SH2D5 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description SH2 domain containing 5| (NCBI Entrez Gene Database, 400745)
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Genes

289 genes differentially expressed following the SH2D5 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
PLA1A phospholipase A1 member A 2.65275
PTPRC protein tyrosine phosphatase, receptor type, C 2.6301
SPAM1 sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding) 2.6301
OR52A5 olfactory receptor, family 52, subfamily A, member 5 2.6301
CD209 CD209 molecule 2.6301
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy 2.6301
KRT20 keratin 20, type I 2.6301
ATXN7 ataxin 7 2.6301
IL5RA interleukin 5 receptor, alpha 2.6301
OSR2 odd-skipped related transciption factor 2 2.6301
IGFL2 IGF-like family member 2 2.6301
SERPINA11 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 11 2.6301
PIGQ phosphatidylinositol glycan anchor biosynthesis, class Q 2.6301
SBK3 SH3 domain binding kinase family, member 3 2.6301
CFHR3 complement factor H-related 3 2.6301
PLEKHG7 pleckstrin homology domain containing, family G (with RhoGef domain) member 7 2.6301
PDE6C phosphodiesterase 6C, cGMP-specific, cone, alpha prime 2.6301
VTN vitronectin 2.6301
SLC26A1 solute carrier family 26 (anion exchanger), member 1 2.6301
ROBO4 roundabout, axon guidance receptor, homolog 4 (Drosophila) 2.6301
SDR9C7 short chain dehydrogenase/reductase family 9C, member 7 2.6301
PERM1 PPARGC1 and ESRR induced regulator, muscle 1 2.6301
OR2J3 olfactory receptor, family 2, subfamily J, member 3 2.6301
NPIPA3 nuclear pore complex interacting protein family, member A3 2.6301
NPIPA8 nuclear pore complex interacting protein family, member A8 2.6301
SMDT1 single-pass membrane protein with aspartate-rich tail 1 2.6301
CRYGA crystallin, gamma A 2.6301
C2ORF78 chromosome 2 open reading frame 78 2.6301
MPP4 membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4) 2.6301
ABCA4 ATP-binding cassette, sub-family A (ABC1), member 4 2.6301
STEAP4 STEAP family member 4 2.6301
SPAG8 sperm associated antigen 8 2.6301
LEMD2 LEM domain containing 2 2.6301
TCP11 t-complex 11, testis-specific 2.6301
SLC16A6 solute carrier family 16, member 6 2.6301
GFAP glial fibrillary acidic protein 2.6301
KCNMB1 potassium channel subfamily M regulatory beta subunit 1 2.6301
NOTUM notum pectinacetylesterase homolog (Drosophila) 2.6301
OR2AJ1 olfactory receptor, family 2, subfamily AJ, member 1 2.6301
GPHB5 glycoprotein hormone beta 5 2.6301
PARP11 poly (ADP-ribose) polymerase family, member 11 2.6301
KCNE2 potassium channel, voltage gated subfamily E regulatory beta subunit 2 2.6301
ACVRL1 activin A receptor type II-like 1 2.6301
BOLA2 bolA family member 2 2.6301
PCDHB11 protocadherin beta 11 2.6301
CATSPERH catsper channel auxiliary subunit eta 2.6301
SPACDR sperm acrosome developmental regulator 2.6301
RTL9 retrotransposon Gag like 9 2.6301
ASDURF ASNSD1 upstream open reading frame 2.6301
TTLL13 tubulin tyrosine ligase like 13 2.6301
VSIR V-set immunoregulatory receptor 2.6301
EIPR1 EARP complex and GARP complex interacting protein 1 2.6301
HAO1 hydroxyacid oxidase (glycolate oxidase) 1 2.6301
GPX5 glutathione peroxidase 5 2.6301
TERB1 telomere repeat binding bouquet formation protein 1 2.6301
CCDC197 coiled-coil domain containing 197 2.6301
CCDC188 coiled-coil domain containing 188 2.6301
OR9H1 olfactory receptor family 9 subfamily H member 1 pseudogene (gene/pseudogene) 2.6301
SPMAP2 sperm microtubule associated protein 2 2.6301
CIMIP7 ciliary microtubule inner protein 7 2.6301
SPEGNB SPEG neighbor 2.6301
THSD8 thrombospondin type 1 domain containing 8 2.6301
RPS21-DT RPS21 divergent transcript 2.6301
CIMAP1C ciliary microtubule associated protein 1C 2.6301
CD8B2 CD8b2 molecule 2.6301
LTB4R2 leukotriene B4 receptor 2 2.6301
LRTM3 leucine rich repeat transmembrane protein 3 2.6301
APOBEC3H apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3H 2.6301
TBX3 T-box 3 2.6301
C12ORF54 chromosome 12 open reading frame 54 2.6301
TLR8 toll-like receptor 8 2.6301
TLR7 toll-like receptor 7 2.6301
NHLRC1 NHL repeat containing E3 ubiquitin protein ligase 1 2.6301
C1ORF162 chromosome 1 open reading frame 162 2.6301
CKM creatine kinase, muscle 2.6301
CD48 CD48 molecule 2.6301
C1QL2 complement component 1, q subcomponent-like 2 2.6301
CREB3L3 cAMP responsive element binding protein 3-like 3 2.6301
OR2L2 olfactory receptor, family 2, subfamily L, member 2 2.6301
TMEM40 transmembrane protein 40 2.6301
SPATA25 spermatogenesis associated 25 2.6301
OR51M1 olfactory receptor, family 51, subfamily M, member 1 2.6301
TAF1L TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa-like 2.6301
VCX3B variable charge, X-linked 3B 2.6301
MTMR11 myotubularin related protein 11 2.6301
POLD3 polymerase (DNA-directed), delta 3, accessory subunit 2.6301
CLDN22 claudin 22 2.6301
IRF5 interferon regulatory factor 5 2.6301
COX7B2 cytochrome c oxidase subunit VIIb2 2.6301
KCNK4 potassium channel, two pore domain subfamily K, member 4 2.6301
SIGLEC15 sialic acid binding Ig-like lectin 15 2.6301
PCDHGB5 protocadherin gamma subfamily B, 5 2.6301
APOD apolipoprotein D 2.6301
APOH apolipoprotein H (beta-2-glycoprotein I) 2.6301
PRSS38 protease, serine, 38 2.6301
ZIM2 zinc finger, imprinted 2 2.6301
HS3ST6 heparan sulfate (glucosamine) 3-O-sulfotransferase 6 2.6301
PHOSPHO1 phosphatase, orphan 1 2.6301
OPRK1 opioid receptor, kappa 1 2.6301
GABRD gamma-aminobutyric acid (GABA) A receptor, delta 2.6301
PENK proenkephalin 2.6301
ZMYND10 zinc finger, MYND-type containing 10 2.6301
TSPAN32 tetraspanin 32 2.6301
EREG epiregulin 2.6301
PLA2G12B phospholipase A2, group XIIB 2.6301
MYLK2 myosin light chain kinase 2 2.6301
PCDHGA7 protocadherin gamma subfamily A, 7 2.6301
RSPH10B radial spoke head 10 homolog B (Chlamydomonas) 2.6301
MUC13 mucin 13, cell surface associated 2.6301
COL6A5 collagen, type VI, alpha 5 2.6301
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) 2.6301
CALHM3 calcium homeostasis modulator 3 2.6301
TMEM132D transmembrane protein 132D 2.6301
MYPOP Myb-related transcription factor, partner of profilin 2.6301
ARR3 arrestin 3, retinal (X-arrestin) 2.6301
C11ORF91 chromosome 11 open reading frame 91 2.6301
CLDN34 claudin 34 2.6301
PIP prolactin-induced protein 2.6301
NXNL1 nucleoredoxin-like 1 2.6301
DYDC1 DPY30 domain containing 1 2.6301
CTSE cathepsin E 2.6301
CARD9 caspase recruitment domain family, member 9 2.6301
PTPN7 protein tyrosine phosphatase, non-receptor type 7 2.6301
PSMA8 proteasome (prosome, macropain) subunit, alpha type, 8 2.6301
LRIG2 leucine-rich repeats and immunoglobulin-like domains 2 2.6301
IFNE interferon, epsilon 2.6301
TAS2R41 taste receptor, type 2, member 41 2.6301
GCSAML germinal center-associated, signaling and motility-like 2.6301
TTC24 tetratricopeptide repeat domain 24 2.6301
SLC17A1 solute carrier family 17 (organic anion transporter), member 1 2.6301
HLA-DQB2 major histocompatibility complex, class II, DQ beta 2 2.6301
GALNT5 polypeptide N-acetylgalactosaminyltransferase 5 2.6301
NLRP8 NLR family, pyrin domain containing 8 2.6301
IRX5 iroquois homeobox 5 2.6301
RNASE6 ribonuclease, RNase A family, k6 2.6301
ALDH8A1 aldehyde dehydrogenase 8 family, member A1 2.6301
ARGFX arginine-fifty homeobox 2.6301
CCDC166 coiled-coil domain containing 166 2.6301
TYR tyrosinase 2.6301
SERPINB7 serpin peptidase inhibitor, clade B (ovalbumin), member 7 2.6301
LPAR5 lysophosphatidic acid receptor 5 2.6301
CARNS1 carnosine synthase 1 2.6301
LHX2 LIM homeobox 2 2.6301
ITPKA inositol-trisphosphate 3-kinase A 2.6301
LAMP3 lysosomal-associated membrane protein 3 2.6301
CD8A CD8a molecule 2.6301
CLCNKA chloride channel, voltage-sensitive Ka 2.6301
FZD1 frizzled class receptor 1 2.6301
STMND1 stathmin domain containing 1 2.6301
NAP1L2 nucleosome assembly protein 1-like 2 2.61185
CKS2 CDC28 protein kinase regulatory subunit 2 2.58758
TMED6 transmembrane emp24 protein transport domain containing 6 2.54908
TCF19 transcription factor 19 2.52246
SF3B3 splicing factor 3b, subunit 3, 130kDa 2.4819
HACL1 2-hydroxyacyl-CoA lyase 1 2.46607
KCTD10 potassium channel tetramerization domain containing 10 2.46092
PTPN3 protein tyrosine phosphatase, non-receptor type 3 2.42924
UNKL unkempt family zinc finger-like 2.42466
MLF1 myeloid leukemia factor 1 2.38289
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 2.38289
PPP3CB protein phosphatase 3, catalytic subunit, beta isozyme 2.32708
UTP20 UTP20, small subunit (SSU) processome component, homolog (yeast) 2.30892
COL9A1 collagen, type IX, alpha 1 2.30132
CCM2L cerebral cavernous malformation 2-like 2.29527
TCHP trichoplein, keratin filament binding 2.29247
UGDH UDP-glucose 6-dehydrogenase 2.29247
SIMC1 SUMO-interacting motifs containing 1 2.29161
H4C16 H4 histone 16 2.28649
ELAPOR2 endosome-lysosome associated apoptosis and autophagy regulator family member 2 2.28649
MYH7B myosin, heavy chain 7B, cardiac muscle, beta 2.28342
ORM2 orosomucoid 2 2.28342
FAM186B family with sequence similarity 186, member B 2.28342
RANGAP1 Ran GTPase activating protein 1 2.28342
SIK2 salt-inducible kinase 2 2.26151
POLB polymerase (DNA directed), beta 2.25582
DPF1 D4, zinc and double PHD fingers family 1 2.22256
E4F1 E4F transcription factor 1 2.19687
MRPL57 mitochondrial ribosomal protein L57 2.19251
PMP22 peripheral myelin protein 22 2.18969
CMYA5 cardiomyopathy associated 5 2.17806
TMEM62 transmembrane protein 62 2.16642
ZNF823 zinc finger protein 823 2.15816
TRIM3 tripartite motif containing 3 2.13651
TMED2 transmembrane emp24 domain trafficking protein 2 2.1297
OTUD5 OTU deubiquitinase 5 2.11933
KDM1B lysine (K)-specific demethylase 1B 2.09569
CHST14 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 14 2.09569
TRIM2 tripartite motif containing 2 2.09569
GSR glutathione reductase 2.09216
TPD52L1 tumor protein D52-like 1 2.08552
DCAF12 DDB1 and CUL4 associated factor 12 2.08552
NEURL4 neuralized E3 ubiquitin protein ligase 4 2.08552
ABHD17B abhydrolase domain containing 17B 2.07008
CREM cAMP responsive element modulator 2.03661
FAH fumarylacetoacetate hydrolase (fumarylacetoacetase) 2.03449

decreased expression

Symbol Name Standardized Value
EGFL6 EGF-like-domain, multiple 6 -2.6301
LIPH lipase, member H -2.6301
DPH6 diphthamine biosynthesis 6 -2.6301
GM2A GM2 ganglioside activator -2.6301
DEFB134 defensin, beta 134 -2.6301
C5AR1 complement component 5a receptor 1 -2.6301
AK1 adenylate kinase 1 -2.6301
TMEM150B transmembrane protein 150B -2.6301
SERPIND1 serpin peptidase inhibitor, clade D (heparin cofactor), member 1 -2.6301
SMYD1 SET and MYND domain containing 1 -2.6301
NGFR nerve growth factor receptor -2.6301
PRSS22 protease, serine, 22 -2.6301
VENTX VENT homeobox -2.6301
NXPH4 neurexophilin 4 -2.6301
SGPP2 sphingosine-1-phosphate phosphatase 2 -2.6301
ANKEF1 ankyrin repeat and EF-hand domain containing 1 -2.6301
FAM90A1 family with sequence similarity 90, member A1 -2.6301
ACTL10 actin-like 10 -2.6301
WNT9B wingless-type MMTV integration site family, member 9B -2.6301
B3GNT8 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8 -2.6301
RASD1 RAS, dexamethasone-induced 1 -2.6301
PRPS2 phosphoribosyl pyrophosphate synthetase 2 -2.6301
NPPC natriuretic peptide C -2.6301
E2F3 E2F transcription factor 3 -2.6301
CCL25 chemokine (C-C motif) ligand 25 -2.6301
HCK HCK proto-oncogene, Src family tyrosine kinase -2.6301
ADAM2 ADAM metallopeptidase domain 2 -2.6301
TIGD3 tigger transposable element derived 3 -2.6301
KASH5 KASH domain containing 5 -2.6301
AQP4 aquaporin 4 -2.6301
ETNPPL ethanolamine-phosphate phospho-lyase -2.6301
ANKRD53 ankyrin repeat domain 53 -2.6301
AWAT1 acyl-CoA wax alcohol acyltransferase 1 -2.6301
CFAP276 cilia and flagella associated protein 276 -2.6301
CFAP65 cilia and flagella associated protein 65 -2.6301
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32) -2.6301
PHF24 PHD finger protein 24 -2.6301
SELENOF selenoprotein F -2.6301
RAB33A RAB33A, member RAS oncogene family -2.6301
OXT oxytocin/neurophysin I prepropeptide -2.6301
SEMA6C sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C -2.58323
GGACT gamma-glutamylamine cyclotransferase -2.57963
CREG2 cellular repressor of E1A-stimulated genes 2 -2.57963
PKLR pyruvate kinase, liver and RBC -2.57963
COL6A6 collagen, type VI, alpha 6 -2.57963
FBLL1 fibrillarin-like 1 -2.56873
SHISAL2A shisa like 2A -2.45084
CFAP299 cilia and flagella associated protein 299 -2.45084
EOGT EGF domain-specific O-linked N-acetylglucosamine (GlcNAc) transferase -2.43937
PXDN peroxidasin -2.42466
UNC5D unc-5 homolog D (C. elegans) -2.42466
RNF185 ring finger protein 185 -2.38639
ARL5B ADP-ribosylation factor-like 5B -2.38196
ERLEC1 endoplasmic reticulum lectin 1 -2.35615
SHISA9 shisa family member 9 -2.33999
NFS1 NFS1 cysteine desulfurase -2.33819
CEP170B centrosomal protein 170B -2.31138
MPZL2 myelin protein zero-like 2 -2.31138
STAG3 stromal antigen 3 -2.29161
STRADB STE20-related kinase adaptor beta -2.28014
METTL1 methyltransferase like 1 -2.26094
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -2.2585
LDHB lactate dehydrogenase B -2.24562
MYRIP myosin VIIA and Rab interacting protein -2.24562
MANEA mannosidase, endo-alpha -2.24202
LRRTM4 leucine rich repeat transmembrane neuronal 4 -2.22227
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein -2.2166
C22ORF15 chromosome 22 open reading frame 15 -2.19528
RPL15 ribosomal protein L15 -2.18032
TMA16 translation machinery associated 16 homolog (S. cerevisiae) -2.17806
RPS25 ribosomal protein S25 -2.17036
SPOCK3 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3 -2.1552
DOCK5 dedicator of cytokinesis 5 -2.11998
NUAK1 NUAK family, SNF1-like kinase, 1 -2.11933
TAF8 TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 43kDa -2.11325
MAML3 mastermind-like 3 (Drosophila) -2.09238
LMNB1 lamin B1 -2.091
HCN3 hyperpolarization activated cyclic nucleotide gated potassium channel 3 -2.09059
RAMP2 receptor (G protein-coupled) activity modifying protein 2 -2.05693
ACAN aggrecan -2.04521
CLDN15 claudin 15 -2.04521
TMC8 transmembrane channel-like 8 -2.04521
TBX6 T-box 6 -2.04521
TRPV2 transient receptor potential cation channel, subfamily V, member 2 -2.04521
SFXN3 sideroflexin 3 -2.04521
RTN1 reticulon 1 -2.04357
ZNF280B zinc finger protein 280B -2.04069
FER1L5 fer-1-like family member 5 -2.03882
PRKCQ protein kinase C, theta -2.03515
DPM2 dolichyl-phosphate mannosyltransferase polypeptide 2, regulatory subunit -2.02282
ZNF28 zinc finger protein 28 -2.01859
MAGT1 magnesium transporter 1 -2.00896
RND2 Rho family GTPase 2 -2.00383
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) -2.00086