SIRPA Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description signal-regulatory protein alpha|The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein can be phosphorylated by tyrosine kinases. The phospho-tyrosine residues of this PTP have been shown to recruit SH2 domain containing tyrosine phosphatases (PTP), and serve as substrates of PTPs. This protein was found to participate in signal transduction mediated by various growth factor receptors. CD47 has been demonstrated to be a ligand for this receptor protein. This gene and its product share very high similarity with several other members of the SIRP family. These related genes are located in close proximity to each other on chromosome 20p13. Multiple alternatively spliced transcript variants have been determined for this gene. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 140885)
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Genes

273 genes differentially expressed following the SIRPA gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
STAB1 stabilin 1 2.93429
B3GNT4 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4 2.93429
BTLA B and T lymphocyte associated 2.93429
NPB neuropeptide B 2.93429
DAO D-amino-acid oxidase 2.93429
AGTR1 angiotensin II receptor, type 1 2.93429
EDN1 endothelin 1 2.93429
ANKRD30B ankyrin repeat domain 30B 2.93429
P2RY13 purinergic receptor P2Y, G-protein coupled, 13 2.93429
CST7 cystatin F (leukocystatin) 2.93429
TRPA1 transient receptor potential cation channel, subfamily A, member 1 2.93429
CLEC4G C-type lectin domain family 4, member G 2.93429
ABCG4 ATP-binding cassette, sub-family G (WHITE), member 4 2.93429
WFDC6 WAP four-disulfide core domain 6 2.93429
ISM2 isthmin 2 2.93429
ELL3 elongation factor RNA polymerase II-like 3 2.93429
GPR146 G protein-coupled receptor 146 2.93429
CCDC92 coiled-coil domain containing 92 2.93429
PTGER4 prostaglandin E receptor 4 (subtype EP4) 2.93429
LEF1 lymphoid enhancer-binding factor 1 2.93429
SAPCD1 suppressor APC domain containing 1 2.93429
ZAN zonadhesin (gene/pseudogene) 2.93429
CFAP299 cilia and flagella associated protein 299 2.93429
NXPE1 neurexophilin and PC-esterase domain family, member 1 2.79693
SLFN14 schlafen family member 14 2.79693
CD6 CD6 molecule 2.79693
MAP3K7CL MAP3K7 C-terminal like 2.79693
FABP9 fatty acid binding protein 9, testis 2.79693
ATP13A4 ATPase type 13A4 2.79693
BEST2 bestrophin 2 2.79693
ERAS ES cell expressed Ras 2.79693
FPR1 formyl peptide receptor 1 2.79693
TBX20 T-box 20 2.79693
CCDC116 coiled-coil domain containing 116 2.79693
ZNF503 zinc finger protein 503 2.79693
ASMT acetylserotonin O-methyltransferase 2.79693
SLC39A5 solute carrier family 39 (zinc transporter), member 5 2.79693
GIMAP4 GTPase, IMAP family member 4 2.79693
GIMAP2 GTPase, IMAP family member 2 2.79693
CEP295NL CEP295 N-terminal like 2.79693
UCP3 uncoupling protein 3 (mitochondrial, proton carrier) 2.79693
SLC25A45 solute carrier family 25, member 45 2.79693
ZBTB42 zinc finger and BTB domain containing 42 2.79693
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15 2.79693
GLYAT glycine-N-acyltransferase 2.79693
HES3 hes family bHLH transcription factor 3 2.79693
AKR1C2 aldo-keto reductase family 1, member C2 2.79693
PLIN4 perilipin 4 2.79693
ANKRD22 ankyrin repeat domain 22 2.79693
SPAM1 sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding) 2.79693
PON1 paraoxonase 1 2.79693
PRR23C proline rich 23C 2.79693
SLC46A3 solute carrier family 46, member 3 2.79693
OR8D4 olfactory receptor, family 8, subfamily D, member 4 2.79693
GRAP GRB2-related adaptor protein 2.79693
XKR3 XK, Kell blood group complex subunit-related family, member 3 2.79693
FCMR Fc fragment of IgM receptor 2.79693
SLC2A2 solute carrier family 2 (facilitated glucose transporter), member 2 2.79693
TBC1D3B TBC1 domain family, member 3B 2.79693
PDC phosducin 2.79693
FOXN4 forkhead box N4 2.79693
SPRR2B small proline-rich protein 2B 2.79693
VN1R1 vomeronasal 1 receptor 1 2.79693
ELFN2 extracellular leucine-rich repeat and fibronectin type III domain containing 2 2.79693
MYORG myogenesis regulating glycosidase (putative) 2.79693
TCIM transcriptional and immune response regulator 2.79693
CFAP206 cilia and flagella associated protein 206 2.79693
H2BK1 H2B.K variant histone 1 2.79693
TNS1-AS1 TNS1 antisense RNA 1 2.79693
DNAAF19 dynein axonemal assembly factor 19 2.79693
SPMIP1 sperm microtubule inner protein 1 2.79693
TSPAN1 tetraspanin 1 2.79693
TBX10 T-box 10 2.79693
IDO2 indoleamine 2,3-dioxygenase 2 2.79693
TLR1 toll-like receptor 1 2.79693
ADGRG1 adhesion G protein-coupled receptor G1 2.79693
TPTE transmembrane phosphatase with tensin homology 2.79693
ODAD1 outer dynein arm docking complex subunit 1 2.79693
SH3TC1 SH3 domain and tetratricopeptide repeats 1 2.79693
C1QTNF9 C1q and tumor necrosis factor related protein 9 2.79693
KCNT1 potassium channel, sodium activated subfamily T, member 1 2.79693
NPFF neuropeptide FF-amide peptide precursor 2.79693
CDSN corneodesmosin 2.79693
ALG10B ALG10B, alpha-1,2-glucosyltransferase 2.79693
HAL histidine ammonia-lyase 2.79693
SOAT2 sterol O-acyltransferase 2 2.79693
HNF1A HNF1 homeobox A 2.79693
CNTN6 contactin 6 2.79693
RPS27L ribosomal protein S27-like 2.79693
DYNLRB2 dynein, light chain, roadblock-type 2 2.79693
COXFA4L3 cytochrome c oxidase associated subunit FA4L3 2.79693
TRPM1 transient receptor potential cation channel, subfamily M, member 1 2.79693
LCNL1 lipocalin-like 1 2.79693
UBQLNL ubiquilin-like 2.79693
FATE1 fetal and adult testis expressed 1 2.79693
AQP7 aquaporin 7 2.79693
CYSLTR1 cysteinyl leukotriene receptor 1 2.79693
CD53 CD53 molecule 2.79693
CCDC27 coiled-coil domain containing 27 2.79693
IFNL4 interferon, lambda 4 (gene/pseudogene) 2.79693
GAL3ST2 galactose-3-O-sulfotransferase 2 2.79693
VHLL von Hippel-Lindau tumor suppressor-like 2.79693
MMP1 matrix metallopeptidase 1 2.79693
CHRM4 cholinergic receptor, muscarinic 4 2.79693
SLITRK6 SLIT and NTRK-like family, member 6 2.79693
EPX eosinophil peroxidase 2.79693
UGT3A2 UDP glycosyltransferase 3 family, polypeptide A2 2.79693
GABRD gamma-aminobutyric acid (GABA) A receptor, delta 2.79693
HLA-DQB2 major histocompatibility complex, class II, DQ beta 2 2.79693
MBOAT4 membrane bound O-acyltransferase domain containing 4 2.79693
MUC17 mucin 17, cell surface associated 2.79693
PPP1R14D protein phosphatase 1, regulatory (inhibitor) subunit 14D 2.79693
HOPX HOP homeobox 2.79693
UBXN10 UBX domain protein 10 2.79693
HMGB4 high mobility group box 4 2.79693
MYLK2 myosin light chain kinase 2 2.79693
LMX1B LIM homeobox transcription factor 1, beta 2.79693
LMX1A LIM homeobox transcription factor 1, alpha 2.79693
LRRN4 leucine rich repeat neuronal 4 2.79693
FKBP1C FK506 binding protein 1C 2.79693
SLC36A2 solute carrier family 36 (proton/amino acid symporter), member 2 2.79693
FERMT3 fermitin family member 3 2.79693
TSPYL6 TSPY-like 6 2.79693
SLC22A24 solute carrier family 22, member 24 2.79693
ASTL astacin-like metallo-endopeptidase (M12 family) 2.79693
LY96 lymphocyte antigen 96 2.79693
AICDA activation-induced cytidine deaminase 2.79693
ITGB7 integrin, beta 7 2.79693
CD200R1 CD200 receptor 1 2.79693
NRP1 neuropilin 1 2.79693
NTN5 netrin 5 2.79693
CCDC170 coiled-coil domain containing 170 2.79693
SPHK1 sphingosine kinase 1 2.79693
TMEM132C transmembrane protein 132C 2.79693
GIMD1 GIMAP family P-loop NTPase domain containing 1 2.79693
ADAT3 adenosine deaminase, tRNA-specific 3 2.79693
TPRX1 tetra-peptide repeat homeobox 1 2.79693
LKAAEAR1 LKAAEAR motif containing 1 2.79693
NOTUM notum pectinacetylesterase homolog (Drosophila) 2.79693
OR6A2 olfactory receptor, family 6, subfamily A, member 2 2.79693
APOBR apolipoprotein B receptor 2.79693
HES2 hes family bHLH transcription factor 2 2.79693
C9ORF152 chromosome 9 open reading frame 152 2.79693
GUCY2F guanylate cyclase 2F, retinal 2.79693
TMPRSS15 transmembrane protease, serine 15 2.79693
HCST hematopoietic cell signal transducer 2.79693
ETV7 ets variant 7 2.79693
CYP3A43 cytochrome P450, family 3, subfamily A, polypeptide 43 2.79693
TSHZ1 teashirt zinc finger homeobox 1 2.79693
SAP25 Sin3A-associated protein, 25kDa 2.79693
FRMPD2 FERM and PDZ domain containing 2 2.79693
PRSS22 protease, serine, 22 2.79693
ARHGAP35 Rho GTPase activating protein 35 2.62987
IL4I1 interleukin 4 induced 1 2.60801
DNAJC27 DnaJ (Hsp40) homolog, subfamily C, member 27 2.60642
GALNT9 polypeptide N-acetylgalactosaminyltransferase 9 2.55878
INSYN2B inhibitory synaptic factor family member 2B 2.55878
A1CF APOBEC1 complementation factor 2.55878
INPP5K inositol polyphosphate-5-phosphatase K 2.52286
MYCT1 myc target 1 2.4241
MATK megakaryocyte-associated tyrosine kinase 2.30864
PTK2 protein tyrosine kinase 2 2.30196
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase 2.30196
ANK1 ankyrin 1, erythrocytic 2.29738
CERCAM cerebral endothelial cell adhesion molecule 2.29653
ERCC3 excision repair cross-complementation group 3 2.28271
OGFOD2 2-oxoglutarate and iron-dependent oxygenase domain containing 2 2.28271
TPH2 tryptophan hydroxylase 2 2.28203
MARCHF11 membrane associated ring-CH-type finger 11 2.22555
COX10 COX10 heme A:farnesyltransferase cytochrome c oxidase assembly factor 2.19925
PRKAB1 protein kinase, AMP-activated, beta 1 non-catalytic subunit 2.17344
FBLIM1 filamin binding LIM protein 1 2.16963
GPR3 G protein-coupled receptor 3 2.12643
ZNF12 zinc finger protein 12 2.1248
GALNT13 polypeptide N-acetylgalactosaminyltransferase 13 2.12363
GALNT10 polypeptide N-acetylgalactosaminyltransferase 10 2.09709
H2AC12 H2A clustered histone 12 2.09517
CRYL1 crystallin, lambda 1 2.08803
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) 2.08514
SLC4A3 solute carrier family 4 (anion exchanger), member 3 2.07593
IPP intracisternal A particle-promoted polypeptide 2.0705
ATXN7L1 ataxin 7-like 1 2.01516

decreased expression

Symbol Name Standardized Value
GJC3 gap junction protein, gamma 3, 30.2kDa -2.93429
PARS2 prolyl-tRNA synthetase 2, mitochondrial (putative) -2.93429
FLT3LG fms-related tyrosine kinase 3 ligand -2.93429
DOC2B double C2-like domains, beta -2.93429
SCARF1 scavenger receptor class F, member 1 -2.93429
RNF128 ring finger protein 128, E3 ubiquitin protein ligase -2.93429
SACK1A scaffolding CK1 anchoring protein A -2.93429
AMH anti-Mullerian hormone -2.79693
CD8A CD8a molecule -2.79693
TMC3 transmembrane channel-like 3 -2.79693
BMP8B bone morphogenetic protein 8b -2.79693
SYTL4 synaptotagmin-like 4 -2.79693
SPMIP9 sperm microtubule inner protein 9 -2.79693
NOCT nocturnin -2.79693
ACAN aggrecan -2.79693
PPP1R3C protein phosphatase 1, regulatory subunit 3C -2.79693
FAM167B family with sequence similarity 167, member B -2.79693
CXCL2 chemokine (C-X-C motif) ligand 2 -2.79693
VPREB3 pre-B lymphocyte 3 -2.79693
LXN latexin -2.79693
PDE1B phosphodiesterase 1B, calmodulin-dependent -2.79693
SMIM41 small integral membrane protein 41 -2.79693
SLITRK5 SLIT and NTRK-like family, member 5 -2.79693
LMO2 LIM domain only 2 (rhombotin-like 1) -2.79693
SLC26A3 solute carrier family 26 (anion exchanger), member 3 -2.79693
GTF2A1L general transcription factor IIA, 1-like -2.79693
WNT3 wingless-type MMTV integration site family, member 3 -2.79693
PVALEF parvalbumin like EF-hand containing -2.79693
APBB3 amyloid beta (A4) precursor protein-binding, family B, member 3 -2.79693
ACTG2 actin, gamma 2, smooth muscle, enteric -2.79693
KCNAB3 potassium channel, voltage gated subfamily A regulatory beta subunit 3 -2.79693
EPB41L3 erythrocyte membrane protein band 4.1-like 3 -2.79693
EBF3 early B-cell factor 3 -2.79693
TCEA3 transcription elongation factor A (SII), 3 -2.79693
SERPINE3 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 3 -2.79693
ADPRH ADP-ribosylarginine hydrolase -2.79693
NKIRAS1 NFKB inhibitor interacting Ras-like 1 -2.6742
KHNYN KH and NYN domain containing -2.62406
ZNF341 zinc finger protein 341 -2.61566
ANXA11 annexin A11 -2.61433
PLEKHA3 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 3 -2.57462
TMEM158 transmembrane protein 158 (gene/pseudogene) -2.55878
FAM168B family with sequence similarity 168, member B -2.55714
EFHB EF-hand domain family, member B -2.52481
TJP3 tight junction protein 3 -2.50437
LY75 lymphocyte antigen 75 -2.46972
TOMM40L translocase of outer mitochondrial membrane 40 homolog (yeast)-like -2.46972
MAP7D3 MAP7 domain containing 3 -2.46154
CNTN1 contactin 1 -2.44852
AP5S1 adaptor-related protein complex 5, sigma 1 subunit -2.43639
ADRA2B adrenoceptor alpha 2B -2.43639
RPS15 ribosomal protein S15 -2.43639
SYTL5 synaptotagmin-like 5 -2.43639
CDCA2 cell division cycle associated 2 -2.43553
CA3 carbonic anhydrase III -2.421
SH3D19 SH3 domain containing 19 -2.41368
FGFR3 fibroblast growth factor receptor 3 -2.36959
NTM neurotrimin -2.36849
UBE2R2 ubiquitin-conjugating enzyme E2R 2 -2.35934
PTGR3 prostaglandin reductase 3 -2.35802
CEBPZOS CEBPZ opposite strand -2.31507
ACP5 acid phosphatase 5, tartrate resistant -2.29653
BSCL2 Berardinelli-Seip congenital lipodystrophy 2 (seipin) -2.27486
AGFG2 ArfGAP with FG repeats 2 -2.23294
NPIPB2 nuclear pore complex interacting protein family member B2 -2.22555
RPH3A rabphilin 3A -2.22555
VPS26B vacuolar protein sorting 26 homolog B (S. pombe) -2.22131
MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2 -2.21188
PELI1 pellino E3 ubiquitin protein ligase 1 -2.20259
SHISA6 shisa family member 6 -2.17992
RASSF4 Ras association (RalGDS/AF-6) domain family member 4 -2.17176
RPL28 ribosomal protein L28 -2.14771
PTP4A3 protein tyrosine phosphatase type IVA, member 3 -2.14135
LTB4R leukotriene B4 receptor -2.11551
CHM choroideremia (Rab escort protein 1) -2.08853
LRIG3 leucine-rich repeats and immunoglobulin-like domains 3 -2.06724
FDXACB1 ferredoxin-fold anticodon binding domain containing 1 -2.05965
FOS FBJ murine osteosarcoma viral oncogene homolog -2.05965
CACNA1F calcium channel, voltage-dependent, L type, alpha 1F subunit -2.05965
CEP70 centrosomal protein 70kDa -2.04352
MARCHF6 membrane associated ring-CH-type finger 6 -2.03698
FLII flightless I homolog (Drosophila) -2.03252
LSM10 LSM10, U7 small nuclear RNA associated -2.03252
FBXO16 F-box protein 16 -2.03223
IFT80 intraflagellar transport 80 -2.02966
RPF2 ribosome production factor 2 homolog (S. cerevisiae) -2.02347
ELOF1 elongation factor 1 homolog (S. cerevisiae) -2.01516
SPMIP4 sperm microtubule inner protein 4 -2.01516
PPARG peroxisome proliferator-activated receptor gamma -2.01516
MPP3 membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3) -2.00225
SH3GL2 SH3-domain GRB2-like 2 -2.00225