SH3D19 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description SH3 domain containing 19|This gene encodes a multiple SH3 domain-containing protein, which interacts with other proteins, such as EBP and members of ADAM family, via the SH3 domains. This protein may be involved in suppression of Ras-induced cellular transformation and Ras-mediated activation of ELK1 by EBP, and regulation of ADAM proteins in the signaling of EGFR-ligand shedding. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011] (NCBI Entrez Gene Database, 152503)
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Genes

367 genes differentially expressed following the SH3D19 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
LRRC36 leucine rich repeat containing 36 3.426
AANAT aralkylamine N-acetyltransferase 3.426
TNNC1 troponin C type 1 (slow) 3.426
ACTA2 actin, alpha 2, smooth muscle, aorta 3.426
FIMP1 fertilization-influencing membrane protein 1 3.426
SULT1C4 sulfotransferase family, cytosolic, 1C, member 4 3.426
CD160 CD160 molecule 3.426
PTGER1 prostaglandin E receptor 1 (subtype EP1), 42kDa 3.426
STAP1 signal transducing adaptor family member 1 3.426
PCDH12 protocadherin 12 3.426
SEC14L3 SEC14-like 3 (S. cerevisiae) 3.426
ARHGAP36 Rho GTPase activating protein 36 3.426
SCN10A sodium channel, voltage gated, type X alpha subunit 3.426
PRR15L proline rich 15-like 3.426
FNDC9 fibronectin type III domain containing 9 3.426
CCDC17 coiled-coil domain containing 17 3.426
CD53 CD53 molecule 3.426
ANGPTL3 angiopoietin-like 3 3.426
LOC112694756 uncharaterized LOC112694756 3.426
HBA2 hemoglobin, alpha 2 3.426
ASCL1 achaete-scute family bHLH transcription factor 1 3.426
SPMIP10 sperm microtubule inner protein 10 3.426
TSPAN19 tetraspanin 19 3.426
CORO6 coronin 6 3.426
CPLANE2 ciliogenesis and planar polarity effector complex subunit 2 3.426
H3C13 H3 clustered histone 13 3.426
GSTT2 glutathione S-transferase theta 2 (gene/pseudogene) 3.426
DNAH8 dynein, axonemal, heavy chain 8 3.426
C21ORF140 chromosome 21 open reading frame 140 3.426
THEMIS thymocyte selection associated 3.35436
NMUR2 neuromedin U receptor 2 3.35436
TDO2 tryptophan 2,3-dioxygenase 3.35436
RASA4B RAS p21 protein activator 4B 3.35436
EPPIN epididymal peptidase inhibitor 3.35436
DCAF4L1 DDB1 and CUL4 associated factor 4-like 1 3.35436
SKOR2 SKI family transcriptional corepressor 2 3.35436
SERPINA12 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12 3.35436
SLC46A2 solute carrier family 46, member 2 3.35436
IL22RA2 interleukin 22 receptor, alpha 2 3.35436
PRICKLE4 prickle homolog 4 (Drosophila) 3.35436
WNT3A wingless-type MMTV integration site family, member 3A 3.35436
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy 3.35436
OR51L1 olfactory receptor, family 51, subfamily L, member 1 3.35436
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2 3.35436
OR2AG1 olfactory receptor, family 2, subfamily AG, member 1 (gene/pseudogene) 3.35436
UCP3 uncoupling protein 3 (mitochondrial, proton carrier) 3.35436
NCCRP1 non-specific cytotoxic cell receptor protein 1 homolog (zebrafish) 3.35436
HBM hemoglobin, mu 3.35436
CCDC38 coiled-coil domain containing 38 3.35436
TAL2 T-cell acute lymphocytic leukemia 2 3.35436
C8ORF74 chromosome 8 open reading frame 74 3.35436
TAS2R19 taste receptor, type 2, member 19 3.35436
SPHK1 sphingosine kinase 1 3.35436
LCN12 lipocalin 12 3.35436
HMX1 H6 family homeobox 1 3.35436
PRAMEF20 PRAME family member 20 3.35436
POSTN periostin, osteoblast specific factor 3.35436
GYS2 glycogen synthase 2 (liver) 3.35436
KCNMB1 potassium channel subfamily M regulatory beta subunit 1 3.35436
LRG1 leucine-rich alpha-2-glycoprotein 1 3.35436
MSC musculin 3.35436
ATOH1 atonal homolog 1 (Drosophila) 3.35436
ACKR5 atypical chemokine receptor 5 3.35436
FYB1 FYN binding protein 1 3.35436
NECTIN4 nectin cell adhesion molecule 4 3.35436
ERVW-1 endogenous retrovirus group W, member 1 3.35436
ZNF726 zinc finger protein 726 3.35436
GPR35 G protein-coupled receptor 35 3.35436
SIM1 single-minded family bHLH transcription factor 1 3.35436
FRG2C FSHD region gene 2 family, member C 3.35436
PDC phosducin 3.35436
TMPRSS3 transmembrane protease, serine 3 3.35436
PLPP4 phospholipid phosphatase 4 3.35436
VXN vexin 3.35436
DUSP29 dual specificity phosphatase 29 3.35436
CSNK2A2IP casein kinase 2 subunit alpha' interacting protein 3.35436
NOTCH2NLC notch 2 N-terminal like C 3.35436
NHERF4 NHERF family PDZ scaffold protein 4 3.35436
DEFB109B defensin beta 109B 3.35436
CIMAP1D CIMAP1 family member D 3.35436
CTXND1 cortexin domain containing 1 3.35436
CALHM4 calcium homeostasis modulator family member 4 3.35436
GLYATL1B glycine-N-acyltransferase like 1B 3.35436
CPHXL cytoplasmic polyadenylated homeobox like 3.35436
FCMR Fc fragment of IgM receptor 3.35436
XKR3 XK, Kell blood group complex subunit-related family, member 3 3.35436
TSPAN8 tetraspanin 8 3.35436
PCDHA8 protocadherin alpha 8 3.35436
ACTL10 actin-like 10 3.35436
CBY2 chibby family member 2 3.35436
ACR acrosin 3.35436
SLFN11 schlafen family member 11 3.35436
CCKAR cholecystokinin A receptor 3.35436
SLC6A18 solute carrier family 6 (neutral amino acid transporter), member 18 3.35436
NYAP2 neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2 3.35436
NPPB natriuretic peptide B 3.35436
RHOXF2 Rhox homeobox family, member 2 3.35436
PTPRC protein tyrosine phosphatase, receptor type, C 3.35436
NXPE1 neurexophilin and PC-esterase domain family, member 1 3.35436
KL klotho 3.35436
LRRC73 leucine rich repeat containing 73 3.35436
C1QTNF9 C1q and tumor necrosis factor related protein 9 3.35436
MYH13 myosin, heavy chain 13, skeletal muscle 3.35436
OR9H1 olfactory receptor family 9 subfamily H member 1 pseudogene (gene/pseudogene) 3.35436
ZIC4 Zic family member 4 3.35436
CBLN3 cerebellin 3 precursor 3.35436
FCER2 Fc fragment of IgE, low affinity II, receptor for (CD23) 3.35436
TNFRSF14 tumor necrosis factor receptor superfamily, member 14 3.35436
IZUMO3 IZUMO family member 3 3.35436
NR4A3 nuclear receptor subfamily 4, group A, member 3 3.35436
RPA4 replication protein A4, 30kDa 3.35436
CTRB1 chymotrypsinogen B1 3.35436
BCO1 beta-carotene oxygenase 1 3.35436
MS4A8 membrane-spanning 4-domains, subfamily A, member 8 3.35436
ISL2 ISL LIM homeobox 2 3.35436
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1 3.35436
SLC22A24 solute carrier family 22, member 24 3.35436
THBD thrombomodulin 3.35436
PLA1A phospholipase A1 member A 3.35436
KLK15 kallikrein-related peptidase 15 3.35436
C16ORF78 chromosome 16 open reading frame 78 3.35436
SLC6A17 solute carrier family 6 (neutral amino acid transporter), member 17 3.35436
KLF1 Kruppel-like factor 1 (erythroid) 3.35436
LRCOL1 leucine rich colipase-like 1 3.35436
NPPA natriuretic peptide A 3.35436
GFI1B growth factor independent 1B transcription repressor 3.35436
BRDT bromodomain, testis-specific 3.35436
TCEA3 transcription elongation factor A (SII), 3 3.35436
SLC13A5 solute carrier family 13 (sodium-dependent citrate transporter), member 5 3.35436
CST1 cystatin SN 3.35436
POF1B premature ovarian failure, 1B 3.35436
ANKRD63 ankyrin repeat domain 63 3.35436
PRDM9 PR domain containing 9 3.35436
SLC31A2 solute carrier family 31 (copper transporter), member 2 3.35436
SLC38A8 solute carrier family 38, member 8 3.35436
CLEC4A C-type lectin domain family 4, member A 3.35436
MYLK2 myosin light chain kinase 2 3.35436
DEFB135 defensin, beta 135 3.35436
SERPINB7 serpin peptidase inhibitor, clade B (ovalbumin), member 7 3.35436
LAMB3 laminin, beta 3 3.35436
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal 3.35436
SLC36A2 solute carrier family 36 (proton/amino acid symporter), member 2 3.35436
FOXS1 forkhead box S1 3.35436
CTSW cathepsin W 3.35436
GPR61 G protein-coupled receptor 61 3.35436
SCNN1D sodium channel, non voltage gated 1 delta subunit 3.35436
EPGN epithelial mitogen 3.35436
SST somatostatin 3.35436
ZNF843 zinc finger protein 843 3.35436
RELN reelin 3.35436
SIRPG signal-regulatory protein gamma 3.35436
SAMD5 sterile alpha motif domain containing 5 3.35436
C8G complement component 8, gamma polypeptide 3.35436
CTXN2 cortexin 2 3.35436
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 3.35436
GSDMA gasdermin A 3.35436
NPAS4 neuronal PAS domain protein 4 3.35436
MC5R melanocortin 5 receptor 3.35436
PATE1 prostate and testis expressed 1 3.35436
ICAM4 intercellular adhesion molecule 4 (Landsteiner-Wiener blood group) 3.35436
RGR retinal G protein coupled receptor 3.35436
PLGLB1 plasminogen-like B1 3.35436
NUTM2B NUT family member 2B 3.35436
KIF12 kinesin family member 12 3.35436
SOX30 SRY (sex determining region Y)-box 30 3.35436
ADGRF1 adhesion G protein-coupled receptor F1 3.35436
SLITRK6 SLIT and NTRK-like family, member 6 3.35436
MMP12 matrix metallopeptidase 12 3.35436
PF4V1 platelet factor 4 variant 1 3.35436
TGM6 transglutaminase 6 3.35436
THEM5 thioesterase superfamily member 5 3.35436
RTN4RL1 reticulon 4 receptor-like 1 3.35436
APOL3 apolipoprotein L, 3 3.35436
TMIGD2 transmembrane and immunoglobulin domain containing 2 3.35436
LPAR5 lysophosphatidic acid receptor 5 3.35436
EMCN endomucin 3.35436
ACRBP acrosin binding protein 3.35436
OR3A1 olfactory receptor, family 3, subfamily A, member 1 3.35436
CCDC83 coiled-coil domain containing 83 3.35436
WFDC13 WAP four-disulfide core domain 13 3.35436
GALP galanin-like peptide 3.35436
CD33 CD33 molecule 3.35436
VPREB3 pre-B lymphocyte 3 3.35436
NEUROD4 neuronal differentiation 4 3.35436
PRSS55 protease, serine, 55 3.35436
OR1B1 olfactory receptor, family 1, subfamily B, member 1 (gene/pseudogene) 3.35436
RAB3IL1 RAB3A interacting protein (rabin3)-like 1 3.3123
SBK2 SH3 domain binding kinase family, member 2 3.3123
PLEKHN1 pleckstrin homology domain containing, family N member 1 3.3123
GLDN gliomedin 3.3123
DNAAF3 dynein, axonemal, assembly factor 3 3.3123
C1QL3 complement component 1, q subcomponent-like 3 3.24158
MRPS23 mitochondrial ribosomal protein S23 3.10275
IL1RAPL2 interleukin 1 receptor accessory protein-like 2 3.10175
SKA2 spindle and kinetochore associated complex subunit 2 3.04914
SMIM47 small integral membrane protein 47 2.99205
H4C1 H4 clustered histone 1 2.86539
SNX9 sorting nexin 9 2.79191
GPA33 glycoprotein A33 (transmembrane) 2.74685
HASPIN histone H3 associated protein kinase 2.69657
MUSTN1 musculoskeletal, embryonic nuclear protein 1 2.69657
DNAH10 dynein, axonemal, heavy chain 10 2.69657
PMP2 peripheral myelin protein 2 2.69657
GPX7 glutathione peroxidase 7 2.67245
OCRL oculocerebrorenal syndrome of Lowe 2.65103
CCDC191 coiled-coil domain containing 191 2.63529
IDS iduronate 2-sulfatase 2.62927
KIAA0040 KIAA0040 2.54453
BDH1 3-hydroxybutyrate dehydrogenase, type 1 2.48861
USP25 ubiquitin specific peptidase 25 2.47825
GPC6 glypican 6 2.42435
EPN1 epsin 1 2.41538
DLG2 discs, large homolog 2 (Drosophila) 2.41328
MOSPD1 motile sperm domain containing 1 2.38874
SELENOK selenoprotein K 2.37544
LIME1 Lck interacting transmembrane adaptor 1 2.37159
TLR5 toll-like receptor 5 2.37159
FAM186B family with sequence similarity 186, member B 2.37159
RAB9B RAB9B, member RAS oncogene family 2.37159
EHD2 EH-domain containing 2 2.32738
LGALS8 lectin, galactoside-binding, soluble, 8 2.32505
NSMAF neutral sphingomyelinase (N-SMase) activation associated factor 2.32397
SACK1D scaffolding CK1 anchoring protein D 2.31031
BORCS7 BLOC-1 related complex subunit 7 2.30226
OXR1 oxidation resistance 1 2.29309
ERCC6 excision repair cross-complementation group 6 2.2783
OXCT1 3-oxoacid CoA transferase 1 2.2659
ECD ecdysoneless homolog (Drosophila) 2.23726
MAK male germ cell-associated kinase 2.23676
SPIN2B spindlin family, member 2B 2.23351
FOXM1 forkhead box M1 2.23242
ROBO3 roundabout, axon guidance receptor, homolog 3 (Drosophila) 2.22839
AFAP1L2 actin filament associated protein 1-like 2 2.22839
DAAM2 dishevelled associated activator of morphogenesis 2 2.22103
GMFB glia maturation factor, beta 2.21876
VPS33B vacuolar protein sorting 33 homolog B (yeast) 2.21001
MISFA mitochondrial sheath formation associated 2.20834
LIFR leukemia inhibitory factor receptor alpha 2.20197
CDH18 cadherin 18, type 2 2.17623
SF3A3 splicing factor 3a, subunit 3, 60kDa 2.17001
TCF7L1 transcription factor 7-like 1 (T-cell specific, HMG-box) 2.16797
UBALD2 UBA-like domain containing 2 2.15986
RBM42 RNA binding motif protein 42 2.1256
MALRD1 MAM and LDL receptor class A domain containing 1 2.10767
ARL8B ADP-ribosylation factor-like 8B 2.10743
RGMA repulsive guidance molecule family member a 2.09938
CGREF1 cell growth regulator with EF-hand domain 1 2.09471
ADH4 alcohol dehydrogenase 4 (class II), pi polypeptide 2.09471
THOC2 THO complex 2 2.08725
TMEM11 transmembrane protein 11 2.08725
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2 2.0838
NOTCH2 notch 2 2.0531
ZNG1A Zn regulated GTPase metalloprotein activator 1A 2.0531
E4F1 E4F transcription factor 1 2.05046
VASH1 vasohibin 1 2.0446
ZNG1C Zn regulated GTPase metalloprotein activator 1C 2.0446
DRAM1 DNA-damage regulated autophagy modulator 1 2.03415
CCAR2 cell cycle and apoptosis regulator 2 2.02407

decreased expression

Symbol Name Standardized Value
CFD complement factor D (adipsin) -3.426
ADAMTSL4 ADAMTS-like 4 -3.426
SH3D19 SH3 domain containing 19 -3.426
SKIDA1 SKI/DACH domain containing 1 -3.38628
STKLD1 serine/threonine kinase-like domain containing 1 -3.38628
CLDN1 claudin 1 -3.38628
SERAC1 serine active site containing 1 -3.35436
LARP1B La ribonucleoprotein domain family, member 1B -3.35436
ELF1 E74-like factor 1 (ets domain transcription factor) -3.35436
SLU7 SLU7 splicing factor homolog (S. cerevisiae) -3.35436
ALAS1 5'-aminolevulinate synthase 1 -3.33138
CHRND cholinergic receptor, nicotinic, delta (muscle) -3.3123
ETNPPL ethanolamine-phosphate phospho-lyase -3.3123
HHEX hematopoietically expressed homeobox -3.3123
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta -3.3123
ERICH6B glutamate-rich 6B -3.3123
CCDC152 coiled-coil domain containing 152 -3.3123
ERAP2 endoplasmic reticulum aminopeptidase 2 -3.3123
GAD1 glutamate decarboxylase 1 (brain, 67kDa) -3.3123
NPIPA2 nuclear pore complex interacting protein family, member A2 -3.3123
TPH1 tryptophan hydroxylase 1 -3.3123
F7 coagulation factor VII (serum prothrombin conversion accelerator) -3.3123
SLC39A4 solute carrier family 39 (zinc transporter), member 4 -3.3123
PAX5 paired box 5 -3.3123
DUSP10 dual specificity phosphatase 10 -3.3123
NACAD NAC alpha domain containing -3.3123
LTBP2 latent transforming growth factor beta binding protein 2 -3.3123
LRRK2 leucine-rich repeat kinase 2 -3.3123
TMEM196 transmembrane protein 196 -3.3123
POM121L2 POM121 transmembrane nucleoporin-like 2 -3.3123
ADCY4 adenylate cyclase 4 -3.3123
AHNAK2 AHNAK nucleoprotein 2 -3.3123
DNAI7 dynein axonemal intermediate chain 7 -3.3123
FKBP1C FK506 binding protein 1C -3.3123
ADRA2A adrenoceptor alpha 2A -3.3123
BHLHA15 basic helix-loop-helix family, member a15 -3.3123
GOLGA8N golgin A8 family, member N -3.3123
CATSPERT catsper channel auxiliary subunit tau -3.3123
FNDC11 fibronectin type III domain containing 11 -3.3123
REP15 RAB15 effector protein -3.3123
CCDC183 coiled-coil domain containing 183 -3.3123
HCK HCK proto-oncogene, Src family tyrosine kinase -3.3123
ERVFRD-1 endogenous retrovirus group FRD, member 1 -3.3123
SLC9A6 solute carrier family 9, subfamily A (NHE6, cation proton antiporter 6), member 6 -3.3123
CFAP52 cilia and flagella associated protein 52 -3.3123
TUBA4B tubulin, alpha 4b -3.3123
IMPG2 interphotoreceptor matrix proteoglycan 2 -3.3123
RASL11A RAS-like, family 11, member A -3.3123
IMPG1 interphotoreceptor matrix proteoglycan 1 -3.3123
SIGLEC15 sialic acid binding Ig-like lectin 15 -3.3123
TRPM6 transient receptor potential cation channel, subfamily M, member 6 -3.26085
STAMBP STAM binding protein -3.22437
TMEM184A transmembrane protein 184A -3.1857
HSPA12B heat shock 70kD protein 12B -3.1857
INPP5F inositol polyphosphate-5-phosphatase F -3.18275
THUMPD1 THUMP domain containing 1 -3.13224
PEBP4 phosphatidylethanolamine-binding protein 4 -3.11923
CDK6 cyclin-dependent kinase 6 -2.87022
IQCC IQ motif containing C -2.82826
CDHR1 cadherin-related family member 1 -2.82826
HMBS hydroxymethylbilane synthase -2.71225
PSMD12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 -2.67006
MBIP MAP3K12 binding inhibitory protein 1 -2.63426
FUNDC1 FUN14 domain containing 1 -2.62046
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta -2.60183
PPP1R26 protein phosphatase 1, regulatory subunit 26 -2.55932
SMC1B structural maintenance of chromosomes 1B -2.54453
COX6B2 cytochrome c oxidase subunit VIb polypeptide 2 (testis) -2.54453
ERVMER34-1 endogenous retrovirus group MER34, member 1 -2.49724
CCDC69 coiled-coil domain containing 69 -2.48903
GLO1 glyoxalase I -2.47468
DOCK11 dedicator of cytokinesis 11 -2.46932
ZNF687 zinc finger protein 687 -2.46218
SLCO2A1 solute carrier organic anion transporter family, member 2A1 -2.41437
UPK1A uroplakin 1A -2.41437
ATP12A ATPase, H+/K+ transporting, nongastric, alpha polypeptide -2.41437
XYLT2 xylosyltransferase II -2.37544
EFCAB8 EF-hand calcium binding domain 8 -2.3571
PRSS50 protease, serine, 50 -2.3571
ZNF143 zinc finger protein 143 -2.32397
NTHL1 nth endonuclease III-like 1 (E. coli) -2.31858
PARP9 poly (ADP-ribose) polymerase family, member 9 -2.31782
MCRIP2 MAPK regulated corepressor interacting protein 2 -2.28992
RALGAPB Ral GTPase activating protein, beta subunit (non-catalytic) -2.26488
CAMSAP1 calmodulin regulated spectrin-associated protein 1 -2.25578
CUL4B cullin 4B -2.25578
NLGN3 neuroligin 3 -2.23726
TTC17 tetratricopeptide repeat domain 17 -2.23676
TP53I11 tumor protein p53 inducible protein 11 -2.23351
LDHD lactate dehydrogenase D -2.2242
TENM1 teneurin transmembrane protein 1 -2.2242
FIP1L1 factor interacting with PAPOLA and CPSF1 -2.21001
SRSF2 serine/arginine-rich splicing factor 2 -2.20973
MMP11 matrix metallopeptidase 11 -2.20834
ACAP2 ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 -2.15018
MAGED1 melanoma antigen family D1 -2.12692
PYCARD PYD and CARD domain containing -2.1256
RUFY2 RUN and FYVE domain containing 2 -2.12278
DNPEP aspartyl aminopeptidase -2.11167
TSPYL5 TSPY-like 5 -2.10597
ZBTB40 zinc finger and BTB domain containing 40 -2.07687
GRINA glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding) -2.07051
EIF4H eukaryotic translation initiation factor 4H -2.05018
CDC23 cell division cycle 23 -2.03415
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -2.01905
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein -2.01536
ATP6V1E1 ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1 -2.01536
NKAIN2 Na+/K+ transporting ATPase interacting 2 -2.00531
EXOG endo/exonuclease (5'-3'), endonuclease G-like -2.0016