SHOC2 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description soc-2 suppressor of clear homolog (C. elegans)|This gene encodes a protein that consists almost entirely of leucine-rich repeats, a domain implicated in protein-protein interactions. The protein may function as a scaffold linking RAS to downstream signal transducers in the RAS/ERK MAP kinase signaling cascade. Mutations in this gene have been associated with Noonan-like syndrome with loose anagen hair. [provided by RefSeq, May 2010] (NCBI Entrez Gene Database, 8036)
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Genes

365 genes differentially expressed following the SHOC2 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
IL15RA interleukin 15 receptor, alpha 2.94487
SPAM1 sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding) 2.94487
ADAM32 ADAM metallopeptidase domain 32 2.94487
CELF3 CUGBP, Elav-like family member 3 2.94487
TMEM176B transmembrane protein 176B 2.94487
TEX13B testis expressed 13B 2.94487
MUC1 mucin 1, cell surface associated 2.94487
TMEM151A transmembrane protein 151A 2.94487
HES7 hes family bHLH transcription factor 7 2.94487
PNMA5 paraneoplastic Ma antigen family member 5 2.94487
UPB1 ureidopropionase, beta 2.94487
CASP5 caspase 5, apoptosis-related cysteine peptidase 2.94487
ROBO4 roundabout, axon guidance receptor, homolog 4 (Drosophila) 2.94487
SLC26A4 solute carrier family 26 (anion exchanger), member 4 2.94487
OR2A1 olfactory receptor, family 2, subfamily A, member 1 2.94487
ELAVL4 ELAV like neuron-specific RNA binding protein 4 2.94487
ERAS ES cell expressed Ras 2.94487
OVGP1 oviductal glycoprotein 1, 120kDa 2.94487
PLVAP plasmalemma vesicle associated protein 2.94487
TSSK6 testis-specific serine kinase 6 2.94487
MYT1L myelin transcription factor 1-like 2.94487
RCOR1 REST corepressor 1 2.94487
CD7 CD7 molecule 2.94487
ALB albumin 2.94487
SLC26A7 solute carrier family 26 (anion exchanger), member 7 2.94487
TBX15 T-box 15 2.94487
FCGBP Fc fragment of IgG binding protein 2.94487
GLRA3 glycine receptor, alpha 3 2.94487
KCNE1 potassium channel, voltage gated subfamily E regulatory beta subunit 1 2.94487
TTLL8 tubulin tyrosine ligase-like family member 8 2.94487
TTLL9 tubulin tyrosine ligase-like family member 9 2.94487
CBY3 chibby homolog 3 (Drosophila) 2.94487
C8ORF74 chromosome 8 open reading frame 74 2.94487
SHE Src homology 2 domain containing E 2.94487
NT5E 5'-nucleotidase, ecto (CD73) 2.94487
BMP5 bone morphogenetic protein 5 2.94487
HMX2 H6 family homeobox 2 2.94487
C2ORF78 chromosome 2 open reading frame 78 2.94487
GUCY2D guanylate cyclase 2D, membrane (retina-specific) 2.94487
OXTR oxytocin receptor 2.94487
LRRC56 leucine rich repeat containing 56 2.94487
ARHGAP36 Rho GTPase activating protein 36 2.94487
COL16A1 collagen, type XVI, alpha 1 2.94487
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) 2.94487
MSC musculin 2.94487
TNC tenascin C 2.94487
FCRL5 Fc receptor-like 5 2.94487
MYOM2 myomesin 2 2.94487
PECAM1 platelet/endothelial cell adhesion molecule 1 2.94487
ARSA arylsulfatase A 2.94487
SFTPB surfactant protein B 2.94487
CSNK2A3 casein kinase 2, alpha 3 polypeptide 2.94487
PRB2 proline-rich protein BstNI subfamily 2 2.94487
SMIM39 small integral membrane protein 39 2.94487
MARCHF10 membrane associated ring-CH-type finger 10 2.94487
HJV hemojuvelin BMP co-receptor 2.94487
MISP3 MISP family member 3 2.94487
PNMA8B PNMA family member 8B 2.94487
GOLGA6L7 golgin A6 family like 7 2.94487
KY kyphoscoliosis peptidase 2.94487
PNLIPRP1 pancreatic lipase-related protein 1 2.94487
RHCE Rh blood group, CcEe antigens 2.94487
FMO1 flavin containing monooxygenase 1 2.94487
GIPR gastric inhibitory polypeptide receptor 2.94487
TRIM31 tripartite motif containing 31 2.94487
KASH5 KASH domain containing 5 2.94487
TEKTIP1 tektin bundle interacting protein 1 2.94487
CIMIP4 ciliary microtubule inner protein 4 2.94487
STRIT1 small transmembrane regulator of ion transport 1 2.94487
CIMAP1B ciliary microtubule associated protein 1B 2.94487
NPIPA6 nuclear pore complex interacting protein family, member A6 2.94487
ACP7 acid phosphatase 7, tartrate resistant (putative) 2.94487
OR52P1 olfactory receptor family 52 subfamily P member 1 (gene/pseudogene) 2.94487
MINDY4B MINDY family member 4B 2.94487
TMEM272 transmembrane protein 272 2.94487
DNAAF6 dynein axonemal assembly factor 6 2.94487
GSTT4 glutathione S-transferase theta 4 2.94487
DEFB131B defensin beta 131B 2.94487
OR1C1 olfactory receptor, family 1, subfamily C, member 1 2.94487
ASB4 ankyrin repeat and SOCS box containing 4 2.94487
MIA melanoma inhibitory activity 2.94487
LEF1 lymphoid enhancer-binding factor 1 2.94487
DMBX1 diencephalon/mesencephalon homeobox 1 2.94487
C1ORF162 chromosome 1 open reading frame 162 2.94487
TACSTD2 tumor-associated calcium signal transducer 2 2.94487
CACNA1S calcium channel, voltage-dependent, L type, alpha 1S subunit 2.94487
FAM43A family with sequence similarity 43, member A 2.94487
CLDN5 claudin 5 2.94487
CFAP99 cilia and flagella associated protein 99 2.94487
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 2.94487
RHOXF2 Rhox homeobox family, member 2 2.94487
SLC12A1 solute carrier family 12 (sodium/potassium/chloride transporter), member 1 2.94487
FOXI2 forkhead box I2 2.94487
TSPAN1 tetraspanin 1 2.94487
GATA3 GATA binding protein 3 2.94487
UGT2A1 UDP glucuronosyltransferase 2 family, polypeptide A1, complex locus 2.94487
LTF lactotransferrin 2.94487
DLK1 delta-like 1 homolog (Drosophila) 2.94487
SOAT2 sterol O-acyltransferase 2 2.94487
IL16 interleukin 16 2.94487
ARHGAP15 Rho GTPase activating protein 15 2.94487
PLB1 phospholipase B1 2.94487
GSC goosecoid homeobox 2.94487
CCR9 chemokine (C-C motif) receptor 9 2.94487
PRB3 proline-rich protein BstNI subfamily 3 2.94487
SLC7A9 solute carrier family 7 (amino acid transporter light chain, bo,+ system), member 9 2.94487
RAD21L1 RAD21-like 1 (S. pombe) 2.94487
DNAH12 dynein, axonemal, heavy chain 12 2.94487
KLHL6 kelch-like family member 6 2.94487
S100A14 S100 calcium binding protein A14 2.94487
NUTM1 NUT midline carcinoma, family member 1 2.94487
GCOM1 GRINL1A complex locus 1 2.94487
NOX3 NADPH oxidase 3 2.94487
TMEM61 transmembrane protein 61 2.94487
TMEM204 transmembrane protein 204 2.94487
PAGE4 P antigen family, member 4 (prostate associated) 2.94487
CLIC2 chloride intracellular channel 2 2.94487
KRTAP5-11 keratin associated protein 5-11 2.94487
CCDC152 coiled-coil domain containing 152 2.94487
TOPAZ1 testis and ovary specific PAZ domain containing 1 2.94487
PRSS53 protease, serine, 53 2.94487
PDCD1 programmed cell death 1 2.94487
SERPIND1 serpin peptidase inhibitor, clade D (heparin cofactor), member 1 2.94487
CPZ carboxypeptidase Z 2.94487
BMX BMX non-receptor tyrosine kinase 2.94487
TTBK1 tau tubulin kinase 1 2.94487
APOB apolipoprotein B 2.94487
PCDHGB5 protocadherin gamma subfamily B, 5 2.94487
PCDHGB1 protocadherin gamma subfamily B, 1 2.94487
SNX31 sorting nexin 31 2.94487
FIBIN fin bud initiation factor homolog (zebrafish) 2.94487
ROPN1L rhophilin associated tail protein 1-like 2.94487
PSG7 pregnancy specific beta-1-glycoprotein 7 (gene/pseudogene) 2.94487
CLEC1A C-type lectin domain family 1, member A 2.94487
HMGB4 high mobility group box 4 2.94487
SLC25A31 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 31 2.94487
ERVV-1 endogenous retrovirus group V, member 1 2.94487
OR8J1 olfactory receptor, family 8, subfamily J, member 1 2.94487
ESPNL espin-like 2.94487
RSPH9 radial spoke head 9 homolog (Chlamydomonas) 2.94487
C22ORF31 chromosome 22 open reading frame 31 2.94487
BHLHA15 basic helix-loop-helix family, member a15 2.94487
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1 2.94487
SDR42E2 short chain dehydrogenase/reductase family 42E, member 2 2.94487
PENK proenkephalin 2.94487
VWA7 von Willebrand factor A domain containing 7 2.94487
TIPE2 TNF alpha induced protein 8 like 2 2.94487
RAB40AL RAB40A, member RAS oncogene family-like 2.94487
PCDHA11 protocadherin alpha 11 2.94487
TTC16 tetratricopeptide repeat domain 16 2.94487
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) 2.94487
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 2.94487
TH tyrosine hydroxylase 2.94487
COL9A2 collagen, type IX, alpha 2 2.94487
NT5C1B 5'-nucleotidase, cytosolic IB 2.94487
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 2.94487
APOA5 apolipoprotein A-V 2.94487
GCM1 glial cells missing homolog 1 (Drosophila) 2.94487
ITPKA inositol-trisphosphate 3-kinase A 2.94487
ARGFX arginine-fifty homeobox 2.94487
ITPKC inositol-trisphosphate 3-kinase C 2.94487
GPRC5A G protein-coupled receptor, class C, group 5, member A 2.94487
MMP12 matrix metallopeptidase 12 2.94487
SLC51B solute carrier family 51, beta subunit 2.94487
RTN4RL1 reticulon 4 receptor-like 1 2.94487
ANXA8 annexin A8 2.94487
TRAF3 TNF receptor-associated factor 3 2.94487
OR5A2 olfactory receptor, family 5, subfamily A, member 2 2.94487
GRAPL GRB2-related adaptor protein-like 2.94487
DNAJB7 DnaJ (Hsp40) homolog, subfamily B, member 7 2.94487
TMEM45B transmembrane protein 45B 2.94487
LY6G5C lymphocyte antigen 6 complex, locus G5C 2.94487
RASGRF1 Ras protein-specific guanine nucleotide-releasing factor 1 2.94487
GLT6D1 glycosyltransferase 6 domain containing 1 2.94487
TBC1D26 TBC1 domain family, member 26 2.94487
LPAR5 lysophosphatidic acid receptor 5 2.94487
CROCC2 ciliary rootlet coiled-coil, rootletin family member 2 2.94487
PLXNA4 plexin A4 2.94487
APOA1 apolipoprotein A-I 2.94487
AMIGO3 adhesion molecule with Ig-like domain 3 2.94487
NUTM2G NUT family member 2G 2.94487
NFE2 nuclear factor, erythroid 2 2.94487
OR52A5 olfactory receptor, family 52, subfamily A, member 5 2.94487
GLB1L galactosidase, beta 1-like 2.94487
FAM161B family with sequence similarity 161, member B 2.94487
THEMIS thymocyte selection associated 2.94487
OXER1 oxoeicosanoid (OXE) receptor 1 2.94487
GLS2 glutaminase 2 (liver, mitochondrial) 2.85819
SLC6A11 solute carrier family 6 (neurotransmitter transporter), member 11 2.85819
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 2.78606
IL23A interleukin 23, alpha subunit p19 2.77475
CRIPTO3 cripto, EGF-CFC family member 3 2.77475
INSYN2B inhibitory synaptic factor family member 2B 2.77475
IL6R interleukin 6 receptor 2.64039
POLR1E polymerase (RNA) I polypeptide E, 53kDa 2.63114
PLN phospholamban 2.60038
CLTCL1 clathrin, heavy chain-like 1 2.55473
CCN1 cellular communication network factor 1 2.52684
ANKFN1 ankyrin-repeat and fibronectin type III domain containing 1 2.50703
KCNC2 potassium channel, voltage gated Shaw related subfamily C, member 2 2.50369
SLC39A13 solute carrier family 39 (zinc transporter), member 13 2.45841
E2F1 E2F transcription factor 1 2.45011
LMNB2 lamin B2 2.45011
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6 2.44638
BTK Bruton agammaglobulinemia tyrosine kinase 2.41874
RNF216 ring finger protein 216 2.4166
NT5C3B 5'-nucleotidase, cytosolic IIIB 2.39978
HAX1 HCLS1 associated protein X-1 2.37209
TGIF1 TGFB-induced factor homeobox 1 2.36645
SLC4A9 solute carrier family 4, sodium bicarbonate cotransporter, member 9 2.35196
TRAPPC3 trafficking protein particle complex 3 2.34804
SUGP2 SURP and G patch domain containing 2 2.34324
FZD2 frizzled class receptor 2 2.34324
PDE5A phosphodiesterase 5A, cGMP-specific 2.30807
HEATR4 HEAT repeat containing 4 2.30385
ABTB3 ankyrin repeat and BTB domain containing 3 2.2687
KIF3A kinesin family member 3A 2.25115
GPR18 G protein-coupled receptor 18 2.24802
ZBTB24 zinc finger and BTB domain containing 24 2.23491
SCAMP1 secretory carrier membrane protein 1 2.20574
PPP6R3 protein phosphatase 6, regulatory subunit 3 2.15413
CACHD1 cache domain containing 1 2.15413
NCAPD2 non-SMC condensin I complex, subunit D2 2.15413
NUP85 nucleoporin 85kDa 2.13784
FAAP100 FA core complex associated protein 100 2.13022
MYCL v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog 2.12399
PRKCD protein kinase C, delta 2.11977
HIGD2A HIG1 hypoxia inducible domain family, member 2A 2.10668
DENND1A DENN/MADD domain containing 1A 2.09669
SLC44A2 solute carrier family 44 (choline transporter), member 2 2.09298
RPS11 ribosomal protein S11 2.08434
CFD complement factor D (adipsin) 2.07342
MFHAS1 malignant fibrous histiocytoma amplified sequence 1 2.06954
FAM53C family with sequence similarity 53, member C 2.06903
EIF4H eukaryotic translation initiation factor 4H 2.05528
KLHL36 kelch-like family member 36 2.05419
TIA1 TIA1 cytotoxic granule-associated RNA binding protein 2.05419
TWNK twinkle mtDNA helicase 2.04431
CCPG1 cell cycle progression 1 2.01149

decreased expression

Symbol Name Standardized Value
PRSS35 protease, serine, 35 -2.94487
LRRTM1 leucine rich repeat transmembrane neuronal 1 -2.94487
CYP4Z1 cytochrome P450, family 4, subfamily Z, polypeptide 1 -2.94487
TIMP4 TIMP metallopeptidase inhibitor 4 -2.94487
ABCC6 ATP-binding cassette, sub-family C (CFTR/MRP), member 6 -2.94487
TMEM144 transmembrane protein 144 -2.94487
FRS3 fibroblast growth factor receptor substrate 3 -2.94487
KPNA7 karyopherin alpha 7 (importin alpha 8) -2.94487
TAS2R30 taste receptor, type 2, member 30 -2.94487
GNG3 guanine nucleotide binding protein (G protein), gamma 3 -2.94487
OR3A2 olfactory receptor, family 3, subfamily A, member 2 -2.94487
DCDC2 doublecortin domain containing 2 -2.94487
SKAP1 src kinase associated phosphoprotein 1 -2.94487
DNAI2 dynein, axonemal, intermediate chain 2 -2.94487
LONP2 lon peptidase 2, peroxisomal -2.94487
FOXJ1 forkhead box J1 -2.94487
LRRIQ4 leucine-rich repeats and IQ motif containing 4 -2.94487
RET ret proto-oncogene -2.94487
FBXO3 F-box protein 3 -2.94487
ENGASE endo-beta-N-acetylglucosaminidase -2.94487
OLFM3 olfactomedin 3 -2.94487
PBX3 pre-B-cell leukemia homeobox 3 -2.94487
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4 -2.94487
SSH1 slingshot protein phosphatase 1 -2.94487
GALC galactosylceramidase -2.94487
IFI27 interferon, alpha-inducible protein 27 -2.94487
IL17D interleukin 17D -2.94487
EFEMP2 EGF containing fibulin-like extracellular matrix protein 2 -2.94487
PRMT7 protein arginine methyltransferase 7 -2.94487
MAP3K4-AS1 MAP3K4 antisense RNA 1 -2.94487
CCL28 chemokine (C-C motif) ligand 28 -2.94487
STARD8 StAR-related lipid transfer (START) domain containing 8 -2.94487
CSAG3 CSAG family, member 3 -2.94487
DENND1C DENN/MADD domain containing 1C -2.94487
TFF3 trefoil factor 3 (intestinal) -2.94487
TTC21B tetratricopeptide repeat domain 21B -2.94487
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1 -2.94487
VWF von Willebrand factor -2.94487
FDXACB1 ferredoxin-fold anticodon binding domain containing 1 -2.94487
UCMA upper zone of growth plate and cartilage matrix associated -2.94487
ADCY6 adenylate cyclase 6 -2.94487
DUSP29 dual specificity phosphatase 29 -2.94487
SBSPON somatomedin B and thrombospondin, type 1 domain containing -2.94487
RASGRP3 RAS guanyl releasing protein 3 (calcium and DAG-regulated) -2.94487
PCDHGB7 protocadherin gamma subfamily B, 7 -2.94487
TAGLN3 transgelin 3 -2.94487
ZNF540 zinc finger protein 540 -2.94487
TMEM233 transmembrane protein 233 -2.94487
CXCL14 chemokine (C-X-C motif) ligand 14 -2.94487
MPZL2 myelin protein zero-like 2 -2.94487
GANC glucosidase, alpha; neutral C -2.94487
MBD5 methyl-CpG binding domain protein 5 -2.94487
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -2.94487
NAP1L4 nucleosome assembly protein 1-like 4 -2.93447
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -2.83887
EPB41L2 erythrocyte membrane protein band 4.1-like 2 -2.83556
APBB1 amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65) -2.80176
OBSL1 obscurin-like 1 -2.79891
PEX11B peroxisomal biogenesis factor 11 beta -2.77781
EVA1B eva-1 homolog B (C. elegans) -2.77781
AGA aspartylglucosaminidase -2.71593
ATXN2 ataxin 2 -2.71482
SELENOI selenoprotein I -2.66891
SIAE sialic acid acetylesterase -2.64039
LSM11 LSM11, U7 small nuclear RNA associated -2.64039
RSPH14 radial spoke head 14 homolog (Chlamydomonas) -2.64039
TMEM200B transmembrane protein 200B -2.62168
KHDRBS2 KH domain containing, RNA binding, signal transduction associated 2 -2.61196
NUDT10 nudix (nucleoside diphosphate linked moiety X)-type motif 10 -2.60038
TOMM7 translocase of outer mitochondrial membrane 7 homolog (yeast) -2.45011
ZNF669 zinc finger protein 669 -2.43837
GOLPH3L golgi phosphoprotein 3-like -2.41875
CEBPZOS CEBPZ opposite strand -2.41875
BNC2 basonuclin 2 -2.40832
DDX24 DEAD (Asp-Glu-Ala-Asp) box helicase 24 -2.3955
SHOC2 soc-2 suppressor of clear homolog (C. elegans) -2.39278
CPT1A carnitine palmitoyltransferase 1A (liver) -2.38078
CAPRIN1 cell cycle associated protein 1 -2.37535
NEDD1 neural precursor cell expressed, developmentally down-regulated 1 -2.36026
CDKL2 cyclin-dependent kinase-like 2 (CDC2-related kinase) -2.35196
DR1 down-regulator of transcription 1, TBP-binding (negative cofactor 2) -2.34804
CIT citron rho-interacting serine/threonine kinase -2.34462
ANAPC10 anaphase promoting complex subunit 10 -2.34324
ATG9A autophagy related 9A -2.30444
TUT4 terminal uridylyl transferase 4 -2.30385
SPRYD4 SPRY domain containing 4 -2.29024
ASIP agouti signaling protein -2.2687
NIN ninein (GSK3B interacting protein) -2.26807
COMTD1 catechol-O-methyltransferase domain containing 1 -2.25246
ANXA5 annexin A5 -2.24406
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 -2.22429
ACADSB acyl-CoA dehydrogenase, short/branched chain -2.22164
ZNF718 zinc finger protein 718 -2.22164
NUDT13 nudix (nucleoside diphosphate linked moiety X)-type motif 13 -2.21569
SMPDL3B sphingomyelin phosphodiesterase, acid-like 3B -2.21569
NR5A2 nuclear receptor subfamily 5, group A, member 2 -2.21211
PAAF1 proteasomal ATPase-associated factor 1 -2.21211
RPL39 ribosomal protein L39 -2.20747
MTUS1 microtubule associated tumor suppressor 1 -2.19005
FADD Fas (TNFRSF6)-associated via death domain -2.19005
ADGRB1 adhesion G protein-coupled receptor B1 -2.1869
EDNRB endothelin receptor type B -2.18366
CEP20 centrosomal protein 20 -2.14416
PARP6 poly (ADP-ribose) polymerase family, member 6 -2.13018
MORN3 MORN repeat containing 3 -2.0994
MTCH2 mitochondrial carrier 2 -2.09593
TMEM183A transmembrane protein 183A -2.08878
ZC3H13 zinc finger CCCH-type containing 13 -2.08878
ZNF528 zinc finger protein 528 -2.08434
EFNB1 ephrin-B1 -2.08434
HDDC3 HD domain containing 3 -2.08434
ONECUT1 one cut homeobox 1 -2.08434
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1 -2.07342
CNNM3 cyclin and CBS domain divalent metal cation transport mediator 3 -2.0674
CIB2 calcium and integrin binding family member 2 -2.06137
COA5 cytochrome c oxidase assembly factor 5 -2.05528
RAB2A RAB2A, member RAS oncogene family -2.05528
CALML4 calmodulin-like 4 -2.05419
MID1 midline 1 -2.05095
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -2.03451
BAG2 BCL2-associated athanogene 2 -2.03178
TTPAL tocopherol (alpha) transfer protein-like -2.0202
TCF7L1 transcription factor 7-like 1 (T-cell specific, HMG-box) -2.01795
RBBP8 retinoblastoma binding protein 8 -2.00991
OTUD6B OTU domain containing 6B -2.00831
ANKRD36B ankyrin repeat domain 36B -2.00242