SIRT1 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description sirtuin 1|This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2008] (NCBI Entrez Gene Database, 23411)
External Link http://www.ncbi.nlm.nih.gov/gene/23411
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326 interacting proteins for SIRT1 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
AASDHPPT aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase
ACACA acetyl-CoA carboxylase alpha
ACSS2 acyl-CoA synthetase short-chain family member 2
AFF4 AF4/FMR2 family, member 4
AGO1 argonaute RISC catalytic component 1
AHCY adenosylhomocysteinase
AHCYL1 adenosylhomocysteinase-like 1
AHCYL2 adenosylhomocysteinase-like 2
AKIP1 A kinase (PRKA) interacting protein 1
AKIRIN2 akirin 2
AKT1 v-akt murine thymoma viral oncogene homolog 1
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
AR androgen receptor
ARHGAP29 Rho GTPase activating protein 29
ARID4B AT rich interactive domain 4B (RBP1-like)
ARNTL aryl hydrocarbon receptor nuclear translocator-like
ARRB2 arrestin, beta 2
ATG5 autophagy related 5
ATG7 autophagy related 7
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide
ATXN7L2 ataxin 7-like 2
ATXN7L3 ataxin 7-like 3
ATXN7L3B ataxin 7-like 3B
AURKB aurora kinase B
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
BHLHE41 basic helix-loop-helix family, member e41
C1QBP complement component 1, q subcomponent binding protein
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast)
CCDC101 coiled-coil domain containing 101
CCNB1 cyclin B1
CCNT1 cyclin T1
CDCA8 cell division cycle associated 8
CDK1 cyclin-dependent kinase 1
CDK6 cyclin-dependent kinase 6
CDK9 cyclin-dependent kinase 9
CDKL1 cyclin-dependent kinase-like 1 (CDC2-related kinase)
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2
CHD3 chromodomain helicase DNA binding protein 3
CIITA class II, major histocompatibility complex, transactivator
CLOCK clock circadian regulator
CMYA5 cardiomyopathy associated 5
CNOT1 CCR4-NOT transcription complex, subunit 1
CNOT10 CCR4-NOT transcription complex, subunit 10
CREB1 cAMP responsive element binding protein 1
CREBBP CREB binding protein
CREBZF CREB/ATF bZIP transcription factor
CSNK2A1 casein kinase 2, alpha 1 polypeptide
CSNK2A2 casein kinase 2, alpha prime polypeptide
CSNK2B casein kinase 2, beta polypeptide
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CTTN cortactin
DCAF16 DDB1 and CUL4 associated factor 16
DDOST dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit (non-catalytic)
DEDD death effector domain containing
DGKA diacylglycerol kinase, alpha 80kDa
DIAPH3 diaphanous-related formin 3
DICER1 dicer 1, ribonuclease type III
DNAJA2 DnaJ (Hsp40) homolog, subfamily A, member 2
DNMT1 DNA (cytosine-5-)-methyltransferase 1
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta
DOT1L DOT1-like histone H3K79 methyltransferase
DVL1 dishevelled segment polarity protein 1
DVL2 dishevelled segment polarity protein 2
DVL3 dishevelled segment polarity protein 3
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
E2F1 E2F transcription factor 1
EBNA1BP2 EBNA1 binding protein 2
ECT2 epithelial cell transforming 2
EDIL3 EGF-like repeats and discoidin I-like domains 3
EED embryonic ectoderm development
EEF1A1 eukaryotic translation elongation factor 1 alpha 1
EEF1G eukaryotic translation elongation factor 1 gamma
EIF2B4 eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa
ELAVL1 ELAV like RNA binding protein 1
ELL3 elongation factor RNA polymerase II-like 3
ENY2 enhancer of yellow 2 homolog (Drosophila)
EP300 E1A binding protein p300
ESR1 estrogen receptor 1
ESRRA estrogen-related receptor alpha
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FASN fatty acid synthase
FBN2 fibrillin 2
FBXO3 F-box protein 3
FHL2 four and a half LIM domains 2
FKBP1A FK506 binding protein 1A, 12kDa
FOS FBJ murine osteosarcoma viral oncogene homolog
FOXO1 forkhead box O1
FOXO3 forkhead box O3
FOXO4 forkhead box O4
GABARAPL1 GABA(A) receptor-associated protein like 1
GAPDH glyceraldehyde-3-phosphate dehydrogenase
GTF2A1 general transcription factor IIA, 1, 19/37kDa
H2AFB1 H2A histone family, member B1
H2AFX H2A histone family, member X
H2AFZ H2A histone family, member Z
H2BFS H2B histone family, member S (pseudogene)
H3F3A H3 histone, family 3A
HCFC1 host cell factor C1
HCFC2 host cell factor C2
HDAC2 histone deacetylase 2
HDAC4 histone deacetylase 4
HES1 hes family bHLH transcription factor 1
HEY2 hes-related family bHLH transcription factor with YRPW motif 2
HIC1 hypermethylated in cancer 1
HIST1H1B histone cluster 1, H1b
HIST1H2AB histone cluster 1, H2ab
HIST1H2AC histone cluster 1, H2ac
HIST1H2AD histone cluster 1, H2ad
HIST1H2AJ histone cluster 1, H2aj
HIST1H2BA histone cluster 1, H2ba
HIST1H2BB histone cluster 1, H2bb
HIST1H2BD histone cluster 1, H2bd
HIST1H2BF histone cluster 1, H2bf
HIST1H2BH histone cluster 1, H2bh
HIST1H2BJ histone cluster 1, H2bj
HIST1H2BK histone cluster 1, H2bk
HIST1H2BL histone cluster 1, H2bl
HIST1H2BM histone cluster 1, H2bm
HIST1H2BN histone cluster 1, H2bn
HIST1H2BO histone cluster 1, H2bo
HIST1H3B histone cluster 1, H3b
HIST1H4F histone cluster 1, H4f
HIST2H2AA4 histone cluster 2, H2aa4
HIST2H2AB histone cluster 2, H2ab
HIST2H2AC histone cluster 2, H2ac
HIST2H2BE histone cluster 2, H2be
HIST2H3A histone cluster 2, H3a
HIST3H2BB histone cluster 3, H2bb
HIST3H3 histone cluster 3, H3
HNF1A HNF1 homeobox A
HNF4A hepatocyte nuclear factor 4, alpha
HNRNPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9)
HNRNPK heterogeneous nuclear ribonucleoprotein K
HNRNPUL1 heterogeneous nuclear ribonucleoprotein U-like 1
HSF1 heat shock transcription factor 1
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA1L heat shock 70kDa protein 1-like
HSPA4 heat shock 70kDa protein 4
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA9 heat shock 70kDa protein 9 (mortalin)
HSPD1 heat shock 60kDa protein 1 (chaperonin)
ING1 inhibitor of growth family, member 1
ING2 inhibitor of growth family, member 2
IPO9 importin 9
IQCB1 IQ motif containing B1
IRS1 insulin receptor substrate 1
IRS2 insulin receptor substrate 2
ITPK1 inositol-tetrakisphosphate 1-kinase
JAK1 Janus kinase 1
JUN jun proto-oncogene
JUND jun D proto-oncogene
KAT2A K(lysine) acetyltransferase 2A
KAT2B K(lysine) acetyltransferase 2B
KAT5 K(lysine) acetyltransferase 5
KAT8 K(lysine) acetyltransferase 8
KCNA4 potassium channel, voltage gated shaker related subfamily A, member 4
KCNA5 potassium channel, voltage gated shaker related subfamily A, member 5
KCNAB2 potassium channel, voltage gated subfamily A regulatory beta subunit 2
KIAA1598
KIF7 kinesin family member 7
KLHL23 kelch-like family member 23
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KPNA3 karyopherin alpha 3 (importin alpha 4)
KRT79 keratin 79, type II
KYNU kynureninase
LAMA3 laminin, alpha 3
LANCL1 LanC lantibiotic synthetase component C-like 1 (bacterial)
LTA4H leukotriene A4 hydrolase
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MAP2K4 mitogen-activated protein kinase kinase 4
MAPK8 mitogen-activated protein kinase 8
MAPT microtubule-associated protein tau
MCF2L2 MCF.2 cell line derived transforming sequence-like 2
MECOM MDS1 and EVI1 complex locus
MEF2C myocyte enhancer factor 2C
MLLT1 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1
MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
MRE11A MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
MRPS7 mitochondrial ribosomal protein S7
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
MYOD1 myogenic differentiation 1
NAT10 N-acetyltransferase 10 (GCN5-related)
NBN nibrin
NCOA2 nuclear receptor coactivator 2
NCOR1 nuclear receptor corepressor 1
NCOR2 nuclear receptor corepressor 2
NEDD8 neural precursor cell expressed, developmentally down-regulated 8
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NHLH2 nescient helix loop helix 2
NMNAT1 nicotinamide nucleotide adenylyltransferase 1
NOC4L nucleolar complex associated 4 homolog (S. cerevisiae)
NOP14 NOP14 nucleolar protein
NOS3 nitric oxide synthase 3 (endothelial cell)
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NR0B2 nuclear receptor subfamily 0, group B, member 2
NR1H2 nuclear receptor subfamily 1, group H, member 2
NR1H3 nuclear receptor subfamily 1, group H, member 3
NR1H4 nuclear receptor subfamily 1, group H, member 4
NUDCD2 NudC domain containing 2
NUDT21 nudix (nucleoside diphosphate linked moiety X)-type motif 21
PAPOLA poly(A) polymerase alpha
PCNA proliferating cell nuclear antigen
PDCD1 programmed cell death 1
PHLDB3 pleckstrin homology-like domain, family B, member 3
PIAS2 protein inhibitor of activated STAT, 2
PIAS3 protein inhibitor of activated STAT, 3
PIAS4 protein inhibitor of activated STAT, 4
PICALM phosphatidylinositol binding clathrin assembly protein
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PML promyelocytic leukemia
POFUT2 protein O-fucosyltransferase 2
POP1 processing of precursor 1, ribonuclease P/MRP subunit (S. cerevisiae)
PPARA peroxisome proliferator-activated receptor alpha
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
PPM1G protein phosphatase, Mg2+/Mn2+ dependent, 1G
PREPL prolyl endopeptidase-like
PRMT5 protein arginine methyltransferase 5
PSMA2 proteasome (prosome, macropain) subunit, alpha type, 2
PSMA4 proteasome (prosome, macropain) subunit, alpha type, 4
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7
PSMB5 proteasome (prosome, macropain) subunit, beta type, 5
PSME3 proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)
PUS7 pseudouridylate synthase 7 (putative)
RAD50 RAD50 homolog (S. cerevisiae)
RAP1A RAP1A, member of RAS oncogene family
RARA retinoic acid receptor, alpha
RB1 retinoblastoma 1
RBM25 RNA binding motif protein 25
RBP1 retinol binding protein 1, cellular
RECQL4 RecQ protein-like 4
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RPL17 ribosomal protein L17
RPL23 ribosomal protein L23
RPL38 ribosomal protein L38
RPS19BP1 ribosomal protein S19 binding protein 1
RPS27L ribosomal protein S27-like
RPS3 ribosomal protein S3
RPTOR regulatory associated protein of MTOR, complex 1
RRP8 ribosomal RNA processing 8, methyltransferase, homolog (yeast)
RSL1D1 ribosomal L1 domain containing 1
RUVBL2 RuvB-like AAA ATPase 2
SART1 squamous cell carcinoma antigen recognized by T cells
SART3 squamous cell carcinoma antigen recognized by T cells 3
SATB1 SATB homeobox 1
SCNM1 sodium channel modifier 1
SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4
SET SET nuclear proto-oncogene
SETD7 SET domain containing (lysine methyltransferase) 7
SIRT2 sirtuin 2
SKI SKI proto-oncogene
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13
SLC25A3 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
SMAD7 SMAD family member 7
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2
SND1 staphylococcal nuclease and tudor domain containing 1
SNW1 SNW domain containing 1
SP1 Sp1 transcription factor
SPDL1 spindle apparatus coiled-coil protein 1
SREBF1 sterol regulatory element binding transcription factor 1
SRRM2 serine/arginine repetitive matrix 2
SSR1 signal sequence receptor, alpha
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STK4 serine/threonine kinase 4
SUPT20H suppressor of Ty 20 homolog (S. cerevisiae)
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae)
SUPT7L suppressor of Ty 7 (S. cerevisiae)-like
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SUZ12 SUZ12 polycomb repressive complex 2 subunit
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TADA1 transcriptional adaptor 1
TADA2B transcriptional adaptor 2B
TADA3 transcriptional adaptor 3
TAF1A TATA box binding protein (TBP)-associated factor, RNA polymerase I, A, 48kDa
TAF1B TATA box binding protein (TBP)-associated factor, RNA polymerase I, B, 63kDa
TAF1C TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TAF2 TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa
TAF5L TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa
TAF6L TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa
TAF9 TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa
TARBP2 TAR (HIV-1) RNA binding protein 2
TBP TATA box binding protein
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TMEM33 transmembrane protein 33
TP53 tumor protein p53
TP63 tumor protein p63
TP73 tumor protein p73
TPM4 tropomyosin 4
TRIM28 tripartite motif containing 28
TRRAP transformation/transcription domain-associated protein
TSC2 tuberous sclerosis 2
TSLIG3A tRNA splicing ligase complex subunit 3A
TSPYL1 TSPY-like 1
TULP3 tubby like protein 3
UBC ubiquitin C
UBE2O ubiquitin-conjugating enzyme E2O
UGDH UDP-glucose 6-dehydrogenase
USP11 ubiquitin specific peptidase 11
USP22 ubiquitin specific peptidase 22
USP27X ubiquitin specific peptidase 27, X-linked
USP9Y ubiquitin specific peptidase 9, Y-linked
UVSSA UV-stimulated scaffold protein A
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
WDR70 WD repeat domain 70
WDR77 WD repeat domain 77
WRN Werner syndrome, RecQ helicase-like
XPA xeroderma pigmentosum, complementation group A
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6
YBX1 Y box binding protein 1
YBX3 Y box binding protein 3
ZBTB7A zinc finger and BTB domain containing 7A
ZEB1 zinc finger E-box binding homeobox 1
ZFP91 ZFP91 zinc finger protein
ZNF346 zinc finger protein 346
ZNF579 zinc finger protein 579
ZNHIT6 zinc finger, HIT-type containing 6