SGK1 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description serum/glucocorticoid regulated kinase 1|This gene encodes a serine/threonine protein kinase that plays an important role in cellular stress response. This kinase activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion. High levels of expression of this gene may contribute to conditions such as hypertension and diabetic nephropathy. Several alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jan 2009] (NCBI Entrez Gene Database, 6446)
External Link http://www.ncbi.nlm.nih.gov/gene/6446
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Genes

216 interacting proteins for SGK1 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase
ATM ATM serine/threonine kinase
ATP5D ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit
ATR ATR serine/threonine kinase
AURKA aurora kinase A
AURKB aurora kinase B
BLK BLK proto-oncogene, Src family tyrosine kinase
BRAF B-Raf proto-oncogene, serine/threonine kinase
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CAMK2A calcium/calmodulin-dependent protein kinase II alpha
CAMK2B calcium/calmodulin-dependent protein kinase II beta
CAMK2D calcium/calmodulin-dependent protein kinase II delta
CAMKK1 calcium/calmodulin-dependent protein kinase kinase 1, alpha
CAMKK2 calcium/calmodulin-dependent protein kinase kinase 2, beta
CARHSP1 calcium regulated heat stable protein 1, 24kDa
CBR3 carbonyl reductase 3
CD40 CD40 molecule, TNF receptor superfamily member 5
CDC37 cell division cycle 37
CDK1 cyclin-dependent kinase 1
CDK12 cyclin-dependent kinase 12
CDK2 cyclin-dependent kinase 2
CDK3 cyclin-dependent kinase 3
CDK5 cyclin-dependent kinase 5
CDK7 cyclin-dependent kinase 7
CDK9 cyclin-dependent kinase 9
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
COMMD1 copper metabolism (Murr1) domain containing 1
CREB1 cAMP responsive element binding protein 1
CS citrate synthase
CSK c-src tyrosine kinase
CSNK1A1 casein kinase 1, alpha 1
CSNK1A1L casein kinase 1, alpha 1-like
CSNK1D casein kinase 1, delta
CSNK1E casein kinase 1, epsilon
CSNK1G1 casein kinase 1, gamma 1
CSNK1G2 casein kinase 1, gamma 2
CSNK1G3 casein kinase 1, gamma 3
CUL1 cullin 1
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6
EFNA1 ephrin-A1
EIF3F eukaryotic translation initiation factor 3, subunit F
EIF3I eukaryotic translation initiation factor 3, subunit I
ELAVL1 ELAV like RNA binding protein 1
EPHA2 EPH receptor A2
EPHA5 EPH receptor A5
EPHA7 EPH receptor A7
EPHB1 EPH receptor B1
EPHB2 EPH receptor B2
EPHB3 EPH receptor B3
EPHB4 EPH receptor B4
ESR1 estrogen receptor 1
EZR ezrin
FANCA Fanconi anemia, complementation group A
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FER fer (fps/fes related) tyrosine kinase
FES FES proto-oncogene, tyrosine kinase
FGR FGR proto-oncogene, Src family tyrosine kinase
FOXO3 forkhead box O3
FSCN1 fascin actin-bundling protein 1
FYN FYN proto-oncogene, Src family tyrosine kinase
GAB1 GRB2-associated binding protein 1
GAB2 GRB2-associated binding protein 2
GADD45G growth arrest and DNA-damage-inducible, gamma
GANAB glucosidase, alpha; neutral AB
GAPDH glyceraldehyde-3-phosphate dehydrogenase
GDI2 GDP dissociation inhibitor 2
GNAL guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1
GNG2 guanine nucleotide binding protein (G protein), gamma 2
GRAP2 GRB2-related adaptor protein 2
GRB14 growth factor receptor-bound protein 14
GRB2 growth factor receptor-bound protein 2
GSK3A glycogen synthase kinase 3 alpha
GSK3B glycogen synthase kinase 3 beta
HCK HCK proto-oncogene, Src family tyrosine kinase
HNF4A hepatocyte nuclear factor 4, alpha
HNRNPL heterogeneous nuclear ribonucleoprotein L
HNRNPM heterogeneous nuclear ribonucleoprotein M
HRAS Harvey rat sarcoma viral oncogene homolog
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA4 heat shock 70kDa protein 4
HTT huntingtin
HYOU1 hypoxia up-regulated 1
IARS isoleucyl-tRNA synthetase
IGF1R insulin-like growth factor 1 receptor
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
IL2 interleukin 2
IL2RA interleukin 2 receptor, alpha
IL2RB interleukin 2 receptor, beta
IL2RG interleukin 2 receptor, gamma
INS insulin
INSR insulin receptor
IPO4 importin 4
JAK1 Janus kinase 1
JAK3 Janus kinase 3
KCNJ1 potassium channel, inwardly rectifying subfamily J, member 1
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KRAS Kirsten rat sarcoma viral oncogene homolog
LAT linker for activation of T cells
LCK LCK proto-oncogene, Src family tyrosine kinase
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
LETM1 leucine zipper-EF-hand containing transmembrane protein 1
LTF lactotransferrin
LYN LYN proto-oncogene, Src family tyrosine kinase
MAGEA1 melanoma antigen family A1
MAP3K11 mitogen-activated protein kinase kinase kinase 11
MAP3K2 mitogen-activated protein kinase kinase kinase 2
MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MAPK15 mitogen-activated protein kinase 15
MAPK3 mitogen-activated protein kinase 3
MAPK7 mitogen-activated protein kinase 7
MAPKAP1 mitogen-activated protein kinase associated protein 1
MAPT microtubule-associated protein tau
MELK maternal embryonic leucine zipper kinase
MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
MLST8 MTOR associated protein, LST8 homolog (S. cerevisiae)
MOB1A MOB kinase activator 1A
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MYH1 myosin, heavy chain 1, skeletal muscle, adult
NASP nuclear autoantigenic sperm protein (histone-binding)
NCSTN nicastrin
NDRG1 N-myc downstream regulated 1
NDRG2 NDRG family member 2
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NEK6 NIMA-related kinase 6
NEK9 NIMA-related kinase 9
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NLK nemo-like kinase
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog
OLA1 Obg-like ATPase 1
PA2G4 proliferation-associated 2G4, 38kDa
PABPC1 poly(A) binding protein, cytoplasmic 1
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PAK4 p21 protein (Cdc42/Rac)-activated kinase 4
PDGFB platelet-derived growth factor beta polypeptide
PDGFRB platelet-derived growth factor receptor, beta polypeptide
PDK1 pyruvate dehydrogenase kinase, isozyme 1
PDK2 pyruvate dehydrogenase kinase, isozyme 2
PDPK1 3-phosphoinositide dependent protein kinase 1
PELP1 proline, glutamate and leucine rich protein 1
PFAS phosphoribosylformylglycinamidine synthase
PHKG2 phosphorylase kinase, gamma 2 (testis)
PIGR polymeric immunoglobulin receptor
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIK3R6 phosphoinositide-3-kinase, regulatory subunit 6
PIKFYVE phosphoinositide kinase, FYVE finger containing
PIP prolactin-induced protein
PLK1 polo-like kinase 1
PPIAL4D peptidylprolyl isomerase A (cyclophilin A)-like 4D
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit
PRKACA protein kinase, cAMP-dependent, catalytic, alpha
PRKCG protein kinase C, gamma
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PRR5 proline rich 5 (renal)
PSMA6 proteasome (prosome, macropain) subunit, alpha type, 6
PSMD6 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6
PTEN phosphatase and tensin homolog
PTK2 protein tyrosine kinase 2
PTK2B protein tyrosine kinase 2 beta
PTPN11 protein tyrosine phosphatase, non-receptor type 11
RABAC1 Rab acceptor 1 (prenylated)
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RICTOR RPTOR independent companion of MTOR, complex 2
ROCK2 Rho-associated, coiled-coil containing protein kinase 2
RPL3 ribosomal protein L3
RPS3A ribosomal protein S3A
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3
RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4
RPS6KA6 ribosomal protein S6 kinase, 90kDa, polypeptide 6
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SCNN1B sodium channel, non voltage gated 1 beta subunit
SCNN1D sodium channel, non voltage gated 1 delta subunit
SCNN1G sodium channel, non voltage gated 1 gamma subunit
SF3B2 splicing factor 3b, subunit 2, 145kDa
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SLC2A4 solute carrier family 2 (facilitated glucose transporter), member 4
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SLC9A3R2 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2
SLK STE20-like kinase
SOS1 son of sevenless homolog 1 (Drosophila)
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STK16 serine/threonine kinase 16
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
SYVN1 synovial apoptosis inhibitor 1, synoviolin
TBK1 TANK-binding kinase 1
TEC tec protein tyrosine kinase
TMEM184C transmembrane protein 184C
TNK1 tyrosine kinase, non-receptor, 1
TRIM28 tripartite motif containing 28
TSC22D3 TSC22 domain family, member 3
TSLIG3B tRNA splicing ligase complex subunit 3B
TUFM Tu translation elongation factor, mitochondrial
TYK2 tyrosine kinase 2
UBC ubiquitin C
ULK3 unc-51 like kinase 3
VARS valyl-tRNA synthetase
VAV1 vav 1 guanine nucleotide exchange factor
VCP valosin containing protein
WEE1 WEE1 G2 checkpoint kinase
WNK1 WNK lysine deficient protein kinase 1
WNK2 WNK lysine deficient protein kinase 2
WNK4 WNK lysine deficient protein kinase 4
YES1 YES proto-oncogene 1, Src family tyrosine kinase