SHC1 Gene Set

Dataset Hub Proteins Protein-Protein Interactions
Category physical interactions
Type hub protein
Description SHC (Src homology 2 domain containing) transforming protein 1|This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms, p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011] (NCBI Entrez Gene Database, 6464)
External Link http://www.ncbi.nlm.nih.gov/gene/6464
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186 interacting proteins for hub protein SHC1 from the curated Hub Proteins Protein-Protein Interactions dataset.

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ACTG1 actin gamma 1
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ALK anaplastic lymphoma receptor tyrosine kinase
AMD1 adenosylmethionine decarboxylase 1
AP2A1 adaptor-related protein complex 2, alpha 1 subunit
AP2A2 adaptor-related protein complex 2, alpha 2 subunit
AP2B1 adaptor-related protein complex 2, beta 1 subunit
AP2M1 adaptor-related protein complex 2, mu 1 subunit
APP amyloid beta (A4) precursor protein
ARHGAP1 Rho GTPase activating protein 1
ARHGEF7 Rho guanine nucleotide exchange factor (GEF) 7
ARNTL aryl hydrocarbon receptor nuclear translocator-like
AXL AXL receptor tyrosine kinase
BCL3 B-cell CLL/lymphoma 3
BCR breakpoint cluster region
BLZF1 basic leucine zipper nuclear factor 1
BRSK1 BR serine/threonine kinase 1
CAD carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
CALCOCO2 calcium binding and coiled-coil domain 2
CALD1 caldesmon 1
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CD22 CD22 molecule
CD247 CD247 molecule
CD3E CD3e molecule, epsilon (CD3-TCR complex)
CD81 CD81 molecule
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDH5 cadherin 5, type 2 (vascular endothelium)
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CHN1 chimerin 1
CLPB ClpB homolog, mitochondrial AAA ATPase chaperonin
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like
CSF1R colony stimulating factor 1 receptor
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
CSF2RBP1 colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) pseudogene 1
CSF3R colony stimulating factor 3 receptor (granulocyte)
CSK c-src tyrosine kinase
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DDR1 discoidin domain receptor tyrosine kinase 1
DDR2 discoidin domain receptor tyrosine kinase 2
DNAJA2 DnaJ (Hsp40) homolog, subfamily A, member 2
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJC2 DnaJ (Hsp40) homolog, subfamily C, member 2
DNM2 dynamin 2
DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1)
DOK2 docking protein 2, 56kDa
EGFR epidermal growth factor receptor
ELN elastin
EPHA2 EPH receptor A2
EPOR erythropoietin receptor
EPS8 epidermal growth factor receptor pathway substrate 8
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
ERBB4 erb-b2 receptor tyrosine kinase 4
ESR1 estrogen receptor 1
FCGR1A Fc fragment of IgG, high affinity Ia, receptor (CD64)
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32)
FCGR3A Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
FGFR1 fibroblast growth factor receptor 1
FGFR2 fibroblast growth factor receptor 2
FLT1 fms-related tyrosine kinase 1
FLT3 fms-related tyrosine kinase 3
FLT4 fms-related tyrosine kinase 4
FOXO3 forkhead box O3
FYN FYN proto-oncogene, Src family tyrosine kinase
GAB1 GRB2-associated binding protein 1
GAB2 GRB2-associated binding protein 2
GH1 growth hormone 1
GHR growth hormone receptor
GRAP GRB2-related adaptor protein
GRAP2 GRB2-related adaptor protein 2
GRB2 growth factor receptor-bound protein 2
GRB7 growth factor receptor-bound protein 7
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HSPA4 heat shock 70kDa protein 4
IGF1R insulin-like growth factor 1 receptor
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
IL2 interleukin 2
IL2RB interleukin 2 receptor, beta
IL2RG interleukin 2 receptor, gamma
IL3RA interleukin 3 receptor, alpha (low affinity)
IL4R interleukin 4 receptor
IL6ST interleukin 6 signal transducer
INPP5D inositol polyphosphate-5-phosphatase, 145kDa
INPPL1 inositol polyphosphate phosphatase-like 1
INSR insulin receptor
IRS1 insulin receptor substrate 1
IRS2 insulin receptor substrate 2
IRS4 insulin receptor substrate 4
ITGAV integrin, alpha V
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
ITGB4 integrin, beta 4
ITGB7 integrin, beta 7
JAK2 Janus kinase 2
KDR kinase insert domain receptor
KLKB1 kallikrein B, plasma (Fletcher factor) 1
KRT18 keratin 18, type I
LCK LCK proto-oncogene, Src family tyrosine kinase
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
LRP1 low density lipoprotein receptor-related protein 1
LTK leukocyte receptor tyrosine kinase
LYN LYN proto-oncogene, Src family tyrosine kinase
MAP4K1 mitogen-activated protein kinase kinase kinase kinase 1
MAPK1 mitogen-activated protein kinase 1
MAPK10 mitogen-activated protein kinase 10
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MAPK8 mitogen-activated protein kinase 8
MAPK9 mitogen-activated protein kinase 9
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
MET MET proto-oncogene, receptor tyrosine kinase
MME membrane metallo-endopeptidase
MPL MPL proto-oncogene, thrombopoietin receptor
MST1R macrophage stimulating 1 receptor
MYO1C myosin IC
MYO1D myosin ID
NABP1 nucleic acid binding protein 1
NGFR nerve growth factor receptor
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NTRK1 neurotrophic tyrosine kinase, receptor, type 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NTRK3 neurotrophic tyrosine kinase, receptor, type 3
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDGFRB platelet-derived growth factor receptor, beta polypeptide
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
PLCG1 phospholipase C, gamma 1
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
PLSCR1 phospholipid scramblase 1
PPAP2B phosphatidic acid phosphatase type 2B
PPP1R9B protein phosphatase 1, regulatory subunit 9B
PPP2R5A protein phosphatase 2, regulatory subunit B', alpha
PRKCA protein kinase C, alpha
PRKCD protein kinase C, delta
PSTPIP2 proline-serine-threonine phosphatase interacting protein 2
PTK2 protein tyrosine kinase 2
PTK2B protein tyrosine kinase 2 beta
PTPN11 protein tyrosine phosphatase, non-receptor type 11
PTPN12 protein tyrosine phosphatase, non-receptor type 12
PTPN2 protein tyrosine phosphatase, non-receptor type 2
PTPN6 protein tyrosine phosphatase, non-receptor type 6
PTPRE protein tyrosine phosphatase, receptor type, E
RAPGEF1 Rap guanine nucleotide exchange factor (GEF) 1
RASA1 RAS p21 protein activator (GTPase activating protein) 1
RBP1 retinol binding protein 1, cellular
RET ret proto-oncogene
RFC1 replication factor C (activator 1) 1, 145kDa
SEC16A SEC16 homolog A (S. cerevisiae)
SH2B2 SH2B adaptor protein 2
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SHCBP1 SHC SH2-domain binding protein 1
SIRPA signal-regulatory protein alpha
SOS1 son of sevenless homolog 1 (Drosophila)
SOS2 son of sevenless homolog 2 (Drosophila)
SP1 Sp1 transcription factor
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1
SPTA1 spectrin, alpha, erythrocytic 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STAT5A signal transducer and activator of transcription 5A
STAT5B signal transducer and activator of transcription 5B
SYK spleen tyrosine kinase
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1
TEC tec protein tyrosine kinase
TEK TEK tyrosine kinase, endothelial
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast)
TOMM22 translocase of outer mitochondrial membrane 22 homolog (yeast)
TPR translocated promoter region, nuclear basket protein
TRIM21 tripartite motif containing 21
TRIM31 tripartite motif containing 31
TROVE2 TROVE domain family, member 2
UBASH3B ubiquitin associated and SH3 domain containing B
USP9X ubiquitin specific peptidase 9, X-linked
USP9Y ubiquitin specific peptidase 9, Y-linked
VAV1 vav 1 guanine nucleotide exchange factor
VAV3 vav 3 guanine nucleotide exchange factor
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa