SGK1 Gene Set

Dataset PhosphoSitePlus Substrates of Kinases
Category physical interactions
Type kinase
Description serum/glucocorticoid regulated kinase 1|This gene encodes a serine/threonine protein kinase that plays an important role in cellular stress response. This kinase activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion. High levels of expression of this gene may contribute to conditions such as hypertension and diabetic nephropathy. Several alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jan 2009] (NCBI Entrez Gene Database, 6446)
External Link http://www.ncbi.nlm.nih.gov/gene/6446
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Genes

24 substrates of the kinase SGK1 from the curated PhosphoSitePlus Substrates of Kinases dataset.

Symbol Name
CARHSP1 calcium regulated heat stable protein 1, 24kDa
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CREB1 cAMP responsive element binding protein 1
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FOXO3 forkhead box O3
HTT huntingtin
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
KCNJ1 potassium channel, inwardly rectifying subfamily J, member 1
MAP2K4 mitogen-activated protein kinase kinase 4
MAP3K3 mitogen-activated protein kinase kinase kinase 3
MAPK1 mitogen-activated protein kinase 1
MAPT microtubule-associated protein tau
NCSTN nicastrin
NDRG1 N-myc downstream regulated 1
NDRG2 NDRG family member 2
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NOS2 nitric oxide synthase 2, inducible
PIKFYVE phosphoinositide kinase, FYVE finger containing
RICTOR RPTOR independent companion of MTOR, complex 2
SLC2A4 solute carrier family 2 (facilitated glucose transporter), member 4
TRPV4 transient receptor potential cation channel, subfamily V, member 4
WNK1 WNK lysine deficient protein kinase 1
WNK4 WNK lysine deficient protein kinase 4