SH2D2A Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description SH2 domain containing 2A|This gene encodes an adaptor protein thought to function in T-cell signal transduction. A related protein in mouse is responsible for the activation of lymphocyte-specific protein-tyrosine kinase and functions in downstream signaling. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010] (NCBI Entrez Gene Database, 9047)
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Genes

305 genes differentially expressed following the SH2D2A gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
CPLX4 complexin 4 3.15186
APOC4 apolipoprotein C-IV 3.15186
NGB neuroglobin 3.15186
ETNPPL ethanolamine-phosphate phospho-lyase 3.15186
CSF1R colony stimulating factor 1 receptor 3.15186
ATP6V1B1 ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1 3.15186
NTRK1 neurotrophic tyrosine kinase, receptor, type 1 3.15186
HBA2 hemoglobin, alpha 2 3.15186
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2 3.15186
AIPL1 aryl hydrocarbon receptor interacting protein-like 1 3.15186
TSPAN1 tetraspanin 1 3.15186
TEX29 testis expressed 29 3.15186
C22ORF31 chromosome 22 open reading frame 31 3.15186
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) 3.15186
SRGN serglycin 3.15186
CXORF58 chromosome X open reading frame 58 3.15186
LRRN4CL LRRN4 C-terminal like 3.15186
TMEM40 transmembrane protein 40 3.15186
LPO lactoperoxidase 3.15186
MRPL53 mitochondrial ribosomal protein L53 3.14153
GPR151 G protein-coupled receptor 151 3.14153
CD163 CD163 molecule 3.14153
ABHD16A abhydrolase domain containing 16A 3.14153
BTC betacellulin 3.14153
SRMS src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites 3.14153
SELPLG selectin P ligand 3.14153
CSRP3 cysteine and glycine-rich protein 3 (cardiac LIM protein) 3.14153
FGD2 FYVE, RhoGEF and PH domain containing 2 3.14153
USP26 ubiquitin specific peptidase 26 3.14153
GPR55 G protein-coupled receptor 55 3.14153
SCN2B sodium channel, voltage gated, type II beta subunit 3.14153
TMEM176A transmembrane protein 176A 3.14153
GJB5 gap junction protein, beta 5, 31.1kDa 3.14153
CPB1 carboxypeptidase B1 (tissue) 3.14153
MISP mitotic spindle positioning 3.14153
CRYGC crystallin, gamma C 3.14153
TBATA thymus, brain and testes associated 3.14153
IL2RA interleukin 2 receptor, alpha 3.14153
CLEC2A C-type lectin domain family 2, member A 3.14153
SPATA31G1 SPATA31 subfamily G member 1 3.14153
C2ORF78 chromosome 2 open reading frame 78 3.14153
PRR29 proline rich 29 3.14153
MEIKIN meiotic kinetochore factor 3.14153
RLN3 relaxin 3 3.14153
SIGLEC1 sialic acid binding Ig-like lectin 1, sialoadhesin 3.14153
TCHHL1 trichohyalin-like 1 3.14153
FABP4 fatty acid binding protein 4, adipocyte 3.14153
GPT glutamic-pyruvate transaminase (alanine aminotransferase) 3.14153
ADGB androglobin 3.14153
TDRD9 tudor domain containing 9 3.14153
GPHB5 glycoprotein hormone beta 5 3.14153
KCNE2 potassium channel, voltage gated subfamily E regulatory beta subunit 2 3.14153
TPH1 tryptophan hydroxylase 1 3.14153
UPK3A uroplakin 3A 3.14153
GBP6 guanylate binding protein family, member 6 3.14153
HAO1 hydroxyacid oxidase (glycolate oxidase) 1 3.14153
SELP selectin P (granule membrane protein 140kDa, antigen CD62) 3.14153
SEPTIN14 septin 14 3.14153
SQOR sulfide quinone oxidoreductase 3.14153
GK3 glycerol kinase 3 3.14153
TBXT T-box transcription factor T 3.14153
CLXN calaxin 3.14153
JAML junction adhesion molecule like 3.14153
MPIG6B megakaryocyte and platelet inhibitory receptor G6b 3.14153
PPDPFL pancreatic progenitor cell differentiation and proliferation factor like 3.14153
CLEC20A C-type lectin domain containing 20A 3.14153
HOATZ HOATZ cilia and flagella associated protein 3.14153
SERTM2 serine rich and transmembrane domain containing 2 3.14153
LOC128125822 uncharacterized LOC128125822 3.14153
CPNE8-AS1 CPNE8 antisense RNA 1 3.14153
PNMA6F PNMA family member 6F 3.14153
BNC1 basonuclin 1 3.14153
C20ORF202 chromosome 20 open reading frame 202 3.14153
IQCF1 IQ motif containing F1 3.14153
HLF hepatic leukemia factor 3.14153
CFHR3 complement factor H-related 3 3.14153
FOXL1 forkhead box L1 3.14153
GPR83 G protein-coupled receptor 83 3.14153
LIPC lipase, hepatic 3.14153
OASL 2'-5'-oligoadenylate synthetase-like 3.14153
CFAP99 cilia and flagella associated protein 99 3.14153
DNASE2B deoxyribonuclease II beta 3.14153
SPDYC speedy/RINGO cell cycle regulator family member C 3.14153
CDK5R2 cyclin-dependent kinase 5, regulatory subunit 2 (p39) 3.14153
EXOC3L1 exocyst complex component 3-like 1 3.14153
MS4A13 membrane-spanning 4-domains, subfamily A, member 13 3.14153
ARHGAP15 Rho GTPase activating protein 15 3.14153
CSAG2 CSAG family, member 2 3.14153
LY6H lymphocyte antigen 6 complex, locus H 3.14153
BDKRB1 bradykinin receptor B1 3.14153
ASB4 ankyrin repeat and SOCS box containing 4 3.14153
OR56B2 olfactory receptor family 56 subfamily B member 2 3.14153
PHACTR3 phosphatase and actin regulator 3 3.14153
SERPINB10 serpin peptidase inhibitor, clade B (ovalbumin), member 10 3.14153
EBLN1 endogenous Bornavirus-like nucleoprotein 1 3.14153
CSTA cystatin A (stefin A) 3.14153
NCOA5 nuclear receptor coactivator 5 3.14153
NXNL1 nucleoredoxin-like 1 3.14153
SUPT20HL1 suppressor of Ty 20 homolog (S. cerevisiae)-like 1 3.14153
EDN3 endothelin 3 3.14153
ZSCAN4 zinc finger and SCAN domain containing 4 3.14153
NACA2 nascent polypeptide-associated complex alpha subunit 2 3.14153
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) 3.14153
TP53AIP1 tumor protein p53 regulated apoptosis inducing protein 1 3.14153
VAX2 ventral anterior homeobox 2 3.14153
MPZL3 myelin protein zero-like 3 3.14153
PLA2G4D phospholipase A2, group IVD (cytosolic) 3.14153
TCF21 transcription factor 21 3.14153
PSORS1C1 psoriasis susceptibility 1 candidate 1 3.14153
LST1 leukocyte specific transcript 1 3.14153
DEFB107B defensin, beta 107B 3.14153
PTGIR prostaglandin I2 (prostacyclin) receptor (IP) 3.14153
GLOD5 glyoxalase domain containing 5 3.14153
FKBP1C FK506 binding protein 1C 3.14153
ETV3L ets variant 3-like 3.14153
OTP orthopedia homeobox 3.14153
KCNA5 potassium channel, voltage gated shaker related subfamily A, member 5 3.14153
TYR tyrosinase 3.14153
SLN sarcolipin 3.14153
NOBOX NOBOX oogenesis homeobox 3.14153
IGLL1 immunoglobulin lambda-like polypeptide 1 3.14153
GPR62 G protein-coupled receptor 62 3.14153
VWA7 von Willebrand factor A domain containing 7 3.14153
PCDHGA3 protocadherin gamma subfamily A, 3 3.14153
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 3.14153
C16ORF78 chromosome 16 open reading frame 78 3.14153
SPATA3 spermatogenesis associated 3 3.14153
HOXD1 homeobox D1 3.14153
WFDC5 WAP four-disulfide core domain 5 3.14153
TAS2R50 taste receptor, type 2, member 50 3.14153
PPEF2 protein phosphatase, EF-hand calcium binding domain 2 3.14153
AQP10 aquaporin 10 3.14153
LAMP3 lysosomal-associated membrane protein 3 3.14153
GRAP2 GRB2-related adaptor protein 2 3.14153
APOL4 apolipoprotein L, 4 3.14153
TAS2R46 taste receptor, type 2, member 46 3.14153
IL10RA interleukin 10 receptor, alpha 3.14153
NEUROD2 neuronal differentiation 2 3.14153
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled 3.14153
KCNK15 potassium channel, two pore domain subfamily K, member 15 3.14153
SSX3 synovial sarcoma, X breakpoint 3 3.14153
ZC3H11B zinc finger CCCH-type containing 11B pseudogene 3.14153
SKOR2 SKI family transcriptional corepressor 2 3.14153
IFNE interferon, epsilon 3.14153
CHRM1 cholinergic receptor, muscarinic 1 3.14153
IRX4 iroquois homeobox 4 3.14153
MMP13 matrix metallopeptidase 13 3.14153
HHIPL2 HHIP-like 2 3.14153
SNTN sentan, cilia apical structure protein 3.14153
RBM24 RNA binding motif protein 24 3.03007
PHLPP2 PH domain and leucine rich repeat protein phosphatase 2 2.99418
RHOBTB3 Rho-related BTB domain containing 3 2.97348
NME5 NME/NM23 family member 5 2.95147
ZC3H7B zinc finger CCCH-type containing 7B 2.86108
TSFM Ts translation elongation factor, mitochondrial 2.83733
DUSP4 dual specificity phosphatase 4 2.83088
C1ORF174 chromosome 1 open reading frame 174 2.80009
MAZ MYC-associated zinc finger protein (purine-binding transcription factor) 2.74886
DNAH2 dynein, axonemal, heavy chain 2 2.71344
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2 2.65065
LINC02560 long intergenic non-protein coding RNA 2560 2.53851
STXBP5L syntaxin binding protein 5-like 2.40804
LUZP2 leucine zipper protein 2 2.36183
ACTN4 actinin, alpha 4 2.36052
ZBTB2 zinc finger and BTB domain containing 2 2.34113
JCAD junctional cadherin 5 associated 2.31896
ZC3H12C zinc finger CCCH-type containing 12C 2.30001
SPDEF SAM pointed domain containing ETS transcription factor 2.29549
MYO1G myosin IG 2.29549
ALDH8A1 aldehyde dehydrogenase 8 family, member A1 2.27722
RAB36 RAB36, member RAS oncogene family 2.27722
TNR tenascin R 2.27722
LMOD2 leiomodin 2 (cardiac) 2.26014
ARF5 ADP-ribosylation factor 5 2.25724
PTPN23 protein tyrosine phosphatase, non-receptor type 23 2.21831
NAV3 neuron navigator 3 2.20895
CHRNA5 cholinergic receptor, nicotinic, alpha 5 (neuronal) 2.20834
ITM2C integral membrane protein 2C 2.20834
ZNF347 zinc finger protein 347 2.19731
DEAF1 DEAF1 transcription factor 2.17385
SHOC2 soc-2 suppressor of clear homolog (C. elegans) 2.16764
CES2 carboxylesterase 2 2.15429
CLEC1A C-type lectin domain family 1, member A 2.15357
TPPP tubulin polymerization promoting protein 2.15357
ZNF366 zinc finger protein 366 2.15357
FABP3 fatty acid binding protein 3, muscle and heart 2.13837
LOC112694756 uncharaterized LOC112694756 2.13619
EMILIN1 elastin microfibril interfacer 1 2.13619
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) 2.11147
POLE polymerase (DNA directed), epsilon, catalytic subunit 2.11147
UBOX5 U-box domain containing 5 2.11147
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1 2.1088
MMD2 monocyte to macrophage differentiation-associated 2 2.08815
OXTR oxytocin receptor 2.08325
DCAF7 DDB1 and CUL4 associated factor 7 2.05947
ZNF732 zinc finger protein 732 2.05637
SLC12A8 solute carrier family 12, member 8 2.05323
CA1 carbonic anhydrase I 2.05066
CDX4 caudal type homeobox 4 2.0426
CITED4 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4 2.0264
TENT5A terminal nucleotidyltransferase 5A 2.01727
SHANK2 SH3 and multiple ankyrin repeat domains 2 2.01727
H3-7 H3.7 histone (putative) 2.01494
IL1A interleukin 1, alpha 2.01494
WFDC8 WAP four-disulfide core domain 8 2.01494
UCN urocortin 2.01494
POLR2J2 polymerase (RNA) II (DNA directed) polypeptide J2 2.01494
NR4A3 nuclear receptor subfamily 4, group A, member 3 2.01494
ADH6 alcohol dehydrogenase 6 (class V) 2.01494
PCDHA5 protocadherin alpha 5 2.01494
WDR12 WD repeat domain 12 2.01494
GBA3 glucosidase, beta, acid 3 (gene/pseudogene) 2.01494
PADI3 peptidyl arginine deiminase, type III 2.01494
BANK1 B-cell scaffold protein with ankyrin repeats 1 2.0145
TMEM87B transmembrane protein 87B 2.00194

decreased expression

Symbol Name Standardized Value
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1 -3.15186
CLDN14 claudin 14 -3.15186
IGFBP7 insulin-like growth factor binding protein 7 -3.14153
TUBA3D tubulin, alpha 3d -3.14153
AMBP alpha-1-microglobulin/bikunin precursor -3.14153
CBLN3 cerebellin 3 precursor -3.14153
CHRNB3 cholinergic receptor, nicotinic, beta 3 (neuronal) -3.14153
ERVW-1 endogenous retrovirus group W, member 1 -3.14153
GIPC3 GIPC PDZ domain containing family, member 3 -3.14153
PATE2 prostate and testis expressed 2 -3.14153
TACSTD2 tumor-associated calcium signal transducer 2 -3.14153
RSPH4A radial spoke head 4 homolog A (Chlamydomonas) -3.14153
DCST1 DC-STAMP domain containing 1 -3.14153
TMPRSS6 transmembrane protease, serine 6 -3.14153
CALML6 calmodulin-like 6 -3.14153
KLHL6 kelch-like family member 6 -3.14153
LMX1A LIM homeobox transcription factor 1, alpha -3.14153
SLC46A2 solute carrier family 46, member 2 -3.14153
SLC38A3 solute carrier family 38, member 3 -3.14153
GARIN6 golgi associated RAB2 interactor family member 6 -3.14153
CHIT1 chitinase 1 (chitotriosidase) -3.14153
TNNI1 troponin I type 1 (skeletal, slow) -3.14153
OR2B6 olfactory receptor, family 2, subfamily B, member 6 -3.14153
SLC6A12 solute carrier family 6 (neurotransmitter transporter), member 12 -3.14153
TPBGL trophoblast glycoprotein-like -3.14153
XCL1 chemokine (C motif) ligand 1 -3.14153
LCN2 lipocalin 2 -3.14153
ADAMTSL4-AS2 ADAMTSL4 antisense RNA 2 -3.14153
CLRN1 clarin 1 -3.14153
CBR3 carbonyl reductase 3 -3.14153
STAB2 stabilin 2 -2.91149
TRAM1L1 translocation associated membrane protein 1-like 1 -2.91149
ATAD3C ATPase family, AAA domain containing 3C -2.86382
ALX3 ALX homeobox 3 -2.86278
MECOM MDS1 and EVI1 complex locus -2.70622
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2 -2.4623
SPTLC2 serine palmitoyltransferase, long chain base subunit 2 -2.45818
CALCRL calcitonin receptor-like -2.43279
CD248 CD248 molecule, endosialin -2.41507
RHOG ras homolog family member G -2.40804
CDH26 cadherin 26 -2.40804
BTLA B and T lymphocyte associated -2.39969
IL32 interleukin 32 -2.39969
FGF22 fibroblast growth factor 22 -2.39958
FRAT1 frequently rearranged in advanced T-cell lymphomas 1 -2.39958
TGM1 transglutaminase 1 -2.39958
GET4 golgi to ER traffic protein 4 homolog (S. cerevisiae) -2.39917
RPH3A rabphilin 3A -2.39917
C2ORF68 chromosome 2 open reading frame 68 -2.39547
NSMCE3 NSE3 homolog, SMC5-SMC6 complex component -2.38622
RPL4 ribosomal protein L4 -2.38622
SRC SRC proto-oncogene, non-receptor tyrosine kinase -2.38622
SLFN12 schlafen family member 12 -2.37991
VSIG1 V-set and immunoglobulin domain containing 1 -2.37098
RHOXF1 Rhox homeobox family, member 1 -2.34584
ACHE acetylcholinesterase (Yt blood group) -2.34113
ACTL6A actin-like 6A -2.32955
IQSEC3 IQ motif and Sec7 domain 3 -2.31896
WSB2 WD repeat and SOCS box containing 2 -2.30867
PRKCZ protein kinase C, zeta -2.27891
MORF4L1 mortality factor 4 like 1 -2.27689
PPP1R21 protein phosphatase 1, regulatory subunit 21 -2.26429
PSTPIP2 proline-serine-threonine phosphatase interacting protein 2 -2.25971
SUB1 SUB1 homolog (S. cerevisiae) -2.24793
PEX19 peroxisomal biogenesis factor 19 -2.24132
P3H4 prolyl 3-hydroxylase family member 4 (non-enzymatic) -2.22563
ATXN7L1 ataxin 7-like 1 -2.21762
ZNF718 zinc finger protein 718 -2.1966
TDRD5 tudor domain containing 5 -2.18641
ATPAF1 ATP synthase mitochondrial F1 complex assembly factor 1 -2.17647
APLP1 amyloid beta (A4) precursor-like protein 1 -2.17638
MYO1D myosin ID -2.17385
OGFOD3 2-oxoglutarate and iron-dependent oxygenase domain containing 3 -2.15819
PLA2G12A phospholipase A2, group XIIA -2.15429
ALG9 ALG9, alpha-1,2-mannosyltransferase -2.13202
MYO1F myosin IF -2.11215
UBIAD1 UbiA prenyltransferase domain containing 1 -2.11147
TMPRSS5 transmembrane protease, serine 5 -2.1088
RPRD1B regulation of nuclear pre-mRNA domain containing 1B -2.09106
PDIA3 protein disulfide isomerase family A, member 3 -2.07738
SLC35D2 solute carrier family 35 (UDP-GlcNAc/UDP-glucose transporter), member D2 -2.0598
MRPL57 mitochondrial ribosomal protein L57 -2.05061
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A -2.0496
GAL galanin/GMAP prepropeptide -2.04363
ZRANB2 zinc finger, RAN-binding domain containing 2 -2.02173
LEAP2 liver expressed antimicrobial peptide 2 -2.02168
TINAGL1 tubulointerstitial nephritis antigen-like 1 -2.01505
SLC24A4 solute carrier family 24 (sodium/potassium/calcium exchanger), member 4 -2.01494
CELA2B chymotrypsin-like elastase family, member 2B -2.01494
SLC30A1 solute carrier family 30 (zinc transporter), member 1 -2.01494