SGC0946 Gene Set

Dataset DeepCoverMOA Drug Mechanisms of Action
Category proteomics
Type drug perturbation
External Link https://pubchem.ncbi.nlm.nih.gov/compound/56962337
Similar Terms
Downloads & Tools

Genes

200 proteins with high or low expression in SGC0946 relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.

high expression

Symbol Name Standardized Value
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase 2.61
PAH phenylalanine hydroxylase 2.39
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 2.24
FDFT1 farnesyl-diphosphate farnesyltransferase 1 2.21
APOB apolipoprotein B 2.06
FGFBP1 fibroblast growth factor binding protein 1 2.01
PCSK9 proprotein convertase subtilisin/kexin type 9 1.89
SCD stearoyl-CoA desaturase (delta-9-desaturase) 1.82
IDI1 isopentenyl-diphosphate delta isomerase 1 1.75
SQLE squalene epoxidase 1.73
MSMO1 methylsterol monooxygenase 1 1.69
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 1.62
NCOA4 nuclear receptor coactivator 4 1.43
ABHD2 abhydrolase domain containing 2 1.32
HSD17B7 hydroxysteroid (17-beta) dehydrogenase 7 1.3
MVK mevalonate kinase 1.29
KMT2B lysine (K)-specific methyltransferase 2B 1.24
TEN1 TEN1 CST complex subunit 1.24
DHCR7 7-dehydrocholesterol reductase 1.18
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) 1.17
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1 1.17
LDLR low density lipoprotein receptor 1.12
ACAT2 acetyl-CoA acetyltransferase 2 1.1
NDFIP2 Nedd4 family interacting protein 2 1.05
ACSS2 acyl-CoA synthetase short-chain family member 2 1.04
LAMA2 laminin, alpha 2 1.03
NBR1 neighbor of BRCA1 gene 1 1.0
NPHP3 nephronophthisis 3 (adolescent) 1.0
LPIN1 lipin 1 0.97
MVD mevalonate (diphospho) decarboxylase 0.96
TPM4 tropomyosin 4 0.95
SC5D sterol-C5-desaturase 0.95
FDPS farnesyl diphosphate synthase 0.94
ELOVL6 ELOVL fatty acid elongase 6 0.94
NDFIP1 Nedd4 family interacting protein 1 0.94
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 0.92
PAQR7 progestin and adipoQ receptor family member VII 0.92
MYH3 myosin, heavy chain 3, skeletal muscle, embryonic 0.91
DHCR24 24-dehydrocholesterol reductase 0.89
RNF130 ring finger protein 130 0.83
FADS1 fatty acid desaturase 1 0.83
ITM2C integral membrane protein 2C 0.81
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.79
LAPTM4A lysosomal protein transmembrane 4 alpha 0.77
NEU1 sialidase 1 (lysosomal sialidase) 0.74
CD63 CD63 molecule 0.74
RNF26 ring finger protein 26 0.73
IRX4 iroquois homeobox 4 0.71
DOCK3 dedicator of cytokinesis 3 0.71
TGFB1I1 transforming growth factor beta 1 induced transcript 1 0.69
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 0.67
FASN fatty acid synthase 0.66
NSDHL NAD(P) dependent steroid dehydrogenase-like 0.65
ITGA1 integrin, alpha 1 0.65
ITM2B integral membrane protein 2B 0.64
FMNL1 formin-like 1 0.64
TSPAN3 tetraspanin 3 0.64
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.64
CLGN calmegin 0.64
MCL1 myeloid cell leukemia 1 0.63
DPYD dihydropyrimidine dehydrogenase 0.62
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase 0.62
KCTD20 potassium channel tetramerization domain containing 20 0.62
TMEM41B transmembrane protein 41B 0.61
SQSTM1 sequestosome 1 0.61
RTN4R reticulon 4 receptor 0.6
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 0.59
RNF149 ring finger protein 149 0.59
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9 0.59
CTSL cathepsin L 0.58
RNF145 ring finger protein 145 0.58
ALDOC aldolase C, fructose-bisphosphate 0.57
PDP2 pyruvate dehyrogenase phosphatase catalytic subunit 2 0.57
TBC1D14 TBC1 domain family, member 14 0.57
ABHD3 abhydrolase domain containing 3 0.57
ACACB acetyl-CoA carboxylase beta 0.57
MLXIPL MLX interacting protein-like 0.57
ACLY ATP citrate lyase 0.56
IL13RA1 interleukin 13 receptor, alpha 1 0.55
SAYSD1 SAYSVFN motif domain containing 1 0.55
MMADHC methylmalonic aciduria (cobalamin deficiency) cblD type, with homocystinuria 0.55
SREBF2 sterol regulatory element binding transcription factor 2 0.55
GINM1 glycoprotein integral membrane 1 0.54
MICA MHC class I polypeptide-related sequence A 0.54
PFKFB1 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 0.54
ZNF564 zinc finger protein 564 0.54
HMOX1 heme oxygenase 1 0.54
GNE glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase 0.53
SCARB1 scavenger receptor class B, member 1 0.53
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.51
SIX5 SIX homeobox 5 0.51
ANKRD13B ankyrin repeat domain 13B 0.51
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.51
REEP1 receptor accessory protein 1 0.51
SPINT2 serine peptidase inhibitor, Kunitz type, 2 0.51
SON SON DNA binding protein 0.51
CALCOCO2 calcium binding and coiled-coil domain 2 0.5
FTH1 ferritin, heavy polypeptide 1 0.5
KIAA1107 KIAA1107 0.5
FRRS1 ferric-chelate reductase 1 0.5

low expression

Symbol Name Standardized Value
PIP prolactin-induced protein -1.58
KLHL23 kelch-like family member 23 -1.42
AZGP1 alpha-2-glycoprotein 1, zinc-binding -1.22
HIST2H2AB histone cluster 2, H2ab -0.94
PRODH proline dehydrogenase (oxidase) 1 -0.9
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal -0.9
PPT1 palmitoyl-protein thioesterase 1 -0.83
CARD8 caspase recruitment domain family, member 8 -0.81
HRH1 histamine receptor H1 -0.81
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1 -0.78
NAAA N-acylethanolamine acid amidase -0.73
COL1A2 collagen, type I, alpha 2 -0.7
ADIPOR1 adiponectin receptor 1 -0.7
TCEA2 transcription elongation factor A (SII), 2 -0.67
GBA glucosidase, beta, acid -0.65
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1 -0.62
FBXO46 F-box protein 46 -0.6
STOML1 stomatin (EPB72)-like 1 -0.59
BCL2L12 BCL2-like 12 (proline rich) -0.57
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) -0.56
CMC2 C-x(9)-C motif containing 2 -0.55
LRRC28 leucine rich repeat containing 28 -0.54
CLTCL1 clathrin, heavy chain-like 1 -0.54
MERTK MER proto-oncogene, tyrosine kinase -0.53
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2 -0.5
CLN5 ceroid-lipofuscinosis, neuronal 5 -0.48
SLC16A7 solute carrier family 16 (monocarboxylate transporter), member 7 -0.48
TMSB10 thymosin beta 10 -0.47
FOXO1 forkhead box O1 -0.46
IGFBP5 insulin-like growth factor binding protein 5 -0.46
HYKK hydroxylysine kinase -0.46
PROSER3 proline and serine rich 3 -0.46
TSPAN31 tetraspanin 31 -0.45
MCFD2 multiple coagulation factor deficiency 2 -0.45
HCFC2 host cell factor C2 -0.44
RAB36 RAB36, member RAS oncogene family -0.44
PHETA1 PH domain containing endocytic trafficking adaptor 1 -0.44
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3 -0.43
HIST2H2AA3 histone cluster 2, H2aa3 -0.43
SSNA1 Sjogren syndrome nuclear autoantigen 1 -0.43
VIM vimentin -0.42
GON7 GON7 subunit of KEOPS complex -0.42
ATP5PF ATP synthase peripheral stalk subunit F6 -0.4
CLTB clathrin, light chain B -0.4
MTFMT mitochondrial methionyl-tRNA formyltransferase -0.4
TCOF1 Treacher Collins-Franceschetti syndrome 1 -0.4
FHIT fragile histidine triad -0.4
PUSL1 pseudouridylate synthase-like 1 -0.39
ARHGEF37 Rho guanine nucleotide exchange factor (GEF) 37 -0.38
TDRD9 tudor domain containing 9 -0.37
SPAG17 sperm associated antigen 17 -0.37
CDK2AP1 cyclin-dependent kinase 2 associated protein 1 -0.37
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha -0.36
MTPN myotrophin -0.36
PTPRB protein tyrosine phosphatase, receptor type, B -0.36
FAM210B family with sequence similarity 210, member B -0.36
CHMP4C charged multivesicular body protein 4C -0.36
ARSK arylsulfatase family, member K -0.36
TRIAP1 TP53 regulated inhibitor of apoptosis 1 -0.35
COA4 cytochrome c oxidase assembly factor 4 homolog (S. cerevisiae) -0.35
S100A6 S100 calcium binding protein A6 -0.35
WARS2 tryptophanyl tRNA synthetase 2, mitochondrial -0.34
MDM1 Mdm1 nuclear protein homolog (mouse) -0.34
ZDHHC3 zinc finger, DHHC-type containing 3 -0.34
BCAM basal cell adhesion molecule (Lutheran blood group) -0.34
MYT1 myelin transcription factor 1 -0.34
FBXW5 F-box and WD repeat domain containing 5 -0.33
HAL histidine ammonia-lyase -0.33
MLYCD malonyl-CoA decarboxylase -0.33
UQCRB ubiquinol-cytochrome c reductase binding protein -0.33
MED8 mediator complex subunit 8 -0.33
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1 -0.33
HIPK3 homeodomain interacting protein kinase 3 -0.33
NIPA2 non imprinted in Prader-Willi/Angelman syndrome 2 -0.32
BCS1L BC1 (ubiquinol-cytochrome c reductase) synthesis-like -0.32
SEPHS2 selenophosphate synthetase 2 -0.31
FBXW2 F-box and WD repeat domain containing 2 -0.31
PFDN1 prefoldin subunit 1 -0.31
HBA1 hemoglobin, alpha 1 -0.31
C15ORF40 chromosome 15 open reading frame 40 -0.31
SCO1 SCO1 cytochrome c oxidase assembly protein -0.31
NENF neudesin neurotrophic factor -0.31
TTYH3 tweety family member 3 -0.31
VTN vitronectin -0.31
LYST lysosomal trafficking regulator -0.31
LPIN2 lipin 2 -0.3
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.3
MUC16 mucin 16, cell surface associated -0.3
POLR2M polymerase (RNA) II (DNA directed) polypeptide M -0.3
ZDHHC2 zinc finger, DHHC-type containing 2 -0.29
ACAD10 acyl-CoA dehydrogenase family, member 10 -0.29
CCN1 cellular communication network factor 1 -0.29
KCTD17 potassium channel tetramerization domain containing 17 -0.29
DSCAML1 Down syndrome cell adhesion molecule like 1 -0.29
ERH enhancer of rudimentary homolog (Drosophila) -0.29
ARL14EPL ADP-ribosylation factor-like 14 effector protein-like -0.29
DPCD deleted in primary ciliary dyskinesia homolog (mouse) -0.29
ATP5IF1 ATP synthase inhibitory factor subunit 1 -0.28
ATP6V1F ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F -0.28
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.28