SETD2 Gene Set

Dataset LINCS L1000 CMAP CRISPR Knockout Consensus Signatures
Category transcriptomics
Type gene perturbation
Description SET domain containing 2|Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein belonging to a class of huntingtin interacting proteins characterized by WW motifs. This protein is a histone methyltransferase that is specific for lysine-36 of histone H3, and methylation of this residue is associated with active chromatin. This protein also contains a novel transcriptional activation domain and has been found associated with hyperphosphorylated RNA polymerase II. [provided by RefSeq, Aug 2008] (NCBI Entrez Gene Database, 29072)
External Link https://ncbi.nlm.nih.gov/gene/29072
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Genes

499 genes differentially expressed following the SETD2 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.

increased expression

Symbol Name Standardized Value
CXCL14 chemokine (C-X-C motif) ligand 14 0.0135888
GPNMB glycoprotein (transmembrane) nmb 0.0105046
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 0.0102219
AMDHD2 amidohydrolase domain containing 2 0.0101667
GATA3 GATA binding protein 3 0.00972612
C2CD2 C2 calcium-dependent domain containing 2 0.00963915
TFPI2 tissue factor pathway inhibitor 2 0.00959647
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B 0.00955052
SPON2 spondin 2, extracellular matrix protein 0.00947283
PDZK1IP1 PDZK1 interacting protein 1 0.00920337
RUNX3 runt-related transcription factor 3 0.00884122
RND3 Rho family GTPase 3 0.00868197
BIRC3 baculoviral IAP repeat containing 3 0.00854423
FKBP11 FK506 binding protein 11, 19 kDa 0.00831867
CARMIL1 capping protein regulator and myosin 1 linker 1 0.00831007
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 0.00829061
NOTCH1 notch 1 0.00825661
MMP7 matrix metallopeptidase 7 0.00823338
PLK2 polo-like kinase 2 0.00813218
FXYD2 FXYD domain containing ion transport regulator 2 0.00813154
ENAH enabled homolog (Drosophila) 0.00812013
PLEKHA5 pleckstrin homology domain containing, family A member 5 0.00811515
HMOX1 heme oxygenase 1 0.00801165
PIEZO1 piezo-type mechanosensitive ion channel component 1 0.00788409
JMJD6 jumonji domain containing 6 0.00784741
AQP3 aquaporin 3 (Gill blood group) 0.00780465
EEF1A2 eukaryotic translation elongation factor 1 alpha 2 0.00778374
RBM34 RNA binding motif protein 34 0.00765297
PLAAT3 phospholipase A and acyltransferase 3 0.00765237
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 0.00761545
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.00758737
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family) 0.00747403
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 0.00739378
GRB7 growth factor receptor-bound protein 7 0.00723452
HOXC6 homeobox C6 0.00718783
HIST1H2AC histone cluster 1, H2ac 0.00708185
LTBP2 latent transforming growth factor beta binding protein 2 0.00694985
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16 0.00688265
GPR137B G protein-coupled receptor 137B 0.00687064
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.00684674
PI3 peptidase inhibitor 3, skin-derived 0.00683966
IL32 interleukin 32 0.00683817
CA12 carbonic anhydrase XII 0.00674459
HOXC10 homeobox C10 0.00670478
P3H2 prolyl 3-hydroxylase 2 0.0066525
TUFT1 tuftelin 1 0.00662462
LYPD3 LY6/PLAUR domain containing 3 0.00658632
IPO13 importin 13 0.00654234
MBD1 methyl-CpG binding domain protein 1 0.00651035
RAB29 RAB29, member RAS oncogene family 0.00650065
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8 0.00649964
CLTB clathrin, light chain B 0.00649114
CTSA cathepsin A 0.00643158
CTSD cathepsin D 0.00638338
CXCL5 chemokine (C-X-C motif) ligand 5 0.00637766
PRR5 proline rich 5 (renal) 0.00633632
CD7 CD7 molecule 0.00621647
RARRES3 retinoic acid receptor responder (tazarotene induced) 3 0.00619697
DGKZ diacylglycerol kinase, zeta 0.00619129
HIP1R huntingtin interacting protein 1 related 0.00616958
NELL2 NEL-like 2 (chicken) 0.00612521
RAMP1 receptor (G protein-coupled) activity modifying protein 1 0.0061165
LPCAT1 lysophosphatidylcholine acyltransferase 1 0.00602349
VNN1 vanin 1 0.00602024
REG1A regenerating islet-derived 1 alpha 0.00601854
TFF1 trefoil factor 1 0.00600992
GATAD2A GATA zinc finger domain containing 2A 0.00598988
KRT17 keratin 17, type I 0.00596371
SLC35F2 solute carrier family 35, member F2 0.00595722
SDC4 syndecan 4 0.00594279
GOLT1B golgi transport 1B 0.00592727
RAI14 retinoic acid induced 14 0.00588902
MINK1 misshapen-like kinase 1 0.0058804
CCL5 chemokine (C-C motif) ligand 5 0.00582299
SCGB2A2 secretoglobin, family 2A, member 2 0.00577377
MGLL monoglyceride lipase 0.0057713
PRKCI protein kinase C, iota 0.00577119
CRYBG1 crystallin beta-gamma domain containing 1 0.00576956
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase) 0.00574416
KRT14 keratin 14, type I 0.00572418
PTGES prostaglandin E synthase 0.00572416
EIF5B eukaryotic translation initiation factor 5B 0.00571118
EMP3 epithelial membrane protein 3 0.00567055
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog 0.00566483
MMP1 matrix metallopeptidase 1 0.00566348
THBS2 thrombospondin 2 0.00565867
KDSR 3-ketodihydrosphingosine reductase 0.00562751
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1 0.00561237
TAPBP TAP binding protein (tapasin) 0.00560955
PLIN2 perilipin 2 0.0056053
AACS acetoacetyl-CoA synthetase 0.00551359
ACADVL acyl-CoA dehydrogenase, very long chain 0.00549084
MMP3 matrix metallopeptidase 3 0.00545516
SNCA synuclein, alpha (non A4 component of amyloid precursor) 0.00541977
TSLIG3A tRNA splicing ligase complex subunit 3A 0.00541488
GOLGA8A golgin A8 family, member A 0.00539513
BAMBI BMP and activin membrane-bound inhibitor 0.00538271
NOTCH3 notch 3 0.00537131
LTF lactotransferrin 0.00537011
H1-2 H1.2 linker histone, cluster member 0.0053687
REXO2 RNA exonuclease 2 0.00536714
ASPN asporin 0.00536504
RANGAP1 Ran GTPase activating protein 1 0.00534325
MAN1C1 mannosidase, alpha, class 1C, member 1 0.00533825
XIC X chromosome inactivation center 0.00533617
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2 0.00531293
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.00531204
GSPT2 G1 to S phase transition 2 0.00530482
TAX1BP3 Tax1 (human T-cell leukemia virus type I) binding protein 3 0.00530387
TFRC transferrin receptor 0.00529848
ATG2A autophagy related 2A 0.00529318
KRT19 keratin 19, type I 0.00529117
GADD45A growth arrest and DNA-damage-inducible, alpha 0.00528559
CCL20 chemokine (C-C motif) ligand 20 0.00524272
JCHAIN joining chain of multimeric IgA and IgM 0.00524235
FBP1 fructose-1,6-bisphosphatase 1 0.00523745
CCN3 cellular communication network factor 3 0.00523475
UPP1 uridine phosphorylase 1 0.00522151
MT1X metallothionein 1X 0.00520589
FBLN2 fibulin 2 0.00519736
PLXNA1 plexin A1 0.00519634
DEGS1 delta(4)-desaturase, sphingolipid 1 0.00519354
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1 0.0051849
BRD4 bromodomain containing 4 0.00516957
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta 0.00515843
ZC3H12A zinc finger CCCH-type containing 12A 0.00513133
GBAP1 glucosidase, beta, acid pseudogene 1 0.00512565
TRIM8 tripartite motif containing 8 0.00511948
CXCL8 chemokine (C-X-C motif) ligand 8 0.00510889
KIAA0930 KIAA0930 0.00508699
TGFB1 transforming growth factor, beta 1 0.00507791
TYMP thymidine phosphorylase 0.00506897
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked 0.00506042
ACP5 acid phosphatase 5, tartrate resistant 0.00505468
UCP2 uncoupling protein 2 (mitochondrial, proton carrier) 0.00499527
BIRC2 baculoviral IAP repeat containing 2 0.00498544
GNG12 guanine nucleotide binding protein (G protein), gamma 12 0.00498378
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1 0.00498181
SLC39A14 solute carrier family 39 (zinc transporter), member 14 0.00497277
ABHD6 abhydrolase domain containing 6 0.00496704
POU2AF1 POU class 2 associating factor 1 0.00494212
REX1BD required for excision 1-B domain containing 0.00494016
VCAM1 vascular cell adhesion molecule 1 0.00493608
INTS13 integrator complex subunit 13 0.00491148
ANXA4 annexin A4 0.00490387
ADAM8 ADAM metallopeptidase domain 8 0.00490323
JADE2 jade family PHD finger 2 0.00489842
SLC38A1 solute carrier family 38, member 1 0.00488198
DUSP5 dual specificity phosphatase 5 0.00486408
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 0.00485948
BCL2L1 BCL2-like 1 0.00483537
PIP4K2C phosphatidylinositol-5-phosphate 4-kinase, type II, gamma 0.00482836
CYFIP2 cytoplasmic FMR1 interacting protein 2 0.00481707
PF4 platelet factor 4 0.00481481
CRYAB crystallin, alpha B 0.00480981
MCOLN1 mucolipin 1 0.00479543
COL6A2 collagen, type VI, alpha 2 0.00478449
EXOSC4 exosome component 4 0.00478343
TNC tenascin C 0.00478246
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 0.00477729
EHD1 EH-domain containing 1 0.00477713
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein) 0.00476883
SPINK1 serine peptidase inhibitor, Kazal type 1 0.00476809
NME3 NME/NM23 nucleoside diphosphate kinase 3 0.00476607
DPP4 dipeptidyl-peptidase 4 0.0047642
ITGAV integrin, alpha V 0.00475514
SLC25A1 solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1 0.00474557
TEX10 testis expressed 10 0.00474059
RAP1GAP2 RAP1 GTPase activating protein 2 0.00472317
OFD1 oral-facial-digital syndrome 1 0.00472031
DGKA diacylglycerol kinase, alpha 80kDa 0.0047143
PRKACB protein kinase, cAMP-dependent, catalytic, beta 0.00470895
PRR13 proline rich 13 0.00470601
PTEN phosphatase and tensin homolog 0.00470521
MMP9 matrix metallopeptidase 9 0.00470121
ATP6V0D1 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1 0.00470016
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2 0.00469581
ZMAT3 zinc finger, matrin-type 3 0.00469437
PICALM phosphatidylinositol binding clathrin assembly protein 0.00469201
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1 0.00467349
S100A11 S100 calcium binding protein A11 0.00467243
MICAL1 microtubule associated monooxygenase, calponin and LIM domain containing 1 0.00467093
SPATA20 spermatogenesis associated 20 0.0046701
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1 0.00466015
KRT7 keratin 7, type II 0.00465829
CDH16 cadherin 16, KSP-cadherin 0.00465014
CCND3 cyclin D3 0.00464593
RHOD ras homolog family member D 0.00463955
PIP prolactin-induced protein 0.00463819
SQSTM1 sequestosome 1 0.00462791
E2F3 E2F transcription factor 3 0.00462279
DUSP7 dual specificity phosphatase 7 0.00461054
TPST2 tyrosylprotein sulfotransferase 2 0.00459477
GCC2 GRIP and coiled-coil domain containing 2 0.0045868
ADA adenosine deaminase 0.00458081
PUM3 pumilio RNA binding family member 3 0.00457173
CHST12 carbohydrate (chondroitin 4) sulfotransferase 12 0.00456952
TUT7 terminal uridylyl transferase 7 0.00456461
NPY1R neuropeptide Y receptor Y1 0.00455044
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.00454976
PHLDA2 pleckstrin homology-like domain, family A, member 2 0.00454375
PHF1 PHD finger protein 1 0.00453556
PARP12 poly (ADP-ribose) polymerase family, member 12 0.0045174
OSBPL8 oxysterol binding protein-like 8 0.00451687
STARD3 StAR-related lipid transfer (START) domain containing 3 0.00451239
SPATA2L spermatogenesis associated 2-like 0.00450918
MAGEA3 melanoma antigen family A3 0.00450341
IER5 immediate early response 5 0.0044973
MICALL2 MICAL-like 2 0.0044965
AGRN agrin 0.0044948
MICALL1 MICAL-like 1 0.00448554
PPIF peptidylprolyl isomerase F 0.00446092
PKP1 plakophilin 1 0.00445714
DST dystonin 0.00445039
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) 0.00444703
MVP major vault protein 0.00444655
PPDPF pancreatic progenitor cell differentiation and proliferation factor 0.00444631
CTSW cathepsin W 0.00442385
LAT2 linker for activation of T cells family, member 2 0.00441212
GAREM1 GRB2 associated regulator of MAPK1 subtype 1 0.00439428
MFAP3L microfibrillar-associated protein 3-like 0.00438847
QSOX1 quiescin Q6 sulfhydryl oxidase 1 0.00438383
C6ORF62 chromosome 6 open reading frame 62 0.00437034
APOL2 apolipoprotein L, 2 0.00436928
ZMIZ2 zinc finger, MIZ-type containing 2 0.00435847
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.00435615
S100A7 S100 calcium binding protein A7 0.00435258
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.00435177
MAPK13 mitogen-activated protein kinase 13 0.00435169
CTSK cathepsin K 0.0043441
ANGPTL2 angiopoietin-like 2 0.0043428
MBOAT7 membrane bound O-acyltransferase domain containing 7 0.00434018
MX2 MX dynamin-like GTPase 2 0.00433255
HIST1H2BD histone cluster 1, H2bd 0.00432804
REG1B regenerating islet-derived 1 beta 0.00432369
TRPM4 transient receptor potential cation channel, subfamily M, member 4 0.00430874
BCL3 B-cell CLL/lymphoma 3 0.00429271
ZMPSTE24 zinc metallopeptidase STE24 0.00428785
POLG2 polymerase (DNA directed), gamma 2, accessory subunit 0.0042846
R3HDM4 R3H domain containing 4 0.00428171
CBX6 chromobox homolog 6 0.00427319
RABEP2 rabaptin, RAB GTPase binding effector protein 2 0.00426231
SBF1 SET binding factor 1 0.00425634
BAZ1A bromodomain adjacent to zinc finger domain, 1A 0.00424802
PXDC1 PX domain containing 1 0.0042376
EHHADH enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase 0.00423513
MME membrane metallo-endopeptidase 0.00423293
TDG thymine-DNA glycosylase 0.00423075
HSPH1 heat shock 105kDa/110kDa protein 1 0.00422852

decreased expression

Symbol Name Standardized Value
TUBB6 tubulin, beta 6 class V -0.0140332
MAP7 microtubule-associated protein 7 -0.013213
RGCC regulator of cell cycle -0.0127681
MAMLD1 mastermind-like domain containing 1 -0.0104433
PCP4 Purkinje cell protein 4 -0.0104382
SPARCL1 SPARC-like 1 (hevin) -0.0101722
PUF60 poly-U binding splicing factor 60KDa -0.00996952
SPON1 spondin 1, extracellular matrix protein -0.00951485
DPYSL3 dihydropyrimidinase-like 3 -0.00940929
CD200 CD200 molecule -0.0091752
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.00892222
SCGB2A1 secretoglobin, family 2A, member 1 -0.00887312
KIF5C kinesin family member 5C -0.00863964
CXCL10 chemokine (C-X-C motif) ligand 10 -0.00860532
NPIPB3 nuclear pore complex interacting protein family, member B3 -0.00852051
SIRT3 sirtuin 3 -0.008388
IFI44L interferon-induced protein 44-like -0.00829442
HACD3 3-hydroxyacyl-CoA dehydratase 3 -0.00825884
ARID4A AT rich interactive domain 4A (RBP1-like) -0.00813135
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 -0.0078594
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 -0.00767866
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) -0.00767459
MUC16 mucin 16, cell surface associated -0.00764374
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -0.0076378
HBB hemoglobin, beta -0.00759748
GUSBP3 glucuronidase, beta pseudogene 3 -0.00759742
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2 -0.00758703
REEP1 receptor accessory protein 1 -0.00748549
FOLR1 folate receptor 1 (adult) -0.00748198
CPE carboxypeptidase E -0.00742413
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase) -0.0073871
SOX17 SRY (sex determining region Y)-box 17 -0.00734424
MYO5C myosin VC -0.0073188
ALDH3A2 aldehyde dehydrogenase 3 family, member A2 -0.00724038
GATA6 GATA binding protein 6 -0.0072019
ESRP1 epithelial splicing regulatory protein 1 -0.00712113
RNASE1 ribonuclease, RNase A family, 1 (pancreatic) -0.0070896
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3 -0.0070673
CCNA2 cyclin A2 -0.00705001
CLU clusterin -0.00699977
MYH11 myosin, heavy chain 11, smooth muscle -0.0069965
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 -0.00694914
PCYOX1 prenylcysteine oxidase 1 -0.0069463
CLIC5 chloride intracellular channel 5 -0.0068716
MSLN mesothelin -0.00683538
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin) -0.00678346
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -0.00676023
DLK1 delta-like 1 homolog (Drosophila) -0.00671021
LAPTM4B lysosomal protein transmembrane 4 beta -0.00665762
RHOBTB3 Rho-related BTB domain containing 3 -0.0066519
LRRC37A3 leucine rich repeat containing 37, member A3 -0.00664938
PDLIM3 PDZ and LIM domain 3 -0.00656503
ANXA3 annexin A3 -0.00654915
CDH3 cadherin 3, type 1, P-cadherin (placental) -0.00653861
ASCL1 achaete-scute family bHLH transcription factor 1 -0.00652261
HHEX hematopoietically expressed homeobox -0.00648295
PTGIS prostaglandin I2 (prostacyclin) synthase -0.00642855
PLN phospholamban -0.00641632
RPA3 replication protein A3, 14kDa -0.00635026
RCN2 reticulocalbin 2, EF-hand calcium binding domain -0.0063312
RPS4Y1 ribosomal protein S4, Y-linked 1 -0.00628028
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 -0.00625172
MYB v-myb avian myeloblastosis viral oncogene homolog -0.00624289
PCLAF PCNA clamp associated factor -0.00620652
KIF20A kinesin family member 20A -0.00617617
NDUFB6 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 6, 17kDa -0.00616882
TMOD3 tropomodulin 3 (ubiquitous) -0.00614083
ACYP2 acylphosphatase 2, muscle type -0.00606947
EXOC5 exocyst complex component 5 -0.00604846
BTBD3 BTB (POZ) domain containing 3 -0.00602903
FGF9 fibroblast growth factor 9 -0.00602499
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2 -0.00601252
ANOS1 anosmin 1 -0.00600413
H1-0 H1.0 linker histone -0.00600243
FAM171A1 family with sequence similarity 171, member A1 -0.00592898
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 -0.00591952
COMMD10 COMM domain containing 10 -0.0058972
C7 complement component 7 -0.00588626
GBP1 guanylate binding protein 1, interferon-inducible -0.00584183
SOX11 SRY (sex determining region Y)-box 11 -0.00582615
HMGB2 high mobility group box 2 -0.0057834
RHOA ras homolog family member A -0.00578121
MPO myeloperoxidase -0.00577925
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5 -0.00576305
GLUL glutamate-ammonia ligase -0.00575325
ACTB actin, beta -0.00574121
HMGB3 high mobility group box 3 -0.00573551
SEPP1 selenoprotein P, plasma, 1 -0.00571255
GSTA4 glutathione S-transferase alpha 4 -0.00570656
FBN1 fibrillin 1 -0.00569482
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2 -0.00569102
PEG10 paternally expressed 10 -0.00567779
ZNF721 zinc finger protein 721 -0.00567318
KDM3A lysine (K)-specific demethylase 3A -0.00567235
PRTN3 proteinase 3 -0.00567142
ATAD2 ATPase family, AAA domain containing 2 -0.00566635
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1 -0.00564017
NDUFS4 NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase) -0.0056352
MRPS28 mitochondrial ribosomal protein S28 -0.00559759
TSPAN6 tetraspanin 6 -0.00559035
CHD7 chromodomain helicase DNA binding protein 7 -0.00557671
TFDP1 transcription factor Dp-1 -0.0055684
AUTS2 autism susceptibility candidate 2 -0.00554838
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2 -0.00553335
PHYH phytanoyl-CoA 2-hydroxylase -0.00552567
ELANE elastase, neutrophil expressed -0.00552182
CXCL11 chemokine (C-X-C motif) ligand 11 -0.00550841
MECOM MDS1 and EVI1 complex locus -0.00550545
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit -0.00548425
EML4 echinoderm microtubule associated protein like 4 -0.00548137
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa -0.00546383
NUDT21 nudix (nucleoside diphosphate linked moiety X)-type motif 21 -0.00544646
EIF1AY eukaryotic translation initiation factor 1A, Y-linked -0.0054419
SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 -0.00544158
WFDC2 WAP four-disulfide core domain 2 -0.00544115
FHL1 four and a half LIM domains 1 -0.0054411
SRP9 signal recognition particle 9kDa -0.00541408
MEIS1 Meis homeobox 1 -0.00540943
FAM107A family with sequence similarity 107, member A -0.00540745
CNTN1 contactin 1 -0.00537072
CALCA calcitonin-related polypeptide alpha -0.00536538
SRSF1 serine/arginine-rich splicing factor 1 -0.00536262
SORBS1 sorbin and SH3 domain containing 1 -0.00535583
FZD6 frizzled class receptor 6 -0.00534597
KIF14 kinesin family member 14 -0.00533411
AKR1C3 aldo-keto reductase family 1, member C3 -0.00533362
RMND1 required for meiotic nuclear division 1 homolog (S. cerevisiae) -0.00531518
DHFR dihydrofolate reductase -0.0053147
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1 -0.00531275
MNAT1 MNAT CDK-activating kinase assembly factor 1 -0.00529841
KRCC1 lysine-rich coiled-coil 1 -0.0052497
GNAS GNAS complex locus -0.00524838
CLC Charcot-Leyden crystal galectin -0.0052273
MATN2 matrilin 2 -0.00519151
SNAP25 synaptosomal-associated protein, 25kDa -0.00518851
NFASC neurofascin -0.00518507
IFITM1 interferon induced transmembrane protein 1 -0.00517906
MRPL13 mitochondrial ribosomal protein L13 -0.00517217
MAGT1 magnesium transporter 1 -0.00516815
HS3ST1 heparan sulfate (glucosamine) 3-O-sulfotransferase 1 -0.00516304
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme -0.00515716
ANG angiogenin, ribonuclease, RNase A family, 5 -0.00513966
NR1D2 nuclear receptor subfamily 1, group D, member 2 -0.00513622
CCL14 chemokine (C-C motif) ligand 14 -0.00512723
ZBTB38 zinc finger and BTB domain containing 38 -0.00512687
TPPP3 tubulin polymerization-promoting protein family member 3 -0.00509573
APOC1 apolipoprotein C-I -0.00509378
KDM5D lysine (K)-specific demethylase 5D -0.00508837
RBBP4 retinoblastoma binding protein 4 -0.00508262
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein) -0.00507299
FOXA2 forkhead box A2 -0.00506636
TIMP3 TIMP metallopeptidase inhibitor 3 -0.00503841
ZSCAN31 zinc finger and SCAN domain containing 31 -0.00500919
FGFR1 fibroblast growth factor receptor 1 -0.0050045
FXYD6 FXYD domain containing ion transport regulator 6 -0.00500358
KLHL23 kelch-like family member 23 -0.00499606
KLF9 Kruppel-like factor 9 -0.00499211
DKK3 dickkopf WNT signaling pathway inhibitor 3 -0.00498502
LAMP5 lysosomal-associated membrane protein family, member 5 -0.00498198
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) -0.00498008
NDUFAB1 NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1, 8kDa -0.00497051
MPZL2 myelin protein zero-like 2 -0.00496287
RBM3 RNA binding motif (RNP1, RRM) protein 3 -0.00496153
PER3 period circadian clock 3 -0.00496011
MARCKS myristoylated alanine-rich protein kinase C substrate -0.00495658
WEE1 WEE1 G2 checkpoint kinase -0.00495163
NDUFA7 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7, 14.5kDa -0.0049464
STMN2 stathmin 2 -0.00493909
MNDA myeloid cell nuclear differentiation antigen -0.00493393
EPHB2 EPH receptor B2 -0.00491434
FTO fat mass and obesity associated -0.00491429
CHKB choline kinase beta -0.0049081
SCNN1A sodium channel, non voltage gated 1 alpha subunit -0.00490399
NKX2-1 NK2 homeobox 1 -0.0049006
TTK TTK protein kinase -0.00489256
RARRES1 retinoic acid receptor responder (tazarotene induced) 1 -0.00488072
CDS1 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1 -0.00487518
HOXA5 homeobox A5 -0.00487057
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa -0.00486672
EREG epiregulin -0.00486341
VLDLR very low density lipoprotein receptor -0.00485813
HSBP1 heat shock factor binding protein 1 -0.00484988
CIT citron rho-interacting serine/threonine kinase -0.00484329
B3GNT2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 -0.00484107
ZNF160 zinc finger protein 160 -0.00483656
TXNIP thioredoxin interacting protein -0.00483569
CXCL9 chemokine (C-X-C motif) ligand 9 -0.00483414
ATP1A2 ATPase, Na+/K+ transporting, alpha 2 polypeptide -0.00482924
GAB2 GRB2-associated binding protein 2 -0.00482158
SCARB2 scavenger receptor class B, member 2 -0.00480649
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.00479293
LGALS1 lectin, galactoside-binding, soluble, 1 -0.00479074
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.00479064
BTG3 BTG family, member 3 -0.00478643
PLAGL2 pleiomorphic adenoma gene-like 2 -0.00477014
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific) -0.00476457
DDHD2 DDHD domain containing 2 -0.00476161
GPHN gephyrin -0.00476015
STON1 stonin 1 -0.00475549
PSRC1 proline/serine-rich coiled-coil 1 -0.0047484
TENT5A terminal nucleotidyltransferase 5A -0.00474688
SV2C synaptic vesicle glycoprotein 2C -0.00474568
CYC1 cytochrome c-1 -0.00474394
CASP2 caspase 2, apoptosis-related cysteine peptidase -0.00474001
SYNGR3 synaptogyrin 3 -0.00473438
FOXF1 forkhead box F1 -0.00472683
PTH2R parathyroid hormone 2 receptor -0.00472287
RAD21 RAD21 homolog (S. pombe) -0.00472041
DUT deoxyuridine triphosphatase -0.00471803
A2M alpha-2-macroglobulin -0.00471243
TMSB15A thymosin beta 15a -0.00470934
IFI27 interferon, alpha-inducible protein 27 -0.004696
GSTA1 glutathione S-transferase alpha 1 -0.00469283
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) -0.00469259
WT1 Wilms tumor 1 -0.00468111
AP1S2 adaptor-related protein complex 1, sigma 2 subunit -0.00467402
KIF15 kinesin family member 15 -0.00467008
COG7 component of oligomeric golgi complex 7 -0.00467005
CLIC4 chloride intracellular channel 4 -0.00466683
ACSL5 acyl-CoA synthetase long-chain family member 5 -0.00464986
ACTA2 actin, alpha 2, smooth muscle, aorta -0.00464839
EXPH5 exophilin 5 -0.00463922
ANXA6 annexin A6 -0.00463775
SPIN1 spindlin 1 -0.00463773
MRPL19 mitochondrial ribosomal protein L19 -0.00462912
PPP1R13B protein phosphatase 1, regulatory subunit 13B -0.00462749
FABP1 fatty acid binding protein 1, liver -0.00461849
FGF13 fibroblast growth factor 13 -0.00461268
NCK1 NCK adaptor protein 1 -0.00460687
DMAC2L distal membrane arm assembly component 2 like -0.00460515
CANX calnexin -0.00459791
HIPK3 homeodomain interacting protein kinase 3 -0.00459675
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein -0.00458918
C8ORF33 chromosome 8 open reading frame 33 -0.00457668
SQLE squalene epoxidase -0.00457306
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2 -0.00456148
RNASE2 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin) -0.00455053
TAGLN transgelin -0.00453925
SRI sorcin -0.00453633
SNX5 sorting nexin 5 -0.00453607
FN1 fibronectin 1 -0.0045328
NES nestin -0.00453048
TSPAN7 tetraspanin 7 -0.00452276
ARAP3 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3 -0.00449566
CYP2B6 cytochrome P450, family 2, subfamily B, polypeptide 6 -0.00449535
CBX1 chromobox homolog 1 -0.00449474
DLGAP5 discs, large (Drosophila) homolog-associated protein 5 -0.00448008
MCF2L MCF.2 cell line derived transforming sequence-like -0.00447818
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) -0.00446377
HMGB1 high mobility group box 1 -0.00446239