SHOX2 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description short stature homeobox 2|This gene is a member of the homeobox family of genes that encode proteins containing a 60-amino acid residue motif that represents a DNA binding domain. Homeobox genes have been characterized extensively as transcriptional regulators involved in pattern formation in both invertebrate and vertebrate species. Several human genetic disorders are caused by aberrations in human homeobox genes. This locus represents a pseudoautosomal homeobox gene that is thought to be responsible for idiopathic short stature, and it is implicated in the short stature phenotype of Turner syndrome patients. This gene is considered to be a candidate gene for Cornelia de Lange syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2009] (NCBI Entrez Gene Database, 6474)
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Genes

295 genes differentially expressed following the SHOX2 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
PRSS55 protease, serine, 55 3.167
POSTN periostin, osteoblast specific factor 3.167
REN renin 3.167
PLGLB1 plasminogen-like B1 3.167
UNC93A unc-93 homolog A (C. elegans) 3.167
TMIGD1 transmembrane and immunoglobulin domain containing 1 3.167
IL1A interleukin 1, alpha 3.167
INSRR insulin receptor-related receptor 3.167
CH25H cholesterol 25-hydroxylase 3.167
CLCNKB chloride channel, voltage-sensitive Kb 3.167
SPI1 Spi-1 proto-oncogene 3.167
SP100 SP100 nuclear antigen 3.167
CNTF ciliary neurotrophic factor 3.167
CT55 cancer/testis antigen 55 3.167
TMPRSS3 transmembrane protease, serine 3 3.167
MYL10 myosin, light chain 10, regulatory 3.167
OPN5 opsin 5 3.167
MYOCOS myocilin opposite strand 3.167
GDPD4 glycerophosphodiester phosphodiesterase domain containing 4 3.167
MMP26 matrix metallopeptidase 26 3.167
SYT5 synaptotagmin V 3.167
CD34 CD34 molecule 3.167
C11ORF42 chromosome 11 open reading frame 42 3.167
RPA4 replication protein A4, 30kDa 3.167
LRRC8C-DT LRRC8C divergent transcript 3.167
PRSS50 protease, serine, 50 3.167
FLACC1 flagellum associated containing coiled-coil domains 1 3.167
PCDHGB4 protocadherin gamma subfamily B, 4 3.167
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3) 3.167
PLCXD3 phosphatidylinositol-specific phospholipase C, X domain containing 3 3.167
MED26 mediator complex subunit 26 3.12585
ASB15 ankyrin repeat and SOCS box containing 15 3.01083
CDX2 caudal type homeobox 2 3.01083
HTR6 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled 3.01083
FAM153A family with sequence similarity 153, member A 3.01083
FAM187B family with sequence similarity 187, member B 3.01083
GATA3 GATA binding protein 3 3.01083
ZACN zinc activated ligand-gated ion channel 3.01083
SRMS src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites 3.01083
NYAP2 neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2 3.01083
OR8A1 olfactory receptor, family 8, subfamily A, member 1 3.01083
SCGB3A1 secretoglobin, family 3A, member 1 3.01083
GNG13 guanine nucleotide binding protein (G protein), gamma 13 3.01083
S100A1 S100 calcium binding protein A1 3.01083
NPIPA8 nuclear pore complex interacting protein family, member A8 3.01083
MUC20 mucin 20, cell surface associated 3.01083
CRYGA crystallin, gamma A 3.01083
LBX2 ladybird homeobox 2 3.01083
TM4SF20 transmembrane 4 L six family member 20 3.01083
GALR2 galanin receptor 2 3.01083
CD68 CD68 molecule 3.01083
KCNE1 potassium channel, voltage gated subfamily E regulatory beta subunit 1 3.01083
DIRAS2 DIRAS family, GTP-binding RAS-like 2 3.01083
TSGA13 testis specific, 13 3.01083
SSTR1 somatostatin receptor 1 3.01083
RRAD Ras-related associated with diabetes 3.01083
PDZD9 PDZ domain containing 9 3.01083
SCNN1G sodium channel, non voltage gated 1 gamma subunit 3.01083
PAX8 paired box 8 3.01083
LYVE1 lymphatic vessel endothelial hyaluronan receptor 1 3.01083
SSMEM1 serine-rich single-pass membrane protein 1 3.01083
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2 3.01083
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 3.01083
PANX3 pannexin 3 3.01083
SPATA46 spermatogenesis associated 46 3.01083
H1-6 H1.6 linker histone, cluster member 3.01083
SELP selectin P (granule membrane protein 140kDa, antigen CD62) 3.01083
PTH1R parathyroid hormone 1 receptor 3.01083
GBP4 guanylate binding protein 4 3.01083
YPEL4 yippee-like 4 (Drosophila) 3.01083
TYROBP TYRO protein tyrosine kinase binding protein 3.01083
CLDN16 claudin 16 3.01083
WDR97 WD repeat domain 97 3.01083
H2BC3 H2B clustered histone 3 3.01083
DRC5 dynein regulatory complex subunit 5 3.01083
H2BK1 H2B.K variant histone 1 3.01083
H4C12 H4 clustered histone 12 3.01083
C20ORF204 chromosome 20 open reading frame 204 3.01083
H4C14 H4 clustered histone 14 3.01083
MAJIN membrane anchored junction protein 3.01083
H2AC1 H2A clustered histone 1 3.01083
SPEM2 SPEM family member 2 3.01083
HBG2 hemoglobin, gamma G 3.01083
ASB11 ankyrin repeat and SOCS box containing 11, E3 ubiquitin protein ligase 3.01083
ODAPH odontogenesis associated phosphoprotein 3.01083
RNF113B ring finger protein 113B 3.01083
MIP major intrinsic protein of lens fiber 3.01083
SCRT2 scratch family zinc finger 2 3.01083
CXCL16 chemokine (C-X-C motif) ligand 16 3.01083
CBLN2 cerebellin 2 precursor 3.01083
FCER2 Fc fragment of IgE, low affinity II, receptor for (CD23) 3.01083
TRIM63 tripartite motif containing 63, E3 ubiquitin protein ligase 3.01083
KLRF1 killer cell lectin-like receptor subfamily F, member 1 3.01083
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) 3.01083
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5 3.01083
C1QTNF9B C1q and tumor necrosis factor related protein 9B 3.01083
PROZ protein Z, vitamin K-dependent plasma glycoprotein 3.01083
MAGIX MAGI family member, X-linked 3.01083
SDR16C5 short chain dehydrogenase/reductase family 16C, member 5 3.01083
OOSP1 oocyte secreted protein 1, pseudogene 3.01083
ALG10B ALG10B, alpha-1,2-glucosyltransferase 3.01083
GLIPR1L2 GLI pathogenesis-related 1 like 2 3.01083
LOC107986837 uncharacterized LOC107986837 3.01083
NMUR2 neuromedin U receptor 2 3.01083
DBX2 developing brain homeobox 2 3.01083
NGB neuroglobin 3.01083
CCL27 chemokine (C-C motif) ligand 27 3.01083
APLNR apelin receptor 3.01083
RGS18 regulator of G-protein signaling 18 3.01083
POF1B premature ovarian failure, 1B 3.01083
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1 3.01083
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6 3.01083
KLF2 Kruppel-like factor 2 3.01083
BPIFB4 BPI fold containing family B, member 4 3.01083
SMIM22 small integral membrane protein 22 3.01083
CLDN34 claudin 34 3.01083
CALML5 calmodulin-like 5 3.01083
KIF4B kinesin family member 4B 3.01083
TCF21 transcription factor 21 3.01083
FOSB FBJ murine osteosarcoma viral oncogene homolog B 3.01083
HSPB7 heat shock 27kDa protein family, member 7 (cardiovascular) 3.01083
ZMYND15 zinc finger, MYND-type containing 15 3.01083
KRT13 keratin 13, type I 3.01083
KRT14 keratin 14, type I 3.01083
ZP1 zona pellucida glycoprotein 1 (sperm receptor) 3.01083
ERICH6B glutamate-rich 6B 3.01083
WFDC9 WAP four-disulfide core domain 9 3.01083
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6 3.01083
IGIP IgA-inducing protein 3.01083
KCNA2 potassium channel, voltage gated shaker related subfamily A, member 2 3.01083
IL27 interleukin 27 3.01083
CNR2 cannabinoid receptor 2 (macrophage) 3.01083
EOMES eomesodermin 3.01083
GOLGA8M golgin A8 family, member M 3.01083
GOLGA8T golgin A8 family, member T 3.01083
PDK4 pyruvate dehydrogenase kinase, isozyme 4 3.01083
AGAP2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 3.01083
IL9R interleukin 9 receptor 3.01083
TDRD10 tudor domain containing 10 3.01083
PHOX2A paired-like homeobox 2a 3.01083
TRIM50 tripartite motif containing 50 3.01083
EMP1 epithelial membrane protein 1 3.01083
ISL2 ISL LIM homeobox 2 3.01083
RGCC regulator of cell cycle 3.01083
PROK1 prokineticin 1 3.01083
EGR2 early growth response 2 3.01083
CTXN2 cortexin 2 3.01083
LRRC24 leucine rich repeat containing 24 3.01083
MC5R melanocortin 5 receptor 3.01083
TWIST1 twist family bHLH transcription factor 1 3.01083
ABCD2 ATP-binding cassette, sub-family D (ALD), member 2 3.01083
GRM6 glutamate receptor, metabotropic 6 3.01083
DMRTC1 DMRT-like family C1 3.01083
GPD1 glycerol-3-phosphate dehydrogenase 1 (soluble) 3.01083
CHRDL2 chordin-like 2 3.01083
GPR179 G protein-coupled receptor 179 3.01083
MAGED4B melanoma antigen family D4B 3.01083
MYNN myoneurin 3.01083
RP1 retinitis pigmentosa 1 (autosomal dominant) 3.01083
CHIA chitinase, acidic 3.01083
FOXP3 forkhead box P3 3.01083
PTPN7 protein tyrosine phosphatase, non-receptor type 7 3.01083
SMCO3 single-pass membrane protein with coiled-coil domains 3 3.01083
SLX1B SLX1 structure-specific endonuclease subunit homolog B (S. cerevisiae) 3.01083
LIMS3 LIM and senescent cell antigen-like domains 3 3.01083
ABCA13 ATP-binding cassette, sub-family A (ABC1), member 13 3.01083
MAEL maelstrom spermatogenic transposon silencer 3.01083
GCSAML germinal center-associated, signaling and motility-like 3.01083
ADGRF5 adhesion G protein-coupled receptor F5 3.01083
FGF3 fibroblast growth factor 3 3.01083
TMEM86A transmembrane protein 86A 3.01083
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19 3.01083
DUOXA1 dual oxidase maturation factor 1 3.01083
ASAH2 N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2 3.01083
GPR135 G protein-coupled receptor 135 3.00717
GREM1 gremlin 1, DAN family BMP antagonist 2.80648
RALBP1 ralA binding protein 1 2.71343
UBXN7 UBX domain protein 7 2.70239
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha 2.52232
PPP1R14A protein phosphatase 1, regulatory (inhibitor) subunit 14A 2.44682
PROSER3 proline and serine rich 3 2.42299
CCDC12 coiled-coil domain containing 12 2.38581
MEF2A myocyte enhancer factor 2A 2.3817
RASSF6 Ras association (RalGDS/AF-6) domain family member 6 2.37898
UBE2L3 ubiquitin-conjugating enzyme E2L 3 2.37812
TBRG1 transforming growth factor beta regulator 1 2.37812
SMIM19 small integral membrane protein 19 2.30259
ADAMTSL1 ADAMTS-like 1 2.29476
LRRC36 leucine rich repeat containing 36 2.28923
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1 2.2413
HTR3E 5-hydroxytryptamine (serotonin) receptor 3E, ionotropic 2.2413
STARD6 StAR-related lipid transfer (START) domain containing 6 2.23088
FAM228A family with sequence similarity 228, member A 2.23088
CDKL2 cyclin-dependent kinase-like 2 (CDC2-related kinase) 2.22781
GULP1 GULP, engulfment adaptor PTB domain containing 1 2.21487
SEC23IP SEC23 interacting protein 2.18885
CLIC6 chloride intracellular channel 6 2.18803
KRABD5 KRAB domain containing 5 2.17438
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 2.17438
ZBTB4 zinc finger and BTB domain containing 4 2.17438
SEC61B Sec61 beta subunit 2.17438
C8ORF33 chromosome 8 open reading frame 33 2.17091
HPS4 Hermansky-Pudlak syndrome 4 2.13181
RBM5 RNA binding motif protein 5 2.12172
INTS3 integrator complex subunit 3 2.11007
ECH1 enoyl CoA hydratase 1, peroxisomal 2.09845
PKMYT1 protein kinase, membrane associated tyrosine/threonine 1 2.08783
ASNS asparagine synthetase (glutamine-hydrolyzing) 2.08055
GPSM2 G-protein signaling modulator 2 2.06598
SEPTIN3 septin 3 2.05518
FGF13 fibroblast growth factor 13 2.04175
ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif, 12 2.03435
ITSN2 intersectin 2 2.03222
MASTL microtubule associated serine/threonine kinase-like 2.01563
NUDT4 nudix (nucleoside diphosphate linked moiety X)-type motif 4 2.01563
CAB39L calcium binding protein 39-like 2.00816
PDE8A phosphodiesterase 8A 2.00116

decreased expression

Symbol Name Standardized Value
PIH1D2 PIH1 domain containing 2 -3.167
CCR10 chemokine (C-C motif) receptor 10 -3.167
DNAAF8 dynein axonemal assembly factor 8 -3.167
VRK1 vaccinia related kinase 1 -3.14198
ART1 ADP-ribosyltransferase 1 -3.01083
SPMIP11 sperm microtubule inner protein 11 -3.01083
MSX1 msh homeobox 1 -3.01083
PTPRQ protein tyrosine phosphatase, receptor type, Q -3.01083
FRG1 FSHD region gene 1 -3.01083
ALDH4A1 aldehyde dehydrogenase 4 family, member A1 -3.01083
LRRTM1 leucine rich repeat transmembrane neuronal 1 -3.01083
EPPIN epididymal peptidase inhibitor -3.01083
C5ORF47 chromosome 5 open reading frame 47 -3.01083
ADTRP androgen-dependent TFPI-regulating protein -3.01083
GMFG glia maturation factor, gamma -3.01083
FOXP2 forkhead box P2 -3.01083
COLQ collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase -3.01083
STRIT1 small transmembrane regulator of ion transport 1 -3.01083
ARHGAP40 Rho GTPase activating protein 40 -3.01083
LOC124903233 uncharacterized LOC124903233 -3.01083
TMEM31 transmembrane protein 31 -3.01083
CHCHD3 coiled-coil-helix-coiled-coil-helix domain containing 3 -3.01083
RBM25 RNA binding motif protein 25 -3.01083
NSG2 neuronal vesicle trafficking associated 2 -3.01083
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2 -3.01083
PDF peptide deformylase (mitochondrial) -3.01083
CYS1 cystin 1 -3.01083
TAF7L TAF7-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 50kDa -3.01083
PROC protein C (inactivator of coagulation factors Va and VIIIa) -3.01083
SRP72 signal recognition particle 72kDa -2.94443
ZBTB17 zinc finger and BTB domain containing 17 -2.81412
RPUSD2 RNA pseudouridylate synthase domain containing 2 -2.79181
YIPF5 Yip1 domain family, member 5 -2.68486
CRYM crystallin, mu -2.68486
NINJ2 ninjurin 2 -2.6249
FH fumarate hydratase -2.57251
SYTL5 synaptotagmin-like 5 -2.52515
CMIP c-Maf inducing protein -2.50434
WBP2NL WBP2 N-terminal like -2.50259
SNX31 sorting nexin 31 -2.50259
MRC2 mannose receptor, C type 2 -2.48999
ALDH9A1 aldehyde dehydrogenase 9 family, member A1 -2.44068
SRPRB signal recognition particle receptor, B subunit -2.40224
TEX2 testis expressed 2 -2.38581
FBXO17 F-box protein 17 -2.3817
MRPS30 mitochondrial ribosomal protein S30 -2.37481
CCDC196 coiled-coil domain containing 196 -2.37178
GARIN2 golgi associated RAB2 interactor family member 2 -2.36993
BLTP3A bridge-like lipid transfer protein family member 3A -2.36993
ANAPC5 anaphase promoting complex subunit 5 -2.36745
CCDC34 coiled-coil domain containing 34 -2.35052
SNRNP48 small nuclear ribonucleoprotein 48kDa (U11/U12) -2.34029
FAM185A family with sequence similarity 185, member A -2.32396
MMD monocyte to macrophage differentiation-associated -2.2453
KCND1 potassium channel, voltage gated Shal related subfamily D, member 1 -2.23501
KCNJ10 potassium channel, inwardly rectifying subfamily J, member 10 -2.23501
ABT1 activator of basal transcription 1 -2.22781
SOD1 superoxide dismutase 1, soluble -2.22208
DCTD dCMP deaminase -2.19836
CSGALNACT2 chondroitin sulfate N-acetylgalactosaminyltransferase 2 -2.17438
LIME1 Lck interacting transmembrane adaptor 1 -2.17438
CFAP100 cilia and flagella associated protein 100 -2.17438
RLN1 relaxin 1 -2.17438
NBPF8 neuroblastoma breakpoint family, member 8 -2.17438
BSN bassoon presynaptic cytomatrix protein -2.17438
EIF3M eukaryotic translation initiation factor 3, subunit M -2.13831
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -2.10754
PURA purine-rich element binding protein A -2.08055
UQCC1 ubiquinol-cytochrome c reductase complex assembly factor 1 -2.07877
GCAT glycine C-acetyltransferase -2.06239
ARHGAP10 Rho GTPase activating protein 10 -2.06226
MPP2 membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2) -2.05469
COQ10B coenzyme Q10 homolog B (S. cerevisiae) -2.04891
PRDM2 PR domain containing 2, with ZNF domain -2.04577
TDRKH tudor and KH domain containing -2.04175
SIMC1 SUMO-interacting motifs containing 1 -2.04101
ZFP36L1 ZFP36 ring finger protein-like 1 -2.0398
MAN1A1 mannosidase, alpha, class 1A, member 1 -2.01563