SETDB1 Gene Set

Dataset LINCS L1000 CMAP CRISPR Knockout Consensus Signatures
Category transcriptomics
Type gene perturbation
Description SET domain, bifurcated 1|This gene encodes a histone methyltransferase which regulates histone methylation, gene silencing, and transcriptional repression. This gene has been identified as a target for treatment in Huntington Disease, given that gene silencing and transcription dysfunction likely play a role in the disease pathogenesis. Alternatively spliced transcript variants of this gene have been described.[provided by RefSeq, Jun 2011] (NCBI Entrez Gene Database, 9869)
External Link https://ncbi.nlm.nih.gov/gene/9869
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Genes

498 genes differentially expressed following the SETDB1 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.

increased expression

Symbol Name Standardized Value
SYNGR3 synaptogyrin 3 0.0137681
GNAS GNAS complex locus 0.0120717
S100A10 S100 calcium binding protein A10 0.0113458
PCCB propionyl CoA carboxylase, beta polypeptide 0.0102702
CXCL8 chemokine (C-X-C motif) ligand 8 0.00941065
PTGER4 prostaglandin E receptor 4 (subtype EP4) 0.00921123
ITM2C integral membrane protein 2C 0.00884252
MATN2 matrilin 2 0.00880726
JMJD6 jumonji domain containing 6 0.00867916
CLTB clathrin, light chain B 0.00857662
FTH1 ferritin, heavy polypeptide 1 0.00850762
PTCH1 patched 1 0.00849301
HSPA1A heat shock 70kDa protein 1A 0.00809861
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) 0.00797376
S100A7 S100 calcium binding protein A7 0.00794565
TNIP1 TNFAIP3 interacting protein 1 0.00781551
CLIC3 chloride intracellular channel 3 0.00777978
HMOX1 heme oxygenase 1 0.0077258
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7 0.00763208
IER5 immediate early response 5 0.00754021
AREG amphiregulin 0.00746099
KRT14 keratin 14, type I 0.00729221
SAT1 spermidine/spermine N1-acetyltransferase 1 0.00722392
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.00720732
HSPA6 heat shock 70kDa protein 6 (HSP70B') 0.00712195
ZMAT3 zinc finger, matrin-type 3 0.0070365
MXRA7 matrix-remodelling associated 7 0.00698808
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 0.00685988
PROM1 prominin 1 0.00680364
ATF3 activating transcription factor 3 0.00674458
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.00671918
PTHLH parathyroid hormone-like hormone 0.00670421
SCPEP1 serine carboxypeptidase 1 0.00666389
HOMER1 homer scaffolding protein 1 0.00662893
LRP4 low density lipoprotein receptor-related protein 4 0.00646026
HSPH1 heat shock 105kDa/110kDa protein 1 0.00644737
SIK1 salt-inducible kinase 1 0.00639045
TGFA transforming growth factor, alpha 0.00637833
PUF60 poly-U binding splicing factor 60KDa 0.00637705
DLK1 delta-like 1 homolog (Drosophila) 0.00630233
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 0.00627998
EDN3 endothelin 3 0.00627183
AQP3 aquaporin 3 (Gill blood group) 0.00626503
PI3 peptidase inhibitor 3, skin-derived 0.00625661
ADO 2-aminoethanethiol (cysteamine) dioxygenase 0.00624715
MAB21L2 mab-21-like 2 (C. elegans) 0.00622488
MIR22HG MIR22 host gene 0.00622158
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2 0.00621445
AMOTL2 angiomotin like 2 0.00616643
FOXD1 forkhead box D1 0.00616188
POLG2 polymerase (DNA directed), gamma 2, accessory subunit 0.00608759
RGS3 regulator of G-protein signaling 3 0.00606778
EIF3F eukaryotic translation initiation factor 3, subunit F 0.0060326
CTSK cathepsin K 0.00599559
FCGBP Fc fragment of IgG binding protein 0.00597218
FAM162A family with sequence similarity 162, member A 0.00594036
DNAJC2 DnaJ (Hsp40) homolog, subfamily C, member 2 0.00593896
MMP3 matrix metallopeptidase 3 0.00592683
GABARAPL1 GABA(A) receptor-associated protein like 1 0.00592151
MCL1 myeloid cell leukemia 1 0.00591459
FHL2 four and a half LIM domains 2 0.00588785
IFI27 interferon, alpha-inducible protein 27 0.00587756
TUBB2B tubulin, beta 2B class IIb 0.0058384
TBCB tubulin folding cofactor B 0.00582894
KLF4 Kruppel-like factor 4 (gut) 0.00582219
RAB29 RAB29, member RAS oncogene family 0.00577509
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase) 0.00577302
EIF5B eukaryotic translation initiation factor 5B 0.00576847
SMAD3 SMAD family member 3 0.00575069
EPHA2 EPH receptor A2 0.00568451
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.00566437
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.00566018
PRAME preferentially expressed antigen in melanoma 0.00563993
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1 0.00562794
PRSS23 protease, serine, 23 0.00562359
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 0.00560773
PNMA8A PNMA family member 8A 0.00560433
LAMB1 laminin, beta 1 0.0056007
PHLDA3 pleckstrin homology-like domain, family A, member 3 0.0055752
DSP desmoplakin 0.00556543
RNF125 ring finger protein 125, E3 ubiquitin protein ligase 0.00555632
LEFTY1 left-right determination factor 1 0.0055432
SPP1 secreted phosphoprotein 1 0.00550078
NUTF2 nuclear transport factor 2 0.0055006
TGFBI transforming growth factor, beta-induced, 68kDa 0.00547675
SIDT2 SID1 transmembrane family, member 2 0.00547369
NVL nuclear VCP-like 0.00545412
SAMD4A sterile alpha motif domain containing 4A 0.00544453
CCNA2 cyclin A2 0.00544163
COLGALT2 collagen beta(1-O)galactosyltransferase 2 0.00541449
NPY1R neuropeptide Y receptor Y1 0.00540703
CRYAB crystallin, alpha B 0.0053952
BCAS1 breast carcinoma amplified sequence 1 0.00538305
PMP2 peripheral myelin protein 2 0.00534604
MPDZ multiple PDZ domain protein 0.00534214
ANXA1 annexin A1 0.00533265
MKNK2 MAP kinase interacting serine/threonine kinase 2 0.00532955
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae) 0.00532462
PCDH9 protocadherin 9 0.00528907
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 0.00528416
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A 0.00528025
NEU1 sialidase 1 (lysosomal sialidase) 0.00524806
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12 0.0052333
TH tyrosine hydroxylase 0.00523096
ACAA1 acetyl-CoA acyltransferase 1 0.00522421
GADD45A growth arrest and DNA-damage-inducible, alpha 0.00522089
ATP5F1E ATP synthase F1 subunit epsilon 0.00521455
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family) 0.00521064
ZIC1 Zic family member 1 0.00520237
ZDHHC7 zinc finger, DHHC-type containing 7 0.00520123
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) 0.0051841
MT1X metallothionein 1X 0.00514906
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0051468
LAMC2 laminin, gamma 2 0.00514628
KIF2A kinesin heavy chain member 2A 0.0051459
TXN thioredoxin 0.00513416
GEM GTP binding protein overexpressed in skeletal muscle 0.00508502
XIC X chromosome inactivation center 0.00507835
HSPA8 heat shock 70kDa protein 8 0.00505189
MUC5B mucin 5B, oligomeric mucus/gel-forming 0.00504979
PRPF4 pre-mRNA processing factor 4 0.00503885
TFF3 trefoil factor 3 (intestinal) 0.00503214
FGF1 fibroblast growth factor 1 (acidic) 0.00502088
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 0.00501568
SOBP sine oculis binding protein homolog (Drosophila) 0.00500823
RHCG Rh family, C glycoprotein 0.00499627
ISG15 ISG15 ubiquitin-like modifier 0.00499436
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa 0.00497828
PLCE1 phospholipase C, epsilon 1 0.00493496
KRT13 keratin 13, type I 0.00493243
TAC1 tachykinin, precursor 1 0.00492961
NOTCH1 notch 1 0.00492574
COL9A3 collagen, type IX, alpha 3 0.00492466
YBX1 Y box binding protein 1 0.00488476
KDSR 3-ketodihydrosphingosine reductase 0.0048818
CLCA4 chloride channel accessory 4 0.00487762
KIF13B kinesin family member 13B 0.00487417
PLAAT3 phospholipase A and acyltransferase 3 0.00487288
CYTL1 cytokine-like 1 0.00486434
COL6A1 collagen, type VI, alpha 1 0.00484624
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.00484619
BAMBI BMP and activin membrane-bound inhibitor 0.00482302
COQ10B coenzyme Q10 homolog B (S. cerevisiae) 0.00482237
CD9 CD9 molecule 0.00481829
ANXA6 annexin A6 0.00481663
TALDO1 transaldolase 1 0.00478859
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1 0.00478771
BMP7 bone morphogenetic protein 7 0.0047684
SRPX sushi-repeat containing protein, X-linked 0.00476628
DYNLL1 dynein, light chain, LC8-type 1 0.00476473
LY6E lymphocyte antigen 6 complex, locus E 0.00474865
HIST1H2AC histone cluster 1, H2ac 0.00474773
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.00473827
FSTL1 follistatin-like 1 0.00472887
FABP4 fatty acid binding protein 4, adipocyte 0.00470108
MAOA monoamine oxidase A 0.00470078
ITIH5 inter-alpha-trypsin inhibitor heavy chain family, member 5 0.0047002
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.00469668
HSPB8 heat shock 22kDa protein 8 0.00469349
CSTB cystatin B (stefin B) 0.0046914
GNLY granulysin 0.00468926
NXPE3 neurexophilin and PC-esterase domain family, member 3 0.00468731
SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4 0.00468666
UBFD1 ubiquitin family domain containing 1 0.00468267
ARPC5L actin related protein 2/3 complex, subunit 5-like 0.00466362
MS4A12 membrane-spanning 4-domains, subfamily A, member 12 0.00463301
MDH2 malate dehydrogenase 2, NAD (mitochondrial) 0.00461234
EGR2 early growth response 2 0.00460289
ANXA2 annexin A2 0.00459777
ABHD4 abhydrolase domain containing 4 0.00459715
QPRT quinolinate phosphoribosyltransferase 0.00459704
SLC31A2 solute carrier family 31 (copper transporter), member 2 0.00459222
COL16A1 collagen, type XVI, alpha 1 0.00458301
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein 0.00457463
TIMP1 TIMP metallopeptidase inhibitor 1 0.00456905
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21 0.00455781
KRT6A keratin 6A, type II 0.00455554
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1 0.00455242
ELF1 E74-like factor 1 (ets domain transcription factor) 0.00454925
TXNL4A thioredoxin-like 4A 0.00453413
ADAM8 ADAM metallopeptidase domain 8 0.00452558
HIST1H2BK histone cluster 1, H2bk 0.00452336
LGALS1 lectin, galactoside-binding, soluble, 1 0.00451395
RND3 Rho family GTPase 3 0.00450699
PLOD3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 0.00450395
MAP9 microtubule-associated protein 9 0.00450145
IL1B interleukin 1, beta 0.00449913
KLK10 kallikrein-related peptidase 10 0.0044853
CD14 CD14 molecule 0.00448087
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) 0.00447671
VPS4B vacuolar protein sorting 4 homolog B (S. cerevisiae) 0.00446572
TMEM255A transmembrane protein 255A 0.00446378
AGTPBP1 ATP/GTP binding protein 1 0.00445634
DDIT3 DNA-damage-inducible transcript 3 0.00444711
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.00443902
MAGEA1 melanoma antigen family A1 0.00443042
HSPA2 heat shock 70kDa protein 2 0.00441927
TM9SF3 transmembrane 9 superfamily member 3 0.00441421
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b 0.00441168
MVP major vault protein 0.00440858
HK2 hexokinase 2 0.00440088
LDHB lactate dehydrogenase B 0.00439655
RRAGC Ras-related GTP binding C 0.00438904
PLXNA1 plexin A1 0.00438261
NKX2-2 NK2 homeobox 2 0.00435808
NAMPT nicotinamide phosphoribosyltransferase 0.00435416
MGLL monoglyceride lipase 0.00434597
COL14A1 collagen, type XIV, alpha 1 0.00434414
WBP4 WW domain binding protein 4 0.0043285
PLAUR plasminogen activator, urokinase receptor 0.00432553
PFDN2 prefoldin subunit 2 0.0043214
RNF114 ring finger protein 114 0.00431677
MAGEA4 melanoma antigen family A4 0.00431136
LRP1B low density lipoprotein receptor-related protein 1B 0.00431093
MAP1LC3B microtubule-associated protein 1 light chain 3 beta 0.00430828
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 0.00430635
RHOF ras homolog family member F (in filopodia) 0.00428936
ACSF2 acyl-CoA synthetase family member 2 0.0042883
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.00428763
C1S complement component 1, s subcomponent 0.00428196
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8 0.00427627
RPS27L ribosomal protein S27-like 0.00426514
VLDLR very low density lipoprotein receptor 0.0042631
ARL14 ADP-ribosylation factor-like 14 0.00426126
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide 0.00426114
MAFG v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G 0.00425865
BHLHE41 basic helix-loop-helix family, member e41 0.00423924
HLA-B major histocompatibility complex, class I, B 0.00423561
RGS16 regulator of G-protein signaling 16 0.00422409
NDUFB2 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2, 8kDa 0.00422235
CXCL2 chemokine (C-X-C motif) ligand 2 0.00421689
KRT15 keratin 15, type I 0.00420014
LAMP1 lysosomal-associated membrane protein 1 0.00419772
ZG16 zymogen granule protein 16 0.0041966
PTPRE protein tyrosine phosphatase, receptor type, E 0.00418101
HOPX HOP homeobox 0.00418077
CCND3 cyclin D3 0.00417142
CPSF6 cleavage and polyadenylation specific factor 6, 68kDa 0.00417062
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 0.00417017
S100P S100 calcium binding protein P 0.00416947
SPRR1B small proline-rich protein 1B 0.00416608
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein 0.00416583
G0S2 G0/G1 switch 2 0.00415626
GPR137B G protein-coupled receptor 137B 0.00415576
SP110 SP110 nuclear body protein 0.00415445
KRT20 keratin 20, type I 0.0041469
PTGES prostaglandin E synthase 0.00413501
SYNM synemin, intermediate filament protein 0.00412897
IGSF3 immunoglobulin superfamily, member 3 0.00412472
PPIF peptidylprolyl isomerase F 0.00411651

decreased expression

Symbol Name Standardized Value
ZDHHC6 zinc finger, DHHC-type containing 6 -0.0186788
USP7 ubiquitin specific peptidase 7 (herpes virus-associated) -0.00997864
LTF lactotransferrin -0.00994255
MAMLD1 mastermind-like domain containing 1 -0.00990757
H1-0 H1.0 linker histone -0.00895613
CPB1 carboxypeptidase B1 (tissue) -0.00876587
IKZF1 IKAROS family zinc finger 1 (Ikaros) -0.00875849
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD) -0.00848643
CPE carboxypeptidase E -0.00830617
CRISP3 cysteine-rich secretory protein 3 -0.00810516
CPA3 carboxypeptidase A3 (mast cell) -0.0080717
CNN3 calponin 3, acidic -0.00804626
NR2F1 nuclear receptor subfamily 2, group F, member 1 -0.00787712
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3 -0.00776019
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase) -0.00775042
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.00765632
HP haptoglobin -0.00753902
SNAP25 synaptosomal-associated protein, 25kDa -0.00753529
AZGP1 alpha-2-glycoprotein 1, zinc-binding -0.00717282
INSIG1 insulin induced gene 1 -0.00700427
HNMT histamine N-methyltransferase -0.00688317
CRABP2 cellular retinoic acid binding protein 2 -0.00685749
COL4A5 collagen, type IV, alpha 5 -0.00680912
ADIRF adipogenesis regulatory factor -0.00669776
SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 -0.00667597
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 -0.00667267
TACSTD2 tumor-associated calcium signal transducer 2 -0.0066111
SRSF1 serine/arginine-rich splicing factor 1 -0.00660185
NUSAP1 nucleolar and spindle associated protein 1 -0.00659853
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2 -0.00656151
NTS neurotensin -0.00651319
CLU clusterin -0.00645652
NREP neuronal regeneration related protein -0.00642715
CD52 CD52 molecule -0.00640219
ACSL5 acyl-CoA synthetase long-chain family member 5 -0.00636929
ALG8 ALG8, alpha-1,3-glucosyltransferase -0.00635759
CASP1 caspase 1, apoptosis-related cysteine peptidase -0.00635547
DUSP1 dual specificity phosphatase 1 -0.00634051
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -0.00633609
FASN fatty acid synthase -0.00630427
GSTA1 glutathione S-transferase alpha 1 -0.00620863
FOLR1 folate receptor 1 (adult) -0.0061878
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein) -0.00615964
ALDH3A2 aldehyde dehydrogenase 3 family, member A2 -0.00611721
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 -0.00608385
MRTFB myocardin related transcription factor B -0.00605214
FBXL5 F-box and leucine-rich repeat protein 5 -0.00603907
CP ceruloplasmin (ferroxidase) -0.00603439
AKR1C3 aldo-keto reductase family 1, member C3 -0.00600869
BASP1 brain abundant, membrane attached signal protein 1 -0.00600526
PPP3CB protein phosphatase 3, catalytic subunit, beta isozyme -0.0059806
PRDX2 peroxiredoxin 2 -0.00594273
NPY neuropeptide Y -0.0059386
LOX lysyl oxidase -0.00593612
COL4A6 collagen, type IV, alpha 6 -0.00593554
ARG1 arginase 1 -0.00592716
MGP matrix Gla protein -0.00590709
MAP7 microtubule-associated protein 7 -0.00589295
BCAT2 branched chain amino-acid transaminase 2, mitochondrial -0.00586458
ST6GALNAC5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5 -0.00582294
ARMCX2 armadillo repeat containing, X-linked 2 -0.00582078
SNX11 sorting nexin 11 -0.00579488
TUG1 taurine up-regulated 1 (non-protein coding) -0.00571117
TPSAB1 tryptase alpha/beta 1 -0.00566764
DCK deoxycytidine kinase -0.0056465
RPL10 ribosomal protein L10 -0.00564506
IDO1 indoleamine 2,3-dioxygenase 1 -0.00564407
MGAM maltase-glucoamylase -0.00562467
CXCL9 chemokine (C-X-C motif) ligand 9 -0.00560906
DACH1 dachshund family transcription factor 1 -0.00560056
RBM3 RNA binding motif (RNP1, RRM) protein 3 -0.00555356
C10ORF10 chromosome 10 open reading frame 10 -0.00554485
MEIS2 Meis homeobox 2 -0.00545388
EPAS1 endothelial PAS domain protein 1 -0.0054447
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6 -0.00541947
C3ORF14 chromosome 3 open reading frame 14 -0.00541918
APOA1 apolipoprotein A-I -0.00541164
NQO1 NAD(P)H dehydrogenase, quinone 1 -0.00539008
APOC1 apolipoprotein C-I -0.0053708
RHOB ras homolog family member B -0.00535342
NPM3 nucleophosmin/nucleoplasmin 3 -0.00534632
APOC3 apolipoprotein C-III -0.00532533
CPS1 carbamoyl-phosphate synthase 1, mitochondrial -0.00532488
SH3BGRL SH3 domain binding glutamate-rich protein like -0.00531692
PPP1R3C protein phosphatase 1, regulatory subunit 3C -0.00528249
CPVL carboxypeptidase, vitellogenic-like -0.00527729
INPP5A inositol polyphosphate-5-phosphatase, 40kDa -0.00525765
TRMT5 tRNA methyltransferase 5 -0.0052401
DEFA4 defensin, alpha 4, corticostatin -0.00522071
TIA1 TIA1 cytotoxic granule-associated RNA binding protein -0.00521858
ARHGAP29 Rho GTPase activating protein 29 -0.00521799
OIP5 Opa interacting protein 5 -0.00520382
SNCA synuclein, alpha (non A4 component of amyloid precursor) -0.00518502
GIMAP6 GTPase, IMAP family member 6 -0.00517713
CAMP cathelicidin antimicrobial peptide -0.00517341
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) -0.00517078
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 -0.00515764
RPS4Y1 ribosomal protein S4, Y-linked 1 -0.00512598
MGST2 microsomal glutathione S-transferase 2 -0.00509848
CAND1 cullin-associated and neddylation-dissociated 1 -0.0050863
DHCR7 7-dehydrocholesterol reductase -0.00507174
P4HB prolyl 4-hydroxylase, beta polypeptide -0.00507173
APOB apolipoprotein B -0.00506227
CFB complement factor B -0.00505836
GARS1 glycyl-tRNA synthetase 1 -0.00505293
WFDC2 WAP four-disulfide core domain 2 -0.00504934
CREB1 cAMP responsive element binding protein 1 -0.00503411
PBX1 pre-B-cell leukemia homeobox 1 -0.00501097
ACAT2 acetyl-CoA acetyltransferase 2 -0.00500774
THAP12 THAP domain containing 12 -0.00500623
ANG angiogenin, ribonuclease, RNase A family, 5 -0.00500181
TBC1D9 TBC1 domain family, member 9 (with GRAM domain) -0.00499822
KIF20A kinesin family member 20A -0.00499458
LTBP1 latent transforming growth factor beta binding protein 1 -0.00499253
MEIS1 Meis homeobox 1 -0.00498381
MDFIC MyoD family inhibitor domain containing -0.00497682
WBP5 WW domain binding protein 5 -0.00496555
ASB13 ankyrin repeat and SOCS box containing 13 -0.00494867
CD40 CD40 molecule, TNF receptor superfamily member 5 -0.00494536
AXL AXL receptor tyrosine kinase -0.00492473
PALMD palmdelphin -0.00491545
LXN latexin -0.00491172
HMGB3 high mobility group box 3 -0.00491165
IL7R interleukin 7 receptor -0.00490233
PDE2A phosphodiesterase 2A, cGMP-stimulated -0.0048704
APOC2 apolipoprotein C-II -0.00487
ANPEP alanyl (membrane) aminopeptidase -0.0048665
LAPTM5 lysosomal protein transmembrane 5 -0.00485784
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.00484933
ZNF91 zinc finger protein 91 -0.00484434
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.00482195
AHSG alpha-2-HS-glycoprotein -0.00480505
UBP1 upstream binding protein 1 (LBP-1a) -0.00479088
GNAO1 guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O -0.00478231
CALD1 caldesmon 1 -0.00478079
GPX1 glutathione peroxidase 1 -0.00476724
MT1E metallothionein 1E -0.00476462
PCP4 Purkinje cell protein 4 -0.00474377
CD300A CD300a molecule -0.00472768
ACOX2 acyl-CoA oxidase 2, branched chain -0.00472115
BUB3 BUB3 mitotic checkpoint protein -0.00472003
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae) -0.00470868
FST follistatin -0.00470805
MS4A4A membrane-spanning 4-domains, subfamily A, member 4A -0.00469596
TK1 thymidine kinase 1, soluble -0.00469148
ECHDC2 enoyl CoA hydratase domain containing 2 -0.00468494
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) -0.00468372
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1 -0.00468229
CHEK2 checkpoint kinase 2 -0.00467811
CUL4B cullin 4B -0.00467624
EMX2 empty spiracles homeobox 2 -0.0046744
SGMS1 sphingomyelin synthase 1 -0.00467376
NMU neuromedin U -0.00466133
PAPOLA poly(A) polymerase alpha -0.00464742
PRC1 protein regulator of cytokinesis 1 -0.00464443
ZNF430 zinc finger protein 430 -0.00463694
ELANE elastase, neutrophil expressed -0.00463385
KIF15 kinesin family member 15 -0.00461546
GLUL glutamate-ammonia ligase -0.00460969
TSPAN6 tetraspanin 6 -0.0046065
HMMR hyaluronan-mediated motility receptor (RHAMM) -0.00459867
LANCL1 LanC lantibiotic synthetase component C-like 1 (bacterial) -0.00458505
PER3 period circadian clock 3 -0.00457874
SPC25 SPC25, NDC80 kinetochore complex component -0.00456737
FTO fat mass and obesity associated -0.00455927
SELENBP1 selenium binding protein 1 -0.00455067
SLC26A2 solute carrier family 26 (anion exchanger), member 2 -0.00455042
LAIR1 leukocyte-associated immunoglobulin-like receptor 1 -0.004543
CREB3L2 cAMP responsive element binding protein 3-like 2 -0.0045393
PRUNE2 prune homolog 2 (Drosophila) -0.00453625
SCGN secretagogin, EF-hand calcium binding protein -0.00452653
GPATCH8 G patch domain containing 8 -0.00452471
FBN1 fibrillin 1 -0.00451919
BEX1 brain expressed, X-linked 1 -0.00451246
NPC1 Niemann-Pick disease, type C1 -0.00448251
MNDA myeloid cell nuclear differentiation antigen -0.00447371
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 -0.00446963
HMGN4 high mobility group nucleosomal binding domain 4 -0.00446796
DPYD dihydropyrimidine dehydrogenase -0.00445913
AK4 adenylate kinase 4 -0.00445035
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 -0.00444897
DNPH1 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 -0.00444743
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific) -0.00443429
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha -0.00442347
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9 -0.00441988
SDC2 syndecan 2 -0.00439661
NUP107 nucleoporin 107kDa -0.00439654
GSTT2 glutathione S-transferase theta 2 (gene/pseudogene) -0.00438937
TGM2 transglutaminase 2 -0.00438626
BPI bactericidal/permeability-increasing protein -0.00438592
RNASE6 ribonuclease, RNase A family, k6 -0.00437315
IPO9 importin 9 -0.00437183
APLP2 amyloid beta (A4) precursor-like protein 2 -0.00437122
PHACTR2 phosphatase and actin regulator 2 -0.00436712
NCAPD2 non-SMC condensin I complex, subunit D2 -0.00435568
PRPF8 pre-mRNA processing factor 8 -0.00434971
TADA2A transcriptional adaptor 2A -0.00434756
ARAP3 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3 -0.00434565
APOA2 apolipoprotein A-II -0.00433378
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) -0.00433335
GPC3 glypican 3 -0.00432808
LMO3 LIM domain only 3 (rhombotin-like 2) -0.00432536
RARRES1 retinoic acid receptor responder (tazarotene induced) 1 -0.00432472
SSBP2 single-stranded DNA binding protein 2 -0.00432454
ENPEP glutamyl aminopeptidase (aminopeptidase A) -0.00432242
RESF1 retroelement silencing factor 1 -0.00431961
ERG v-ets avian erythroblastosis virus E26 oncogene homolog -0.00431368
SLC2A4RG SLC2A4 regulator -0.0043116
NME4 NME/NM23 nucleoside diphosphate kinase 4 -0.00431026
EPHX2 epoxide hydrolase 2, cytoplasmic -0.00430537
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.00430411
GCK glucokinase (hexokinase 4) -0.00429498
TPM4 tropomyosin 4 -0.00429069
SMCO4 single-pass membrane protein with coiled-coil domains 4 -0.0042849
SUMO3 small ubiquitin-like modifier 3 -0.00428475
PFKL phosphofructokinase, liver -0.00428457
ATXN7L3B ataxin 7-like 3B -0.00428182
RNASE2 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin) -0.00427427
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1 -0.00427135
DUT deoxyuridine triphosphatase -0.0042567
TMSB15A thymosin beta 15a -0.00425623
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) -0.00425384
NRGN neurogranin (protein kinase C substrate, RC3) -0.00423917
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic) -0.00423784
INSM1 insulinoma-associated 1 -0.0042265
PLN phospholamban -0.00422583
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) -0.00421858
CDK14 cyclin-dependent kinase 14 -0.00421824
HES1 hes family bHLH transcription factor 1 -0.00421494
SEC24D SEC24 family member D -0.00421469
MAP3K5 mitogen-activated protein kinase kinase kinase 5 -0.00421281
MANSC1 MANSC domain containing 1 -0.0042096
EFR3A EFR3 homolog A (S. cerevisiae) -0.0042043
FOXF1 forkhead box F1 -0.00419274
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast) -0.00418897
ASF1B anti-silencing function 1B histone chaperone -0.00416895
SPTSSA serine palmitoyltransferase, small subunit A -0.00416314
RBKS ribokinase -0.00415841
CAMKK2 calcium/calmodulin-dependent protein kinase kinase 2, beta -0.00414959
MTL5 metallothionein-like 5, testis-specific (tesmin) -0.00414559
ANKRD17 ankyrin repeat domain 17 -0.00413473
TMEM135 transmembrane protein 135 -0.00413161
ADARB1 adenosine deaminase, RNA-specific, B1 -0.00411697
SIX3 SIX homeobox 3 -0.00410681
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 -0.00409542
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated) -0.00407579
PON3 paraoxonase 3 -0.00407272
TFEC transcription factor EC -0.00406365