SETD2 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description SET domain containing 2|Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein belonging to a class of huntingtin interacting proteins characterized by WW motifs. This protein is a histone methyltransferase that is specific for lysine-36 of histone H3, and methylation of this residue is associated with active chromatin. This protein also contains a novel transcriptional activation domain and has been found associated with hyperphosphorylated RNA polymerase II. [provided by RefSeq, Aug 2008] (NCBI Entrez Gene Database, 29072)
External Link http://www.ncbi.nlm.nih.gov/gene/29072
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Genes

95 interacting proteins for SETD2 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ALYREF Aly/REF export factor
ATXN1 ataxin 1
BCLAF1 BCL2-associated transcription factor 1
BMI1 BMI1 proto-oncogene, polycomb ring finger
CBX8 chromobox homolog 8
CHAMP1 chromosome alignment maintaining phosphoprotein 1
CIC capicua transcriptional repressor
CLK2 CDC-like kinase 2
CPSF1 cleavage and polyadenylation specific factor 1, 160kDa
CPSF2 cleavage and polyadenylation specific factor 2, 100kDa
CPSF4 cleavage and polyadenylation specific factor 4, 30kDa
CSNK2A1 casein kinase 2, alpha 1 polypeptide
CSNK2B casein kinase 2, beta polypeptide
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5
DGKZ diacylglycerol kinase, zeta
DIMT1 DIM1 dimethyladenosine transferase 1 homolog (S. cerevisiae)
ELAVL1 ELAV like RNA binding protein 1
EP300 E1A binding protein p300
ESCO2 establishment of sister chromatid cohesion N-acetyltransferase 2
FBL fibrillarin
FIP1L1 factor interacting with PAPOLA and CPSF1
GNB2L1 guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1
GTPBP4 GTP binding protein 4
HIST1H2AB histone cluster 1, H2ab
HIST1H2BA histone cluster 1, H2ba
HIST1H2BB histone cluster 1, H2bb
HIST1H3B histone cluster 1, H3b
HIST1H4F histone cluster 1, H4f
HLF hepatic leukemia factor
HMGN5 high mobility group nucleosome binding domain 5
HNRNPM heterogeneous nuclear ribonucleoprotein M
HTT huntingtin
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase
IGF2BP1 insulin-like growth factor 2 mRNA binding protein 1
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
ILF2 interleukin enhancer binding factor 2
ILF3 interleukin enhancer binding factor 3, 90kDa
IWS1 IWS1 homolog (S. cerevisiae)
KIAA0020 KIAA0020
KIF20B kinesin family member 20B
KRI1 KRI1 homolog (S. cerevisiae)
KRR1 KRR1, small subunit (SSU) processome component, homolog (yeast)
LIG3 ligase III, DNA, ATP-dependent
LTV1 LTV1 ribosome biogenesis factor
LUC7L LUC7-like (S. cerevisiae)
MGEA5 meningioma expressed antigen 5 (hyaluronidase)
MOV10 Mov10 RISC complex RNA helicase
NBN nibrin
NFIL3 nuclear factor, interleukin 3 regulated
NOP2 NOP2 nucleolar protein
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NUCLEOLIN nucleolin multifunctional protein
PABPC1 poly(A) binding protein, cytoplasmic 1
PCGF1 polycomb group ring finger 1
PCGF2 polycomb group ring finger 2
PCGF3 polycomb group ring finger 3
PCGF5 polycomb group ring finger 5
PCGF6 polycomb group ring finger 6
PDCD11 programmed cell death 11
PHC2 polyhomeotic homolog 2 (Drosophila)
PKP2 plakophilin 2
PNN pinin, desmosome associated protein
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa
PPAN peter pan homolog (Drosophila)
PPHLN1 periphilin 1
PSME3 proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)
RARA retinoic acid receptor, alpha
RBBP6 retinoblastoma binding protein 6
RBM39 RNA binding motif protein 39
RBM7 RNA binding motif protein 7
RING1 ring finger protein 1
RNF2 ring finger protein 2
SIAH2 siah E3 ubiquitin protein ligase 2
SKIV2L2 superkiller viralicidic activity 2-like 2 (S. cerevisiae)
SMAD3 SMAD family member 3
SON SON DNA binding protein
SOX2 SRY (sex determining region Y)-box 2
SPAG9 sperm associated antigen 9
STAU1 staufen double-stranded RNA binding protein 1
TGFBR1 transforming growth factor, beta receptor 1
TNPO3 transportin 3
TP53 tumor protein p53
TSR1 TSR1, 20S rRNA accumulation, homolog (S. cerevisiae)
UBC ubiquitin C
UBR1 ubiquitin protein ligase E3 component n-recognin 1
WDR33 WD repeat domain 33
YBX1 Y box binding protein 1
YBX3 Y box binding protein 3
YTHDC2 YTH domain containing 2
ZCCHC3 zinc finger, CCHC domain containing 3
ZCCHC8 zinc finger, CCHC domain containing 8
ZFR zinc finger RNA binding protein
ZNF30 zinc finger protein 30
ZNF717 zinc finger protein 717