SIK3 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description SIK family kinase 3| (NCBI Entrez Gene Database, 23387)
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Genes

354 genes differentially expressed following the SIK3 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2 2.62236
MEIG1 meiosis/spermiogenesis associated 1 2.62236
MAEL maelstrom spermatogenic transposon silencer 2.62236
OTOA otoancorin 2.62236
UBQLNL ubiquilin-like 2.62236
RAG2 recombination activating gene 2 2.62236
AMN amnion associated transmembrane protein 2.62236
DUSP10 dual specificity phosphatase 10 2.62236
GATA4 GATA binding protein 4 2.62236
NHLRC4 NHL repeat containing 4 2.62236
IGFL3 IGF-like family member 3 2.62236
HKDC1 hexokinase domain containing 1 2.62236
HRH4 histamine receptor H4 2.62236
C4BPA complement component 4 binding protein, alpha 2.62236
ADAD2 adenosine deaminase domain containing 2 2.62236
LRRIQ3 leucine-rich repeats and IQ motif containing 3 2.62236
CEL carboxyl ester lipase 2.62236
FAM131C family with sequence similarity 131, member C 2.62236
SLC28A2 solute carrier family 28 (concentrative nucleoside transporter), member 2 2.62236
CAPN14 calpain 14 2.62236
DEPP1 DEPP autophagy regulator 1 2.62236
DNAAF19 dynein axonemal assembly factor 19 2.62236
GPR78 G protein-coupled receptor 78 2.62236
C1ORF105 chromosome 1 open reading frame 105 2.62236
DHRS2 dehydrogenase/reductase (SDR family) member 2 2.62236
DNMT3L DNA (cytosine-5-)-methyltransferase 3-like 2.52137
ARHGDIG Rho GDP dissociation inhibitor (GDI) gamma 2.52137
LBHD1 LBH domain containing 1 2.52137
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) 2.52137
P2RY2 purinergic receptor P2Y, G-protein coupled, 2 2.52137
CD1C CD1c molecule 2.52137
SIX6 SIX homeobox 6 2.52137
MS4A4E membrane-spanning 4-domains, subfamily A, member 4E 2.52137
HRH1 histamine receptor H1 2.52137
TMPRSS11A transmembrane protease, serine 11A 2.52137
FAM90A26 family with sequence similarity 90, member A26, pseudogene 2.52137
ELF4 E74-like factor 4 (ets domain transcription factor) 2.52137
LILRA5 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 5 2.52137
NAPSA napsin A aspartic peptidase 2.52137
LAPTM5 lysosomal protein transmembrane 5 2.52137
CARD18 caspase recruitment domain family, member 18 2.52137
RASAL3 RAS protein activator like 3 2.52137
NXPH4 neurexophilin 4 2.52137
DNASE1L2 deoxyribonuclease I-like 2 2.52137
TRPV3 transient receptor potential cation channel, subfamily V, member 3 2.52137
TTLL8 tubulin tyrosine ligase-like family member 8 2.52137
ARSI arylsulfatase family, member I 2.52137
HAS2 hyaluronan synthase 2 2.52137
C1ORF141 chromosome 1 open reading frame 141 2.52137
PHYHIPL phytanoyl-CoA 2-hydroxylase interacting protein-like 2.52137
MEIKIN meiotic kinetochore factor 2.52137
S100A2 S100 calcium binding protein A2 2.52137
S100A4 S100 calcium binding protein A4 2.52137
S100A5 S100 calcium binding protein A5 2.52137
OR2A42 olfactory receptor, family 2, subfamily A, member 42 2.52137
SCNN1G sodium channel, non voltage gated 1 gamma subunit 2.52137
LRG1 leucine-rich alpha-2-glycoprotein 1 2.52137
RAX retina and anterior neural fold homeobox 2.52137
HES7 hes family bHLH transcription factor 7 2.52137
HES3 hes family bHLH transcription factor 3 2.52137
HORMAD1 HORMA domain containing 1 2.52137
RRAD Ras-related associated with diabetes 2.52137
OR2AG1 olfactory receptor, family 2, subfamily AG, member 1 (gene/pseudogene) 2.52137
PAX3 paired box 3 2.52137
OLIG3 oligodendrocyte transcription factor 3 2.52137
OLIG2 oligodendrocyte lineage transcription factor 2 2.52137
SIGLEC1 sialic acid binding Ig-like lectin 1, sialoadhesin 2.52137
TMEM121 transmembrane protein 121 2.52137
CIROZ ciliated left-right organizer protein containing ZP-N domains 2.52137
GIPC3 GIPC PDZ domain containing family, member 3 2.52137
GBP3 guanylate binding protein 3 2.52137
ROPN1L rhophilin associated tail protein 1-like 2.52137
GPX5 glutathione peroxidase 5 2.52137
PNLIPRP3 pancreatic lipase-related protein 3 2.52137
MYH3 myosin, heavy chain 3, skeletal muscle, embryonic 2.52137
RHCE Rh blood group, CcEe antigens 2.52137
FOXN4 forkhead box N4 2.52137
RDH8 retinol dehydrogenase 8 (all-trans) 2.52137
ZNF441 zinc finger protein 441 2.52137
MMD2 monocyte to macrophage differentiation-associated 2 2.52137
VSIR V-set immunoregulatory receptor 2.52137
PLAAT2 phospholipase A and acyltransferase 2 2.52137
PRR20G proline rich 20G 2.52137
PRRT1B proline rich transmembrane protein 1B 2.52137
LOC124902436 talanin 2.52137
FNDC11 fibronectin type III domain containing 11 2.52137
ODAPH odontogenesis associated phosphoprotein 2.52137
TMEM273 transmembrane protein 273 2.52137
CFAP157 cilia and flagella associated protein 157 2.52137
CFAP20DC CFAP20 domain containing 2.52137
AJM1 apical junction component 1 homolog 2.52137
ACOD1 aconitate decarboxylase 1 2.52137
CBLIF cobalamin binding intrinsic factor 2.52137
ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 2.52137
HAL histidine ammonia-lyase 2.52137
CKM creatine kinase, muscle 2.52137
THPO thrombopoietin 2.52137
DAO D-amino-acid oxidase 2.52137
LOC124905976 uncharacterized LOC124905976 2.52137
BIK BCL2-interacting killer (apoptosis-inducing) 2.52137
MAGEB2 melanoma antigen family B2 2.52137
ARL5C ADP-ribosylation factor-like 5C 2.52137
GGTLC3 gamma-glutamyltransferase light chain 3 2.52137
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 2.52137
GGT6 gamma-glutamyltransferase 6 2.52137
ACTL10 actin-like 10 2.52137
FCER2 Fc fragment of IgE, low affinity II, receptor for (CD23) 2.52137
ANXA13 annexin A13 2.52137
FGFBP1 fibroblast growth factor binding protein 1 2.52137
CAPN8 calpain 8 2.52137
C7 complement component 7 2.52137
MTMR11 myotubularin related protein 11 2.52137
UTS2 urotensin 2 2.52137
GSC goosecoid homeobox 2.52137
CLDN22 claudin 22 2.52137
PIWIL3 piwi-like RNA-mediated gene silencing 3 2.52137
CFAP45 cilia and flagella associated protein 45 2.52137
NPIPB9 nuclear pore complex interacting protein family, member B9 2.52137
OR2AT4 olfactory receptor, family 2, subfamily AT, member 4 2.52137
ELAVL4 ELAV like neuron-specific RNA binding protein 4 2.52137
HSPB9 heat shock protein, alpha-crystallin-related, B9 2.52137
CXCR5 chemokine (C-X-C motif) receptor 5 2.52137
CALHM1 calcium homeostasis modulator 1 2.52137
SLC52A1 solute carrier family 52 (riboflavin transporter), member 1 2.52137
LAIR1 leukocyte-associated immunoglobulin-like receptor 1 2.52137
F2RL2 coagulation factor II (thrombin) receptor-like 2 2.52137
CPA5 carboxypeptidase A5 2.52137
CPA4 carboxypeptidase A4 2.52137
CLEC4C C-type lectin domain family 4, member C 2.52137
PSKH2 protein serine kinase H2 2.52137
C2CD4A C2 calcium-dependent domain containing 4A 2.52137
LMOD2 leiomodin 2 (cardiac) 2.52137
MUC13 mucin 13, cell surface associated 2.52137
CXCR4 chemokine (C-X-C motif) receptor 4 2.52137
HHLA2 HERV-H LTR-associating 2 2.52137
SMYD1 SET and MYND domain containing 1 2.52137
CMTM5 CKLF-like MARVEL transmembrane domain containing 5 2.52137
TBPL2 TATA box binding protein like 2 2.52137
IMPACT impact RWD domain protein 2.52137
DUSP26 dual specificity phosphatase 26 (putative) 2.52137
NPIPB15 nuclear pore complex interacting protein family, member B15 2.52137
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1 2.52137
OR56A3 olfactory receptor, family 56, subfamily A, member 3 2.52137
KCNA6 potassium channel, voltage gated shaker related subfamily A, member 6 2.52137
CMC1 C-x(9)-C motif containing 1 2.52137
ZNRF1 zinc and ring finger 1, E3 ubiquitin protein ligase 2.52137
GSTT2B glutathione S-transferase theta 2B (gene/pseudogene) 2.52137
TEKT3 tektin 3 2.52137
COL6A5 collagen, type VI, alpha 5 2.52137
CLEC4A C-type lectin domain family 4, member A 2.52137
CD27 CD27 molecule 2.52137
NKX6-3 NK6 homeobox 3 2.52137
DEFB135 defensin, beta 135 2.52137
GPHRA golgi pH regulator A 2.52137
GPR150 G protein-coupled receptor 150 2.52137
RIN1 Ras and Rab interactor 1 2.52137
KCNA7 potassium channel, voltage gated shaker related subfamily A, member 7 2.52137
IL26 interleukin 26 2.52137
WNT2 wingless-type MMTV integration site family member 2 2.52137
TEX29 testis expressed 29 2.52137
ZNF831 zinc finger protein 831 2.52137
IDI2 isopentenyl-diphosphate delta isomerase 2 2.52137
DND1 DND microRNA-mediated repression inhibitor 1 2.52137
PCDHA13 protocadherin alpha 13 2.52137
SST somatostatin 2.52137
CTXN2 cortexin 2 2.52137
KRT5 keratin 5, type II 2.52137
TMPPE transmembrane protein with metallophosphoesterase domain 2.52137
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 2.52137
TG thyroglobulin 2.52137
TPPP2 tubulin polymerization-promoting protein family member 2 2.52137
DMRT1 doublesex and mab-3 related transcription factor 1 2.52137
PRSS37 protease, serine, 37 2.52137
INSM1 insulinoma-associated 1 2.52137
GPR61 G protein-coupled receptor 61 2.52137
PHOX2A paired-like homeobox 2a 2.52137
KRTAP9-3 keratin associated protein 9-3 2.52137
ATP6V0D2 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2 2.52137
KCNK15 potassium channel, two pore domain subfamily K, member 15 2.52137
ABRA actin binding Rho activating protein 2.52137
LRRC31 leucine rich repeat containing 31 2.52137
GRM6 glutamate receptor, metabotropic 6 2.52137
PRSS21 protease, serine, 21 (testisin) 2.52137
APOL6 apolipoprotein L, 6 2.52137
SLC51B solute carrier family 51, beta subunit 2.52137
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) 2.52137
TMEM52B transmembrane protein 52B 2.52137
IL32 interleukin 32 2.52137
NLRP3 NLR family, pyrin domain containing 3 2.52137
CLEC2A C-type lectin domain family 2, member A 2.52137
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase) 2.52137
MNX1 motor neuron and pancreas homeobox 1 2.52137
TMPRSS15 transmembrane protease, serine 15 2.52137
TMPRSS13 transmembrane protease, serine 13 2.52137
PSMA8 proteasome (prosome, macropain) subunit, alpha type, 8 2.52137
RERGL RERG/RAS-like 2.52137
GLT6D1 glycosyltransferase 6 domain containing 1 2.52137
TMIGD2 transmembrane and immunoglobulin domain containing 2 2.52137
OVCH1 ovochymase 1 2.52137
ECM1 extracellular matrix protein 1 2.52137
CPLX1 complexin 1 2.52137
AVP arginine vasopressin 2.52137
SPINK14 serine peptidase inhibitor, Kazal type 14 (putative) 2.52137
PRSS57 protease, serine, 57 2.52137
CLCNKB chloride channel, voltage-sensitive Kb 2.52137
SHOX short stature homeobox 2.52137
PSORS1C1 psoriasis susceptibility 1 candidate 1 2.52137
CAMK1G calcium/calmodulin-dependent protein kinase IG 2.52137
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4 2.52137
OR2B11 olfactory receptor, family 2, subfamily B, member 11 2.52137
SLITRK6 SLIT and NTRK-like family, member 6 2.52137
AMER2 APC membrane recruitment protein 2 2.52137
SCIMP SLP adaptor and CSK interacting membrane protein 2.47118
CPNE2 copine II 2.43667
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 2.40502
ZNF740 zinc finger protein 740 2.39267
GRAMD2A GRAM domain containing 2A 2.35212
ART3 ADP-ribosyltransferase 3 2.35212
ERFE erythroferrone 2.32969
IDUA iduronidase, alpha-L- 2.32969
GLUD2 glutamate dehydrogenase 2 2.32969
SLC22A1 solute carrier family 22 (organic cation transporter), member 1 2.29772
FSTL4 follistatin-like 4 2.29421
RGPD8 RANBP2-like and GRIP domain containing 8 2.29364
ZMAT3 zinc finger, matrin-type 3 2.29184
KAT6B K(lysine) acetyltransferase 6B 2.27525
RBM12 RNA binding motif protein 12 2.25605
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) 2.25261
SDHD succinate dehydrogenase complex, subunit D, integral membrane protein 2.25143
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) 2.25143
FAM120C family with sequence similarity 120C 2.24794
COX6C cytochrome c oxidase subunit VIc 2.23954
UBA5 ubiquitin-like modifier activating enzyme 5 2.22359
STAG2 stromal antigen 2 2.21891
IFT140 intraflagellar transport 140 2.21891
EXOC2 exocyst complex component 2 2.19779
B4GAT1 beta-1,4-glucuronyltransferase 1 2.18828
RNF185 ring finger protein 185 2.15071
KIF2A kinesin heavy chain member 2A 2.10766
GSR glutathione reductase 2.09419
SERGEF secretion regulating guanine nucleotide exchange factor 2.09066
CCR6 chemokine (C-C motif) receptor 6 2.07254
RAB31 RAB31, member RAS oncogene family 2.06749
FLT4 fms-related tyrosine kinase 4 2.06414
CHMP4C charged multivesicular body protein 4C 2.06091
PTPN14 protein tyrosine phosphatase, non-receptor type 14 2.01334
PDCD5 programmed cell death 5 2.00582
USP36 ubiquitin specific peptidase 36 2.00582
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2 2.00582
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 2.00412
SSX2IP synovial sarcoma, X breakpoint 2 interacting protein 2.0018
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha 2.00174

decreased expression

Symbol Name Standardized Value
SIK3 SIK family kinase 3 -2.79814
MPDU1 mannose-P-dolichol utilization defect 1 -2.62236
CERCAM cerebral endothelial cell adhesion molecule -2.62236
SYTL3 synaptotagmin-like 3 -2.62236
SEMA7A semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group) -2.62236
BMP8A bone morphogenetic protein 8a -2.62236
SLC45A1 solute carrier family 45, member 1 -2.62236
GP1BA glycoprotein Ib (platelet), alpha polypeptide -2.62236
TMEM160 transmembrane protein 160 -2.62236
DLEC1 deleted in lung and esophageal cancer 1 -2.62236
SCD5 stearoyl-CoA desaturase 5 -2.62236
ADAT3 adenosine deaminase, tRNA-specific 3 -2.52137
AADACL3 arylacetamide deacetylase-like 3 -2.52137
FUT3 fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group) -2.52137
HSPB2 heat shock 27kDa protein 2 -2.52137
KIRREL2 kin of IRRE like 2 (Drosophila) -2.52137
ADAM33 ADAM metallopeptidase domain 33 -2.52137
THY1 Thy-1 cell surface antigen -2.52137
PRSS35 protease, serine, 35 -2.52137
RGPD6 RANBP2-like and GRIP domain containing 6 -2.52137
FN1 fibronectin 1 -2.52137
TRPC5OS TRPC5 opposite strand -2.52137
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1 -2.52137
PODNL1 podocan-like 1 -2.52137
ATF4 activating transcription factor 4 -2.52137
GCKR glucokinase (hexokinase 4) regulator -2.52137
MFAP4 microfibrillar-associated protein 4 -2.52137
LBP lipopolysaccharide binding protein -2.52137
PCDHGB2 protocadherin gamma subfamily B, 2 -2.52137
RNF13 ring finger protein 13 -2.52137
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -2.52137
RNF20 ring finger protein 20, E3 ubiquitin protein ligase -2.52137
NTN5 netrin 5 -2.52137
PLAAT4 phospholipase A and acyltransferase 4 -2.52137
WIPF3 WAS/WASL interacting protein family, member 3 -2.52137
UBXN10 UBX domain protein 10 -2.52137
ZNF493 zinc finger protein 493 -2.52137
SPATA2L spermatogenesis associated 2-like -2.52137
EFCAB12 EF-hand calcium binding domain 12 -2.52137
LOC124903372 uncharacterized LOC124903372 -2.52137
ADGRB2 adhesion G protein-coupled receptor B2 -2.52137
CAGE1 cancer antigen 1 -2.52137
NTRK2 neurotrophic tyrosine kinase, receptor, type 2 -2.52137
TRAPPC10 trafficking protein particle complex 10 -2.52137
ISM2 isthmin 2 -2.52137
ZNF432 zinc finger protein 432 -2.52137
ZNF547 zinc finger protein 547 -2.52137
INHA inhibin, alpha -2.52137
SCT secretin -2.52137
MMGT1 membrane magnesium transporter 1 -2.52137
TLR2 toll-like receptor 2 -2.52137
EVI2B ecotropic viral integration site 2B -2.52137
COLEC12 collectin sub-family member 12 -2.51875
ZNF222 zinc finger protein 222 -2.51056
STK11 serine/threonine kinase 11 -2.48659
ZSWIM1 zinc finger, SWIM-type containing 1 -2.47542
PPM1E protein phosphatase, Mg2+/Mn2+ dependent, 1E -2.44744
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7 -2.44288
CTTNBP2NL CTTNBP2 N-terminal like -2.41522
CCDC34 coiled-coil domain containing 34 -2.35212
ST6GALNAC4 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4 -2.34094
LTAP1 lipid transport auxiliary protein 1 -2.31556
H4C4 H4 clustered histone 4 -2.29184
OGDHL oxoglutarate dehydrogenase-like -2.25905
CLPSL1 colipase-like 1 -2.25905
H2BC13 H2B clustered histone 13 -2.25905
C22ORF23 chromosome 22 open reading frame 23 -2.25905
HTR3A 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic -2.24794
FBXO4 F-box protein 4 -2.23954
SDE2 SDE2 telomere maintenance homolog (S. pombe) -2.22788
EPS8L1 EPS8-like 1 -2.2201
TMED4 transmembrane emp24 protein transport domain containing 4 -2.21546
CNTN2 contactin 2 (axonal) -2.15378
B4GALT7 xylosylprotein beta 1,4-galactosyltransferase, polypeptide 7 -2.15084
TMEM106C transmembrane protein 106C -2.14581
CDKL2 cyclin-dependent kinase-like 2 (CDC2-related kinase) -2.13836
ODAD4 outer dynein arm docking complex subunit 4 -2.13179
RHOU ras homolog family member U -2.12384
TCEANC2 transcription elongation factor A (SII) N-terminal and central domain containing 2 -2.10645
NTN4 netrin 4 -2.08615
WFDC10B WAP four-disulfide core domain 10B -2.08006
VIPR1 vasoactive intestinal peptide receptor 1 -2.08006
FBRSL1 fibrosin-like 1 -2.06749
ACTR1A ARP1 actin-related protein 1 homolog A, centractin alpha (yeast) -2.06232
TRMT1 tRNA methyltransferase 1 homolog (S. cerevisiae) -2.05333
RFC2 replication factor C (activator 1) 2, 40kDa -2.05247
ARHGAP27 Rho GTPase activating protein 27 -2.04998
AGBL3 ATP/GTP binding protein-like 3 -2.04998
KCNQ3 potassium channel, voltage gated KQT-like subfamily Q, member 3 -2.04629
OSBPL2 oxysterol binding protein-like 2 -2.04016
DYNLT2B dynein light chain Tctex-type 2B -2.03779
TMOD1 tropomodulin 1 -2.03152
THYN1 thymocyte nuclear protein 1 -2.01707
NDUFA8 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 8, 19kDa -2.01334
GTF2H3 general transcription factor IIH, polypeptide 3, 34kDa -2.01334
RGL3 ral guanine nucleotide dissociation stimulator-like 3 -2.00921
TOB2 transducer of ERBB2, 2 -2.00582
EFCAB13 EF-hand calcium binding domain 13 -2.00582
FKBP3 FK506 binding protein 3, 25kDa -2.00412
FOXK2 forkhead box K2 -2.00412
ZIM3 zinc finger, imprinted 3 -2.00412
ARMH3 armadillo like helical domain containing 3 -2.00175