SIX1 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description SIX homeobox 1|The protein encoded by this gene is a homeobox protein that is similar to the Drosophila 'sine oculis' gene product. This gene is found in a cluster of related genes on chromosome 14 and is thought to be involved in limb development. Defects in this gene are a cause of autosomal dominant deafness type 23 (DFNA23) and branchiootic syndrome type 3 (BOS3). [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 6495)
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Genes

357 genes differentially expressed following the SIX1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
ATP13A5 ATPase type 13A5 2.48475
DHX58 DEXH (Asp-Glu-X-His) box polypeptide 58 2.48475
DNASE1L2 deoxyribonuclease I-like 2 2.48475
CELA3B chymotrypsin-like elastase family, member 3B 2.48475
HES7 hes family bHLH transcription factor 7 2.48475
MCCC2 methylcrotonoyl-CoA carboxylase 2 (beta) 2.48475
TM4SF20 transmembrane 4 L six family member 20 2.48475
PCDHGB3 protocadherin gamma subfamily B, 3 2.48475
MYBPC3 myosin binding protein C, cardiac 2.48475
GSTM5 glutathione S-transferase mu 5 2.48475
CCL5 chemokine (C-C motif) ligand 5 2.48475
KCNJ9 potassium channel, inwardly rectifying subfamily J, member 9 2.48475
CELF3 CUGBP, Elav-like family member 3 2.48475
GNLY granulysin 2.48475
CYP26C1 cytochrome P450, family 26, subfamily C, polypeptide 1 2.48475
FPR3 formyl peptide receptor 3 2.48475
SLC22A10 solute carrier family 22, member 10 2.48475
P2RY4 pyrimidinergic receptor P2Y, G-protein coupled, 4 2.48475
ATG2A autophagy related 2A 2.48475
TPBGL trophoblast glycoprotein-like 2.48475
TMPRSS11A transmembrane protease, serine 11A 2.48475
LY86 lymphocyte antigen 86 2.48475
CSRP3 cysteine and glycine-rich protein 3 (cardiac LIM protein) 2.48475
ASB15 ankyrin repeat and SOCS box containing 15 2.48475
GPR52 G protein-coupled receptor 52 2.48475
ARHGAP33 Rho GTPase activating protein 33 2.48475
FOLR2 folate receptor 2 (fetal) 2.48475
C1GALT1C1L C1GALT1-specific chaperone 1 like 2.48475
RFX6 regulatory factor X, 6 2.48475
MUC20 mucin 20, cell surface associated 2.48475
HBD hemoglobin, delta 2.48475
KRT72 keratin 72, type II 2.48475
B3GNT6 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6 2.48475
ACOT12 acyl-CoA thioesterase 12 2.48475
AVP arginine vasopressin 2.48475
BMP5 bone morphogenetic protein 5 2.48475
STK35 serine/threonine kinase 35 2.48475
TDO2 tryptophan 2,3-dioxygenase 2.48475
TRIM42 tripartite motif containing 42 2.48475
RTN4IP1 reticulon 4 interacting protein 1 2.48475
SCNN1G sodium channel, non voltage gated 1 gamma subunit 2.48475
SSTR5 somatostatin receptor 5 2.48475
PECAM1 platelet/endothelial cell adhesion molecule 1 2.48475
ZNF236 zinc finger protein 236 2.48475
PAIP2B poly(A) binding protein interacting protein 2B 2.48475
RFPL2 ret finger protein-like 2 2.48475
TRPV5 transient receptor potential cation channel, subfamily V, member 5 2.48475
B3GALT2 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2 2.48475
RPL32 ribosomal protein L32 2.48475
LCN10 lipocalin 10 2.48475
KCNE1 potassium channel, voltage gated subfamily E regulatory beta subunit 1 2.48475
ENC1 ectodermal-neural cortex 1 (with BTB domain) 2.48475
CIMAP1D CIMAP1 family member D 2.48475
PNLIPRP2 pancreatic lipase-related protein 2 2.48475
MYH7 myosin, heavy chain 7, cardiac muscle, beta 2.48475
DNAAF1 dynein, axonemal, assembly factor 1 2.48475
OR2T8 olfactory receptor, family 2, subfamily T, member 8 2.48475
FIMP1 fertilization-influencing membrane protein 1 2.48475
PIRT phosphoinositide-interacting regulator of transient receptor potential channels 2.48475
RDH8 retinol dehydrogenase 8 (all-trans) 2.48475
RAB38 RAB38, member RAS oncogene family 2.48475
OR52E4 olfactory receptor, family 52, subfamily E, member 4 2.48475
SPATA25 spermatogenesis associated 25 2.48475
VSIG2 V-set and immunoglobulin domain containing 2 2.48475
ALX4 ALX homeobox 4 2.48475
AVPR1B arginine vasopressin receptor 1B 2.48475
CPHXL cytoplasmic polyadenylated homeobox like 2.48475
CFAP107 cilia and flagella associated protein 107 2.48475
GARIN6 golgi associated RAB2 interactor family member 6 2.48475
CFAP206 cilia and flagella associated protein 206 2.48475
DUSP29 dual specificity phosphatase 29 2.48475
ELAPOR2 endosome-lysosome associated apoptosis and autophagy regulator family member 2 2.48475
PLPP4 phospholipid phosphatase 4 2.48475
GGTA1 glycoprotein alpha-galactosyltransferase 1 (inactive) 2.48475
STING1 stimulator of interferon response cGAMP interactor 1 2.48475
GIPC3 GIPC PDZ domain containing family, member 3 2.48475
ZAR1 zygote arrest 1 2.48475
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8 2.48475
GATA2 GATA binding protein 2 2.48475
ARMS2 age-related maculopathy susceptibility 2 2.48475
SLC12A3 solute carrier family 12 (sodium/chloride transporter), member 3 2.48475
APOBEC1 apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1 2.48475
SLAMF8 SLAM family member 8 2.48475
FCER2 Fc fragment of IgE, low affinity II, receptor for (CD23) 2.48475
MAL mal, T-cell differentiation protein 2.48475
DAO D-amino-acid oxidase 2.48475
FOSL2 FOS-like antigen 2 2.48475
TNFRSF14 tumor necrosis factor receptor superfamily, member 14 2.48475
RHOXF2 Rhox homeobox family, member 2 2.48475
RPS18 ribosomal protein S18 2.48475
CDSN corneodesmosin 2.48475
SBSN suprabasin 2.48475
OR7D2 olfactory receptor, family 7, subfamily D, member 2 2.48475
KL klotho 2.48475
LTA lymphotoxin alpha 2.48475
MOV10L1 Mov10 RISC complex RNA helicase like 1 2.48475
ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 2.48475
FRK fyn-related Src family tyrosine kinase 2.48475
PABPC1L2A poly(A) binding protein, cytoplasmic 1-like 2A 2.48475
IL7R interleukin 7 receptor 2.48475
SAMD15 sterile alpha motif domain containing 15 2.48475
OPN5 opsin 5 2.48475
CSN2 casein beta 2.48475
KLHL33 kelch-like family member 33 2.48475
MAGEB17 melanoma antigen family B17 2.48475
ADAM2 ADAM metallopeptidase domain 2 2.48475
GLT1D1 glycosyltransferase 1 domain containing 1 2.48475
SULT2A1 sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 2.48475
MAB21L3 mab-21-like 3 (C. elegans) 2.48475
IRGM immunity-related GTPase family, M 2.48475
POU2AF1 POU class 2 associating factor 1 2.48475
RASGRP3 RAS guanyl releasing protein 3 (calcium and DAG-regulated) 2.48475
OR2L3 olfactory receptor, family 2, subfamily L, member 3 2.48475
CCL17 chemokine (C-C motif) ligand 17 2.48475
IL19 interleukin 19 2.48475
KLF4 Kruppel-like factor 4 (gut) 2.48475
NANOGNB NANOG neighbor homeobox 2.48475
CYSLTR2 cysteinyl leukotriene receptor 2 2.48475
MORC1 MORC family CW-type zinc finger 1 2.48475
PLSCR2 phospholipid scramblase 2 2.48475
CH25H cholesterol 25-hydroxylase 2.48475
CST7 cystatin F (leukocystatin) 2.48475
S100A14 S100 calcium binding protein A14 2.48475
BTNL2 butyrophilin-like 2 2.48475
CLRN1 clarin 1 2.48475
CLRN2 clarin 2 2.48475
CXCR6 chemokine (C-X-C motif) receptor 6 2.48475
CTAGE4 CTAGE family, member 4 2.48475
IL1A interleukin 1, alpha 2.48475
GRIN3B glutamate receptor, ionotropic, N-methyl-D-aspartate 3B 2.48475
LMAN1L lectin, mannose-binding, 1 like 2.48475
POU4F1 POU class 4 homeobox 1 2.48475
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5 2.48475
SERPINB8 serpin peptidase inhibitor, clade B (ovalbumin), member 8 2.48475
PPP1R27 protein phosphatase 1, regulatory subunit 27 2.48475
CLEC18B C-type lectin domain family 18, member B 2.48475
DRC7 dynein regulatory complex subunit 7 2.48475
BTG4 B-cell translocation gene 4 2.48475
MSMB microseminoprotein, beta- 2.48475
SLC36A3 solute carrier family 36, member 3 2.48475
IGIP IgA-inducing protein 2.48475
ZFP42 ZFP42 zinc finger protein 2.48475
LGALS14 lectin, galactoside-binding, soluble, 14 2.48475
SLC22A24 solute carrier family 22, member 24 2.48475
ZNF843 zinc finger protein 843 2.48475
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor 2.48475
TH tyrosine hydroxylase 2.48475
ITGA8 integrin, alpha 8 2.48475
CD200R1 CD200 receptor 1 2.48475
PTHLH parathyroid hormone-like hormone 2.48475
NT5C1A 5'-nucleotidase, cytosolic IA 2.48475
QRFP pyroglutamylated RFamide peptide 2.48475
CFAP126 cilia and flagella associated protein 126 2.48475
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 2.48475
HHIPL2 HHIP-like 2 2.48475
PRSS22 protease, serine, 22 2.48475
CHRDL2 chordin-like 2 2.48475
FGF16 fibroblast growth factor 16 2.48475
METTL15 methyltransferase like 15 2.48475
R3HDML R3H domain containing-like 2.48475
GLT6D1 glycosyltransferase 6 domain containing 1 2.48475
GPBAR1 G protein-coupled bile acid receptor 1 2.48475
TEX38 testis expressed 38 2.48475
LOXL4 lysyl oxidase-like 4 2.48475
UBR5 ubiquitin protein ligase E3 component n-recognin 5 2.48475
CD80 CD80 molecule 2.48475
GPD1 glycerol-3-phosphate dehydrogenase 1 (soluble) 2.48475
PTPN7 protein tyrosine phosphatase, non-receptor type 7 2.48475
NLRP4 NLR family, pyrin domain containing 4 2.48475
PXT1 peroxisomal, testis specific 1 2.48475
POTEI POTE ankyrin domain family, member I 2.48475
RPL31 ribosomal protein L31 2.48475
PRSS57 protease, serine, 57 2.48475
CD180 CD180 molecule 2.48475
OR14A2 olfactory receptor, family 14, subfamily A, member 2 2.48475
ALOX15B arachidonate 15-lipoxygenase, type B 2.48475
BTBD16 BTB (POZ) domain containing 16 2.48475
C5AR2 complement component 5a receptor 2 2.48475
C17ORF78 chromosome 17 open reading frame 78 2.48475
PF4V1 platelet factor 4 variant 1 2.48475
ANGPTL3 angiopoietin-like 3 2.48475
PGPEP1L pyroglutamyl-peptidase I-like 2.48475
LPA lipoprotein, Lp(a) 2.48475
DAND5 DAN domain family member 5, BMP antagonist 2.48475
MRGPRX3 MAS-related GPR, member X3 2.48475
CYB561 cytochrome b561 2.46387
TESK2 testis-specific kinase 2 2.45532
ERVV-2 endogenous retrovirus group V, member 2 2.41612
NOS2 nitric oxide synthase 2, inducible 2.41612
EDNRA endothelin receptor type A 2.40538
KIF6 kinesin family member 6 2.3802
AHRR aryl-hydrocarbon receptor repressor 2.37421
OR2A42 olfactory receptor, family 2, subfamily A, member 42 2.35166
SRSF6 serine/arginine-rich splicing factor 6 2.31804
NFE2L2 nuclear factor, erythroid 2-like 2 2.31589
LRRC20 leucine rich repeat containing 20 2.31391
EPS15 epidermal growth factor receptor pathway substrate 15 2.31391
NPNT nephronectin 2.28918
SBK1 SH3 domain binding kinase 1 2.2779
UBE2Z ubiquitin-conjugating enzyme E2Z 2.25883
LCORL ligand dependent nuclear receptor corepressor-like 2.21064
JARID2 jumonji, AT rich interactive domain 2 2.21031
SELENOW selenoprotein W 2.20908
AGBL1 ATP/GTP binding protein-like 1 2.20908
ASXL2 additional sex combs like transcriptional regulator 2 2.1945
RBBP9 retinoblastoma binding protein 9 2.15761
ISCU iron-sulfur cluster assembly enzyme 2.12235
TMEM160 transmembrane protein 160 2.1125
AUP1 ancient ubiquitous protein 1 2.08711
PPARD peroxisome proliferator-activated receptor delta 2.08711
FIGNL2 fidgetin-like 2 2.08519
C1ORF56 chromosome 1 open reading frame 56 2.08113
GPD2 glycerol-3-phosphate dehydrogenase 2 (mitochondrial) 2.07732
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) 2.07732
COLGALT2 collagen beta(1-O)galactosyltransferase 2 2.07397
TUSC3 tumor suppressor candidate 3 2.0651
GPX1 glutathione peroxidase 1 2.06051
PDIA5 protein disulfide isomerase family A, member 5 2.05697
ADPRH ADP-ribosylarginine hydrolase 2.05669
SPOPL speckle-type POZ protein-like 2.052
RPL7L1 ribosomal protein L7-like 1 2.04703
H4C9 H4 clustered histone 9 2.04442
EME2 essential meiotic structure-specific endonuclease subunit 2 2.04092
ZBTB26 zinc finger and BTB domain containing 26 2.04077
INPP5B inositol polyphosphate-5-phosphatase, 75kDa 2.02929
PPRC1 peroxisome proliferator-activated receptor gamma, coactivator-related 1 2.02586
TMEM135 transmembrane protein 135 2.02586
TXNL4B thioredoxin-like 4B 2.01686
PRR19 proline rich 19 2.01686
TSR1 TSR1, 20S rRNA accumulation, homolog (S. cerevisiae) 2.00855
STK31 serine/threonine kinase 31 2.00619
ADGRL4 adhesion G protein-coupled receptor L4 2.00098

decreased expression

Symbol Name Standardized Value
BMP1 bone morphogenetic protein 1 -2.48475
SYCP1 synaptonemal complex protein 1 -2.48475
EDNRB endothelin receptor type B -2.48475
ZNF563 zinc finger protein 563 -2.48475
ZNF704 zinc finger protein 704 -2.48475
EGF epidermal growth factor -2.48475
IBA57 IBA57, iron-sulfur cluster assembly homolog (S. cerevisiae) -2.48475
GTF2A1L general transcription factor IIA, 1-like -2.48475
PCDHA10 protocadherin alpha 10 -2.48475
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 -2.48475
LACC1 laccase (multicopper oxidoreductase) domain containing 1 -2.48475
MPZ myelin protein zero -2.48475
KAT5 K(lysine) acetyltransferase 5 -2.48475
CXCL5 chemokine (C-X-C motif) ligand 5 -2.48475
INPP5J inositol polyphosphate-5-phosphatase J -2.48475
LRCH3 leucine-rich repeats and calponin homology (CH) domain containing 3 -2.48475
MED30 mediator complex subunit 30 -2.48475
NUTM2E NUT family member 2E -2.48475
C3ORF52 chromosome 3 open reading frame 52 -2.48475
XKRX XK, Kell blood group complex subunit-related, X-linked -2.48475
LMNTD2 lamin tail domain containing 2 -2.48475
LHX8 LIM homeobox 8 -2.48475
GCHFR GTP cyclohydrolase I feedback regulator -2.48475
CLDN18 claudin 18 -2.48475
C20ORF203 chromosome 20 open reading frame 203 -2.48475
SLC35E2B solute carrier family 35, member E2B -2.48475
CRYZL2P-SEC16B CRYZL2P-SEC16B readthrough -2.48475
UFSP1 UFM1-specific peptidase 1 (non-functional) -2.48475
IFT70A intraflagellar transport 70A -2.48475
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3 -2.48475
TMEM255A transmembrane protein 255A -2.48475
ADGRG6 adhesion G protein-coupled receptor G6 -2.48475
ZNF184 zinc finger protein 184 -2.46387
SSX2IP synovial sarcoma, X breakpoint 2 interacting protein -2.45044
H2BC17 H2B clustered histone 17 -2.4495
NUDT19 nudix (nucleoside diphosphate linked moiety X)-type motif 19 -2.42762
LHFPL3 lipoma HMGIC fusion partner-like 3 -2.41612
CCDC74B coiled-coil domain containing 74B -2.394
COL23A1 collagen, type XXIII, alpha 1 -2.394
ZCCHC10 zinc finger, CCHC domain containing 10 -2.394
SKIC3 SKI3 subunit of superkiller complex -2.39396
EFNA2 ephrin-A2 -2.36656
FBXW5 F-box and WD repeat domain containing 5 -2.34264
GABPB2 GA binding protein transcription factor, beta subunit 2 -2.33211
WIZ widely interspaced zinc finger motifs -2.31973
ACTR6 ARP6 actin-related protein 6 homolog (yeast) -2.31973
TMEM8B transmembrane protein 8B -2.31463
SLC1A2 solute carrier family 1 (glial high affinity glutamate transporter), member 2 -2.31391
C4ORF50 chromosome 4 open reading frame 50 -2.31391
SLC5A11 solute carrier family 5 (sodium/inositol cotransporter), member 11 -2.31391
MUSK muscle, skeletal, receptor tyrosine kinase -2.31391
TNS1-AS1 TNS1 antisense RNA 1 -2.31391
LOC124902436 talanin -2.31391
CPED1 cadherin-like and PC-esterase domain containing 1 -2.31391
SPDYE6 speedy/RINGO cell cycle regulator family member E6 -2.31391
RNF103 ring finger protein 103 -2.31391
CD96 CD96 molecule -2.31391
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3 -2.31391
ZNF501 zinc finger protein 501 -2.31391
KLRF1 killer cell lectin-like receptor subfamily F, member 1 -2.31391
CHCT1 CHD1 helical C-terminal domain containing 1 -2.31391
CTXND1 cortexin domain containing 1 -2.31391
TMEM151A transmembrane protein 151A -2.31391
NHLRC1 NHL repeat containing E3 ubiquitin protein ligase 1 -2.31391
CLCNKB chloride channel, voltage-sensitive Kb -2.31391
LCN1 lipocalin 1 -2.31391
IGFBP7 insulin-like growth factor binding protein 7 -2.31391
PTGDR prostaglandin D2 receptor (DP) -2.31391
TCAP titin-cap -2.31391
NRGN neurogranin (protein kinase C substrate, RC3) -2.31391
CITED1 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1 -2.31391
LRRC43 leucine rich repeat containing 43 -2.31391
GPR146 G protein-coupled receptor 146 -2.31391
CCNA1 cyclin A1 -2.31391
ABHD6 abhydrolase domain containing 6 -2.31391
GYS2 glycogen synthase 2 (liver) -2.31391
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide -2.31391
CNGB1 cyclic nucleotide gated channel beta 1 -2.31391
PLET1 placenta expressed transcript 1 -2.31391
RPP21 ribonuclease P/MRP 21kDa subunit -2.31053
CCDC150 coiled-coil domain containing 150 -2.30805
ZFP69B ZFP69 zinc finger protein B -2.2779
TET3 tet methylcytosine dioxygenase 3 -2.25883
GDF3 growth differentiation factor 3 -2.25719
DNAAF3 dynein, axonemal, assembly factor 3 -2.24725
THOC3 THO complex 3 -2.246
FZD9 frizzled class receptor 9 -2.22841
MDGA1 MAM domain containing glycosylphosphatidylinositol anchor 1 -2.22841
CCDC66 coiled-coil domain containing 66 -2.22603
FAT4 FAT atypical cadherin 4 -2.22603
CFLAR CASP8 and FADD-like apoptosis regulator -2.21455
TJAP1 tight junction associated protein 1 (peripheral) -2.18418
NEK11 NIMA-related kinase 11 -2.1663
TMEM170B transmembrane protein 170B -2.15761
KCNJ6 potassium channel, inwardly rectifying subfamily J, member 6 -2.13299
HNRNPL heterogeneous nuclear ribonucleoprotein L -2.12872
BMP7 bone morphogenetic protein 7 -2.12641
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2 -2.12235
SPOCK3 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3 -2.09645
RAB19 RAB19, member RAS oncogene family -2.096
ZNF230 zinc finger protein 230 -2.096
ELOA elongin A -2.08997
DTD2 D-tyrosyl-tRNA deacylase 2 (putative) -2.07732
FAM151B family with sequence similarity 151, member B -2.07566
SRP19 signal recognition particle 19kDa -2.07091
NOC2L nucleolar complex associated 2 homolog (S. cerevisiae) -2.0651
ZNF892 zinc finger protein 892 -2.06491
NTF4 neurotrophin 4 -2.05486
BCL2 B-cell CLL/lymphoma 2 -2.04952
FBLN2 fibulin 2 -2.04703
JHY junctional cadherin complex regulator -2.04703
TMEM25 transmembrane protein 25 -2.04192
RELL2 RELT-like 2 -2.04092
PGM1 phosphoglucomutase 1 -2.04088
RRP9 ribosomal RNA processing 9, small subunit (SSU) processome component, homolog (yeast) -2.04077
CADPS2 Ca++-dependent secretion activator 2 -2.02929
PATL1 protein associated with topoisomerase II homolog 1 (yeast) -2.02586
ZNF618 zinc finger protein 618 -2.01686
MTUS2 microtubule associated tumor suppressor candidate 2 -2.01686
MCCC1 methylcrotonoyl-CoA carboxylase 1 (alpha) -2.01668
GAS2L3 growth arrest-specific 2 like 3 -2.01075
CYP2C8 cytochrome P450, family 2, subfamily C, polypeptide 8 -2.00855
ADGRG3 adhesion G protein-coupled receptor G3 -2.00855
LAD1 ladinin 1 -2.00831
ATP9B ATPase, class II, type 9B -2.00706