SETDB1 Gene Set

Dataset Hub Proteins Protein-Protein Interactions
Category physical interactions
Type hub protein
Description SET domain, bifurcated 1|This gene encodes a histone methyltransferase which regulates histone methylation, gene silencing, and transcriptional repression. This gene has been identified as a target for treatment in Huntington Disease, given that gene silencing and transcription dysfunction likely play a role in the disease pathogenesis. Alternatively spliced transcript variants of this gene have been described.[provided by RefSeq, Jun 2011] (NCBI Entrez Gene Database, 9869)
External Link http://www.ncbi.nlm.nih.gov/gene/9869
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Genes

114 interacting proteins for hub protein SETDB1 from the curated Hub Proteins Protein-Protein Interactions dataset.

Symbol Name
AIFM1 apoptosis-inducing factor, mitochondrion-associated, 1
AKT1 v-akt murine thymoma viral oncogene homolog 1
AKT2 v-akt murine thymoma viral oncogene homolog 2
APC adenomatous polyposis coli
APLP1 amyloid beta (A4) precursor-like protein 1
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1
ATF7IP activating transcription factor 7 interacting protein
ATF7IP2 activating transcription factor 7 interacting protein 2
BAG6 BCL2-associated athanogene 6
BARD1 BRCA1 associated RING domain 1
BHLHE40 basic helix-loop-helix family, member e40
BRIX1 BRX1, biogenesis of ribosomes
BTBD2 BTB (POZ) domain containing 2
C11ORF1 chromosome 11 open reading frame 1
CBX5 chromobox homolog 5
CBX8 chromobox homolog 8
CCDC106 coiled-coil domain containing 106
CDK2 cyclin-dependent kinase 2
CDK4 cyclin-dependent kinase 4
CDYL chromodomain protein, Y-like
CHAF1A chromatin assembly factor 1, subunit A (p150)
CHAF1B chromatin assembly factor 1, subunit B (p60)
CLSTN1 calsyntenin 1
CRELD1 cysteine-rich with EGF-like domains 1
CSNK2A1 casein kinase 2, alpha 1 polypeptide
DAP death-associated protein
DLEU1 deleted in lymphocytic leukemia 1 (non-protein coding)
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta
ECSIT ECSIT signalling integrator
ERG v-ets avian erythroblastosis virus E26 oncogene homolog
ERH enhancer of rudimentary homolog (Drosophila)
ESCO2 establishment of sister chromatid cohesion N-acetyltransferase 2
FLYWCH1 FLYWCH-type zinc finger 1
GIPC2 GIPC PDZ domain containing family, member 2
GPS2 G protein pathway suppressor 2
GSTO1 glutathione S-transferase omega 1
GUSBP1 glucuronidase, beta pseudogene 1
HDAC1 histone deacetylase 1
HDAC2 histone deacetylase 2
HIST1H3A histone cluster 1, H3a
HIST2H3A histone cluster 2, H3a
HIST3H3 histone cluster 3, H3
HIST4H4 histone cluster 4, H4
HMOX2 heme oxygenase 2
HSPB3 heat shock 27kDa protein 3
KDM1A lysine (K)-specific demethylase 1A
LRIF1 ligand dependent nuclear receptor interacting factor 1
MAD2L1BP MAD2L1 binding protein
MBD1 methyl-CpG binding domain protein 1
MOB4 MOB family member 4, phocein
MRPL44 mitochondrial ribosomal protein L44
NCOA3 nuclear receptor coactivator 3
NIPSNAP3A nipsnap homolog 3A (C. elegans)
NLK nemo-like kinase
OLFML3 olfactomedin-like 3
ORAI2 ORAI calcium release-activated calcium modulator 2
PABPC4 poly(A) binding protein, cytoplasmic 4 (inducible form)
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)
PCDHA4 protocadherin alpha 4
PCNA proliferating cell nuclear antigen
PGAM5 phosphoglycerate mutase family member 5
PHF10 PHD finger protein 10
PIAS1 protein inhibitor of activated STAT, 1
PIAS4 protein inhibitor of activated STAT, 4
PLEKHA4 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4
POLA2 polymerase (DNA directed), alpha 2, accessory subunit
POU5F1 POU class 5 homeobox 1
PPA1 pyrophosphatase (inorganic) 1
PPARG peroxisome proliferator-activated receptor gamma
PPP1R8 protein phosphatase 1, regulatory subunit 8
PRKRA protein kinase, interferon-inducible double stranded RNA dependent activator
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
PTPRS protein tyrosine phosphatase, receptor type, S
QTRT1 queuine tRNA-ribosyltransferase 1
RASGRF2 Ras protein-specific guanine nucleotide-releasing factor 2
RIF1 replication timing regulatory factor 1
RNF10 ring finger protein 10
RNF2 ring finger protein 2
S100A10 S100 calcium binding protein A10
SAT1 spermidine/spermine N1-acetyltransferase 1
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SIN3A SIN3 transcription regulator family member A
SIN3B SIN3 transcription regulator family member B
SKIL SKI-like proto-oncogene
SLC38A3 solute carrier family 38, member 3
SMPD3 sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II)
SNIP1 Smad nuclear interacting protein 1
SUFU suppressor of fused homolog (Drosophila)
SULT1E1 sulfotransferase family 1E, estrogen-preferring, member 1
SUMO2 small ubiquitin-like modifier 2
SUZ12 SUZ12 polycomb repressive complex 2 subunit
TARDBP TAR DNA binding protein
TAT tyrosine aminotransferase
TCERG1 transcription elongation regulator 1
THAP8 THAP domain containing 8
TK1 thymidine kinase 1, soluble
TOB1 transducer of ERBB2, 1
TOLLIP toll interacting protein
TPI1 triosephosphate isomerase 1
TRBV2 T cell receptor beta variable 2
TRDMT1 tRNA aspartic acid methyltransferase 1
TRIB3 tribbles pseudokinase 3
TRIM16 tripartite motif containing 16
TRIM28 tripartite motif containing 28
TSC22D1 TSC22 domain family, member 1
TTR transthyretin
TXNDC9 thioredoxin domain containing 9
UBE2I ubiquitin-conjugating enzyme E2I
ULK2 unc-51 like autophagy activating kinase 2
USP11 ubiquitin specific peptidase 11
VIM vimentin
ZFP64 ZFP64 zinc finger protein
ZNF24 zinc finger protein 24