| Dataset | LINCS L1000 CMAP CRISPR Knockout Consensus Signatures |
| Category | transcriptomics |
| Type | gene perturbation |
| Description | SHC (Src homology 2 domain containing) transforming protein 1|This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms, p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011] (NCBI Entrez Gene Database, 6464) |
| External Link | https://ncbi.nlm.nih.gov/gene/6464 |
| Similar Terms | |
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498 genes differentially expressed following the SHC1 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0208065 |
| ADM | adrenomedullin | 0.0109185 |
| ASS1 | argininosuccinate synthase 1 | 0.00970582 |
| EXT1 | exostosin glycosyltransferase 1 | 0.00918165 |
| GATA6 | GATA binding protein 6 | 0.00849183 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | 0.00828022 |
| STC2 | stanniocalcin 2 | 0.00771368 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | 0.00731577 |
| PTGER4 | prostaglandin E receptor 4 (subtype EP4) | 0.00714817 |
| TIMM22 | translocase of inner mitochondrial membrane 22 homolog (yeast) | 0.00710763 |
| GSTA1 | glutathione S-transferase alpha 1 | 0.00702405 |
| VTCN1 | V-set domain containing T cell activation inhibitor 1 | 0.00664666 |
| ZDHHC6 | zinc finger, DHHC-type containing 6 | 0.0065215 |
| ABLIM1 | actin binding LIM protein 1 | 0.00645703 |
| NDRG1 | N-myc downstream regulated 1 | 0.00622392 |
| GPNMB | glycoprotein (transmembrane) nmb | 0.00616323 |
| CCN3 | cellular communication network factor 3 | 0.00608167 |
| SPINK1 | serine peptidase inhibitor, Kazal type 1 | 0.00588918 |
| PCDH9 | protocadherin 9 | 0.00588203 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | 0.00572547 |
| ADAMTS5 | ADAM metallopeptidase with thrombospondin type 1 motif, 5 | 0.00564832 |
| ENPP2 | ectonucleotide pyrophosphatase/phosphodiesterase 2 | 0.00561649 |
| SNAI2 | snail family zinc finger 2 | 0.00560232 |
| PI3 | peptidase inhibitor 3, skin-derived | 0.00558078 |
| MID1 | midline 1 | 0.00555181 |
| IGFBP5 | insulin-like growth factor binding protein 5 | 0.00553718 |
| OXTR | oxytocin receptor | 0.00546941 |
| MXI1 | MAX interactor 1, dimerization protein | 0.00538325 |
| POLG2 | polymerase (DNA directed), gamma 2, accessory subunit | 0.00537974 |
| IFI27 | interferon, alpha-inducible protein 27 | 0.00531774 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.00531378 |
| CD14 | CD14 molecule | 0.00529624 |
| CADM1 | cell adhesion molecule 1 | 0.00526512 |
| RHOB | ras homolog family member B | 0.00523911 |
| UGT2B17 | UDP glucuronosyltransferase 2 family, polypeptide B17 | 0.00523671 |
| UBE2L6 | ubiquitin-conjugating enzyme E2L 6 | 0.00523512 |
| ZNF395 | zinc finger protein 395 | 0.005196 |
| RHOBTB3 | Rho-related BTB domain containing 3 | 0.00519452 |
| CTH | cystathionine gamma-lyase | 0.00519379 |
| TNFSF10 | tumor necrosis factor (ligand) superfamily, member 10 | 0.00517474 |
| HMOX1 | heme oxygenase 1 | 0.00513042 |
| PLEKHM1 | pleckstrin homology domain containing, family M (with RUN domain) member 1 | 0.00510684 |
| AKR1B10 | aldo-keto reductase family 1, member B10 (aldose reductase) | 0.00507029 |
| CAST | calpastatin | 0.00504112 |
| DNAJB2 | DnaJ (Hsp40) homolog, subfamily B, member 2 | 0.00502085 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.00500705 |
| INHBB | inhibin, beta B | 0.00498756 |
| CP | ceruloplasmin (ferroxidase) | 0.0049787 |
| COL5A1 | collagen, type V, alpha 1 | 0.00495726 |
| MCM2 | minichromosome maintenance complex component 2 | 0.00486516 |
| KCNK3 | potassium channel, two pore domain subfamily K, member 3 | 0.00483776 |
| GAB2 | GRB2-associated binding protein 2 | 0.00482227 |
| CASP7 | caspase 7, apoptosis-related cysteine peptidase | 0.0048071 |
| KIF5C | kinesin family member 5C | 0.00480195 |
| AMOTL2 | angiomotin like 2 | 0.00477386 |
| RND3 | Rho family GTPase 3 | 0.00473463 |
| JAM3 | junctional adhesion molecule 3 | 0.00470879 |
| RTP4 | receptor (chemosensory) transporter protein 4 | 0.00470315 |
| MYO6 | myosin VI | 0.00469595 |
| WDR45B | WD repeat domain 45B | 0.00468337 |
| SASH1 | SAM and SH3 domain containing 1 | 0.00465131 |
| SOX4 | SRY (sex determining region Y)-box 4 | 0.00464959 |
| PEG10 | paternally expressed 10 | 0.00463268 |
| SAT1 | spermidine/spermine N1-acetyltransferase 1 | 0.00462239 |
| LIMA1 | LIM domain and actin binding 1 | 0.00461978 |
| EFHD1 | EF-hand domain family, member D1 | 0.0046061 |
| ACKR3 | atypical chemokine receptor 3 | 0.00455528 |
| RRAGD | Ras-related GTP binding D | 0.00455051 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | 0.00453661 |
| C1S | complement component 1, s subcomponent | 0.00453034 |
| SYT17 | synaptotagmin XVII | 0.00452109 |
| PLAAT3 | phospholipase A and acyltransferase 3 | 0.00451915 |
| EDN1 | endothelin 1 | 0.00451779 |
| PALLD | palladin, cytoskeletal associated protein | 0.00448822 |
| COL5A2 | collagen, type V, alpha 2 | 0.00448679 |
| H3F3B | H3 histone, family 3B (H3.3B) | 0.00447214 |
| MYOF | myoferlin | 0.00446532 |
| RAB11FIP1 | RAB11 family interacting protein 1 (class I) | 0.00445456 |
| PODXL | podocalyxin-like | 0.00445137 |
| CARMIL1 | capping protein regulator and myosin 1 linker 1 | 0.00444997 |
| HLA-E | major histocompatibility complex, class I, E | 0.00444952 |
| ABCC5 | ATP-binding cassette, sub-family C (CFTR/MRP), member 5 | 0.00444623 |
| TRIM22 | tripartite motif containing 22 | 0.00443393 |
| EPB41L3 | erythrocyte membrane protein band 4.1-like 3 | 0.0044291 |
| NUPR1 | nuclear protein, transcriptional regulator, 1 | 0.00442557 |
| OSR2 | odd-skipped related transciption factor 2 | 0.004417 |
| ADIPOR2 | adiponectin receptor 2 | 0.00440083 |
| LYN | LYN proto-oncogene, Src family tyrosine kinase | 0.00439605 |
| FZD5 | frizzled class receptor 5 | 0.00438662 |
| SLC39A14 | solute carrier family 39 (zinc transporter), member 14 | 0.00438098 |
| PIEZO2 | piezo-type mechanosensitive ion channel component 2 | 0.00437249 |
| C10ORF10 | chromosome 10 open reading frame 10 | 0.00437213 |
| NEDD9 | neural precursor cell expressed, developmentally down-regulated 9 | 0.0043694 |
| AEBP1 | AE binding protein 1 | 0.0043606 |
| RNF167 | ring finger protein 167 | 0.004327 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.00432177 |
| DNMBP | dynamin binding protein | 0.00431923 |
| UBL3 | ubiquitin-like 3 | 0.00431526 |
| BRD2 | bromodomain containing 2 | 0.0043128 |
| C14ORF132 | chromosome 14 open reading frame 132 | 0.00431235 |
| ATF4 | activating transcription factor 4 | 0.00430548 |
| MAFB | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B | 0.00430447 |
| RARRES3 | retinoic acid receptor responder (tazarotene induced) 3 | 0.0043018 |
| CYP17A1 | cytochrome P450, family 17, subfamily A, polypeptide 1 | 0.0042928 |
| IFI44L | interferon-induced protein 44-like | 0.00429027 |
| PUF60 | poly-U binding splicing factor 60KDa | 0.00426363 |
| HPSE | heparanase | 0.00425846 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0042541 |
| MAGEA3 | melanoma antigen family A3 | 0.00424991 |
| UPK1B | uroplakin 1B | 0.00424971 |
| KRT23 | keratin 23, type I | 0.00424064 |
| DUOX2 | dual oxidase 2 | 0.00424036 |
| MMP1 | matrix metallopeptidase 1 | 0.00423239 |
| S100A10 | S100 calcium binding protein A10 | 0.00422901 |
| NCOA3 | nuclear receptor coactivator 3 | 0.0042211 |
| ARHGAP44 | Rho GTPase activating protein 44 | 0.00421224 |
| CEACAM7 | carcinoembryonic antigen-related cell adhesion molecule 7 | 0.00420958 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.00419638 |
| PHLPP1 | PH domain and leucine rich repeat protein phosphatase 1 | 0.00419308 |
| REG3A | regenerating islet-derived 3 alpha | 0.00418811 |
| PFKL | phosphofructokinase, liver | 0.00415996 |
| VLDLR | very low density lipoprotein receptor | 0.00414544 |
| CDK5RAP3 | CDK5 regulatory subunit associated protein 3 | 0.00414467 |
| PMEL | premelanosome protein | 0.00412488 |
| IRAG2 | inositol 1,4,5-triphosphate receptor associated 2 | 0.0041114 |
| RGS5 | regulator of G-protein signaling 5 | 0.00409994 |
| NCK1 | NCK adaptor protein 1 | 0.00408286 |
| RSRC2 | arginine/serine-rich coiled-coil 2 | 0.00406314 |
| CRISPLD2 | cysteine-rich secretory protein LCCL domain containing 2 | 0.00405339 |
| NOP53 | NOP53 ribosome biogenesis factor | 0.00403862 |
| KDM5D | lysine (K)-specific demethylase 5D | 0.00403762 |
| INSR | insulin receptor | 0.00403717 |
| PDGFA | platelet-derived growth factor alpha polypeptide | 0.00402276 |
| TAOK3 | TAO kinase 3 | 0.00401613 |
| C1QA | complement component 1, q subcomponent, A chain | 0.0040084 |
| CPA4 | carboxypeptidase A4 | 0.00399727 |
| MAPRE2 | microtubule-associated protein, RP/EB family, member 2 | 0.00399398 |
| RRAS2 | related RAS viral (r-ras) oncogene homolog 2 | 0.00397826 |
| MYO1D | myosin ID | 0.00397492 |
| MSX1 | msh homeobox 1 | 0.00397316 |
| KLF4 | Kruppel-like factor 4 (gut) | 0.00396322 |
| RNPS1 | RNA binding protein S1, serine-rich domain | 0.00396171 |
| PSMB9 | proteasome (prosome, macropain) subunit, beta type, 9 | 0.00394942 |
| USP18 | ubiquitin specific peptidase 18 | 0.00394228 |
| HSPA2 | heat shock 70kDa protein 2 | 0.00393734 |
| MIR22HG | MIR22 host gene | 0.00392431 |
| MED1 | mediator complex subunit 1 | 0.00392033 |
| ACSL1 | acyl-CoA synthetase long-chain family member 1 | 0.00391387 |
| SLC2A10 | solute carrier family 2 (facilitated glucose transporter), member 10 | 0.0039008 |
| CASP1 | caspase 1, apoptosis-related cysteine peptidase | 0.00389921 |
| CSRP2 | cysteine and glycine-rich protein 2 | 0.0038908 |
| ADH1B | alcohol dehydrogenase 1B (class I), beta polypeptide | 0.00388836 |
| ENAH | enabled homolog (Drosophila) | 0.00388794 |
| IER2 | immediate early response 2 | 0.00388661 |
| JMJD6 | jumonji domain containing 6 | 0.00388626 |
| DDIT3 | DNA-damage-inducible transcript 3 | 0.00387342 |
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | 0.00387212 |
| SEPTIN4 | septin 4 | 0.00386911 |
| MAP7 | microtubule-associated protein 7 | 0.00386894 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0038646 |
| FGFBP1 | fibroblast growth factor binding protein 1 | 0.00385021 |
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | 0.00384206 |
| KLF2 | Kruppel-like factor 2 | 0.00383772 |
| APOBEC3A | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A | 0.00383337 |
| TSC22D2 | TSC22 domain family, member 2 | 0.00383189 |
| CTSV | cathepsin V | 0.00382432 |
| NRCAM | neuronal cell adhesion molecule | 0.00381732 |
| CTBP2 | C-terminal binding protein 2 | 0.00381442 |
| LGALS3 | lectin, galactoside-binding, soluble, 3 | 0.00381144 |
| MYLIP | myosin regulatory light chain interacting protein | 0.00379307 |
| AHCYL1 | adenosylhomocysteinase-like 1 | 0.00379022 |
| H1-2 | H1.2 linker histone, cluster member | 0.00378194 |
| CYP1A1 | cytochrome P450, family 1, subfamily A, polypeptide 1 | 0.0037813 |
| TAGLN | transgelin | 0.00377984 |
| SLC7A7 | solute carrier family 7 (amino acid transporter light chain, y+L system), member 7 | 0.00377465 |
| CDR2L | cerebellar degeneration-related protein 2-like | 0.00377375 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.00375948 |
| PAX5 | paired box 5 | 0.00374684 |
| MMP10 | matrix metallopeptidase 10 | 0.00374459 |
| RRAGC | Ras-related GTP binding C | 0.0037444 |
| CALCOCO2 | calcium binding and coiled-coil domain 2 | 0.00373804 |
| VWF | von Willebrand factor | 0.00373256 |
| BLNK | B-cell linker | 0.00373139 |
| PPL | periplakin | 0.00373038 |
| CXCR4 | chemokine (C-X-C motif) receptor 4 | 0.00369095 |
| SERINC5 | serine incorporator 5 | 0.00368949 |
| TSPAN12 | tetraspanin 12 | 0.00368524 |
| GBP1 | guanylate binding protein 1, interferon-inducible | 0.00367653 |
| FGF9 | fibroblast growth factor 9 | 0.00367597 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.00366554 |
| SPINK4 | serine peptidase inhibitor, Kazal type 4 | 0.00366408 |
| COL4A1 | collagen, type IV, alpha 1 | 0.00366333 |
| GDF15 | growth differentiation factor 15 | 0.00366077 |
| IRF9 | interferon regulatory factor 9 | 0.00364723 |
| GADD45B | growth arrest and DNA-damage-inducible, beta | 0.0036371 |
| FADS3 | fatty acid desaturase 3 | 0.00363541 |
| MLANA | melan-A | 0.003633 |
| STX7 | syntaxin 7 | 0.0036321 |
| KLHL9 | kelch-like family member 9 | 0.00363151 |
| BPTF | bromodomain PHD finger transcription factor | 0.00362763 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.00361302 |
| CXCL10 | chemokine (C-X-C motif) ligand 10 | 0.00360741 |
| SYTL2 | synaptotagmin-like 2 | 0.00360636 |
| DAAM1 | dishevelled associated activator of morphogenesis 1 | 0.00360244 |
| CXADR | coxsackie virus and adenovirus receptor | 0.00359868 |
| KLF6 | Kruppel-like factor 6 | 0.0035951 |
| CLCA4 | chloride channel accessory 4 | 0.0035938 |
| GDPD3 | glycerophosphodiester phosphodiesterase domain containing 3 | 0.00359199 |
| EIF6 | eukaryotic translation initiation factor 6 | 0.00358939 |
| CDA | cytidine deaminase | 0.00358794 |
| TBX2 | T-box 2 | 0.00358611 |
| MYO5A | myosin VA (heavy chain 12, myoxin) | 0.00358513 |
| IFITM1 | interferon induced transmembrane protein 1 | 0.00358449 |
| GSE1 | Gse1 coiled-coil protein | 0.0035836 |
| MLXIP | MLX interacting protein | 0.00357536 |
| PPFIBP2 | PTPRF interacting protein, binding protein 2 (liprin beta 2) | 0.0035725 |
| CRABP2 | cellular retinoic acid binding protein 2 | 0.00357086 |
| EZR | ezrin | 0.00356162 |
| WNT4 | wingless-type MMTV integration site family, member 4 | 0.00354774 |
| LRRC32 | leucine rich repeat containing 32 | 0.00354555 |
| RELB | v-rel avian reticuloendotheliosis viral oncogene homolog B | 0.00354228 |
| USP7 | ubiquitin specific peptidase 7 (herpes virus-associated) | 0.00354156 |
| CBX1 | chromobox homolog 1 | 0.00353908 |
| MX1 | MX dynamin-like GTPase 1 | 0.00353458 |
| SERPING1 | serpin peptidase inhibitor, clade G (C1 inhibitor), member 1 | 0.00353118 |
| GBP2 | guanylate binding protein 2, interferon-inducible | 0.00352941 |
| SLC18A1 | solute carrier family 18 (vesicular monoamine transporter), member 1 | 0.00352787 |
| CTSA | cathepsin A | 0.00352235 |
| FNDC3B | fibronectin type III domain containing 3B | 0.00352065 |
| JUNB | jun B proto-oncogene | 0.00351988 |
| RXRA | retinoid X receptor, alpha | 0.00351855 |
| MAB21L1 | mab-21-like 1 (C. elegans) | 0.00351776 |
| COL11A1 | collagen, type XI, alpha 1 | 0.00351562 |
| TCF7L1 | transcription factor 7-like 1 (T-cell specific, HMG-box) | 0.00350751 |
| LRRC59 | leucine rich repeat containing 59 | 0.00350365 |
| JAG1 | jagged 1 | 0.00350272 |
| CNTN1 | contactin 1 | 0.00348986 |
| TRIOBP | TRIO and F-actin binding protein | 0.00348804 |
| DCLK1 | doublecortin-like kinase 1 | 0.00348266 |
| MARCH3 | membrane-associated ring finger (C3HC4) 3, E3 ubiquitin protein ligase | 0.00348246 |
| EPHB2 | EPH receptor B2 | 0.00348192 |
| WIPI1 | WD repeat domain, phosphoinositide interacting 1 | 0.00347261 |
| SMPDL3A | sphingomyelin phosphodiesterase, acid-like 3A | 0.00346925 |
| CNN3 | calponin 3, acidic | 0.00346524 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | 0.00346267 |
| PAWR | PRKC, apoptosis, WT1, regulator | 0.00345466 |
| ADGRE1 | adhesion G protein-coupled receptor E1 | 0.00345332 |
| RPL13A | ribosomal protein L13a | 0.00345314 |
| EIF2AK3 | eukaryotic translation initiation factor 2-alpha kinase 3 | 0.00345162 |
| Symbol | Name | Standardized Value |
|---|---|---|
| LYZ | lysozyme | -0.011905 |
| NT5E | 5'-nucleotidase, ecto (CD73) | -0.0109295 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.00935724 |
| CHI3L1 | chitinase 3-like 1 (cartilage glycoprotein-39) | -0.00883919 |
| ELK3 | ELK3, ETS-domain protein (SRF accessory protein 2) | -0.00827991 |
| HMGA1 | high mobility group AT-hook 1 | -0.00793463 |
| CHRDL1 | chordin-like 1 | -0.00792442 |
| TSPAN8 | tetraspanin 8 | -0.00774002 |
| DENND1B | DENN/MADD domain containing 1B | -0.00769715 |
| LCP1 | lymphocyte cytosolic protein 1 (L-plastin) | -0.00764157 |
| EIF5A | eukaryotic translation initiation factor 5A | -0.00734126 |
| AREG | amphiregulin | -0.00732694 |
| PDGFC | platelet derived growth factor C | -0.00727366 |
| AQP3 | aquaporin 3 (Gill blood group) | -0.00726952 |
| SLC1A1 | solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 | -0.00715405 |
| PCP4 | Purkinje cell protein 4 | -0.0070559 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.00700134 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.00657347 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.00654881 |
| COCH | cochlin | -0.00636339 |
| KIF14 | kinesin family member 14 | -0.00631646 |
| WIF1 | WNT inhibitory factor 1 | -0.00629078 |
| TSPAN13 | tetraspanin 13 | -0.00628604 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.00615811 |
| ZBTB18 | zinc finger and BTB domain containing 18 | -0.00605841 |
| SCG5 | secretogranin V | -0.00604788 |
| CRABP1 | cellular retinoic acid binding protein 1 | -0.00599578 |
| LBR | lamin B receptor | -0.00598954 |
| OPN3 | opsin 3 | -0.00598803 |
| CPVL | carboxypeptidase, vitellogenic-like | -0.00597814 |
| LMO3 | LIM domain only 3 (rhombotin-like 2) | -0.00589649 |
| AZGP1 | alpha-2-glycoprotein 1, zinc-binding | -0.00587183 |
| GPR183 | G protein-coupled receptor 183 | -0.00583486 |
| CST3 | cystatin C | -0.00580988 |
| MYBL1 | v-myb avian myeloblastosis viral oncogene homolog-like 1 | -0.00579976 |
| STEAP1 | six transmembrane epithelial antigen of the prostate 1 | -0.00579303 |
| CEP170 | centrosomal protein 170kDa | -0.00578763 |
| RAMP1 | receptor (G protein-coupled) activity modifying protein 1 | -0.00573546 |
| DNAJA3 | DnaJ (Hsp40) homolog, subfamily A, member 3 | -0.00573238 |
| NEFH | neurofilament, heavy polypeptide | -0.00572103 |
| CDC42 | cell division cycle 42 | -0.00567743 |
| HMG20B | high mobility group 20B | -0.00567195 |
| RFX5 | regulatory factor X, 5 (influences HLA class II expression) | -0.00565271 |
| NIBAN1 | niban apoptosis regulator 1 | -0.00561274 |
| SYNGR3 | synaptogyrin 3 | -0.00557398 |
| RELN | reelin | -0.0055688 |
| RGS1 | regulator of G-protein signaling 1 | -0.00556828 |
| MANSC1 | MANSC domain containing 1 | -0.00556239 |
| DNM1L | dynamin 1-like | -0.00554907 |
| TXNDC9 | thioredoxin domain containing 9 | -0.00549675 |
| FASN | fatty acid synthase | -0.0054854 |
| PLAUR | plasminogen activator, urokinase receptor | -0.00546397 |
| TSPAN1 | tetraspanin 1 | -0.00544791 |
| SPINT2 | serine peptidase inhibitor, Kunitz type, 2 | -0.00542434 |
| SNCA | synuclein, alpha (non A4 component of amyloid precursor) | -0.00540194 |
| IL7R | interleukin 7 receptor | -0.00539673 |
| CYTL1 | cytokine-like 1 | -0.00539531 |
| SMYD2 | SET and MYND domain containing 2 | -0.00533975 |
| KYNU | kynureninase | -0.00532143 |
| PENK | proenkephalin | -0.00528597 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | -0.00527819 |
| HOPX | HOP homeobox | -0.00526881 |
| SLC15A2 | solute carrier family 15 (oligopeptide transporter), member 2 | -0.00526728 |
| SLC30A1 | solute carrier family 30 (zinc transporter), member 1 | -0.00522895 |
| NPY1R | neuropeptide Y receptor Y1 | -0.00519417 |
| BAG3 | BCL2-associated athanogene 3 | -0.00517725 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0051756 |
| TPK1 | thiamin pyrophosphokinase 1 | -0.00515403 |
| NME4 | NME/NM23 nucleoside diphosphate kinase 4 | -0.00514437 |
| FZD10 | frizzled class receptor 10 | -0.0050822 |
| NQO1 | NAD(P)H dehydrogenase, quinone 1 | -0.00507577 |
| CYRIA | CYFIP related Rac1 interactor A | -0.00502361 |
| NELL2 | NEL-like 2 (chicken) | -0.00501294 |
| PLEKHO1 | pleckstrin homology domain containing, family O member 1 | -0.00500153 |
| ACAT2 | acetyl-CoA acetyltransferase 2 | -0.00498818 |
| KCNN4 | potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4 | -0.00498373 |
| PPA2 | pyrophosphatase (inorganic) 2 | -0.00493286 |
| PLK1 | polo-like kinase 1 | -0.00492757 |
| APOD | apolipoprotein D | -0.00491239 |
| GREM1 | gremlin 1, DAN family BMP antagonist | -0.00489334 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | -0.00485958 |
| SELENOW | selenoprotein W | -0.00484673 |
| RAB29 | RAB29, member RAS oncogene family | -0.00481736 |
| HSPA8 | heat shock 70kDa protein 8 | -0.0048096 |
| DESI1 | desumoylating isopeptidase 1 | -0.00478262 |
| TPBG | trophoblast glycoprotein | -0.00478068 |
| ANKS1B | ankyrin repeat and sterile alpha motif domain containing 1B | -0.00477504 |
| ATP1A2 | ATPase, Na+/K+ transporting, alpha 2 polypeptide | -0.00476869 |
| IL10RA | interleukin 10 receptor, alpha | -0.00475664 |
| MSR1 | macrophage scavenger receptor 1 | -0.00474387 |
| HMGB3 | high mobility group box 3 | -0.00473384 |
| CENPF | centromere protein F, 350/400kDa | -0.00472976 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | -0.00471664 |
| LTB | lymphotoxin beta (TNF superfamily, member 3) | -0.00471168 |
| RNF128 | ring finger protein 128, E3 ubiquitin protein ligase | -0.00470724 |
| CD200 | CD200 molecule | -0.00470557 |
| LY75 | lymphocyte antigen 75 | -0.00469843 |
| SVIL | supervillin | -0.00468152 |
| FN1 | fibronectin 1 | -0.00467519 |
| EPCAM | epithelial cell adhesion molecule | -0.00466357 |
| A2M | alpha-2-macroglobulin | -0.00463565 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.00461758 |
| C1ORF54 | chromosome 1 open reading frame 54 | -0.00460743 |
| FZD1 | frizzled class receptor 1 | -0.00459523 |
| APOC1 | apolipoprotein C-I | -0.00459352 |
| PDE2A | phosphodiesterase 2A, cGMP-stimulated | -0.00457374 |
| DES | desmin | -0.00456928 |
| TSPYL5 | TSPY-like 5 | -0.00455553 |
| SLC20A1 | solute carrier family 20 (phosphate transporter), member 1 | -0.00454571 |
| LAMP5 | lysosomal-associated membrane protein family, member 5 | -0.00451777 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.00449464 |
| HOMER1 | homer scaffolding protein 1 | -0.00449041 |
| CCL22 | chemokine (C-C motif) ligand 22 | -0.00447636 |
| HBB | hemoglobin, beta | -0.00447507 |
| C8ORF4 | chromosome 8 open reading frame 4 | -0.00446942 |
| TSNAX | translin-associated factor X | -0.00446899 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | -0.00446414 |
| RACGAP1 | Rac GTPase activating protein 1 | -0.00445629 |
| CNPY3 | canopy FGF signaling regulator 3 | -0.00444453 |
| GALNT7 | polypeptide N-acetylgalactosaminyltransferase 7 | -0.00444286 |
| NELL1 | NEL-like 1 (chicken) | -0.00444276 |
| PON2 | paraoxonase 2 | -0.00440289 |
| JCHAIN | joining chain of multimeric IgA and IgM | -0.00439226 |
| NMU | neuromedin U | -0.00438767 |
| MDFIC | MyoD family inhibitor domain containing | -0.00438048 |
| SORBS1 | sorbin and SH3 domain containing 1 | -0.00438021 |
| CDCP1 | CUB domain containing protein 1 | -0.00437254 |
| TADA2A | transcriptional adaptor 2A | -0.00434482 |
| DCK | deoxycytidine kinase | -0.00434071 |
| G3BP2 | GTPase activating protein (SH3 domain) binding protein 2 | -0.0043357 |
| PCOLCE | procollagen C-endopeptidase enhancer | -0.00433456 |
| SLITRK5 | SLIT and NTRK-like family, member 5 | -0.00432412 |
| ACVR1 | activin A receptor, type I | -0.00431908 |
| CASP2 | caspase 2, apoptosis-related cysteine peptidase | -0.00431897 |
| BAG2 | BCL2-associated athanogene 2 | -0.00431809 |
| CYBA | cytochrome b-245, alpha polypeptide | -0.00431202 |
| BCL11A | B-cell CLL/lymphoma 11A (zinc finger protein) | -0.00430425 |
| ITGA6 | integrin, alpha 6 | -0.00430183 |
| TM7SF3 | transmembrane 7 superfamily member 3 | -0.00430161 |
| AP1S1 | adaptor-related protein complex 1, sigma 1 subunit | -0.00429552 |
| ARID4A | AT rich interactive domain 4A (RBP1-like) | -0.00429384 |
| PLGRKT | plasminogen receptor, C-terminal lysine transmembrane protein | -0.00428771 |
| MAPK13 | mitogen-activated protein kinase 13 | -0.00428376 |
| AMH | anti-Mullerian hormone | -0.00426553 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.00426145 |
| SDC2 | syndecan 2 | -0.00424846 |
| SRGN | serglycin | -0.00424719 |
| SRPK1 | SRSF protein kinase 1 | -0.00424156 |
| GPSM2 | G-protein signaling modulator 2 | -0.00423865 |
| DOCK4 | dedicator of cytokinesis 4 | -0.00423474 |
| COBL | cordon-bleu WH2 repeat protein | -0.00421952 |
| MLF1 | myeloid leukemia factor 1 | -0.00421577 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.00421374 |
| CTPS1 | CTP synthase 1 | -0.00421108 |
| SMARCA2 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 | -0.00420987 |
| ADAM8 | ADAM metallopeptidase domain 8 | -0.004208 |
| CD52 | CD52 molecule | -0.00420741 |
| CDKN2C | cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) | -0.00420696 |
| SUCO | SUN domain containing ossification factor | -0.00420676 |
| CLIC2 | chloride intracellular channel 2 | -0.00420281 |
| COL14A1 | collagen, type XIV, alpha 1 | -0.00419965 |
| C1ORF56 | chromosome 1 open reading frame 56 | -0.00419617 |
| CNIH3 | cornichon family AMPA receptor auxiliary protein 3 | -0.00416376 |
| CACYBP | calcyclin binding protein | -0.00415294 |
| EDN3 | endothelin 3 | -0.0041484 |
| ATP5F1D | ATP synthase F1 subunit delta | -0.00414633 |
| NEK2 | NIMA-related kinase 2 | -0.00413274 |
| SELENBP1 | selenium binding protein 1 | -0.00413167 |
| UCHL5 | ubiquitin carboxyl-terminal hydrolase L5 | -0.00412709 |
| UQCR11 | ubiquinol-cytochrome c reductase, complex III subunit XI | -0.00411581 |
| DCSTAMP | dendrocyte expressed seven transmembrane protein | -0.00410624 |
| FABP4 | fatty acid binding protein 4, adipocyte | -0.00410603 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | -0.00409474 |
| KRT18 | keratin 18, type I | -0.00409207 |
| POLR2D | polymerase (RNA) II (DNA directed) polypeptide D | -0.00408775 |
| DCAF6 | DDB1 and CUL4 associated factor 6 | -0.0040833 |
| ATP2A2 | ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 | -0.00408132 |
| MS4A4A | membrane-spanning 4-domains, subfamily A, member 4A | -0.00407702 |
| OSBPL3 | oxysterol binding protein-like 3 | -0.00407388 |
| GRAMD1C | GRAM domain containing 1C | -0.00407098 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | -0.00406816 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -0.0040638 |
| AQP1 | aquaporin 1 (Colton blood group) | -0.00406013 |
| PRUNE1 | prune exopolyphosphatase 1 | -0.00405813 |
| DUSP22 | dual specificity phosphatase 22 | -0.00405587 |
| TMEM63A | transmembrane protein 63A | -0.00404322 |
| TACSTD2 | tumor-associated calcium signal transducer 2 | -0.00403052 |
| SERPINF1 | serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 | -0.00402065 |
| IL13RA2 | interleukin 13 receptor, alpha 2 | -0.00401646 |
| TIMM17B | translocase of inner mitochondrial membrane 17 homolog B (yeast) | -0.00401506 |
| KIF2A | kinesin heavy chain member 2A | -0.00400039 |
| PBX1 | pre-B-cell leukemia homeobox 1 | -0.00399779 |
| UCK2 | uridine-cytidine kinase 2 | -0.00399514 |
| BCL2A1 | BCL2-related protein A1 | -0.00397736 |
| IGF1 | insulin-like growth factor 1 (somatomedin C) | -0.00396127 |
| MSMO1 | methylsterol monooxygenase 1 | -0.00395733 |
| C3ORF14 | chromosome 3 open reading frame 14 | -0.00394711 |
| THYN1 | thymocyte nuclear protein 1 | -0.00394548 |
| EDEM3 | ER degradation enhancer, mannosidase alpha-like 3 | -0.00393491 |
| IL17RB | interleukin 17 receptor B | -0.00392636 |
| ZNF652 | zinc finger protein 652 | -0.00392248 |
| TOMM34 | translocase of outer mitochondrial membrane 34 | -0.00391952 |
| ANPEP | alanyl (membrane) aminopeptidase | -0.0039103 |
| FCER1A | Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide | -0.00390613 |
| SACS | sacsin molecular chaperone | -0.00389748 |
| ANP32E | acidic (leucine-rich) nuclear phosphoprotein 32 family, member E | -0.00389273 |
| SOX9 | SRY (sex determining region Y)-box 9 | -0.00388093 |
| SNUPN | snurportin 1 | -0.00387917 |
| HLA-DOB | major histocompatibility complex, class II, DO beta | -0.00387784 |
| C12ORF29 | chromosome 12 open reading frame 29 | -0.00386837 |
| MPZL2 | myelin protein zero-like 2 | -0.00386594 |
| PIGC | phosphatidylinositol glycan anchor biosynthesis, class C | -0.00385592 |
| PEG3 | paternally expressed 3 | -0.00385337 |
| CREM | cAMP responsive element modulator | -0.00385194 |
| CKS1B | CDC28 protein kinase regulatory subunit 1B | -0.00384882 |
| LAMP3 | lysosomal-associated membrane protein 3 | -0.00383545 |
| FAM20B | family with sequence similarity 20, member B | -0.0038317 |
| TNFAIP8 | tumor necrosis factor, alpha-induced protein 8 | -0.00383053 |
| CD96 | CD96 molecule | -0.00383052 |
| GPX7 | glutathione peroxidase 7 | -0.00382907 |
| ECH1 | enoyl CoA hydratase 1, peroxisomal | -0.00381771 |
| SQOR | sulfide quinone oxidoreductase | -0.00381608 |
| GCHFR | GTP cyclohydrolase I feedback regulator | -0.00381589 |
| SLA | Src-like-adaptor | -0.00381437 |
| SYNM | synemin, intermediate filament protein | -0.00381167 |
| CNIH1 | cornichon family AMPA receptor auxiliary protein 1 | -0.00381143 |
| GALC | galactosylceramidase | -0.00381075 |
| TNFAIP6 | tumor necrosis factor, alpha-induced protein 6 | -0.0038041 |
| UROD | uroporphyrinogen decarboxylase | -0.00380147 |
| PRSS21 | protease, serine, 21 (testisin) | -0.00378971 |
| SAP30 | Sin3A-associated protein, 30kDa | -0.00378684 |
| PRKAR1B | protein kinase, cAMP-dependent, regulatory, type I, beta | -0.00377986 |
| MUC5B | mucin 5B, oligomeric mucus/gel-forming | -0.00377974 |
| DEGS1 | delta(4)-desaturase, sphingolipid 1 | -0.00377603 |
| MRPL34 | mitochondrial ribosomal protein L34 | -0.00377471 |
| BCL11B | B-cell CLL/lymphoma 11B (zinc finger protein) | -0.00377348 |
| CCL15 | chemokine (C-C motif) ligand 15 | -0.00377227 |
| PERP | PERP, TP53 apoptosis effector | -0.0037674 |
| ALOX15B | arachidonate 15-lipoxygenase, type B | -0.00376402 |
| CSRP1 | cysteine and glycine-rich protein 1 | -0.00375715 |
| EHBP1L1 | EH domain binding protein 1-like 1 | -0.00375464 |
| KMO | kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) | -0.00375332 |
| PKIA | protein kinase (cAMP-dependent, catalytic) inhibitor alpha | -0.00375097 |
| EMILIN1 | elastin microfibril interfacer 1 | -0.00373919 |
| SLC43A3 | solute carrier family 43, member 3 | -0.00373198 |
| CRLF1 | cytokine receptor-like factor 1 | -0.00371454 |
| NRGN | neurogranin (protein kinase C substrate, RC3) | -0.00371146 |
| ENPP1 | ectonucleotide pyrophosphatase/phosphodiesterase 1 | -0.00371095 |
| SLC38A1 | solute carrier family 38, member 1 | -0.00370729 |
