SHROOM3 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description shroom family member 3|This gene encodes a PDZ-domain-containing protein that belongs to a family of Shroom-related proteins. This protein may be involved in regulating cell shape in certain tissues. A similar protein in mice is required for proper neurulation. [provided by RefSeq, Jan 2011] (NCBI Entrez Gene Database, 57619)
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Genes

335 genes differentially expressed following the SHROOM3 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
USH1G Usher syndrome 1G (autosomal recessive) 2.86217
ANKRD22 ankyrin repeat domain 22 2.86217
EGFL6 EGF-like-domain, multiple 6 2.86217
NANOS3 nanos homolog 3 (Drosophila) 2.86217
HES5 hes family bHLH transcription factor 5 2.86217
UNC13C unc-13 homolog C (C. elegans) 2.86217
TM4SF20 transmembrane 4 L six family member 20 2.86217
PCDHGB3 protocadherin gamma subfamily B, 3 2.86217
MYBPC1 myosin binding protein C, slow type 2.86217
CCL3 chemokine (C-C motif) ligand 3 2.86217
HEATR9 HEAT repeat containing 9 2.86217
CTRC chymotrypsin C (caldecrin) 2.86217
TREM2 triggering receptor expressed on myeloid cells 2 2.86217
MEP1A meprin A, alpha (PABA peptide hydrolase) 2.86217
KLHL35 kelch-like family member 35 2.86217
HNF4A hepatocyte nuclear factor 4, alpha 2.86217
LOX lysyl oxidase 2.86217
SBK3 SH3 domain binding kinase family, member 3 2.86217
SBK2 SH3 domain binding kinase family, member 2 2.86217
SIX3 SIX homeobox 3 2.86217
TMPRSS11D transmembrane protease, serine 11D 2.86217
CARD16 caspase recruitment domain family, member 16 2.86217
GJB5 gap junction protein, beta 5, 31.1kDa 2.86217
BMP8B bone morphogenetic protein 8b 2.86217
HSD3B7 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 2.86217
CCDC38 coiled-coil domain containing 38 2.86217
NUDT18 nudix (nucleoside diphosphate linked moiety X)-type motif 18 2.86217
NPIPA8 nuclear pore complex interacting protein family, member A8 2.86217
GNRHR gonadotropin-releasing hormone receptor 2.86217
MYO1G myosin IG 2.86217
TMC3 transmembrane channel-like 3 2.86217
OR4D9 olfactory receptor, family 4, subfamily D, member 9 2.86217
CREB1 cAMP responsive element binding protein 1 2.86217
HMX1 H6 family homeobox 1 2.86217
TDRD1 tudor domain containing 1 2.86217
TRPV6 transient receptor potential cation channel, subfamily V, member 6 2.86217
ANKRD34C ankyrin repeat domain 34C 2.86217
LRG1 leucine-rich alpha-2-glycoprotein 1 2.86217
BATF basic leucine zipper transcription factor, ATF-like 2.86217
ASB17 ankyrin repeat and SOCS box containing 17 2.86217
TAS2R1 taste receptor, type 2, member 1 2.86217
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 2.86217
MFAP5 microfibrillar associated protein 5 2.86217
SPINT3 serine peptidase inhibitor, Kunitz type, 3 2.86217
C11ORF86 chromosome 11 open reading frame 86 2.86217
FBLN7 fibulin 7 2.86217
CHRNB4 cholinergic receptor, nicotinic, beta 4 (neuronal) 2.86217
COX7A1 cytochrome c oxidase subunit VIIa polypeptide 1 (muscle) 2.86217
DNAAF19 dynein axonemal assembly factor 19 2.86217
AVPR1B arginine vasopressin receptor 1B 2.86217
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 2.86217
RAX2 retina and anterior neural fold homeobox 2 2.86217
CAPN9 calpain 9 2.86217
ACER1 alkaline ceramidase 1 2.86217
ACTA2 actin, alpha 2, smooth muscle, aorta 2.86217
ELOVL3 ELOVL fatty acid elongase 3 2.86217
FMO2 flavin containing monooxygenase 2 (non-functional) 2.86217
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) 2.86217
ZAR1 zygote arrest 1 2.86217
C3AR1 complement component 3a receptor 1 2.86217
CCN6 cellular communication network factor 6 2.86217
EXOC1L exocyst complex component 1 like 2.86217
LRRC8C-DT LRRC8C divergent transcript 2.86217
NOTCH2NLB notch 2 N-terminal like B 2.86217
SMIM35 small integral membrane protein 35 2.86217
TMEM272 transmembrane protein 272 2.86217
PPDPFL pancreatic progenitor cell differentiation and proliferation factor like 2.86217
HYCC2 hyccin PI4KA lipid kinase complex subunit 2 2.86217
CLXN calaxin 2.86217
G6PC1 glucose-6-phosphatase catalytic subunit 1 2.86217
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 2.86217
APOBEC3G apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G 2.86217
CYP2C8 cytochrome P450, family 2, subfamily C, polypeptide 8 2.86217
CFAP43 cilia and flagella associated protein 43 2.86217
SPMIP9 sperm microtubule inner protein 9 2.86217
TMCO2 transmembrane and coiled-coil domains 2 2.86217
PSAPL1 prosaposin-like 1 (gene/pseudogene) 2.86217
CD48 CD48 molecule 2.86217
THPO thrombopoietin 2.86217
CLDN9 claudin 9 2.86217
TUBA3E tubulin, alpha 3e 2.86217
PCDHA8 protocadherin alpha 8 2.86217
C1QL2 complement component 1, q subcomponent-like 2 2.86217
RASAL3 RAS protein activator like 3 2.86217
NPFF neuropeptide FF-amide peptide precursor 2.86217
C1QTNF9B C1q and tumor necrosis factor related protein 9B 2.86217
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 2.86217
NEURL3 neuralized E3 ubiquitin protein ligase 3 2.86217
ACSL5 acyl-CoA synthetase long-chain family member 5 2.86217
MYPN myopalladin 2.86217
TUBA4B tubulin, alpha 4b 2.86217
LTF lactotransferrin 2.86217
ASIC3 acid sensing (proton gated) ion channel 3 2.86217
EXOC3L1 exocyst complex component 3-like 1 2.86217
ACTL8 actin-like 8 2.86217
PRR22 proline rich 22 2.86217
ADGRF4 adhesion G protein-coupled receptor F4 2.86217
VAX1 ventral anterior homeobox 1 2.86217
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) 2.86217
DACT3 dishevelled-binding antagonist of beta-catenin 3 2.86217
EBF2 early B-cell factor 2 2.86217
IL17REL interleukin 17 receptor E-like 2.86217
RND3 Rho family GTPase 3 2.86217
MYF6 myogenic factor 6 (herculin) 2.86217
SLA2 Src-like-adaptor 2 2.86217
NOG noggin 2.86217
TIGIT T cell immunoreceptor with Ig and ITIM domains 2.86217
TBPL2 TATA box binding protein like 2 2.86217
SLC7A4 solute carrier family 7, member 4 2.86217
SCN3A sodium channel, voltage gated, type III alpha subunit 2.86217
ACKR2 atypical chemokine receptor 2 2.86217
TMIGD3 transmembrane and immunoglobulin domain containing 3 2.86217
PDCD1 programmed cell death 1 2.86217
ZMYND12 zinc finger, MYND-type containing 12 2.86217
ZNF471 zinc finger protein 471 2.86217
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 2.86217
KRT17 keratin 17, type I 2.86217
CST1 cystatin SN 2.86217
CTAGE15 CTAGE family, member 15 2.86217
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1 2.86217
AMN amnion associated transmembrane protein 2.86217
OTOP2 otopetrin 2 2.86217
PENK proenkephalin 2.86217
C1ORF105 chromosome 1 open reading frame 105 2.86217
IGIP IgA-inducing protein 2.86217
ACSS1 acyl-CoA synthetase short-chain family member 1 2.86217
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal 2.86217
SRD5A2 steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) 2.86217
SIDT1 SID1 transmembrane family, member 1 2.86217
SLC17A8 solute carrier family 17 (vesicular glutamate transporter), member 8 2.86217
EPGN epithelial mitogen 2.86217
ANKRD63 ankyrin repeat domain 63 2.86217
C2ORF66 chromosome 2 open reading frame 66 2.86217
SLC7A9 solute carrier family 7 (amino acid transporter light chain, bo,+ system), member 9 2.86217
SLC52A1 solute carrier family 52 (riboflavin transporter), member 1 2.86217
POLR3E polymerase (RNA) III (DNA directed) polypeptide E (80kD) 2.86217
CLEC4D C-type lectin domain family 4, member D 2.86217
IL36R interleukin 36 receptor 2.86217
PSKH2 protein serine kinase H2 2.86217
SFRP5 secreted frizzled-related protein 5 2.86217
CFI complement factor I 2.86217
SLITRK1 SLIT and NTRK-like family, member 1 2.86217
FITM1 fat storage-inducing transmembrane protein 1 2.86217
SLC51B solute carrier family 51, beta subunit 2.86217
TMEM88 transmembrane protein 88 2.86217
NLRP5 NLR family, pyrin domain containing 5 2.86217
ST18 suppression of tumorigenicity 18, zinc finger 2.86217
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain 2.86217
TMEM52B transmembrane protein 52B 2.86217
CYP3A43 cytochrome P450, family 3, subfamily A, polypeptide 43 2.86217
FRMPD1 FERM and PDZ domain containing 1 2.86217
ISLR2 immunoglobulin superfamily containing leucine-rich repeat 2 2.86217
TGM7 transglutaminase 7 2.86217
SDSL serine dehydratase-like 2.86217
ANXA2R annexin A2 receptor 2.86217
ASCL3 achaete-scute family bHLH transcription factor 3 2.86217
KCNK15 potassium channel, two pore domain subfamily K, member 15 2.86217
POTEI POTE ankyrin domain family, member I 2.86217
MMP3 matrix metallopeptidase 3 2.86217
C4BPA complement component 4 binding protein, alpha 2.86217
OXER1 oxoeicosanoid (OXE) receptor 1 2.86217
ERAP2 endoplasmic reticulum aminopeptidase 2 2.86217
PCDHGA12 protocadherin gamma subfamily A, 12 2.86217
LRRC74A leucine rich repeat containing 74A 2.86217
PRSS22 protease, serine, 22 2.86217
SLCO1C1 solute carrier organic anion transporter family, member 1C1 2.86217
ERAL1 Era-like 12S mitochondrial rRNA chaperone 1 2.86217
NAT10 N-acetyltransferase 10 (GCN5-related) 2.86217
IAPP islet amyloid polypeptide 2.85254
CIZ1 CDKN1A interacting zinc finger protein 1 2.80344
H2AC13 H2A clustered histone 13 2.73479
DNMT1 DNA (cytosine-5-)-methyltransferase 1 2.7079
PLK2 polo-like kinase 2 2.70136
THOC1 THO complex 1 2.68373
PGBD5 piggyBac transposable element derived 5 2.67721
BRPF1 bromodomain and PHD finger containing, 1 2.6333
VAMP8 vesicle-associated membrane protein 8 2.6333
HMGCL 3-hydroxymethyl-3-methylglutaryl-CoA lyase 2.5883
CBX6 chromobox homolog 6 2.58521
FHL2 four and a half LIM domains 2 2.57539
DNAJC10 DnaJ (Hsp40) homolog, subfamily C, member 10 2.54537
GPX4 glutathione peroxidase 4 2.53665
FGFBP3 fibroblast growth factor binding protein 3 2.52998
WDR17 WD repeat domain 17 2.52615
ZNF333 zinc finger protein 333 2.50952
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 2.5015
CYP11A1 cytochrome P450, family 11, subfamily A, polypeptide 1 2.47341
RELN reelin 2.45926
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1 2.45548
TWNK twinkle mtDNA helicase 2.45492
PNMA8B PNMA family member 8B 2.44559
FOXK1 forkhead box K1 2.44439
SRP9 signal recognition particle 9kDa 2.33403
ZNF664-RFLNA ZNF664-RFLNA readthrough 2.32352
NECAB1 N-terminal EF-hand calcium binding protein 1 2.32352
AKIRIN1 akirin 1 2.29816
AHSP alpha hemoglobin stabilizing protein 2.2833
SYNRG synergin, gamma 2.26266
GNG11 guanine nucleotide binding protein (G protein), gamma 11 2.25633
RPS12 ribosomal protein S12 2.23299
ZKSCAN2 zinc finger with KRAB and SCAN domains 2 2.23033
SASH1 SAM and SH3 domain containing 1 2.22058
NXT1 nuclear transport factor 2-like export factor 1 2.20909
TDGF1 teratocarcinoma-derived growth factor 1 2.19949
KDR kinase insert domain receptor 2.19178
ZNF709 zinc finger protein 709 2.16749
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 2.16696
ARHGAP26 Rho GTPase activating protein 26 2.15001
THSD7A thrombospondin, type I, domain containing 7A 2.14375
PHLDB2 pleckstrin homology-like domain, family B, member 2 2.14345
ZNF69 zinc finger protein 69 2.1046
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 2.09806
WWOX WW domain containing oxidoreductase 2.09806
GGNBP2 gametogenetin binding protein 2 2.09486
TBP TATA box binding protein 2.09486
ACMSD aminocarboxymuconate semialdehyde decarboxylase 2.08762
PPP1R1C protein phosphatase 1, regulatory (inhibitor) subunit 1C 2.08474
PRRC2B proline-rich coiled-coil 2B 2.08474
LMBRD2 LMBR1 domain containing 2 2.07565
ABRAXAS1 abraxas 1, BRCA1 A complex subunit 2.07149
HACL1 2-hydroxyacyl-CoA lyase 1 2.06875
ATP5MC3 ATP synthase membrane subunit c locus 3 2.06875
PTPA protein phosphatase 2 phosphatase activator 2.06517
DMD dystrophin 2.06338
LYPLA1 lysophospholipase I 2.06053
YIPF5 Yip1 domain family, member 5 2.05993
UNC13B unc-13 homolog B (C. elegans) 2.04262
AGAP3 ArfGAP with GTPase domain, ankyrin repeat and PH domain 3 2.03603
TCF7L1 transcription factor 7-like 1 (T-cell specific, HMG-box) 2.00937

decreased expression

Symbol Name Standardized Value
GNMT glycine N-methyltransferase -2.86217
STUM stum, mechanosensory transduction mediator homolog -2.86217
CCDC74B coiled-coil domain containing 74B -2.86217
FRAT1 frequently rearranged in advanced T-cell lymphomas 1 -2.86217
GPRC5C G protein-coupled receptor, class C, group 5, member C -2.86217
MYH3 myosin, heavy chain 3, skeletal muscle, embryonic -2.86217
RBP7 retinol binding protein 7, cellular -2.86217
PNPLA5 patatin-like phospholipase domain containing 5 -2.86217
LIN37 lin-37 DREAM MuvB core complex component -2.86217
ADORA2A adenosine A2a receptor -2.86217
STYX serine/threonine/tyrosine interacting protein -2.86217
RAI14 retinoic acid induced 14 -2.86217
GDF3 growth differentiation factor 3 -2.86217
LRTM3 leucine rich repeat transmembrane protein 3 -2.80344
ELFN2 extracellular leucine-rich repeat and fibronectin type III domain containing 2 -2.80344
NECTIN4 nectin cell adhesion molecule 4 -2.80344
MROH5 maestro heat-like repeat family member 5 -2.80344
ANKRD37 ankyrin repeat domain 37 -2.80344
MPPED1 metallophosphoesterase domain containing 1 -2.80344
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) -2.80344
SGK2 serum/glucocorticoid regulated kinase 2 -2.80344
DCST1 DC-STAMP domain containing 1 -2.80344
MSC musculin -2.80344
TGFB3 transforming growth factor, beta 3 -2.80344
RSBN1L round spermatid basic protein 1-like -2.80344
HAS1 hyaluronan synthase 1 -2.80344
BEST2 bestrophin 2 -2.80344
ACOT12 acyl-CoA thioesterase 12 -2.80344
TMOD4 tropomodulin 4 (muscle) -2.80344
EFCAB9 EF-hand calcium binding domain 9 -2.80344
CHL1 cell adhesion molecule L1-like -2.80344
NPM2 nucleophosmin/nucleoplasmin 2 -2.80344
SPACDR sperm acrosome developmental regulator -2.80344
INSL3 insulin-like 3 (Leydig cell) -2.80344
FNDC11 fibronectin type III domain containing 11 -2.80344
NAT2 N-acetyltransferase 2 (arylamine N-acetyltransferase) -2.80344
GPR150 G protein-coupled receptor 150 -2.80344
HPX hemopexin -2.80344
ZCCHC18 zinc finger, CCHC domain containing 18 -2.80344
CFAP100 cilia and flagella associated protein 100 -2.80344
GRIN3B glutamate receptor, ionotropic, N-methyl-D-aspartate 3B -2.80344
CYP2C18 cytochrome P450, family 2, subfamily C, polypeptide 18 -2.80344
SAXO5 stabilizer of axonemal microtubules 5 -2.80344
VSTM1 V-set and transmembrane domain containing 1 -2.80344
TEKT3 tektin 3 -2.80251
CBX4 chromobox homolog 4 -2.80251
FBXO41 F-box protein 41 -2.77341
RBBP6 retinoblastoma binding protein 6 -2.73479
CASP10 caspase 10, apoptosis-related cysteine peptidase -2.73014
RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4 -2.73014
MAP7 microtubule-associated protein 7 -2.68562
DESI2 desumoylating isopeptidase 2 -2.68373
SBSPON somatomedin B and thrombospondin, type 1 domain containing -2.68373
TMEM178B transmembrane protein 178B -2.62386
KIFC1 kinesin family member C1 -2.62386
ZNF732 zinc finger protein 732 -2.61916
TM6SF2 transmembrane 6 superfamily member 2 -2.60891
MOB1B MOB kinase activator 1B -2.60016
SHANK3 SH3 and multiple ankyrin repeat domains 3 -2.55368
PDLIM3 PDZ and LIM domain 3 -2.50952
GABPB2 GA binding protein transcription factor, beta subunit 2 -2.48937
ALPK1 alpha-kinase 1 -2.44439
CYP4Z1 cytochrome P450, family 4, subfamily Z, polypeptide 1 -2.44439
DNAJB7 DnaJ (Hsp40) homolog, subfamily B, member 7 -2.44439
PEX39 peroxisomal biogenesis factor 39 -2.39801
KDM4D lysine (K)-specific demethylase 4D -2.38975
ANKFY1 ankyrin repeat and FYVE domain containing 1 -2.37705
ESCO1 establishment of sister chromatid cohesion N-acetyltransferase 1 -2.36833
MINPP1 multiple inositol-polyphosphate phosphatase 1 -2.36376
CIAO2A cytosolic iron-sulfur assembly component 2A -2.31424
CNOT10 CCR4-NOT transcription complex, subunit 10 -2.28627
NUDT12 nudix (nucleoside diphosphate linked moiety X)-type motif 12 -2.23623
MEGF11 multiple EGF-like-domains 11 -2.23181
UBFD1 ubiquitin family domain containing 1 -2.23135
ARSL arylsulfatase L -2.22075
RBKS ribokinase -2.22075
PARD6G par-6 family cell polarity regulator gamma -2.21393
GPM6A glycoprotein M6A -2.21337
CAMK2D calcium/calmodulin-dependent protein kinase II delta -2.20725
STRIP1 striatin interacting protein 1 -2.20396
AAMDC adipogenesis associated, Mth938 domain containing -2.20113
KIRREL1 kirre like nephrin family adhesion molecule 1 -2.1915
NUP50 nucleoporin 50kDa -2.16574
MRPL37 mitochondrial ribosomal protein L37 -2.16399
STMN2 stathmin 2 -2.15923
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 -2.15307
ARPC5L actin related protein 2/3 complex, subunit 5-like -2.15079
STOX1 storkhead box 1 -2.12955
CASTOR1 cytosolic arginine sensor for mTORC1 subunit 1 -2.12574
PPP4R4 protein phosphatase 4, regulatory subunit 4 -2.11415
IARS1 isoleucyl-tRNA synthetase 1 -2.10395
KNSTRN kinetochore-localized astrin/SPAG5 binding protein -2.09049
BEND5 BEN domain containing 5 -2.08762
ZIC1 Zic family member 1 -2.08762
FOXI3 forkhead box I3 -2.08762
GCNT7 glucosaminyl (N-acetyl) transferase family member 7 -2.07734
C19ORF44 chromosome 19 open reading frame 44 -2.07216
MBOAT2 membrane bound O-acyltransferase domain containing 2 -2.07149
RACGAP1 Rac GTPase activating protein 1 -2.07149
TAF1B TATA box binding protein (TBP)-associated factor, RNA polymerase I, B, 63kDa -2.06875
CABLES2 Cdk5 and Abl enzyme substrate 2 -2.06485
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme -2.06439
C3ORF70 chromosome 3 open reading frame 70 -2.02787
KIN Kin17 DNA and RNA binding protein -2.01773
SLC35A5 solute carrier family 35, member A5 -2.01469
ZNF490 zinc finger protein 490 -2.00428