SIX2 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description SIX homeobox 2|This gene is a member of the vertebrate gene family which encode proteins homologous to the Drosophila 'sine oculis' homeobox protein. The encoded protein is a transcription factor which, like other members of this gene family, may be involved in limb or eye development. [provided by RefSeq, Dec 2008] (NCBI Entrez Gene Database, 10736)
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Genes

333 genes differentially expressed following the SIX2 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
DCDC2B doublecortin domain containing 2B 3.00851
SAMD11 sterile alpha motif domain containing 11 3.00851
HLA-DOB major histocompatibility complex, class II, DO beta 3.00851
CD300LF CD300 molecule-like family member f 3.00851
HCRT hypocretin (orexin) neuropeptide precursor 3.00851
NUDT18 nudix (nucleoside diphosphate linked moiety X)-type motif 18 3.00851
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6 3.00851
CIROZ ciliated left-right organizer protein containing ZP-N domains 3.00851
GPR179 G protein-coupled receptor 179 3.00851
SEMA3G sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G 3.00851
ENTPD3 ectonucleoside triphosphate diphosphohydrolase 3 3.00851
OR10A2 olfactory receptor, family 10, subfamily A, member 2 3.00851
C3ORF22 chromosome 3 open reading frame 22 3.00851
TRPM5 transient receptor potential cation channel, subfamily M, member 5 3.00851
ST8SIA4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 3.00851
KNG1 kininogen 1 3.00851
PENK proenkephalin 3.00851
SDS serine dehydratase 3.00851
OIT3 oncoprotein induced transcript 3 3.00851
CPHXL2 cytoplasmic polyadenylated homeobox like 2 3.00851
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 3.00851
ZNF875 zinc finger protein 875 3.00851
PLEKHG7 pleckstrin homology domain containing, family G (with RhoGef domain) member 7 2.91708
DMRTC1B DMRT-like family C1B 2.91708
GJA5 gap junction protein, alpha 5, 40kDa 2.91708
NDRG1 N-myc downstream regulated 1 2.91708
CCNB3 cyclin B3 2.91708
ELF4 E74-like factor 4 (ets domain transcription factor) 2.91708
SELPLG selectin P ligand 2.91708
SOX14 SRY (sex determining region Y)-box 14 2.91708
NAPSA napsin A aspartic peptidase 2.91708
ASB15 ankyrin repeat and SOCS box containing 15 2.91708
HES3 hes family bHLH transcription factor 3 2.91708
FGL2 fibrinogen-like 2 2.91708
SLC35G5 solute carrier family 35, member G5 2.91708
TNIP3 TNFAIP3 interacting protein 3 2.91708
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13 2.91708
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1 2.91708
ATOH8 atonal homolog 8 (Drosophila) 2.91708
CORO6 coronin 6 2.91708
CLEC14A C-type lectin domain family 14, member A 2.91708
CSNK2A3 casein kinase 2, alpha 3 polypeptide 2.91708
ACY3 aminoacylase 3 2.91708
SPACA5 sperm acrosome associated 5 2.91708
TPPP tubulin polymerization promoting protein 2.91708
EPPIN epididymal peptidase inhibitor 2.91708
SPINK13 serine peptidase inhibitor, Kazal type 13 (putative) 2.91708
PRODH proline dehydrogenase (oxidase) 1 2.91708
SPP2 secreted phosphoprotein 2, 24kDa 2.91708
KCNE2 potassium channel, voltage gated subfamily E regulatory beta subunit 2 2.91708
DLX4 distal-less homeobox 4 2.91708
PRSS36 protease, serine, 36 2.91708
PLK5 polo-like kinase 5 2.91708
GNG13 guanine nucleotide binding protein (G protein), gamma 13 2.91708
H3-5 H3.5 histone 2.91708
COL15A1 collagen, type XV, alpha 1 2.91708
HNF4A hepatocyte nuclear factor 4, alpha 2.91708
ANKRD42-DT ANKRD42 divergent transcript 2.91708
HBG1 hemoglobin, gamma A 2.91708
ACER1 alkaline ceramidase 1 2.91708
DUSP8 dual specificity phosphatase 8 2.91708
FMO2 flavin containing monooxygenase 2 (non-functional) 2.91708
NHLRC1 NHL repeat containing E3 ubiquitin protein ligase 1 2.91708
TBC1D3L TBC1 domain family, member 3L 2.91708
ASB4 ankyrin repeat and SOCS box containing 4 2.91708
TMEM190 transmembrane protein 190 2.91708
SELP selectin P (granule membrane protein 140kDa, antigen CD62) 2.91708
PNMA8B PNMA family member 8B 2.91708
H1-6 H1.6 linker histone, cluster member 2.91708
LOC124903233 uncharacterized LOC124903233 2.91708
TMEM238L transmembrane protein 238 like 2.91708
MAJIN membrane anchored junction protein 2.91708
SPATA46 spermatogenesis associated 46 2.91708
CCDC163 CCDC163 homolog 2.91708
CLXN calaxin 2.91708
CBLIF cobalamin binding intrinsic factor 2.91708
GUCY1A1 guanylate cyclase 1 soluble subunit alpha 1 2.91708
C10ORF53 chromosome 10 open reading frame 53 2.91708
FCMR Fc fragment of IgM receptor 2.91708
THPO thrombopoietin 2.91708
OR7C1 olfactory receptor, family 7, subfamily C, member 1 2.91708
FOSL2 FOS-like antigen 2 2.91708
EDAR ectodysplasin A receptor 2.91708
PCDHA3 protocadherin alpha 3 2.91708
IZUMO1 izumo sperm-egg fusion 1 2.91708
TBX20 T-box 20 2.91708
SYCP2 synaptonemal complex protein 2 2.91708
ZIC4 Zic family member 4 2.91708
S1PR1 sphingosine-1-phosphate receptor 1 2.91708
TLR5 toll-like receptor 5 2.91708
TSPAN1 tetraspanin 1 2.91708
KL klotho 2.91708
LTB lymphotoxin beta (TNF superfamily, member 3) 2.91708
GPR85 G protein-coupled receptor 85 2.91708
TIMD4 T-cell immunoglobulin and mucin domain containing 4 2.91708
MS4A13 membrane-spanning 4-domains, subfamily A, member 13 2.91708
S100G S100 calcium binding protein G 2.91708
INSRR insulin receptor-related receptor 2.91708
MS4A6E membrane-spanning 4-domains, subfamily A, member 6E 2.91708
LIMS3 LIM and senescent cell antigen-like domains 3 2.91708
BPIFB1 BPI fold containing family B, member 1 2.91708
CNTF ciliary neurotrophic factor 2.91708
CLDN34 claudin 34 2.91708
OTC ornithine carbamoyltransferase 2.91708
ARR3 arrestin 3, retinal (X-arrestin) 2.91708
CRYBB3 crystallin, beta B3 2.91708
KLF1 Kruppel-like factor 1 (erythroid) 2.91708
HOXD1 homeobox D1 2.91708
EBF2 early B-cell factor 2 2.91708
PCDHGB4 protocadherin gamma subfamily B, 4 2.91708
TBC1D28 TBC1 domain family, member 28 2.91708
SHOX short stature homeobox 2.91708
ECM1 extracellular matrix protein 1 2.91708
KIF4B kinesin family member 4B 2.91708
OR1B1 olfactory receptor, family 1, subfamily B, member 1 (gene/pseudogene) 2.91708
PDCD1 programmed cell death 1 2.91708
SPRN shadow of prion protein homolog (zebrafish) 2.91708
CIDEA cell death-inducing DFFA-like effector a 2.91708
SERINC4 serine incorporator 4 2.91708
CYP4F22 cytochrome P450, family 4, subfamily F, polypeptide 22 2.91708
IL36R interleukin 36 receptor 2.91708
IL9R interleukin 9 receptor 2.91708
GCGR glucagon receptor 2.91708
TRIM7 tripartite motif containing 7 2.91708
NMBR neuromedin B receptor 2.91708
RDM1 RAD52 motif containing 1 2.91708
FKBP1C FK506 binding protein 1C 2.91708
NPY2R neuropeptide Y receptor Y2 2.91708
GOLGA8K golgin A8 family, member K 2.91708
CTXN2 cortexin 2 2.91708
PTPN20 protein tyrosine phosphatase, non-receptor type 20 2.91708
GABRR2 gamma-aminobutyric acid (GABA) A receptor, rho 2 2.91708
CGB7 chorionic gonadotropin, beta polypeptide 7 2.91708
TAT tyrosine aminotransferase 2.91708
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4 2.91708
KLK11 kallikrein-related peptidase 11 2.91708
CFP complement factor properdin 2.91708
KLK4 kallikrein-related peptidase 4 2.91708
FSHR follicle stimulating hormone receptor 2.91708
GALNTL5 polypeptide N-acetylgalactosaminyltransferase-like 5 2.91708
EPX eosinophil peroxidase 2.91708
TWIST1 twist family bHLH transcription factor 1 2.91708
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) 2.91708
PNLDC1 poly(A)-specific ribonuclease (PARN)-like domain containing 1 2.91708
APOL4 apolipoprotein L, 4 2.91708
GALNT15 polypeptide N-acetylgalactosaminyltransferase 15 2.91708
LRRC31 leucine rich repeat containing 31 2.91708
TAS2R43 taste receptor, type 2, member 43 2.91708
PMCH pro-melanin-concentrating hormone 2.91708
NLRP7 NLR family, pyrin domain containing 7 2.91708
ICAM5 intercellular adhesion molecule 5, telencephalin 2.91708
IRX1 iroquois homeobox 1 2.91708
TECTB tectorin beta 2.91708
LRRC74B leucine rich repeat containing 74B 2.91708
TDO2 tryptophan 2,3-dioxygenase 2.91708
THEMIS thymocyte selection associated 2.91708
POTEI POTE ankyrin domain family, member I 2.91708
CLCA2 chloride channel accessory 2 2.91708
EPO erythropoietin 2.91708
LOC105378220 macrophage receptor MARCO-like 2.91708
RAD54L2 RAD54-like 2 (S. cerevisiae) 2.82261
YPEL1 yippee-like 1 (Drosophila) 2.78549
MARS1 methionyl-tRNA synthetase 1 2.74356
CIAO2B cytosolic iron-sulfur assembly component 2B 2.7375
ASNS asparagine synthetase (glutamine-hydrolyzing) 2.65472
RABGAP1 RAB GTPase activating protein 1 2.57661
APOBEC3D apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D 2.57661
TYK2 tyrosine kinase 2 2.5621
MYO3B myosin IIIB 2.55246
RGPD4 RANBP2-like and GRIP domain containing 4 2.55116
PAX5 paired box 5 2.55116
FOXP3 forkhead box P3 2.55116
SCNN1D sodium channel, non voltage gated 1 delta subunit 2.55116
TEX46 testis expressed 46 2.55116
SUGCT succinyl-CoA:glutarate-CoA transferase 2.53103
PCID2 PCI domain containing 2 2.50242
AQP4 aquaporin 4 2.47218
COPS9 COP9 signalosome subunit 9 2.46773
SULT1A3 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3 2.43374
SHISA9 shisa family member 9 2.40343
PTGES2 prostaglandin E synthase 2 2.39444
NFKBID nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, delta 2.36577
COIL coilin 2.34472
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.34018
TAFAZZIN tafazzin, phospholipid-lysophospholipid transacylase 2.30567
ZNF688 zinc finger protein 688 2.29114
CRK v-crk avian sarcoma virus CT10 oncogene homolog 2.29114
PAPPA pregnancy-associated plasma protein A, pappalysin 1 2.28382
RELL1 RELT-like 1 2.25913
FXYD6 FXYD domain containing ion transport regulator 6 2.24908
NDUFS1 NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase) 2.2442
STX16 syntaxin 16 2.24056
GALNT9 polypeptide N-acetylgalactosaminyltransferase 9 2.22914
ZNF804A zinc finger protein 804A 2.22914
CXCL13 chemokine (C-X-C motif) ligand 13 2.22914
ZNF616 zinc finger protein 616 2.20211
COASY CoA synthase 2.19504
AKAP13 A kinase (PRKA) anchor protein 13 2.19504
WDR18 WD repeat domain 18 2.18043
AKTIP AKT interacting protein 2.15428
TRIM47 tripartite motif containing 47 2.15184
RANBP6 RAN binding protein 6 2.15184
AREL1 apoptosis resistant E3 ubiquitin protein ligase 1 2.14102
TBC1D32 TBC1 domain family, member 32 2.13011
HYLS1 hydrolethalus syndrome 1 2.13011
TACR1 tachykinin receptor 1 2.09324
CYTH1 cytohesin 1 2.0929
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial) 2.08614
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 2.08217
ETV4 ets variant 4 2.07434
MATN4 matrilin 4 2.07014
MCM3AP minichromosome maintenance complex component 3 associated protein 2.0575
ZCWPW2 zinc finger, CW type with PWWP domain 2 2.03145
ERBB4 erb-b2 receptor tyrosine kinase 4 2.02139
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2 2.02139
INSIG2 insulin induced gene 2 2.01432
COQ2 coenzyme Q2 4-hydroxybenzoate polyprenyltransferase 2.01432
CDK12 cyclin-dependent kinase 12 2.00808
ARHGAP29 Rho GTPase activating protein 29 2.00797
ARL4D ADP-ribosylation factor-like 4D 2.00108
CERT1 ceramide transporter 1 2.00108
TEN1 TEN1 CST complex subunit 2.00108
MSR1 macrophage scavenger receptor 1 2.00108

decreased expression

Symbol Name Standardized Value
ECEL1 endothelin converting enzyme-like 1 -3.00851
RGPD1 RANBP2-like and GRIP domain containing 1 -3.00851
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9 -3.00851
KISS1R KISS1 receptor -3.00851
CAPN11 calpain 11 -3.00851
PCDHB15 protocadherin beta 15 -3.00851
NGFR nerve growth factor receptor -3.00851
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 -3.00851
PLGLB1 plasminogen-like B1 -3.00851
LDB3 LIM domain binding 3 -3.00851
MID2 midline 2 -3.00851
ZNF396 zinc finger protein 396 -3.00851
ST8SIA5 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5 -2.91708
BAAT bile acid CoA:amino acid N-acyltransferase -2.91708
CLNK cytokine-dependent hematopoietic cell linker -2.91708
S100A2 S100 calcium binding protein A2 -2.91708
PTK6 protein tyrosine kinase 6 -2.91708
LGALS3 lectin, galactoside-binding, soluble, 3 -2.91708
KRTAP13-4 keratin associated protein 13-4 -2.91708
ETV2 ets variant 2 -2.91708
SLC5A12 solute carrier family 5 (sodium/monocarboxylate cotransporter), member 12 -2.91708
TNFAIP8L2-SCNM1 TNFAIP8L2-SCNM1 readthrough -2.91708
BMPR1A bone morphogenetic protein receptor, type IA -2.91708
OPRM1 opioid receptor, mu 1 -2.91708
PNLIPRP1 pancreatic lipase-related protein 1 -2.91708
RASD1 RAS, dexamethasone-induced 1 -2.91708
POU2F3 POU class 2 homeobox 3 -2.91708
PGA5 pepsinogen 5, group I (pepsinogen A) -2.91708
PLB1 phospholipase B1 -2.91708
REXO4 REX4, RNA exonuclease 4 homolog (S. cerevisiae) -2.91708
ACP7 acid phosphatase 7, tartrate resistant (putative) -2.91708
SRL sarcalumenin -2.91708
FOLR1 folate receptor 1 (adult) -2.91708
SOX7 SRY (sex determining region Y)-box 7 -2.91708
ELFN1 extracellular leucine-rich repeat and fibronectin type III domain containing 1 -2.91708
TRPC6 transient receptor potential cation channel, subfamily C, member 6 -2.91708
CCNH cyclin H -2.91708
PLA2G2C phospholipase A2, group IIC -2.91708
ACOX2 acyl-CoA oxidase 2, branched chain -2.91708
SPATA16 spermatogenesis associated 16 -2.91708
NAT2 N-acetyltransferase 2 (arylamine N-acetyltransferase) -2.91708
ADGRD2 adhesion G protein-coupled receptor D2 -2.91708
PCSK1 proprotein convertase subtilisin/kexin type 1 -2.91708
GBX1 gastrulation brain homeobox 1 -2.91708
TTC22 tetratricopeptide repeat domain 22 -2.91708
TCTN2 tectonic family member 2 -2.91708
LPAR5 lysophosphatidic acid receptor 5 -2.91708
TMEM255A transmembrane protein 255A -2.91708
CCDC177 coiled-coil domain containing 177 -2.91708
MLC1 megalencephalic leukoencephalopathy with subcortical cysts 1 -2.91708
DYNLL1 dynein, light chain, LC8-type 1 -2.91708
CD86 CD86 molecule -2.91708
CCDC178 coiled-coil domain containing 178 -2.91708
KLF9 Kruppel-like factor 9 -2.91708
ERVV-2 endogenous retrovirus group V, member 2 -2.91708
ATR ATR serine/threonine kinase -2.90911
ASL argininosuccinate lyase -2.84594
SERAC1 serine active site containing 1 -2.83894
XKR9 XK, Kell blood group complex subunit-related family, member 9 -2.78848
LAD1 ladinin 1 -2.73169
ZNF816 zinc finger protein 816 -2.72579
PHETA1 PH domain containing endocytic trafficking adaptor 1 -2.67553
KLHL24 kelch-like family member 24 -2.63616
LIMK2 LIM domain kinase 2 -2.6167
KLF6 Kruppel-like factor 6 -2.61067
VKORC1L1 vitamin K epoxide reductase complex, subunit 1-like 1 -2.5621
RAD51 RAD51 recombinase -2.52165
HRC histidine rich calcium binding protein -2.45763
HCN2 hyperpolarization activated cyclic nucleotide gated potassium channel 2 -2.45763
PMP22 peripheral myelin protein 22 -2.45763
CACNA1F calcium channel, voltage-dependent, L type, alpha 1F subunit -2.45763
RPS27L ribosomal protein S27-like -2.42045
ACTC1 actin, alpha, cardiac muscle 1 -2.42045
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -2.41022
LLGL1 lethal giant larvae homolog 1 (Drosophila) -2.39644
CCDC39 coiled-coil domain containing 39 -2.31919
TUSC2 tumor suppressor candidate 2 -2.31545
FSD1L fibronectin type III and SPRY domain containing 1-like -2.29197
LHCGR luteinizing hormone/choriogonadotropin receptor -2.29114
GSR glutathione reductase -2.29114
CPNE5 copine V -2.29094
SP2 Sp2 transcription factor -2.28987
FUOM fucose mutarotase -2.28382
PLSCR4 phospholipid scramblase 4 -2.28087
RPGR retinitis pigmentosa GTPase regulator -2.26869
DCAF4 DDB1 and CUL4 associated factor 4 -2.22914
MRPL38 mitochondrial ribosomal protein L38 -2.21171
ZNF540 zinc finger protein 540 -2.20362
TEX15 testis expressed 15 -2.19296
GRIK1 glutamate receptor, ionotropic, kainate 1 -2.18738
MCM3 minichromosome maintenance complex component 3 -2.17142
LRRC1 leucine rich repeat containing 1 -2.16601
FES FES proto-oncogene, tyrosine kinase -2.13011
PRR36 proline rich 36 -2.13011
PTGIS prostaglandin I2 (prostacyclin) synthase -2.12835
SPRY4 sprouty homolog 4 (Drosophila) -2.09324
ANAPC4 anaphase promoting complex subunit 4 -2.08967
LATS2 large tumor suppressor kinase 2 -2.07665
NSD1 nuclear receptor binding SET domain protein 1 -2.07296
STAC SH3 and cysteine rich domain -2.0436
CCDC90B coiled-coil domain containing 90B -2.04037
INA internexin neuronal intermediate filament protein, alpha -2.04037
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1 -2.03145
EPM2A epilepsy, progressive myoclonus type 2A, Lafora disease (laforin) -2.03112
INTS4 integrator complex subunit 4 -2.01432
DDX49 DEAD (Asp-Glu-Ala-Asp) box polypeptide 49 -2.01432
HLA-DRB1 major histocompatibility complex, class II, DR beta 1 -2.01098
LAMTOR5 late endosomal/lysosomal adaptor, MAPK and MTOR activator 5 -2.00808
INTS9 integrator complex subunit 9 -2.00757
NAA80 N-alpha-acetyltransferase 80, NatH catalytic subunit -2.00108