SIRPA Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description signal-regulatory protein alpha|The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein can be phosphorylated by tyrosine kinases. The phospho-tyrosine residues of this PTP have been shown to recruit SH2 domain containing tyrosine phosphatases (PTP), and serve as substrates of PTPs. This protein was found to participate in signal transduction mediated by various growth factor receptors. CD47 has been demonstrated to be a ligand for this receptor protein. This gene and its product share very high similarity with several other members of the SIRP family. These related genes are located in close proximity to each other on chromosome 20p13. Multiple alternatively spliced transcript variants have been determined for this gene. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 140885)
External Link http://www.ncbi.nlm.nih.gov/gene/140885
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165 interacting proteins for SIRPA from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
AGER advanced glycosylation end product-specific receptor
ALDOC aldolase C, fructose-bisphosphate
ARAP1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
ARHGAP12 Rho GTPase activating protein 12
ARHGAP20 Rho GTPase activating protein 20
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
BASP1 brain abundant, membrane attached signal protein 1
BCR breakpoint cluster region
C11ORF84 chromosome 11 open reading frame 84
C1ORF27 chromosome 1 open reading frame 27
CA4 carbonic anhydrase IV
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CD2AP CD2-associated protein
CD47 CD47 molecule
CD59 CD59 molecule, complement regulatory protein
CLTC clathrin, heavy chain (Hc)
CNP 2',3'-cyclic nucleotide 3' phosphodiesterase
CNTN1 contactin 1
COX5A cytochrome c oxidase subunit Va
COX5B cytochrome c oxidase subunit Vb
COX6A1 cytochrome c oxidase subunit VIa polypeptide 1
COX6B1 cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous)
COX6C cytochrome c oxidase subunit VIc
CSK c-src tyrosine kinase
CSRP1 cysteine and glycine-rich protein 1
CTTN cortactin
CYC1 cytochrome c-1
DIAPH1 diaphanous-related formin 1
DIRAS2 DIRAS family, GTP-binding RAS-like 2
DNM1 dynamin 1
DNM2 dynamin 2
DNM3 dynamin 3
DOCK4 dedicator of cytokinesis 4
DOCK5 dedicator of cytokinesis 5
DPYSL2 dihydropyrimidinase-like 2
EGFR epidermal growth factor receptor
ELMO2 engulfment and cell motility 2
EPB41L3 erythrocyte membrane protein band 4.1-like 3
EPS15L1 epidermal growth factor receptor pathway substrate 15-like 1
ERRFI1 ERBB receptor feedback inhibitor 1
FAU Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed
FBN2 fibrillin 2
FGD6 FYVE, RhoGEF and PH domain containing 6
FRS2 fibroblast growth factor receptor substrate 2
GAB1 GRB2-associated binding protein 1
GAB2 GRB2-associated binding protein 2
GAREM GRB2 associated, regulator of MAPK1
GAREML GRB2 associated, regulator of MAPK1-like
GFAP glial fibrillary acidic protein
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
GNAO1 guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
GNAZ guanine nucleotide binding protein (G protein), alpha z polypeptide
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1
GNB2 guanine nucleotide binding protein (G protein), beta polypeptide 2
GPM6A glycoprotein M6A
GRB2 growth factor receptor-bound protein 2
HACD3 3-hydroxyacyl-CoA dehydratase 3
HGS hepatocyte growth factor-regulated tyrosine kinase substrate
HTT huntingtin
HUNK hormonally up-regulated Neu-associated kinase
IGF2BP1 insulin-like growth factor 2 mRNA binding protein 1
IL1RAP interleukin 1 receptor accessory protein
INPPL1 inositol polyphosphate phosphatase-like 1
IRS1 insulin receptor substrate 1
IRS2 insulin receptor substrate 2
IRS4 insulin receptor substrate 4
JAK2 Janus kinase 2
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1
KIRREL kin of IRRE like (Drosophila)
LANCL1 LanC lantibiotic synthetase component C-like 1 (bacterial)
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5
MYCBP MYC binding protein
NCKAP1 NCK-associated protein 1
NDUFA13 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13
NDUFA9 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39kDa
NDUFB10 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 10, 22kDa
NDUFB9 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 9, 22kDa
NDUFS1 NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase)
NDUFS3 NADH dehydrogenase (ubiquinone) Fe-S protein 3, 30kDa (NADH-coenzyme Q reductase)
NDUFS5 NADH dehydrogenase (ubiquinone) Fe-S protein 5, 15kDa (NADH-coenzyme Q reductase)
NDUFV1 NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa
NEGR1 neuronal growth regulator 1
NISCH nischarin
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain)
NPTN neuroplastin
NTM neurotrimin
OPCML opioid binding protein/cell adhesion molecule-like
PIK3AP1 phosphoinositide-3-kinase adaptor protein 1
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PLCG1 phospholipase C, gamma 1
PLP1 proteolipid protein 1
PPM1B protein phosphatase, Mg2+/Mn2+ dependent, 1B
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme
PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme
PPP5C protein phosphatase 5, catalytic subunit
PRNP prion protein
PSTPIP2 proline-serine-threonine phosphatase interacting protein 2
PTK2 protein tyrosine kinase 2
PTPN11 protein tyrosine phosphatase, non-receptor type 11
PTPN12 protein tyrosine phosphatase, non-receptor type 12
PTPN18 protein tyrosine phosphatase, non-receptor type 18 (brain-derived)
PTPN6 protein tyrosine phosphatase, non-receptor type 6
PTPRJ protein tyrosine phosphatase, receptor type, J
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RADIL Ras association and DIL domains
RBBP6 retinoblastoma binding protein 6
SEPT7 septin 7
SH2D5 SH2 domain containing 5
SH3PXD2A SH3 and PX domains 2A
SH3PXD2B SH3 and PX domains 2B
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SLAIN2 SLAIN motif family, member 2
SLC25A12 solute carrier family 25 (aspartate/glutamate carrier), member 12
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
SLC6A1 solute carrier family 6 (neurotransmitter transporter), member 1
SNAP25 synaptosomal-associated protein, 25kDa
SNX18 sorting nexin 18
SOS1 son of sevenless homolog 1 (Drosophila)
SOS2 son of sevenless homolog 2 (Drosophila)
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STAMBP STAM binding protein
STX1A syntaxin 1A (brain)
STX1B syntaxin 1B
STXBP1 syntaxin binding protein 1
SYNJ1 synaptojanin 1
SYP synaptophysin
SYT2 synaptotagmin II
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TEC tec protein tyrosine kinase
THY1 Thy-1 cell surface antigen
TPP1 tripeptidyl peptidase I
TRIM2 tripartite motif containing 2
TSG101 tumor susceptibility 101
TTYH2 tweety family member 2
UBC ubiquitin C
UQCRC1 ubiquinol-cytochrome c reductase core protein I
UQCRC2 ubiquinol-cytochrome c reductase core protein II
UQCRH ubiquinol-cytochrome c reductase hinge protein
VAV3 vav 3 guanine nucleotide exchange factor
VDAC1 voltage-dependent anion channel 1
VDAC2 voltage-dependent anion channel 2
VDAC3 voltage-dependent anion channel 3
WASL Wiskott-Aldrich syndrome-like
WDR44 WD repeat domain 44
WDR6 WD repeat domain 6
WDR77 WD repeat domain 77
WIPF1 WAS/WASL interacting protein family, member 1
WIPF2 WAS/WASL interacting protein family, member 2
WIPF3 WAS/WASL interacting protein family, member 3
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta