SIHA Gene Set

Dataset DepMap CRISPR Gene Dependency
Category disease or phenotype associations
Type cell line
External Link https://depmap.org/portal/cell_line/ACH-000556
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Genes

195 gene knockdowns changing fitness of SIHA relative to other cell lines from the DepMap CRISPR Gene Dependency Dataset.

Symbol Name Standardized Value
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit 7.47104
COL8A1 collagen, type VIII, alpha 1 7.35552
KDM4A lysine (K)-specific demethylase 4A 7.26732
GJB2 gap junction protein, beta 2, 26kDa 7.05325
ZER1 zyg-11 related, cell cycle regulator 6.31547
UBE3A ubiquitin protein ligase E3A 6.24456
RAPGEF3 Rap guanine nucleotide exchange factor (GEF) 3 5.80856
ARPC5L actin related protein 2/3 complex, subunit 5-like 5.60635
SMR3A submaxillary gland androgen regulated protein 3A 5.51596
ISL2 ISL LIM homeobox 2 4.66694
KRT18 keratin 18, type I 4.63066
SIRT1 sirtuin 1 4.61936
DRC7 dynein regulatory complex subunit 7 4.55902
BIN2 bridging integrator 2 4.45275
S100Z S100 calcium binding protein Z 4.43989
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B 4.39756
ITGA10 integrin, alpha 10 4.32811
SLC28A1 solute carrier family 28 (concentrative nucleoside transporter), member 1 4.1653
OTOP3 otopetrin 3 4.10765
FAM234B family with sequence similarity 234 member B 4.09187
SLC25A25 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25 3.97447
CDH16 cadherin 16, KSP-cadherin 3.94254
TXNIP thioredoxin interacting protein 3.94251
KIAA0895L KIAA0895-like 3.92743
EIF2AK4 eukaryotic translation initiation factor 2 alpha kinase 4 3.89762
ZNF226 zinc finger protein 226 3.85796
ITGA7 integrin, alpha 7 3.80534
OLFML2B olfactomedin-like 2B 3.75625
ANKRD35 ankyrin repeat domain 35 3.62217
CRB2 crumbs family member 2 3.6062
CREBBP CREB binding protein 3.57044
PTP4A3 protein tyrosine phosphatase type IVA, member 3 3.52226
ANKRD62 ankyrin repeat domain 62 3.50205
GPD1 glycerol-3-phosphate dehydrogenase 1 (soluble) 3.49632
CMTM3 CKLF-like MARVEL transmembrane domain containing 3 3.44373
GLUL glutamate-ammonia ligase 3.42379
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2 3.41906
MAPK13 mitogen-activated protein kinase 13 3.40383
ING4 inhibitor of growth family, member 4 3.40376
TBX19 T-box 19 3.38679
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa 3.35168
TSACC TSSK6 activating co-chaperone 3.32571
NFIC nuclear factor I/C (CCAAT-binding transcription factor) 3.31141
TMEM174 transmembrane protein 174 3.28561
SLAMF8 SLAM family member 8 3.22786
ZDHHC1 zinc finger, DHHC-type containing 1 3.17687
TPPP tubulin polymerization promoting protein 3.16486
GNLY granulysin 3.16123
OOEP oocyte expressed protein 3.14321
IL36A interleukin 36, alpha 3.11708
ZC3H7B zinc finger CCCH-type containing 7B 3.10041
SP7 Sp7 transcription factor 3.09695
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta 3.08538
LRRC71 leucine rich repeat containing 71 3.06279
CTXN3 cortexin 3 3.06247
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 3.01377
SYT17 synaptotagmin XVII 2.99812
FGF21 fibroblast growth factor 21 2.99768
CARTPT CART prepropeptide 2.9689
FGFR1 fibroblast growth factor receptor 1 2.96467
PLIN4 perilipin 4 2.96351
HEBP1 heme binding protein 1 2.95742
CCDC65 coiled-coil domain containing 65 2.95225
CHRNA9 cholinergic receptor, nicotinic, alpha 9 (neuronal) 2.9449
ASNS asparagine synthetase (glutamine-hydrolyzing) 2.9378
CST6 cystatin E/M 2.93608
HORMAD2 HORMA domain containing 2 2.87452
PDPR pyruvate dehydrogenase phosphatase regulatory subunit 2.86338
IMPACT impact RWD domain protein 2.8554
OGFOD3 2-oxoglutarate and iron-dependent oxygenase domain containing 3 2.84533
DCAF15 DDB1 and CUL4 associated factor 15 2.84478
TMEM215 transmembrane protein 215 2.84065
GUCA2B guanylate cyclase activator 2B (uroguanylin) 2.82665
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 2.82512
ZNF319 zinc finger protein 319 2.81413
PGLYRP1 peptidoglycan recognition protein 1 2.79664
ACOX2 acyl-CoA oxidase 2, branched chain 2.79079
ZNF697 zinc finger protein 697 2.78179
ODAD1 outer dynein arm docking complex subunit 1 2.75197
HEXD hexosaminidase D 2.74708
TMEM8B transmembrane protein 8B 2.74215
RIT2 Ras-like without CAAX 2 2.73333
PPY pancreatic polypeptide 2.72691
GRASP GRP1 (general receptor for phosphoinositides 1)-associated scaffold protein 2.70958
ATP1B2 ATPase, Na+/K+ transporting, beta 2 polypeptide 2.70179
TEX19 testis expressed 19 2.69468
MEX3B mex-3 RNA binding family member B 2.68576
CCL17 chemokine (C-C motif) ligand 17 2.68406
GSG1 germ cell associated 1 2.67803
FPR2 formyl peptide receptor 2 2.66898
TJAP1 tight junction associated protein 1 (peripheral) 2.62562
CELF3 CUGBP, Elav-like family member 3 2.59454
CD5 CD5 molecule 2.58929
AZIN1 antizyme inhibitor 1 2.58442
KPNA6 karyopherin alpha 6 (importin alpha 7) 2.57025
BCAT2 branched chain amino-acid transaminase 2, mitochondrial 2.55923
OR10P1 olfactory receptor, family 10, subfamily P, member 1 2.55184
CD80 CD80 molecule 2.53438
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor 2.53134
APOLD1 apolipoprotein L domain containing 1 2.52128
CRIP3 cysteine-rich protein 3 2.51895
TRPV2 transient receptor potential cation channel, subfamily V, member 2 2.50573
S100B S100 calcium binding protein B 2.50247
C16ORF70 chromosome 16 open reading frame 70 2.49964
PLAC8 placenta-specific 8 2.49557
CNGA3 cyclic nucleotide gated channel alpha 3 2.48109
SETD1B SET domain containing 1B 2.46655
NPHS1 nephrosis 1, congenital, Finnish type (nephrin) 2.45915
HFE2 hemochromatosis type 2 (juvenile) 2.45757
DNAJC18 DnaJ (Hsp40) homolog, subfamily C, member 18 2.45318
ZNF720 zinc finger protein 720 2.45161
SLC6A9 solute carrier family 6 (neurotransmitter transporter, glycine), member 9 2.44852
SLC4A9 solute carrier family 4, sodium bicarbonate cotransporter, member 9 2.44465
KEAP1 kelch-like ECH-associated protein 1 2.43281
NPPB natriuretic peptide B 2.41383
PLA2G4F phospholipase A2, group IVF 2.40768
CSPG4 chondroitin sulfate proteoglycan 4 2.40008
TCP11 t-complex 11, testis-specific 2.3967
BCAN brevican 2.39602
SMIM14 small integral membrane protein 14 2.35966
C16ORF90 chromosome 16 open reading frame 90 2.35963
PLVAP plasmalemma vesicle associated protein 2.35758
DRGX dorsal root ganglia homeobox 2.35748
NLRC5 NLR family, CARD domain containing 5 2.3536
C1QC complement component 1, q subcomponent, C chain 2.3504
UGDH UDP-glucose 6-dehydrogenase 2.3456
CD7 CD7 molecule 2.34443
PAK6 p21 protein (Cdc42/Rac)-activated kinase 6 2.34075
AXIN1 axin 1 2.33393
TUBB4A tubulin, beta 4A class IVa 2.31647
CHRM4 cholinergic receptor, muscarinic 4 2.29886
NMNAT1 nicotinamide nucleotide adenylyltransferase 1 2.28524
PRF1 perforin 1 (pore forming protein) 2.28456
BOC BOC cell adhesion associated, oncogene regulated 2.27349
SIT1 signaling threshold regulating transmembrane adaptor 1 2.26817
DCTN1 dynactin 1 2.26557
LRCH2 leucine-rich repeats and calponin homology (CH) domain containing 2 2.26487
GUCA1B guanylate cyclase activator 1B (retina) 2.25833
CHST8 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8 2.25739
RSPH1 radial spoke head 1 homolog (Chlamydomonas) 2.25359
MINDY1 MINDY lysine 48 deubiquitinase 1 2.25297
ZNF287 zinc finger protein 287 2.24869
WNT8A wingless-type MMTV integration site family, member 8A 2.24043
NIN ninein (GSK3B interacting protein) 2.22863
PPARGC1B peroxisome proliferator-activated receptor gamma, coactivator 1 beta 2.22063
LCE6A late cornified envelope 6A 2.20733
MAPT microtubule-associated protein tau 2.20633
ADRA2B adrenoceptor alpha 2B 2.2054
RB1 retinoblastoma 1 2.2051
ST6GALNAC4 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4 2.20393
RFX8 RFX family member 8, lacking RFX DNA binding domain 2.19412
EXT2 exostosin glycosyltransferase 2 2.19173
CCDC88B coiled-coil domain containing 88B 2.1864
CORO7 coronin 7 2.18615
SLAMF1 signaling lymphocytic activation molecule family member 1 2.18596
B3GAT3 beta-1,3-glucuronyltransferase 3 2.18434
PGF placental growth factor 2.18388
ZNF317 zinc finger protein 317 2.18186
CFP complement factor properdin 2.17263
CDKL3 cyclin-dependent kinase-like 3 2.16359
KIAA1755 KIAA1755 2.16184
CLEC18B C-type lectin domain family 18, member B 2.15551
AKNA AT-hook transcription factor 2.15286
LHFPL5 lipoma HMGIC fusion partner-like 5 2.14483
CNKSR2 connector enhancer of kinase suppressor of Ras 2 2.13939
M1AP meiosis 1 associated protein 2.11585
AMIGO1 adhesion molecule with Ig-like domain 1 2.11493
ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) 2.1149
TEX101 testis expressed 101 2.11054
CXCL5 chemokine (C-X-C motif) ligand 5 2.10725
FOXN1 forkhead box N1 2.10572
RORC RAR-related orphan receptor C 2.09488
PLCH1 phospholipase C, eta 1 2.09433
ENDOU endonuclease, polyU-specific 2.08098
SLC22A25 solute carrier family 22, member 25 2.07015
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A 2.05092
OVOL1 ovo-like zinc finger 1 2.04904
UXS1 UDP-glucuronate decarboxylase 1 2.04542
FAM229B family with sequence similarity 229, member B 2.0381
SLC4A8 solute carrier family 4, sodium bicarbonate cotransporter, member 8 2.03351
DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1) 2.03131
MYL7 myosin, light chain 7, regulatory 2.02946
CES5A carboxylesterase 5A 2.02943
EPS8L3 EPS8-like 3 2.02932
PF4 platelet factor 4 2.02676
ANXA9 annexin A9 2.02372
GHRH growth hormone releasing hormone 2.01882
MSRB1 methionine sulfoxide reductase B1 2.01712
UGT2B11 UDP glucuronosyltransferase 2 family, polypeptide B11 2.01599
ALX3 ALX homeobox 3 2.01531
CTRB1 chymotrypsinogen B1 2.01139
GPR182 G protein-coupled receptor 182 2.01121
CLDN4 claudin 4 2.00896
DPEP2 dipeptidase 2 2.00736
MT1G metallothionein 1G 2.00676