SISO Gene Set

Dataset DepMap CRISPR Gene Dependency
Category disease or phenotype associations
Type cell line
Description cell line derived from Cervical Carcinoma Tumour (Cell Model Passports, SIDM00394)
External Link https://depmap.org/portal/cell_line/ACH-001650
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Genes

331 gene knockdowns changing fitness of SISO relative to other cell lines from the DepMap CRISPR Gene Dependency Dataset.

Symbol Name Standardized Value
YES1 YES proto-oncogene 1, Src family tyrosine kinase 10.2329
NFIC nuclear factor I/C (CCAAT-binding transcription factor) 9.50183
UBE2G1 ubiquitin-conjugating enzyme E2G 1 8.46018
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa 7.34538
LEFTY1 left-right determination factor 1 6.77417
UBE3A ubiquitin protein ligase E3A 6.58467
OR52E2 olfactory receptor, family 52, subfamily E, member 2 6.51824
LHB luteinizing hormone beta polypeptide 6.32164
MYLPF myosin light chain, phosphorylatable, fast skeletal muscle 6.26806
KIR2DL1 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1 5.90786
PSG6 pregnancy specific beta-1-glycoprotein 6 5.82282
OR2A25 olfactory receptor, family 2, subfamily A, member 25 5.66244
DCLRE1C DNA cross-link repair 1C 5.64688
BCL10 B-cell CLL/lymphoma 10 5.33849
RFFL ring finger and FYVE-like domain containing E3 ubiquitin protein ligase 5.20569
OR2H2 olfactory receptor, family 2, subfamily H, member 2 5.10925
FCN2 ficolin (collagen/fibrinogen domain containing lectin) 2 5.08345
ATPAF2 ATP synthase mitochondrial F1 complex assembly factor 2 4.99462
PAPOLA poly(A) polymerase alpha 4.80874
CEP44 centrosomal protein 44kDa 4.71412
GP2 glycoprotein 2 (zymogen granule membrane) 4.70737
ARHGEF35 Rho guanine nucleotide exchange factor (GEF) 35 4.68505
ZER1 zyg-11 related, cell cycle regulator 4.6724
TNS4 tensin 4 4.56373
CMPK2 cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial 4.47261
PASK PAS domain containing serine/threonine kinase 4.44187
CLUH clustered mitochondria (cluA/CLU1) homolog 4.37757
BCAR3 breast cancer anti-estrogen resistance 3 4.36293
CCDC166 coiled-coil domain containing 166 4.31586
CYP4F3 cytochrome P450, family 4, subfamily F, polypeptide 3 4.29492
RAB42 RAB42, member RAS oncogene family 4.28579
OR2D2 olfactory receptor, family 2, subfamily D, member 2 4.27718
PTCHD4 patched domain containing 4 4.27379
FOXD4L5 forkhead box D4-like 5 4.23518
BEND4 BEN domain containing 4 4.18845
SIRAL2 SIR2 antiphage like 2 4.10097
ZNF284 zinc finger protein 284 4.08971
DDAH2 dimethylarginine dimethylaminohydrolase 2 4.06265
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha 4.03769
GALNT13 polypeptide N-acetylgalactosaminyltransferase 13 4.01895
METTL8 methyltransferase like 8 4.01829
ST6GALNAC4 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4 3.96646
KIAA0232 KIAA0232 3.9622
SLC26A11 solute carrier family 26 (anion exchanger), member 11 3.95876
ACP3 acid phosphatase 3 3.94781
OR13C2 olfactory receptor, family 13, subfamily C, member 2 3.94633
SPDYE4 speedy/RINGO cell cycle regulator family member E4 3.90178
GAS2L3 growth arrest-specific 2 like 3 3.89851
FUBP3 far upstream element (FUSE) binding protein 3 3.86412
KRTAP9-9 keratin associated protein 9-9 3.7944
TGIF1 TGFB-induced factor homeobox 1 3.78887
IDH3G isocitrate dehydrogenase 3 (NAD+) gamma 3.77462
KRTAP9-8 keratin associated protein 9-8 3.7456
CHP1 calcineurin-like EF-hand protein 1 3.74502
DIAPH1 diaphanous-related formin 1 3.742
IFNA17 interferon, alpha 17 3.73739
PSG8 pregnancy specific beta-1-glycoprotein 8 3.72239
RAB40A RAB40A, member RAS oncogene family 3.70372
NMNAT3 nicotinamide nucleotide adenylyltransferase 3 3.69428
CENPO centromere protein O 3.69328
ZNF177 zinc finger protein 177 3.68456
PSG4 pregnancy specific beta-1-glycoprotein 4 3.66383
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 3.61245
RGL2 ral guanine nucleotide dissociation stimulator-like 2 3.59438
KIR3DL2 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 2 3.56524
OR2B11 olfactory receptor, family 2, subfamily B, member 11 3.55422
LEMD1 LEM domain containing 1 3.54292
CUL4B cullin 4B 3.54288
ZNF35 zinc finger protein 35 3.52059
MYD88 myeloid differentiation primary response 88 3.51294
GALP galanin-like peptide 3.47317
SHISA6 shisa family member 6 3.45654
DNAJC24 DnaJ (Hsp40) homolog, subfamily C, member 24 3.43804
PIGB phosphatidylinositol glycan anchor biosynthesis, class B 3.42218
H2BC1 H2B clustered histone 1 3.41213
ARSG arylsulfatase G 3.40246
SH2D5 SH2 domain containing 5 3.39725
KIF2A kinesin heavy chain member 2A 3.3966
SPOP speckle-type POZ protein 3.36626
DLGAP2 discs, large (Drosophila) homolog-associated protein 2 3.3425
OR2M7 olfactory receptor, family 2, subfamily M, member 7 3.32018
CELF1 CUGBP, Elav-like family member 1 3.30978
RAD23B RAD23 homolog B (S. cerevisiae) 3.30137
DMBX1 diencephalon/mesencephalon homeobox 1 3.29988
DCHS2 dachsous cadherin-related 2 3.29562
CCP110 centriolar coiled coil protein 110kDa 3.29467
ZNF124 zinc finger protein 124 3.277
XAGE2 X antigen family, member 2 3.27478
ZNF808 zinc finger protein 808 3.26129
PCDHB12 protocadherin beta 12 3.25576
ERCC6L excision repair cross-complementation group 6-like 3.24038
TDP2 tyrosyl-DNA phosphodiesterase 2 3.23648
PBRM1 polybromo 1 3.23552
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 3.22084
TMOD2 tropomodulin 2 (neuronal) 3.21125
ZBTB7B zinc finger and BTB domain containing 7B 3.20094
PSG9 pregnancy specific beta-1-glycoprotein 9 3.19469
RER1 retention in endoplasmic reticulum sorting receptor 1 3.18698
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 3.18442
LPA lipoprotein, Lp(a) 3.17842
ZNF490 zinc finger protein 490 3.17076
TBC1D31 TBC1 domain family, member 31 3.16356
MIDEAS mitotic deacetylase associated SANT domain protein 3.15675
UGT2B7 UDP glucuronosyltransferase 2 family, polypeptide B7 3.15378
PLTP phospholipid transfer protein 3.12827
NPAP1 nuclear pore associated protein 1 3.09961
C11ORF94 chromosome 11 open reading frame 94 3.09324
MAP3K7 mitogen-activated protein kinase kinase kinase 7 3.08562
YIF1B Yip1 interacting factor homolog B (S. cerevisiae) 3.06501
IL1B interleukin 1, beta 3.04806
GPR83 G protein-coupled receptor 83 3.04792
DOCK5 dedicator of cytokinesis 5 3.02126
ZNF511 zinc finger protein 511 3.00157
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 3.00151
GSG1L GSG1-like 3.00122
FAM120C family with sequence similarity 120C 2.99616
KRTAP13-4 keratin associated protein 13-4 2.97564
SLC30A10 solute carrier family 30, member 10 2.964
VMAC vimentin-type intermediate filament associated coiled-coil protein 2.92199
ATAD3B ATPase family, AAA domain containing 3B 2.89752
FAM167A family with sequence similarity 167, member A 2.88687
TET2 tet methylcytosine dioxygenase 2 2.88661
TMEM74 transmembrane protein 74 2.87803
TGFBR1 transforming growth factor, beta receptor 1 2.87291
MALT1 MALT1 paracaspase 2.86884
ADAMTS20 ADAM metallopeptidase with thrombospondin type 1 motif, 20 2.86797
AOX1 aldehyde oxidase 1 2.85357
MATR3 matrin 3 2.8527
C16ORF71 chromosome 16 open reading frame 71 2.84852
HOXD4 homeobox D4 2.8468
ASF1B anti-silencing function 1B histone chaperone 2.8439
ALOX15 arachidonate 15-lipoxygenase 2.83162
DOLPP1 dolichyldiphosphatase 1 2.82801
SLC26A3 solute carrier family 26 (anion exchanger), member 3 2.8228
C1QTNF2 C1q and tumor necrosis factor related protein 2 2.82041
BCAT2 branched chain amino-acid transaminase 2, mitochondrial 2.813
RAD50 RAD50 homolog (S. cerevisiae) 2.81237
EXOC7 exocyst complex component 7 2.8064
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2 2.79415
SYT6 synaptotagmin VI 2.78968
IRAK1 interleukin-1 receptor-associated kinase 1 2.7881
CRTC3 CREB regulated transcription coactivator 3 2.76866
FGD1 FYVE, RhoGEF and PH domain containing 1 2.76745
DHX35 DEAH (Asp-Glu-Ala-His) box polypeptide 35 2.7627
OR5V1 olfactory receptor, family 5, subfamily V, member 1 2.75966
AHR aryl hydrocarbon receptor 2.75961
KRT10 keratin 10, type I 2.75892
TMEM131 transmembrane protein 131 2.75557
MCTS1 malignant T cell amplified sequence 1 2.75375
FKBPL FK506 binding protein like 2.73013
RHOXF2B Rhox homeobox family, member 2B 2.72674
FBXO28 F-box protein 28 2.72353
PRRX2 paired related homeobox 2 2.7117
UBTD1 ubiquitin domain containing 1 2.7078
CYS1 cystin 1 2.70659
PRAMEF12 PRAME family member 12 2.70593
FLG filaggrin 2.70567
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 2.70417
FAM46D family with sequence similarity 46, member D 2.69474
MTERF1 mitochondrial transcription termination factor 1 2.68792
ZNF675 zinc finger protein 675 2.68479
KIR2DL4 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4 2.68296
SLX4 SLX4 structure-specific endonuclease subunit 2.6791
UBB ubiquitin B 2.66772
PDE6G phosphodiesterase 6G, cGMP-specific, rod, gamma 2.66613
TMCO6 transmembrane and coiled-coil domains 6 2.65853
ZNF573 zinc finger protein 573 2.6496
POU3F4 POU class 3 homeobox 4 2.63954
SPEM1 spermatid maturation 1 2.63524
TEX29 testis expressed 29 2.63465
CCDC89 coiled-coil domain containing 89 2.63184
MUC5B mucin 5B, oligomeric mucus/gel-forming 2.63107
GTF2I general transcription factor IIi 2.63083
PATL2 protein associated with topoisomerase II homolog 2 (yeast) 2.62785
ALG8 ALG8, alpha-1,3-glucosyltransferase 2.62448
PRAM1 PML-RARA regulated adaptor molecule 1 2.6178
ISL2 ISL LIM homeobox 2 2.61472
BAX BCL2-associated X protein 2.60913
MUS81 MUS81 structure-specific endonuclease subunit 2.60723
OAZ3 ornithine decarboxylase antizyme 3 2.60496
CTRB1 chymotrypsinogen B1 2.6038
FLYWCH1 FLYWCH-type zinc finger 1 2.59969
SST somatostatin 2.59641
ACSS2 acyl-CoA synthetase short-chain family member 2 2.59638
TRPV6 transient receptor potential cation channel, subfamily V, member 6 2.59514
SLC35C2 solute carrier family 35 (GDP-fucose transporter), member C2 2.58532
EXOC2 exocyst complex component 2 2.58527
OR4K5 olfactory receptor, family 4, subfamily K, member 5 2.58328
IFNA21 interferon, alpha 21 2.58122
ZNF775 zinc finger protein 775 2.5787
VSX2 visual system homeobox 2 2.57257
KIAA0556 KIAA0556 2.57116
SEC14L5 SEC14-like 5 (S. cerevisiae) 2.56955
MIIP migration and invasion inhibitory protein 2.56093
ZNF518B zinc finger protein 518B 2.55524
ZNF583 zinc finger protein 583 2.55121
OR10A3 olfactory receptor, family 10, subfamily A, member 3 2.53194
UNKL unkempt family zinc finger-like 2.52831
KRT7 keratin 7, type II 2.52706
MPDU1 mannose-P-dolichol utilization defect 1 2.52647
GPR50 G protein-coupled receptor 50 2.51582
LCE3E late cornified envelope 3E 2.51427
GIMAP6 GTPase, IMAP family member 6 2.51174
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1 2.50547
DSCC1 DNA replication and sister chromatid cohesion 1 2.49434
NTRK2 neurotrophic tyrosine kinase, receptor, type 2 2.4867
GBP2 guanylate binding protein 2, interferon-inducible 2.48615
PSME3 proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki) 2.47581
HCN2 hyperpolarization activated cyclic nucleotide gated potassium channel 2 2.46988
SLC25A2 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 2 2.46796
RNF43 ring finger protein 43 2.46749
CIB4 calcium and integrin binding family member 4 2.46261
SLC2A14 solute carrier family 2 (facilitated glucose transporter), member 14 2.45217
WASF2 WAS protein family, member 2 2.44845
LTBP2 latent transforming growth factor beta binding protein 2 2.44686
MAGEA11 melanoma antigen family A11 2.44457
RANBP3 RAN binding protein 3 2.43824
TOMM70 translocase of outer mitochondrial membrane 70 2.43484
TNFRSF9 tumor necrosis factor receptor superfamily, member 9 2.4347
KCNA2 potassium channel, voltage gated shaker related subfamily A, member 2 2.42841
CENPU centromere protein U 2.4262
TMEM174 transmembrane protein 174 2.4258
TRIP13 thyroid hormone receptor interactor 13 2.42192
RSU1 Ras suppressor protein 1 2.41575
SUSD4 sushi domain containing 4 2.41028
CELA2A chymotrypsin-like elastase family, member 2A 2.40104
KRTAP10-1 keratin associated protein 10-1 2.40062
DTX2 deltex 2, E3 ubiquitin ligase 2.38597
RPL39L ribosomal protein L39-like 2.38567
PANX3 pannexin 3 2.37935
ZNF577 zinc finger protein 577 2.37455
UGP2 UDP-glucose pyrophosphorylase 2 2.3569
ZNF230 zinc finger protein 230 2.35628
SP1 Sp1 transcription factor 2.35299
TAS1R2 taste receptor, type 1, member 2 2.34797
ALG5 ALG5, dolichyl-phosphate beta-glucosyltransferase 2.34428
AOAH acyloxyacyl hydrolase (neutrophil) 2.34403
BASP1 brain abundant, membrane attached signal protein 1 2.34022
KLK9 kallikrein-related peptidase 9 2.33706
PTPRD protein tyrosine phosphatase, receptor type, D 2.33404
SPTY2D1 SPT2, Suppressor of Ty, domain containing 1 (S. cerevisiae) 2.3302
PITRM1 pitrilysin metallopeptidase 1 2.31783
CMTM2 CKLF-like MARVEL transmembrane domain containing 2 2.31025
HECTD1 HECT domain containing E3 ubiquitin protein ligase 1 2.30806
ADH6 alcohol dehydrogenase 6 (class V) 2.30406
AASS aminoadipate-semialdehyde synthase 2.30274
FLYWCH2 FLYWCH family member 2 2.30218
PTP4A1 protein tyrosine phosphatase type IVA, member 1 2.29912
LDHA lactate dehydrogenase A 2.29621
C15ORF41 chromosome 15 open reading frame 41 2.29186
CHST6 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 6 2.29003
PXN paxillin 2.28959
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 2.28387
GOLT1B golgi transport 1B 2.27878
CFAP97 cilia and flagella associated protein 97 2.278
GCAT glycine C-acetyltransferase 2.27481
UBALD1 UBA-like domain containing 1 2.2712
FOXK1 forkhead box K1 2.26888
CHCHD3 coiled-coil-helix-coiled-coil-helix domain containing 3 2.26859
TTC31 tetratricopeptide repeat domain 31 2.26815
C18ORF21 chromosome 18 open reading frame 21 2.26723
POC1A POC1 centriolar protein A 2.26534
IGF1R insulin-like growth factor 1 receptor 2.26385
TRMT6 tRNA methyltransferase 6 2.2623
SEMA3F sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F 2.2583
OLFM1 olfactomedin 1 2.25427
KIAA1109 KIAA1109 2.25383
IMMT inner membrane protein, mitochondrial 2.2484
KRT6B keratin 6B, type II 2.24444
PARN poly(A)-specific ribonuclease 2.24153
GLMN glomulin, FKBP associated protein 2.24124
MTCH2 mitochondrial carrier 2 2.23517
CYSRT1 cysteine-rich tail protein 1 2.22026
TRMT61A tRNA methyltransferase 61A 2.2192
DYDC2 DPY30 domain containing 2 2.21885
GPR6 G protein-coupled receptor 6 2.21599
MDFI MyoD family inhibitor 2.21301
PTDSS1 phosphatidylserine synthase 1 2.21167
EPSTI1 epithelial stromal interaction 1 (breast) 2.20656
ABHD17A abhydrolase domain containing 17A 2.20001
SPATA31A7 SPATA31 subfamily A, member 7 2.19793
PALB2 partner and localizer of BRCA2 2.19381
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast) 2.19324
FASN fatty acid synthase 2.19145
IWS1 IWS1 homolog (S. cerevisiae) 2.18849
TMEM132B transmembrane protein 132B 2.18823
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 2.17768
FBXW10 F-box and WD repeat domain containing 10 2.17627
LEMD2 LEM domain containing 2 2.17329
DNAJC7 DnaJ (Hsp40) homolog, subfamily C, member 7 2.17138
KRTAP19-3 keratin associated protein 19-3 2.1661
DNTTIP1 deoxynucleotidyltransferase, terminal, interacting protein 1 2.16362
C1D C1D nuclear receptor corepressor 2.15848
PTGES3 prostaglandin E synthase 3 (cytosolic) 2.15636
ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1 2.15366
RBM45 RNA binding motif protein 45 2.14913
PRB2 proline-rich protein BstNI subfamily 2 2.14911
CNN2 calponin 2 2.14832
IFNA14 interferon, alpha 14 2.14812
FBXL18 F-box and leucine-rich repeat protein 18 2.1461
ZNF100 zinc finger protein 100 2.13472
TMEM180 transmembrane protein 180 2.12331
MGLL monoglyceride lipase 2.11714
KRTAP10-11 keratin associated protein 10-11 2.1142
TEAD4 TEA domain family member 4 2.1113
EPC1 enhancer of polycomb homolog 1 (Drosophila) 2.1068
ACTA1 actin, alpha 1, skeletal muscle 2.10516
SOCS3 suppressor of cytokine signaling 3 2.10414
HIST1H2BB histone cluster 1, H2bb 2.10111
DLG5 discs, large homolog 5 (Drosophila) 2.08852
SNTG2 syntrophin, gamma 2 2.08663
BARX2 BARX homeobox 2 2.0843
CYP4F11 cytochrome P450, family 4, subfamily F, polypeptide 11 2.08127
SMIM14 small integral membrane protein 14 2.07871
CEP85 centrosomal protein 85kDa 2.0759
CDH26 cadherin 26 2.07534
VEZT vezatin, adherens junctions transmembrane protein 2.0745
LIG4 ligase IV, DNA, ATP-dependent 2.07017
OR1L1 olfactory receptor, family 1, subfamily L, member 1 2.05803
RAX retina and anterior neural fold homeobox 2.05735
GBP6 guanylate binding protein family, member 6 2.05463
TAPBPL TAP binding protein-like 2.04584
AIP aryl hydrocarbon receptor interacting protein 2.0392
KLHL1 kelch-like family member 1 2.02427
RHOU ras homolog family member U 2.02369
DNTT DNA nucleotidylexotransferase 2.02314
GPR152 G protein-coupled receptor 152 2.02062
TRERF1 transcriptional regulating factor 1 2.01941
KRTAP4-4 keratin associated protein 4-4 2.01165
KRTAP10-9 keratin associated protein 10-9 2.00779
TCTN3 tectonic family member 3 2.00428