SHH Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description sonic hedgehog|This gene encodes a protein that is instrumental in patterning the early embryo. It has been implicated as the key inductive signal in patterning of the ventral neural tube, the anterior-posterior limb axis, and the ventral somites. Of three human proteins showing sequence and functional similarity to the sonic hedgehog protein of Drosophila, this protein is the most similar. The protein is made as a precursor that is autocatalytically cleaved; the N-terminal portion is soluble and contains the signalling activity while the C-terminal portion is involved in precursor processing. More importantly, the C-terminal product covalently attaches a cholesterol moiety to the N-terminal product, restricting the N-terminal product to the cell surface and preventing it from freely diffusing throughout the developing embryo. Defects in this protein or in its signalling pathway are a cause of holoprosencephaly (HPE), a disorder in which the developing forebrain fails to correctly separate into right and left hemispheres. HPE is manifested by facial deformities. It is also thought that mutations in this gene or in its signalling pathway may be responsible for VACTERL syndrome, which is characterized by vertebral defects, anal atresia, tracheoesophageal fistula with esophageal atresia, radial and renal dysplasia, cardiac anomalies, and limb abnormalities. Additionally, mutations in a long range enhancer located approximately 1 megabase upstream of this gene disrupt limb patterning and can result in preaxial polydactyly. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 6469)
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Genes

351 genes differentially expressed following the SHH gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
SRPX2 sushi-repeat containing protein, X-linked 2 3.52199
NRAP nebulin-related anchoring protein 3.52199
ADTRP androgen-dependent TFPI-regulating protein 3.52199
DUSP10 dual specificity phosphatase 10 3.52199
SKOR2 SKI family transcriptional corepressor 2 3.52199
FETUB fetuin B 3.52199
C6ORF58 chromosome 6 open reading frame 58 3.52199
MANSC4 MANSC domain containing 4 3.52199
MUSK muscle, skeletal, receptor tyrosine kinase 3.52199
ABCG5 ATP-binding cassette, sub-family G (WHITE), member 5 3.52199
RRAD Ras-related associated with diabetes 3.52199
CD160 CD160 molecule 3.52199
TSGA13 testis specific, 13 3.52199
HLF hepatic leukemia factor 3.52199
HLX H2.0-like homeobox 3.52199
CST11 cystatin 11 3.52199
AGTR1 angiotensin II receptor, type 1 3.52199
LIPH lipase, member H 3.52199
SLC46A2 solute carrier family 46, member 2 3.52199
CD14 CD14 molecule 3.52199
IL22RA1 interleukin 22 receptor, alpha 1 3.52199
PRICKLE4 prickle homolog 4 (Drosophila) 3.52199
NOTUM notum pectinacetylesterase homolog (Drosophila) 3.52199
GNAT1 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1 3.52199
SPAG6 sperm associated antigen 6 3.52199
ERAP2 endoplasmic reticulum aminopeptidase 2 3.52199
PRSS22 protease, serine, 22 3.52199
NR2F2 nuclear receptor subfamily 2, group F, member 2 3.52199
ZC2HC1B zinc finger, C2HC-type containing 1B 3.52199
CD3E CD3e molecule, epsilon (CD3-TCR complex) 3.52199
ASCL2 achaete-scute family bHLH transcription factor 2 3.52199
CHRDL2 chordin-like 2 3.52199
SLX1A SLX1 structure-specific endonuclease subunit homolog A (S. cerevisiae) 3.52199
GAD1 glutamate decarboxylase 1 (brain, 67kDa) 3.52199
CFAP53 cilia and flagella associated protein 53 3.52199
SP6 Sp6 transcription factor 3.52199
LCN12 lipocalin 12 3.52199
C8ORF74 chromosome 8 open reading frame 74 3.52199
LGI1 leucine-rich, glioma inactivated 1 3.52199
GNRHR gonadotropin-releasing hormone receptor 3.52199
CRYGB crystallin, gamma B 3.52199
AVP arginine vasopressin 3.52199
BMP5 bone morphogenetic protein 5 3.52199
MYO1A myosin IA 3.52199
GALR3 galanin receptor 3 3.52199
ST18 suppression of tumorigenicity 18, zinc finger 3.52199
SPMIP10 sperm microtubule inner protein 10 3.52199
ST6GALNAC1 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 3.52199
VN1R1 vomeronasal 1 receptor 1 3.52199
SMLR1 small leucine-rich protein 1 3.52199
WDR64 WD repeat domain 64 3.52199
LY6K lymphocyte antigen 6 complex, locus K 3.52199
GATA6 GATA binding protein 6 3.52199
KL klotho 3.52199
PRDM7 PR domain containing 7 3.52199
SDR16C5 short chain dehydrogenase/reductase family 16C, member 5 3.52199
BGN biglycan 3.52199
GIPC3 GIPC PDZ domain containing family, member 3 3.52199
SEPTIN14 septin 14 3.52199
SPMIP9 sperm microtubule inner protein 9 3.52199
SPATA31H1 SPATA31 subfamily H member 1 3.52199
CPNE8-AS1 CPNE8 antisense RNA 1 3.52199
H4C15 H4 clustered histone 15 3.52199
CFAP299 cilia and flagella associated protein 299 3.52199
DIPK2B divergent protein kinase domain 2B 3.52199
GPRASP3 G protein-coupled receptor associated sorting protein family member 3 3.52199
ANGPTL8 angiopoietin like 8 3.52199
H2BC1 H2B clustered histone 1 3.52199
DLK2 delta-like 2 homolog (Drosophila) 3.52199
BEST1 bestrophin 1 3.52199
KCNG2 potassium channel, voltage gated modifier subfamily G, member 2 3.52199
CLDN9 claudin 9 3.52199
PTPRH protein tyrosine phosphatase, receptor type, H 3.52199
PRB4 proline-rich protein BstNI subfamily 4 3.52199
IL12RB1 interleukin 12 receptor, beta 1 3.52199
ELAVL4 ELAV like neuron-specific RNA binding protein 4 3.52199
HHEX hematopoietically expressed homeobox 3.52199
MS4A6E membrane-spanning 4-domains, subfamily A, member 6E 3.52199
NTRK1 neurotrophic tyrosine kinase, receptor, type 1 3.52199
C10ORF67 chromosome 10 open reading frame 67 3.52199
DMBX1 diencephalon/mesencephalon homeobox 1 3.52199
ZNF575 zinc finger protein 575 3.52199
BEST3 bestrophin 3 3.52199
GDF6 growth differentiation factor 6 3.52199
SHC4 SHC (Src homology 2 domain containing) family, member 4 3.52199
VCX3A variable charge, X-linked 3A 3.52199
SASH3 SAM and SH3 domain containing 3 3.52199
GLIPR1L2 GLI pathogenesis-related 1 like 2 3.52199
ATP2B3 ATPase, Ca++ transporting, plasma membrane 3 3.52199
EXOC3L1 exocyst complex component 3-like 1 3.52199
APOBEC4 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 4 (putative) 3.52199
PLVAP plasmalemma vesicle associated protein 3.52199
CCNO cyclin O 3.52199
STAB1 stabilin 1 3.52199
CRYBB3 crystallin, beta B3 3.52199
LRRIQ3 leucine-rich repeats and IQ motif containing 3 3.52199
GML glycosylphosphatidylinositol anchored molecule like 3.52199
ADAM7 ADAM metallopeptidase domain 7 3.52199
TPSB2 tryptase beta 2 (gene/pseudogene) 3.52199
FAM177B family with sequence similarity 177, member B 3.52199
ENTPD8 ectonucleoside triphosphate diphosphohydrolase 8 3.52199
NUPR1 nuclear protein, transcriptional regulator, 1 3.52199
P2RX1 purinergic receptor P2X, ligand gated ion channel, 1 3.52199
TSLP thymic stromal lymphopoietin 3.52199
TNN tenascin N 3.52199
RAD51AP2 RAD51 associated protein 2 3.52199
ALAS2 5'-aminolevulinate synthase 2 3.52199
VAX2 ventral anterior homeobox 2 3.52199
EBF3 early B-cell factor 3 3.52199
DNAJB13 DnaJ (Hsp40) homolog, subfamily B, member 13 3.52199
HAMP hepcidin antimicrobial peptide 3.52199
CNTF ciliary neurotrophic factor 3.52199
KCNA6 potassium channel, voltage gated shaker related subfamily A, member 6 3.52199
EDN3 endothelin 3 3.52199
LCNL1 lipocalin-like 1 3.52199
FBXO40 F-box protein 40 3.52199
EGR2 early growth response 2 3.52199
UTS2B urotensin 2B 3.52199
FAIM2 Fas apoptotic inhibitory molecule 2 3.52199
GPR146 G protein-coupled receptor 146 3.52199
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3 3.52199
CPN2 carboxypeptidase N, polypeptide 2 3.52199
DRC1 dynein regulatory complex subunit 1 3.52199
GOLGA8K golgin A8 family, member K 3.52199
GOLGA8Q golgin A8 family, member Q 3.52199
OR52N2 olfactory receptor, family 52, subfamily N, member 2 3.52199
SLC36A3 solute carrier family 36, member 3 3.52199
MYADML2 myeloid-associated differentiation marker-like 2 3.52199
SEL1L2 sel-1 suppressor of lin-12-like 2 (C. elegans) 3.52199
CTRB1 chymotrypsinogen B1 3.52199
SPATA31G1 SPATA31 subfamily G member 1 3.52199
PIDD1 p53-induced death domain protein 1 3.52199
SULT1E1 sulfotransferase family 1E, estrogen-preferring, member 1 3.52199
EPHA5 EPH receptor A5 3.52199
GFRAL GDNF family receptor alpha like 3.52199
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled 3.52199
SI sucrase-isomaltase (alpha-glucosidase) 3.52199
DLX3 distal-less homeobox 3 3.52199
SLC6A20 solute carrier family 6 (proline IMINO transporter), member 20 3.52199
SLC4A1 solute carrier family 4 (anion exchanger), member 1 (Diego blood group) 3.52199
PRSS54 protease, serine, 54 3.52199
CYP2W1 cytochrome P450, family 2, subfamily W, polypeptide 1 3.52199
DMBT1 deleted in malignant brain tumors 1 3.52199
TRIM29 tripartite motif containing 29 3.52199
AQP1 aquaporin 1 (Colton blood group) 3.52199
GALNT15 polypeptide N-acetylgalactosaminyltransferase 15 3.52199
ZNF534 zinc finger protein 534 3.52199
OR13A1 olfactory receptor, family 13, subfamily A, member 1 3.52199
FIGLA folliculogenesis specific basic helix-loop-helix 3.52199
ZMYND10 zinc finger, MYND-type containing 10 3.52199
POTEJ POTE ankyrin domain family, member J 3.52199
CLCA1 chloride channel accessory 1 3.52199
OR14A16 olfactory receptor, family 14, subfamily A, member 16 3.52199
CMPK2 cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial 3.52199
PLA2G4D phospholipase A2, group IVD (cytosolic) 3.52199
PRND prion protein 2 (dublet) 3.52199
MAEL maelstrom spermatogenic transposon silencer 3.52199
PDCD1 programmed cell death 1 3.52199
PPP1R42 protein phosphatase 1, regulatory subunit 42 3.43802
TMPRSS5 transmembrane protease, serine 5 3.43802
TMEM154 transmembrane protein 154 3.15282
IL17C interleukin 17C 3.08065
SHQ1 SHQ1, H/ACA ribonucleoprotein assembly factor 3.06086
TRMT44 tRNA methyltransferase 44 homolog (S. cerevisiae) 3.03392
BAAT bile acid CoA:amino acid N-acyltransferase 2.95791
GJD3 gap junction protein, delta 3, 31.9kDa 2.95791
PPM1G protein phosphatase, Mg2+/Mn2+ dependent, 1G 2.88552
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4 2.84841
PATJ PATJ crumbs cell polarity complex component 2.83297
ITGAV integrin, alpha V 2.72176
MRPS18A mitochondrial ribosomal protein S18A 2.72079
HAUS3 HAUS augmin-like complex, subunit 3 2.71628
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3 2.63802
CLPP caseinolytic mitochondrial matrix peptidase proteolytic subunit 2.624
CFAP144 cilia and flagella associated protein 144 2.5924
SLC37A2 solute carrier family 37 (glucose-6-phosphate transporter), member 2 2.5924
STAB2 stabilin 2 2.5924
ZBED6 zinc finger, BED-type containing 6 2.5924
SPHKAP SPHK1 interactor, AKAP domain containing 2.5924
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 2.5924
LBHD1 LBH domain containing 1 2.5924
NPB neuropeptide B 2.5924
APEX2 APEX nuclease (apurinic/apyrimidinic endonuclease) 2 2.55977
SGCZ sarcoglycan, zeta 2.47207
CEP95 centrosomal protein 95kDa 2.46246
LIMCH1 LIM and calponin homology domains 1 2.46076
OGFRL1 opioid growth factor receptor-like 1 2.43466
CCDC160 coiled-coil domain containing 160 2.43104
RPRM reprimo, TP53 dependent G2 arrest mediator candidate 2.42617
AGTPBP1 ATP/GTP binding protein 1 2.42617
CARNS1 carnosine synthase 1 2.40618
TMEM40 transmembrane protein 40 2.38948
AP2A1 adaptor-related protein complex 2, alpha 1 subunit 2.38948
CDIP1 cell death-inducing p53 target 1 2.38948
SNX7 sorting nexin 7 2.37856
HSPA2 heat shock 70kDa protein 2 2.36854
SLC10A1 solute carrier family 10 (sodium/bile acid cotransporter), member 1 2.36758
TUT7 terminal uridylyl transferase 7 2.31167
RNF5 ring finger protein 5, E3 ubiquitin protein ligase 2.28124
HPDL 4-hydroxyphenylpyruvate dioxygenase-like 2.28124
TMEM63A transmembrane protein 63A 2.26687
TSPAN12 tetraspanin 12 2.23917
TNRC6A trinucleotide repeat containing 6A 2.23479
INHBA inhibin, beta A 2.23344
SDAD1 SDA1 domain containing 1 2.23173
SLC30A9 solute carrier family 30 (zinc transporter), member 9 2.23122
CHST7 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 7 2.22304
ZFP90 ZFP90 zinc finger protein 2.20508
RALGAPB Ral GTPase activating protein, beta subunit (non-catalytic) 2.18124
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 2.16767
NECTIN1 nectin cell adhesion molecule 1 2.15199
LSMEM2 leucine-rich single-pass membrane protein 2 2.14855
TRAPPC9 trafficking protein particle complex 9 2.14044
RAD23B RAD23 homolog B (S. cerevisiae) 2.13244
RMDN1 regulator of microtubule dynamics 1 2.12618
HAL histidine ammonia-lyase 2.12378
RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4 2.11283
BTF3 basic transcription factor 3 2.1126
MDH2 malate dehydrogenase 2, NAD (mitochondrial) 2.09381
ZNF791 zinc finger protein 791 2.08941
MKRN2 makorin ring finger protein 2 2.07422
RBL1 retinoblastoma-like 1 2.07422
MAP3K8 mitogen-activated protein kinase kinase kinase 8 2.06479
MOB1B MOB kinase activator 1B 2.06479
PIAS3 protein inhibitor of activated STAT, 3 2.06296
H4C16 H4 histone 16 2.05653
EPM2A epilepsy, progressive myoclonus type 2A, Lafora disease (laforin) 2.04223
MAGEL2 melanoma antigen family L2 2.03302
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 2.02615

decreased expression

Symbol Name Standardized Value
UFSP1 UFM1-specific peptidase 1 (non-functional) -3.52199
OR6A2 olfactory receptor, family 6, subfamily A, member 2 -3.52199
FBXO6 F-box protein 6 -3.52199
NECAB1 N-terminal EF-hand calcium binding protein 1 -3.52199
OR2F1 olfactory receptor, family 2, subfamily F, member 1 (gene/pseudogene) -3.52199
ESRP1 epithelial splicing regulatory protein 1 -3.52199
GLIPR1L1 GLI pathogenesis-related 1 like 1 -3.52199
FAM133A family with sequence similarity 133, member A -3.52199
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -3.52199
MYEOV myeloma overexpressed -3.38561
MINAR2 membrane integral NOTCH2 associated receptor 2 -3.38561
TSC22D4 TSC22 domain family, member 4 -3.38561
ZNF98 zinc finger protein 98 -3.38561
PEAK3 PEAK family member 3 -3.38561
PHYHIPL phytanoyl-CoA 2-hydroxylase interacting protein-like -3.38561
GMNC geminin coiled-coil domain containing -3.38561
CNDP1 carnosine dipeptidase 1 (metallopeptidase M20 family) -3.38561
PCDHGA12 protocadherin gamma subfamily A, 12 -3.38561
NRSN1 neurensin 1 -3.38561
UNC13C unc-13 homolog C (C. elegans) -3.38561
GRAP2 GRB2-related adaptor protein 2 -3.38561
TICAM1 toll-like receptor adaptor molecule 1 -3.38561
APOL6 apolipoprotein L, 6 -3.38561
GABRA4 gamma-aminobutyric acid (GABA) A receptor, alpha 4 -3.38561
HES4 hes family bHLH transcription factor 4 -3.38561
ASB9 ankyrin repeat and SOCS box containing 9 -3.38561
TPTE transmembrane phosphatase with tensin homology -3.38561
THPO thrombopoietin -3.38561
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -3.38561
OR2A1 olfactory receptor, family 2, subfamily A, member 1 -3.38561
CAPN3 calpain 3, (p94) -3.38561
HRH1 histamine receptor H1 -3.38561
UPK3A uroplakin 3A -3.38561
CFAP74 cilia and flagella associated protein 74 -3.38561
CLDN14 claudin 14 -3.38561
SEPTIN6 septin 6 -3.38561
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) -3.38561
ZFP57 ZFP57 zinc finger protein -3.38561
FGF18 fibroblast growth factor 18 -3.38561
KLK14 kallikrein-related peptidase 14 -3.38561
CHST5 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5 -3.38561
ACSBG2 acyl-CoA synthetase bubblegum family member 2 -3.38561
KLK4 kallikrein-related peptidase 4 -3.38561
RRP9 ribosomal RNA processing 9, small subunit (SSU) processome component, homolog (yeast) -3.38561
OPRK1 opioid receptor, kappa 1 -3.38561
TCP10L t-complex 10-like -3.38561
TMEM255A transmembrane protein 255A -3.38561
ZDHHC11B zinc finger, DHHC-type containing 11B -3.38561
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type -3.38561
HSPA1L heat shock 70kDa protein 1-like -3.38561
DOC2B double C2-like domains, beta -3.38561
RUFY4 RUN and FYVE domain containing 4 -3.38561
DDX25 DEAD (Asp-Glu-Ala-Asp) box helicase 25 -3.30727
CHRM2 cholinergic receptor, muscarinic 2 -3.22851
TMEM121B transmembrane protein 121B -3.22851
GORASP2 golgi reassembly stacking protein 2, 55kDa -3.20729
RELT RELT tumor necrosis factor receptor -3.18053
AURKC aurora kinase C -3.12162
SLC35B3 solute carrier family 35 (adenosine 3'-phospho 5'-phosphosulfate transporter), member B3 -3.01061
NOCT nocturnin -2.97636
NONO non-POU domain containing, octamer-binding -2.95791
PRSS3 protease, serine, 3 -2.95791
SUPT16H suppressor of Ty 16 homolog (S. cerevisiae) -2.86908
ZNF354C zinc finger protein 354C -2.84741
SLC5A10 solute carrier family 5 (sodium/sugar cotransporter), member 10 -2.79806
MBLAC2 metallo-beta-lactamase domain containing 2 -2.78968
COLGALT2 collagen beta(1-O)galactosyltransferase 2 -2.77468
MARVELD3 MARVEL domain containing 3 -2.75661
RFTN1 raftlin, lipid raft linker 1 -2.74755
ZMIZ1 zinc finger, MIZ-type containing 1 -2.68787
CCT6A chaperonin containing TCP1, subunit 6A (zeta 1) -2.68787
TPD52L1 tumor protein D52-like 1 -2.67967
ZNF497 zinc finger protein 497 -2.67858
ANG angiogenin, ribonuclease, RNase A family, 5 -2.67858
GSN gelsolin -2.60649
TOP3A topoisomerase (DNA) III alpha -2.60401
NXN nucleoredoxin -2.53552
DCTD dCMP deaminase -2.53429
SLC7A14 solute carrier family 7, member 14 -2.51568
TM2D1 TM2 domain containing 1 -2.44362
DYNC1LI1 dynein, cytoplasmic 1, light intermediate chain 1 -2.43664
PARP8 poly (ADP-ribose) polymerase family, member 8 -2.43664
LIN7C lin-7 homolog C (C. elegans) -2.42617
SCUBE1 signal peptide, CUB domain, EGF-like 1 -2.41779
VSTM2B V-set and transmembrane domain containing 2B -2.41779
NCR3LG1 natural killer cell cytotoxicity receptor 3 ligand 1 -2.41779
ZDHHC4 zinc finger, DHHC-type containing 4 -2.37856
COTL1 coactosin-like F-actin binding protein 1 -2.36115
CDCA5 cell division cycle associated 5 -2.36039
CCDC12 coiled-coil domain containing 12 -2.30211
ITLN2 intelectin 2 -2.28925
LAT linker for activation of T cells -2.28925
EFNA1 ephrin-A1 -2.28925
ANXA11 annexin A11 -2.28535
STT3B STT3B, subunit of the oligosaccharyltransferase complex (catalytic) -2.2681
BICC1 BicC family RNA binding protein 1 -2.2188
APTX aprataxin -2.21692
CD276 CD276 molecule -2.20508
SLC25A38 solute carrier family 25, member 38 -2.18124
S1PR5 sphingosine-1-phosphate receptor 5 -2.18124
PDCL2 phosducin-like 2 -2.18124
AIFM1 apoptosis-inducing factor, mitochondrion-associated, 1 -2.18124
GABRB1 gamma-aminobutyric acid (GABA) A receptor, beta 1 -2.18124
FLT3 fms-related tyrosine kinase 3 -2.18124
TMEM60 transmembrane protein 60 -2.17191
FOXL2 forkhead box L2 -2.17191
TMEM229B transmembrane protein 229B -2.17191
SPNS1 spinster homolog 1 (Drosophila) -2.11394
PGBD1 piggyBac transposable element derived 1 -2.10732
ZNF555 zinc finger protein 555 -2.10729
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B -2.10251
GNPNAT1 glucosamine-phosphate N-acetyltransferase 1 -2.10236
EEIG1 estrogen-induced osteoclastogenesis regulator 1 -2.09713
CENPO centromere protein O -2.09381
PIWIL4 piwi-like RNA-mediated gene silencing 4 -2.08435
FYCO1 FYVE and coiled-coil domain containing 1 -2.07393
SNIP1 Smad nuclear interacting protein 1 -2.05931
IFFO1 intermediate filament family orphan 1 -2.05931
ACTR6 ARP6 actin-related protein 6 homolog (yeast) -2.05573
UNK unkempt family zinc finger -2.04223
TMEM268 transmembrane protein 268 -2.01799
ATP7B ATPase, Cu++ transporting, beta polypeptide -2.00996