SHROOM2 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description shroom family member 2|The protein encoded by this gene shares significant similarities with the apical protein from Xenopus laevis which is implicated in amiloride-sensitive sodium channel activity. This gene is a strong candidate gene for ocular albinism type 1 syndrome. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 357)
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Genes

324 genes differentially expressed following the SHROOM2 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
LMOD2 leiomodin 2 (cardiac) 3.20111
ANGPTL6 angiopoietin-like 6 3.20111
PRH2 proline-rich protein HaeIII subfamily 2 3.20111
C1ORF146 chromosome 1 open reading frame 146 3.20111
CXCR5 chemokine (C-X-C motif) receptor 5 3.20111
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32) 3.20111
ULBP3 UL16 binding protein 3 3.20111
SUSD2 sushi domain containing 2 3.20111
FBXO40 F-box protein 40 3.20111
IL10RA interleukin 10 receptor, alpha 3.20111
FMO3 flavin containing monooxygenase 3 3.20111
COL19A1 collagen, type XIX, alpha 1 3.20111
MUC5B mucin 5B, oligomeric mucus/gel-forming 3.20111
ARHGAP36 Rho GTPase activating protein 36 3.20111
MFAP5 microfibrillar associated protein 5 3.20111
DERPC DERPC proline and glycine rich nuclear protein 3.20111
FOSB FBJ murine osteosarcoma viral oncogene homolog B 3.20111
EBF2 early B-cell factor 2 3.20111
REELD1 reeler domain containing 1 3.20111
TPPP tubulin polymerization promoting protein 3.20111
GAGE10 G antigen 10 3.20111
PON3 paraoxonase 3 3.20111
PDE6C phosphodiesterase 6C, cGMP-specific, cone, alpha prime 3.20111
SLC5A7 solute carrier family 5 (sodium/choline cotransporter), member 7 3.14531
SSMEM1 serine-rich single-pass membrane protein 1 3.14531
TM4SF20 transmembrane 4 L six family member 20 3.14531
SCG2 secretogranin II 3.14531
SCN2B sodium channel, voltage gated, type II beta subunit 3.14531
TMEM176B transmembrane protein 176B 3.14531
MAGEA8 melanoma antigen family A8 3.14531
CNTNAP4 contactin associated protein-like 4 3.14531
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) 3.14531
HYAL4 hyaluronoglucosaminidase 4 3.14531
CLEC12A C-type lectin domain family 12, member A 3.14531
XCL1 chemokine (C motif) ligand 1 3.14531
TUBB8 tubulin, beta 8 class VIII 3.14531
SYCE3 synaptonemal complex central element protein 3 3.14531
SHE Src homology 2 domain containing E 3.14531
SPINK14 serine peptidase inhibitor, Kazal type 14 (putative) 3.14531
RFX6 regulatory factor X, 6 3.14531
SLC37A2 solute carrier family 37 (glucose-6-phosphate transporter), member 2 3.14531
AVP arginine vasopressin 3.14531
THSD1 thrombospondin, type I, domain containing 1 3.14531
PNLDC1 poly(A)-specific ribonuclease (PARN)-like domain containing 1 3.14531
FAM9C family with sequence similarity 9, member C 3.14531
MAGED4 melanoma antigen family D4 3.14531
SMIM5 small integral membrane protein 5 3.14531
GPR20 G protein-coupled receptor 20 3.14531
SLC23A3 solute carrier family 23, member 3 3.14531
OR52E8 olfactory receptor, family 52, subfamily E, member 8 3.14531
STRA8 stimulated by retinoic acid 8 3.14531
BAAT bile acid CoA:amino acid N-acyltransferase 3.14531
PCDH8 protocadherin 8 3.14531
OR1L8 olfactory receptor, family 1, subfamily L, member 8 3.14531
MS4A18 membrane-spanning 4-domains, subfamily A, member 18 3.14531
PRLH prolactin releasing hormone 3.14531
SLC10A6 solute carrier family 10 (sodium/bile acid cotransporter), member 6 3.14531
LOC124906892 uncharacterized LOC124906892 3.14531
ERFE erythroferrone 3.14531
CPLANE2 ciliogenesis and planar polarity effector complex subunit 2 3.14531
SMIM38 small integral membrane protein 38 3.14531
ALPG alkaline phosphatase, germ cell 3.14531
NECTIN4 nectin cell adhesion molecule 4 3.14531
SPATS1 spermatogenesis associated, serine-rich 1 3.14531
GBP3 guanylate binding protein 3 3.14531
ROPN1B rhophilin associated tail protein 1B 3.14531
TYROBP TYRO protein tyrosine kinase binding protein 3.14531
DEFB131B defensin beta 131B 3.14531
TEX13C TEX13 family member C 3.14531
FAM90A11 family with sequence similarity 90 member A11 3.14531
SPATA31H1 SPATA31 subfamily H member 1 3.14531
THSD8 thrombospondin type 1 domain containing 8 3.14531
NOTCH2NLB notch 2 N-terminal like B 3.14531
SPMIP3 sperm microtubule inner protein 3 3.14531
LOC124903233 uncharacterized LOC124903233 3.14531
CTXND1 cortexin domain containing 1 3.14531
H3-7 H3.7 histone (putative) 3.14531
H3C3 H3 clustered histone 3 3.14531
PHF13 PHD finger protein 13 3.14531
OR2T8 olfactory receptor, family 2, subfamily T, member 8 3.14531
PCDHB11 protocadherin beta 11 3.14531
OR1F1 olfactory receptor, family 1, subfamily F, member 1 3.14531
SLC35D3 solute carrier family 35, member D3 3.14531
TMEM229B transmembrane protein 229B 3.14531
FPR1 formyl peptide receptor 1 3.14531
PLEKHA7 pleckstrin homology domain containing, family A member 7 3.14531
NDRG1 N-myc downstream regulated 1 3.14531
CST11 cystatin 11 3.14531
CSRP3 cysteine and glycine-rich protein 3 (cardiac LIM protein) 3.14531
CLDN5 claudin 5 3.14531
OR8D4 olfactory receptor, family 8, subfamily D, member 4 3.14531
SLC2A7 solute carrier family 2 (facilitated glucose transporter), member 7 3.14531
SAG S-antigen; retina and pineal gland (arrestin) 3.14531
GATA3 GATA binding protein 3 3.14531
LTK leukocyte receptor tyrosine kinase 3.14531
VCX3B variable charge, X-linked 3B 3.14531
SAA1 serum amyloid A1 3.14531
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) 3.14531
CCR9 chemokine (C-C motif) receptor 9 3.14531
SLC9A2 solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2 3.14531
TXLNB taxilin beta 3.14531
PRR15L proline rich 15-like 3.14531
C11ORF91 chromosome 11 open reading frame 91 3.14531
ARR3 arrestin 3, retinal (X-arrestin) 3.14531
KLHL41 kelch-like family member 41 3.14531
WFDC8 WAP four-disulfide core domain 8 3.14531
TMEM204 transmembrane protein 204 3.14531
CD5L CD5 molecule-like 3.14531
C16ORF78 chromosome 16 open reading frame 78 3.14531
ALDH3B2 aldehyde dehydrogenase 3 family, member B2 3.14531
FOS FBJ murine osteosarcoma viral oncogene homolog 3.14531
OPRK1 opioid receptor, kappa 1 3.14531
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 3.14531
TBC1D26 TBC1 domain family, member 26 3.14531
AZIN2 antizyme inhibitor 2 3.14531
GBA3 glucosidase, beta, acid 3 (gene/pseudogene) 3.14531
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled 3.14531
NGB neuroglobin 3.14531
EBF3 early B-cell factor 3 3.14531
EBF4 early B-cell factor 4 3.14531
GAL3ST2 galactose-3-O-sulfotransferase 2 3.14531
LRRC43 leucine rich repeat containing 43 3.14531
PCDH12 protocadherin 12 3.14531
PPP1R14C protein phosphatase 1, regulatory (inhibitor) subunit 14C 3.14531
P2RX2 purinergic receptor P2X, ligand gated ion channel, 2 3.14531
UBXN10 UBX domain protein 10 3.14531
IDI2 isopentenyl-diphosphate delta isomerase 2 3.14531
GNMT glycine N-methyltransferase 3.14531
CSF1R colony stimulating factor 1 receptor 3.14531
FAIM2 Fas apoptotic inhibitory molecule 2 3.14531
GPR150 G protein-coupled receptor 150 3.14531
GPR142 G protein-coupled receptor 142 3.14531
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type 3.14531
LY6G6C lymphocyte antigen 6 complex, locus G6C 3.14531
PGR progesterone receptor 3.14531
HIGD2B HIG1 hypoxia inducible domain family, member 2B 3.14531
C8ORF89 chromosome 8 open reading frame 89 3.14531
KLK14 kallikrein-related peptidase 14 3.14531
PTPN20 protein tyrosine phosphatase, non-receptor type 20 3.14531
TG thyroglobulin 3.14531
SMIM17 small integral membrane protein 17 3.14531
PRSS38 protease, serine, 38 3.14531
PRSS33 protease, serine, 33 3.14531
CTSF cathepsin F 3.14531
IBSP integrin-binding sialoprotein 3.14531
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) 3.14531
OR6J1 olfactory receptor, family 6, subfamily J, member 1 (gene/pseudogene) 3.14531
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1 3.14531
PAX3 paired box 3 3.14531
FRMPD1 FERM and PDZ domain containing 1 3.14531
C4BPA complement component 4 binding protein, alpha 3.14531
BTBD16 BTB (POZ) domain containing 16 3.14531
THEM5 thioesterase superfamily member 5 3.14531
MAGEA12 melanoma antigen family A12 3.14531
LRRC31 leucine rich repeat containing 31 3.14531
POPDC2 popeye domain containing 2 3.14531
NLRP1 NLR family, pyrin domain containing 1 3.14531
GRAP2 GRB2-related adaptor protein 2 3.14531
KRTAP5-5 keratin associated protein 5-5 3.14531
DDX53 DEAD (Asp-Glu-Ala-Asp) box polypeptide 53 3.14531
DGKB diacylglycerol kinase, beta 90kDa 3.14531
DHRS9 dehydrogenase/reductase (SDR family) member 9 3.14531
FXYD3 FXYD domain containing ion transport regulator 3 3.14531
PASD1 PAS domain containing 1 3.14531
C5ORF46 chromosome 5 open reading frame 46 3.14531
NLRP9 NLR family, pyrin domain containing 9 3.14531
RTN4RL1 reticulon 4 receptor-like 1 3.14531
NAT16 N-acetyltransferase 16 (GCN5-related, putative) 3.14531
MLC1 megalencephalic leukoencephalopathy with subcortical cysts 1 3.14531
FADS6 fatty acid desaturase 6 3.14531
RERGL RERG/RAS-like 3.14531
ACKR2 atypical chemokine receptor 2 3.14531
TIMM23 translocase of inner mitochondrial membrane 23 homolog (yeast) 3.02722
TRPC6 transient receptor potential cation channel, subfamily C, member 6 2.98889
CEPT1 choline/ethanolamine phosphotransferase 1 2.94289
PWWP3B PWWP domain containing 3B 2.93599
SCD5 stearoyl-CoA desaturase 5 2.93599
KCTD11 potassium channel tetramerization domain containing 11 2.93599
LUC7L3 LUC7-like 3 (S. cerevisiae) 2.76937
CBLN1 cerebellin 1 precursor 2.70677
F13A1 coagulation factor XIII, A1 polypeptide 2.69234
OR2A42 olfactory receptor, family 2, subfamily A, member 42 2.68663
ANAPC11 anaphase promoting complex subunit 11 2.68232
SLC67A2 solute carrier family 67 member 2 2.64604
GRM2 glutamate receptor, metabotropic 2 2.54251
ZNF611 zinc finger protein 611 2.52651
VMA22 vacuolar ATPase assembly factor VMA22 2.51849
INSYN1 inhibitory synaptic factor 1 2.48559
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13 2.48559
VCF1 VCP nuclear cofactor family member 1 2.46351
MAGOHB mago-nashi homolog B (Drosophila) 2.46129
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.43117
DUSP26 dual specificity phosphatase 26 (putative) 2.39456
NOP14 NOP14 nucleolar protein 2.39434
OSBP oxysterol binding protein 2.38555
BAG1 BCL2-associated athanogene 2.28011
SPDL1 spindle apparatus coiled-coil protein 1 2.28011
DAB2IP DAB2 interacting protein 2.25834
MORF4L1 mortality factor 4 like 1 2.24969
NBPF15 neuroblastoma breakpoint family, member 15 2.24786
TTLL9 tubulin tyrosine ligase-like family member 9 2.2447
GPC6 glypican 6 2.22917
NXF1 nuclear RNA export factor 1 2.22917
ZNF674 zinc finger protein 674 2.2245
ZBTB7A zinc finger and BTB domain containing 7A 2.21313
TRMT2A tRNA methyltransferase 2 homolog A (S. cerevisiae) 2.21132
SENP2 SUMO1/sentrin/SMT3 specific peptidase 2 2.19246
MUSTN1 musculoskeletal, embryonic nuclear protein 1 2.16806
PTPRQ protein tyrosine phosphatase, receptor type, Q 2.16806
FSD1 fibronectin type III and SPRY domain containing 1 2.15067
LPGAT1 lysophosphatidylglycerol acyltransferase 1 2.14989
MIB1 mindbomb E3 ubiquitin protein ligase 1 2.14091
PGA5 pepsinogen 5, group I (pepsinogen A) 2.12218
SPIRE1 spire-type actin nucleation factor 1 2.0942
CCDC191 coiled-coil domain containing 191 2.09285
KDR kinase insert domain receptor 2.09215
SYTL2 synaptotagmin-like 2 2.08632
PRPF6 pre-mRNA processing factor 6 2.05921
NKAIN3 Na+/K+ transporting ATPase interacting 3 2.05704
MAPK8 mitogen-activated protein kinase 8 2.05413
PRKG2 protein kinase, cGMP-dependent, type II 2.0365
SLC7A3 solute carrier family 7 (cationic amino acid transporter, y+ system), member 3 2.03109
CLCN3 chloride channel, voltage-sensitive 3 2.02014
KLHL3 kelch-like family member 3 2.01615
GLIS3 GLIS family zinc finger 3 2.01211

decreased expression

Symbol Name Standardized Value
ITGB1BP2 integrin beta 1 binding protein (melusin) 2 -3.20111
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain -3.20111
TNFSF13B tumor necrosis factor (ligand) superfamily, member 13b -3.20111
ZNF837 zinc finger protein 837 -3.20111
H2BC26 H2B clustered histone 26 -3.20111
ANO9 anoctamin 9 -3.16881
FAM43B family with sequence similarity 43, member B -3.14531
SPDYE2B speedy/RINGO cell cycle regulator family member E2B -3.14531
DDX47 DEAD (Asp-Glu-Ala-Asp) box polypeptide 47 -3.14531
ACOT6 acyl-CoA thioesterase 6 -3.14531
LBHD1 LBH domain containing 1 -3.14531
GTSE1 G-2 and S-phase expressed 1 -3.14531
IL32 interleukin 32 -3.14531
ANPEP alanyl (membrane) aminopeptidase -3.14531
SPDYE6 speedy/RINGO cell cycle regulator family member E6 -3.14531
MAMSTR MEF2 activating motif and SAP domain containing transcriptional regulator -3.14531
CORIN corin, serine peptidase -3.14531
NWD1 NACHT and WD repeat domain containing 1 -3.14531
AGTR1 angiotensin II receptor, type 1 -3.14531
TP53INP2 tumor protein p53 inducible nuclear protein 2 -3.14531
GRHL3 grainyhead-like 3 (Drosophila) -3.14531
AQP3 aquaporin 3 (Gill blood group) -3.14531
LCN2 lipocalin 2 -3.14531
CSAG3 CSAG family, member 3 -3.14531
TMC3 transmembrane channel-like 3 -3.14531
ABO ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase) -3.14531
SHROOM2 shroom family member 2 -3.14531
GOLGA6L10 golgin A6 family-like 10 -3.14531
EIF4EBP3 eukaryotic translation initiation factor 4E binding protein 3 -3.14531
RIN3 Ras and Rab interactor 3 -3.14531
TEDC1 tubulin epsilon and delta complex 1 -3.14531
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -3.14531
PCBP4 poly(rC) binding protein 4 -3.14531
FAM163A family with sequence similarity 163, member A -3.14531
LIME1 Lck interacting transmembrane adaptor 1 -3.14531
CFAP52 cilia and flagella associated protein 52 -3.14531
OOSP1 oocyte secreted protein 1, pseudogene -3.14531
SH3RF2 SH3 domain containing ring finger 2 -3.12537
AGGF1 angiogenic factor with G patch and FHA domains 1 -3.00845
CDC14A cell division cycle 14A -2.93487
UBE2I ubiquitin-conjugating enzyme E2I -2.80237
RPS14 ribosomal protein S14 -2.74464
COL5A2 collagen, type V, alpha 2 -2.74464
FHL1 four and a half LIM domains 1 -2.65361
FXYD7 FXYD domain containing ion transport regulator 7 -2.65171
PEMT phosphatidylethanolamine N-methyltransferase -2.61701
CAMK4 calcium/calmodulin-dependent protein kinase IV -2.61701
FADS3 fatty acid desaturase 3 -2.59432
RBM47 RNA binding motif protein 47 -2.59029
IDNK idnK, gluconokinase homolog (E. coli) -2.57281
DYNC1I2 dynein, cytoplasmic 1, intermediate chain 2 -2.56107
GRAMD1C GRAM domain containing 1C -2.51849
CASS4 Cas scaffolding protein family member 4 -2.51849
XKR9 XK, Kell blood group complex subunit-related family, member 9 -2.51517
APP-DT APP divergent transcript -2.51517
CBX4 chromobox homolog 4 -2.50755
ADH4 alcohol dehydrogenase 4 (class II), pi polypeptide -2.50755
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2 -2.50755
CFAP44 cilia and flagella associated protein 44 -2.50755
CCNA2 cyclin A2 -2.49441
CYP2J2 cytochrome P450, family 2, subfamily J, polypeptide 2 -2.47948
NLRP7 NLR family, pyrin domain containing 7 -2.47948
RASGRP3 RAS guanyl releasing protein 3 (calcium and DAG-regulated) -2.47948
CNGA4 cyclic nucleotide gated channel alpha 4 -2.47948
CLPSL2 colipase-like 2 -2.47948
KLHDC8A kelch domain containing 8A -2.47948
SPATA24 spermatogenesis associated 24 -2.47529
SRBD1 S1 RNA binding domain 1 -2.47492
EIF5A2 eukaryotic translation initiation factor 5A2 -2.46946
EXO5 exonuclease 5 -2.46081
DIXDC1 DIX domain containing 1 -2.46081
HSH2D hematopoietic SH2 domain containing -2.45453
IL6ST-DT IL6ST divergent transcript -2.4425
HSPA9 heat shock 70kDa protein 9 (mortalin) -2.44022
CNST consortin, connexin sorting protein -2.39893
KDM2A lysine (K)-specific demethylase 2A -2.39478
CNTNAP2 contactin associated protein-like 2 -2.39478
SYT17 synaptotagmin XVII -2.39434
PLA2G12A phospholipase A2, group XIIA -2.32395
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6 -2.29934
GPS1 G protein pathway suppressor 1 -2.24533
NOL9 nucleolar protein 9 -2.22917
B3GALT5 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 5 -2.2124
C1ORF198 chromosome 1 open reading frame 198 -2.19991
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 -2.16806
RPS6KB2 ribosomal protein S6 kinase, 70kDa, polypeptide 2 -2.15575
PSAT1 phosphoserine aminotransferase 1 -2.14091
MCOLN2 mucolipin 2 -2.13744
DNM1 dynamin 1 -2.11631
TSPAN5 tetraspanin 5 -2.11062
BBS12 Bardet-Biedl syndrome 12 -2.10057
RHOB ras homolog family member B -2.10057
SATL1 spermidine/spermine N1-acetyl transferase-like 1 -2.07488
PPIA peptidylprolyl isomerase A (cyclophilin A) -2.05921
RNF122 ring finger protein 122 -2.05893
CEP19 centrosomal protein 19kDa -2.05704
GNPTAB N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits -2.05515
ZDHHC14 zinc finger, DHHC-type containing 14 -2.0365
WHAMM WAS protein homolog associated with actin, golgi membranes and microtubules -2.01211