 2 -2.32641
CD247 CD247 molecule -2.32261
TMEM187 transmembrane protein 187 -2.32261
XPO5 exportin 5 -2.31276
TSPYL2 TSPY-like 2 -2.31002
PBX1 pre-B-cell leukemia homeobox 1 -2.30774
NKAIN1 Na+/K+ transporting ATPase interacting 1 -2.29834
SLC39A7 solute carrier family 39 (zinc transporter), member 7 -2.29289
ZNF654 zinc finger protein 654 -2.26551
ZNF500 zinc finger protein 500 -2.26336
RUNX1 runt-related transcription factor 1 -2.24862
CHRNB4 cholinergic receptor, nicotinic, beta 4 (neuronal) -2.23622
CRHR1 corticotropin releasing hormone receptor 1 -2.23622
DOLPP1 dolichyldiphosphatase 1 -2.22332
ZNF75A zinc finger protein 75a -2.22273
PPHLN1 periphilin 1 -2.21162
PLAAT5 phospholipase A and acyltransferase 5 -2.19878
DAB1 Dab, reelin signal transducer, homolog 1 (Drosophila) -2.19852
LETM1 leucine zipper-EF-hand containing transmembrane protein 1 -2.1704
SFRP1 secreted frizzled-related protein 1 -2.16771
KDM5C lysine (K)-specific demethylase 5C -2.16479
LHFPL2 lipoma HMGIC fusion partner-like 2 -2.15509
KCNS3 potassium voltage-gated channel, modifier subfamily S, member 3 -2.15403
OCLN occludin -2.15089
LENG9 leukocyte receptor cluster (LRC) member 9 -2.14914
UVRAG UV radiation resistance associated -2.13592
ZNF777 zinc finger protein 777 -2.12002
NR1H3 nuclear receptor subfamily 1, group H, member 3 -2.10993
DOK4 docking protein 4 -2.10949
DTD1 D-tyrosyl-tRNA deacylase 1 -2.10949
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta -2.09563
MMAA methylmalonic aciduria (cobalamin deficiency) cblA type -2.08135
ANKMY1 ankyrin repeat and MYND domain containing 1 -2.07567
ZC3H15 zinc finger CCCH-type containing 15 -2.07567
HNRNPUL1 heterogeneous nuclear ribonucleoprotein U-like 1 -2.06118
RABL2B RAB, member of RAS oncogene family-like 2B -2.04204
RPS8 ribosomal protein S8 -2.01888
AKAP17A A kinase (PRKA) anchor protein 17A -2.01022
VPS4B vacuolar protein sorting 4 homolog B (S. cerevisiae) -2.01022
SPATA2L spermatogenesis associated 2-like -2.00572
RARA retinoic acid receptor, alpha -2.00572
DCUN1D2 DCN1, defective in cullin neddylation 1, domain containing 2 -2.00572
SLC39A11 solute carrier family 39, member 11 -2.00083