| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/24795070 |
| Similar Terms | |
| Downloads & Tools |
198 proteins with high or low expression in SGI-1776 relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| F13A1 | coagulation factor XIII, A1 polypeptide | 1.69 |
| CLK1 | CDC-like kinase 1 | 0.62 |
| CCNF | cyclin F | 0.62 |
| PRKCQ | protein kinase C, theta | 0.54 |
| PAQR7 | progestin and adipoQ receptor family member VII | 0.51 |
| DHFR | dihydrofolate reductase | 0.5 |
| SPRYD3 | SPRY domain containing 3 | 0.49 |
| ODC1 | ornithine decarboxylase 1 | 0.47 |
| ZDHHC23 | zinc finger, DHHC-type containing 23 | 0.44 |
| RGL3 | ral guanine nucleotide dissociation stimulator-like 3 | 0.44 |
| RCE1 | Ras converting CAAX endopeptidase 1 | 0.44 |
| HYKK | hydroxylysine kinase | 0.43 |
| MDK | midkine (neurite growth-promoting factor 2) | 0.43 |
| C2ORF72 | chromosome 2 open reading frame 72 | 0.42 |
| FN1 | fibronectin 1 | 0.42 |
| ZFAT | zinc finger and AT hook domain containing | 0.41 |
| HPS4 | Hermansky-Pudlak syndrome 4 | 0.41 |
| COL2A1 | collagen, type II, alpha 1 | 0.4 |
| CD81 | CD81 molecule | 0.39 |
| ZNF317 | zinc finger protein 317 | 0.39 |
| CLCN5 | chloride channel, voltage-sensitive 5 | 0.39 |
| CNTLN | centlein, centrosomal protein | 0.39 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.39 |
| CYP1A1 | cytochrome P450, family 1, subfamily A, polypeptide 1 | 0.38 |
| CCN1 | cellular communication network factor 1 | 0.38 |
| FICD | FIC domain containing | 0.38 |
| SKP2 | S-phase kinase-associated protein 2, E3 ubiquitin protein ligase | 0.38 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.36 |
| RPS27A | ribosomal protein S27a | 0.36 |
| POP7 | processing of precursor 7, ribonuclease P/MRP subunit (S. cerevisiae) | 0.36 |
| CLK4 | CDC-like kinase 4 | 0.35 |
| UCK1 | uridine-cytidine kinase 1 | 0.35 |
| TMED3 | transmembrane emp24 protein transport domain containing 3 | 0.35 |
| SP100 | SP100 nuclear antigen | 0.35 |
| RAB19 | RAB19, member RAS oncogene family | 0.34 |
| MAFF | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F | 0.34 |
| CIT | citron rho-interacting serine/threonine kinase | 0.33 |
| CUTA | cutA divalent cation tolerance homolog (E. coli) | 0.33 |
| HMMR | hyaluronan-mediated motility receptor (RHAMM) | 0.33 |
| CRLF1 | cytokine receptor-like factor 1 | 0.33 |
| HOXB8 | homeobox B8 | 0.33 |
| PBK | PDZ binding kinase | 0.33 |
| PCLAF | PCNA clamp associated factor | 0.33 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | 0.32 |
| ALAS1 | 5'-aminolevulinate synthase 1 | 0.32 |
| CTSV | cathepsin V | 0.32 |
| UBE2E3 | ubiquitin-conjugating enzyme E2E 3 | 0.32 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.32 |
| HBA1 | hemoglobin, alpha 1 | 0.31 |
| KCTD5 | potassium channel tetramerization domain containing 5 | 0.31 |
| CCNB1 | cyclin B1 | 0.31 |
| ZNF367 | zinc finger protein 367 | 0.31 |
| FCF1 | FCF1 rRNA-processing protein | 0.31 |
| DTL | denticleless E3 ubiquitin protein ligase homolog (Drosophila) | 0.3 |
| CCDC14 | coiled-coil domain containing 14 | 0.3 |
| BAD | BCL2-associated agonist of cell death | 0.3 |
| SCARA3 | scavenger receptor class A, member 3 | 0.3 |
| CHCHD1 | coiled-coil-helix-coiled-coil-helix domain containing 1 | 0.3 |
| AMACR | alpha-methylacyl-CoA racemase | 0.3 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.3 |
| NDUFB8 | NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19kDa | 0.3 |
| RAD51 | RAD51 recombinase | 0.3 |
| FBXW4 | F-box and WD repeat domain containing 4 | 0.29 |
| DCAF4 | DDB1 and CUL4 associated factor 4 | 0.29 |
| CDC25C | cell division cycle 25C | 0.29 |
| CNTRL | centriolin | 0.29 |
| RAB26 | RAB26, member RAS oncogene family | 0.29 |
| ERI1 | exoribonuclease 1 | 0.28 |
| IMPA2 | inositol(myo)-1(or 4)-monophosphatase 2 | 0.28 |
| NUSAP1 | nucleolar and spindle associated protein 1 | 0.27 |
| RAD51D | RAD51 paralog D | 0.27 |
| FAM174A | family with sequence similarity 174, member A | 0.27 |
| OIP5 | Opa interacting protein 5 | 0.27 |
| CHCHD2P9 | coiled-coil-helix-coiled-coil-helix domain containing 2 pseudogene 9 | 0.27 |
| TEDC1 | tubulin epsilon and delta complex 1 | 0.27 |
| PCBP4 | poly(rC) binding protein 4 | 0.27 |
| DNAH5 | dynein, axonemal, heavy chain 5 | 0.27 |
| ATXN7L1 | ataxin 7-like 1 | 0.27 |
| PKN3 | protein kinase N3 | 0.27 |
| PWWP3A | PWWP domain containing 3A, DNA repair factor | 0.26 |
| ZNF12 | zinc finger protein 12 | 0.26 |
| TGFB1I1 | transforming growth factor beta 1 induced transcript 1 | 0.26 |
| CCDC170 | coiled-coil domain containing 170 | 0.26 |
| BAHCC1 | BAH domain and coiled-coil containing 1 | 0.26 |
| SLC25A52 | solute carrier family 25, member 52 | 0.26 |
| IER5L | immediate early response 5-like | 0.26 |
| EML3 | echinoderm microtubule associated protein like 3 | 0.26 |
| H1-4 | H1.4 linker histone, cluster member | 0.26 |
| SINHCAF | SIN3-HDAC complex associated factor | 0.25 |
| CENPT | centromere protein T | 0.25 |
| SEMA4D | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D | 0.25 |
| ESCO2 | establishment of sister chromatid cohesion N-acetyltransferase 2 | 0.25 |
| EMG1 | EMG1 N1-specific pseudouridine methyltransferase | 0.25 |
| CDC42 | cell division cycle 42 | 0.25 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.25 |
| MCM5 | minichromosome maintenance complex component 5 | 0.25 |
| RHOA | ras homolog family member A | 0.25 |
| DCAF16 | DDB1 and CUL4 associated factor 16 | 0.25 |
| RBX1 | ring-box 1, E3 ubiquitin protein ligase | 0.25 |
| PRIM1 | primase, DNA, polypeptide 1 (49kDa) | 0.25 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PER2 | period circadian clock 2 | -2.69 |
| PIP | prolactin-induced protein | -1.46 |
| IKBKG | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma | -0.96 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.82 |
| HPCAL4 | hippocalcin like 4 | -0.82 |
| SS18L1 | synovial sarcoma translocation gene on chromosome 18-like 1 | -0.81 |
| STMN2 | stathmin 2 | -0.8 |
| HPCAL1 | hippocalcin-like 1 | -0.79 |
| PSAP | prosaposin | -0.7 |
| PPP1R14B | protein phosphatase 1, regulatory (inhibitor) subunit 14B | -0.7 |
| BAG3 | BCL2-associated athanogene 3 | -0.69 |
| STMN1 | stathmin 1 | -0.68 |
| UBE2G1 | ubiquitin-conjugating enzyme E2G 1 | -0.68 |
| CALB2 | calbindin 2 | -0.68 |
| TANK | TRAF family member-associated NFKB activator | -0.66 |
| TPM4 | tropomyosin 4 | -0.65 |
| UBE2A | ubiquitin-conjugating enzyme E2A | -0.65 |
| MYO3A | myosin IIIA | -0.65 |
| EGR1 | early growth response 1 | -0.64 |
| WTAP | Wilms tumor 1 associated protein | -0.62 |
| FKBP14 | FK506 binding protein 14, 22 kDa | -0.62 |
| MT1X | metallothionein 1X | -0.62 |
| CD2BP2 | CD2 (cytoplasmic tail) binding protein 2 | -0.6 |
| NABP1 | nucleic acid binding protein 1 | -0.6 |
| COL14A1 | collagen, type XIV, alpha 1 | -0.6 |
| ZBED1 | zinc finger, BED-type containing 1 | -0.6 |
| CARHSP1 | calcium regulated heat stable protein 1, 24kDa | -0.59 |
| UNC13A | unc-13 homolog A (C. elegans) | -0.58 |
| PDRG1 | p53 and DNA-damage regulated 1 | -0.58 |
| CDA | cytidine deaminase | -0.57 |
| RNF126 | ring finger protein 126 | -0.57 |
| CD58 | CD58 molecule | -0.56 |
| PDCD5 | programmed cell death 5 | -0.56 |
| TMOD3 | tropomodulin 3 (ubiquitous) | -0.56 |
| BLOC1S3 | biogenesis of lysosomal organelles complex-1, subunit 3 | -0.56 |
| PXN | paxillin | -0.55 |
| GTDC1 | glycosyltransferase-like domain containing 1 | -0.55 |
| NAA38 | N(alpha)-acetyltransferase 38, NatC auxiliary subunit | -0.55 |
| SH2D5 | SH2 domain containing 5 | -0.55 |
| ZNF675 | zinc finger protein 675 | -0.55 |
| DDAH2 | dimethylarginine dimethylaminohydrolase 2 | -0.54 |
| PLAUR | plasminogen activator, urokinase receptor | -0.54 |
| PLEKHG4 | pleckstrin homology domain containing, family G (with RhoGef domain) member 4 | -0.54 |
| AXIN1 | axin 1 | -0.54 |
| MED8 | mediator complex subunit 8 | -0.54 |
| LZIC | leucine zipper and CTNNBIP1 domain containing | -0.54 |
| IGBP1 | immunoglobulin (CD79A) binding protein 1 | -0.53 |
| SESN2 | sestrin 2 | -0.52 |
| JPT1 | Jupiter microtubule associated homolog 1 | -0.52 |
| FAM160A1 | family with sequence similarity 160, member A1 | -0.51 |
| ZDHHC9 | zinc finger, DHHC-type containing 9 | -0.51 |
| NR4A2 | nuclear receptor subfamily 4, group A, member 2 | -0.5 |
| KITLG | KIT ligand | -0.5 |
| ADGRE2 | adhesion G protein-coupled receptor E2 | -0.5 |
| CRELD2 | cysteine-rich with EGF-like domains 2 | -0.5 |
| PPIE | peptidylprolyl isomerase E (cyclophilin E) | -0.5 |
| TACSTD2 | tumor-associated calcium signal transducer 2 | -0.5 |
| OPTN | optineurin | -0.5 |
| TPM3 | tropomyosin 3 | -0.49 |
| B2M | beta-2-microglobulin | -0.49 |
| PSME1 | proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) | -0.49 |
| ANKRD40 | ankyrin repeat domain 40 | -0.49 |
| ZC3H6 | zinc finger CCCH-type containing 6 | -0.48 |
| TERF2IP | telomeric repeat binding factor 2, interacting protein | -0.48 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | -0.48 |
| SLC25A39 | solute carrier family 25, member 39 | -0.48 |
| POLR1D | polymerase (RNA) I polypeptide D, 16kDa | -0.48 |
| TMUB1 | transmembrane and ubiquitin-like domain containing 1 | -0.48 |
| RNF139 | ring finger protein 139 | -0.47 |
| IRGQ | immunity-related GTPase family, Q | -0.47 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.47 |
| COA6 | cytochrome c oxidase assembly factor 6 | -0.47 |
| DFFA | DNA fragmentation factor, 45kDa, alpha polypeptide | -0.47 |
| SFN | stratifin | -0.47 |
| CETN3 | centrin, EF-hand protein, 3 | -0.46 |
| RCN1 | reticulocalbin 1, EF-hand calcium binding domain | -0.46 |
| SOD1 | superoxide dismutase 1, soluble | -0.45 |
| VSNL1 | visinin-like 1 | -0.45 |
| FKBPL | FK506 binding protein like | -0.45 |
| S100A16 | S100 calcium binding protein A16 | -0.45 |
| CSTB | cystatin B (stefin B) | -0.45 |
| YAP1 | Yes-associated protein 1 | -0.44 |
| SRXN1 | sulfiredoxin 1 | -0.43 |
| MCOLN1 | mucolipin 1 | -0.43 |
| UBE2N | ubiquitin-conjugating enzyme E2N | -0.43 |
| PPP1R2B | PPP1R2 family member B | -0.43 |
| NSFL1C | NSFL1 (p97) cofactor (p47) | -0.42 |
| C1ORF52 | chromosome 1 open reading frame 52 | -0.42 |
| VPS37A | vacuolar protein sorting 37 homolog A (S. cerevisiae) | -0.42 |
| NAAA | N-acylethanolamine acid amidase | -0.42 |
| SF3B4 | splicing factor 3b, subunit 4, 49kDa | -0.42 |
| OTC | ornithine carbamoyltransferase | -0.42 |
| RAD23B | RAD23 homolog B (S. cerevisiae) | -0.41 |
| GINM1 | glycoprotein integral membrane 1 | -0.41 |
| ABRACL | ABRA C-terminal like | -0.41 |
| TOB1 | transducer of ERBB2, 1 | -0.41 |
| HSPB1 | heat shock 27kDa protein 1 | -0.41 |
| TSSC4 | tumor suppressing subtransferable candidate 4 | -0.41 |
