SIX3 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description SIX homeobox 3|This gene encodes a member of the sine oculis homeobox transcription factor family. The encoded protein plays a role in eye development. Mutations in this gene have been associated with holoprosencephaly type 2. [provided by RefSeq, Oct 2009] (NCBI Entrez Gene Database, 6496)
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Genes

313 genes differentially expressed following the SIX3 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
PRLHR prolactin releasing hormone receptor 3.08422
OPRL1 opiate receptor-like 1 3.08422
DIRAS2 DIRAS family, GTP-binding RAS-like 2 3.08422
DIRAS3 DIRAS family, GTP-binding RAS-like 3 3.08422
ADAD1 adenosine deaminase domain containing 1 (testis-specific) 3.08422
SLC39A5 solute carrier family 39 (zinc transporter), member 5 3.08422
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa 3.08422
MS4A15 membrane-spanning 4-domains, subfamily A, member 15 3.08422
MS4A14 membrane-spanning 4-domains, subfamily A, member 14 3.08422
GLRA3 glycine receptor, alpha 3 3.08422
RSPO1 R-spondin 1 3.08422
CEP295NL CEP295 N-terminal like 3.08422
TSSK4 testis-specific serine kinase 4 3.08422
SRPX2 sushi-repeat containing protein, X-linked 2 3.08422
CCDC116 coiled-coil domain containing 116 3.08422
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2 3.08422
SLC5A9 solute carrier family 5 (sodium/sugar cotransporter), member 9 3.08422
GPR55 G protein-coupled receptor 55 3.08422
OSGIN1 oxidative stress induced growth inhibitor 1 3.08422
DSG3 desmoglein 3 3.08422
PTH2 parathyroid hormone 2 3.08422
CCDC38 coiled-coil domain containing 38 3.08422
MUC22 mucin 22 3.08422
FAM216B family with sequence similarity 216, member B 3.08422
TMEM52B transmembrane protein 52B 3.08422
VPREB3 pre-B lymphocyte 3 3.08422
ZC3H11B zinc finger CCCH-type containing 11B pseudogene 3.08422
LOXL4 lysyl oxidase-like 4 3.08422
PADI6 peptidyl arginine deiminase, type VI 3.08422
TGM3 transglutaminase 3 3.08422
PARP15 poly (ADP-ribose) polymerase family, member 15 3.08422
ABCD2 ATP-binding cassette, sub-family D (ALD), member 2 3.08422
CGA glycoprotein hormones, alpha polypeptide 3.08422
ABRA actin binding Rho activating protein 3.08422
ZC2HC1B zinc finger, C2HC-type containing 1B 3.08422
VSX1 visual system homeobox 1 3.08422
PRR29 proline rich 29 3.08422
NMUR1 neuromedin U receptor 1 3.08422
EVPL envoplakin 3.08422
OR56A5 olfactory receptor, family 56, subfamily A, member 5 3.08422
TIE1 tyrosine kinase with immunoglobulin-like and EGF-like domains 1 3.08422
FGF6 fibroblast growth factor 6 3.08422
WFDC11 WAP four-disulfide core domain 11 3.08422
CA6 carbonic anhydrase VI 3.08422
TRPM5 transient receptor potential cation channel, subfamily M, member 5 3.08422
LOC122455340 uncharacterized LOC122455340 3.08422
G6PC1 glucose-6-phosphatase catalytic subunit 1 3.08422
ALPG alkaline phosphatase, germ cell 3.08422
ALDOB aldolase B, fructose-bisphosphate 3.08422
LTB4R2 leukotriene B4 receptor 2 3.08422
PNLIPRP1 pancreatic lipase-related protein 1 3.08422
CXCL13 chemokine (C-X-C motif) ligand 13 3.08422
OR2T8 olfactory receptor, family 2, subfamily T, member 8 3.08422
FMO1 flavin containing monooxygenase 1 3.08422
SMPX small muscle protein, X-linked 3.08422
ETFBKMT electron transfer flavoprotein subunit beta lysine methyltransferase 3.08422
TEKTIP1 tektin bundle interacting protein 1 3.08422
CIMIP3 ciliary microtubule inner protein 3 3.08422
LOC124903372 uncharacterized LOC124903372 3.08422
H3C13 H3 clustered histone 13 3.08422
RHEX regulator of hemoglobinization and erythroid cell expansion 3.08422
CALHM4 calcium homeostasis modulator family member 4 3.08422
MINDY4B MINDY family member 4B 3.08422
H3C3 H3 clustered histone 3 3.08422
PEAK3 PEAK family member 3 3.08422
SEPTIN12 septin 12 3.08422
BDKRB2 bradykinin receptor B2 3.08422
MYEOV myeloma overexpressed 3.08422
TTR transthyretin 3.08422
NR0B1 nuclear receptor subfamily 0, group B, member 1 3.08422
EXOC3L4 exocyst complex component 3-like 4 3.08422
SPDYC speedy/RINGO cell cycle regulator family member C 3.08422
C1QTNF8 C1q and tumor necrosis factor related protein 8 3.08422
TLR6 toll-like receptor 6 3.08422
SCRT2 scratch family zinc finger 2 3.08422
NKX2-5 NK2 homeobox 5 3.08422
TBX20 T-box 20 3.08422
RNF151 ring finger protein 151 3.08422
CNTFR ciliary neurotrophic factor receptor 3.08422
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 3.08422
SPATA25 spermatogenesis associated 25 3.08422
IMPG1 interphotoreceptor matrix proteoglycan 1 3.08422
DYNLRB2 dynein, light chain, roadblock-type 2 3.08422
ABCA9 ATP-binding cassette, sub-family A (ABC1), member 9 3.08422
LRRN4CL LRRN4 C-terminal like 3.08422
HNF1B HNF1 homeobox B 3.08422
GPR83 G protein-coupled receptor 83 3.08422
ZAR1L zygote arrest 1-like 3.08422
VCX3B variable charge, X-linked 3B 3.08422
KLHL34 kelch-like family member 34 3.08422
CYP2W1 cytochrome P450, family 2, subfamily W, polypeptide 1 3.08422
CCDC154 coiled-coil domain containing 154 3.08422
FAM177B family with sequence similarity 177, member B 3.08422
NPFFR1 neuropeptide FF receptor 1 3.08422
SPINK9 serine peptidase inhibitor, Kazal type 9 3.08422
CCDC27 coiled-coil domain containing 27 3.08422
BAHCC1 BAH domain and coiled-coil containing 1 3.08422
MUC13 mucin 13, cell surface associated 3.08422
IL19 interleukin 19 3.08422
DHH desert hedgehog 3.08422
ZCCHC12 zinc finger, CCHC domain containing 12 3.08422
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) 3.08422
HPX hemopexin 3.08422
MRLN myoregulin 3.08422
RAD21L1 RAD21-like 1 (S. pombe) 3.08422
EDN2 endothelin 2 3.08422
CLDN34 claudin 34 3.08422
OR2M3 olfactory receptor, family 2, subfamily M, member 3 3.08422
CRYBB2 crystallin, beta B2 3.08422
CYSLTR1 cysteinyl leukotriene receptor 1 3.08422
LCN9 lipocalin 9 3.08422
GOLGA6C golgin A6 family, member C 3.08422
PATE4 prostate and testis expressed 4 3.08422
EGR2 early growth response 2 3.08422
POU4F1 POU class 4 homeobox 1 3.08422
SERPINB8 serpin peptidase inhibitor, clade B (ovalbumin), member 8 3.08422
ESPNL espin-like 3.08422
MGP matrix Gla protein 3.08422
ADAM18 ADAM metallopeptidase domain 18 3.08422
LMX1A LIM homeobox transcription factor 1, alpha 3.08422
STRC stereocilin 3.08422
GOLGA8T golgin A8 family, member T 3.08422
CCDC177 coiled-coil domain containing 177 3.08422
CAPSL calcyphosine-like 3.08422
CLEC1B C-type lectin domain family 1, member B 3.08422
TTC16 tetratricopeptide repeat domain 16 3.08422
CWH43 cell wall biogenesis 43 C-terminal homolog (S. cerevisiae) 3.08422
SPATA9 spermatogenesis associated 9 3.08422
CHRNA1 cholinergic receptor, nicotinic, alpha 1 (muscle) 3.08422
SAMD7 sterile alpha motif domain containing 7 3.08422
CHIT1 chitinase 1 (chitotriosidase) 3.08422
ANKRD55 ankyrin repeat domain 55 3.08422
CTSF cathepsin F 3.08422
TRIM7 tripartite motif containing 7 3.08422
MZB1 marginal zone B and B1 cell-specific protein 3.08422
CHAD chondroadherin 3.08422
SLITRK1 SLIT and NTRK-like family, member 1 3.08422
PLGLB2 plasminogen-like B2 3.08422
BCL2A1 BCL2-related protein A1 3.08422
RGR retinal G protein coupled receptor 3.08422
FAM25A family with sequence similarity 25, member A 3.08422
STMND1 stathmin domain containing 1 3.08422
CLEC7A C-type lectin domain family 7, member A 3.08422
AGR2 anterior gradient 2 3.08422
SPRN shadow of prion protein homolog (zebrafish) 3.08422
BLID BH3-like motif containing, cell death inducer 3.08422
SLC30A10 solute carrier family 30, member 10 3.08422
CYP2J2 cytochrome P450, family 2, subfamily J, polypeptide 2 3.08422
VAX2 ventral anterior homeobox 2 3.08422
CHRM4 cholinergic receptor, muscarinic 4 3.08422
ZNF366 zinc finger protein 366 3.08422
OR14A16 olfactory receptor, family 14, subfamily A, member 16 3.08422
UROD uroporphyrinogen decarboxylase 3.05498
SCN2A sodium channel, voltage gated, type II alpha subunit 3.01983
HS6ST1 heparan sulfate 6-O-sulfotransferase 1 2.99218
SMYD3 SET and MYND domain containing 3 2.98198
ZNF175 zinc finger protein 175 2.98198
NIFK nucleolar protein interacting with the FHA domain of MKI67 2.98198
CACNB2 calcium channel, voltage-dependent, beta 2 subunit 2.90278
PIKFYVE phosphoinositide kinase, FYVE finger containing 2.90172
ARPC3 actin related protein 2/3 complex, subunit 3, 21kDa 2.70561
DDX56 DEAD (Asp-Glu-Ala-Asp) box helicase 56 2.65889
SIMC1 SUMO-interacting motifs containing 1 2.6572
CFAP70 cilia and flagella associated protein 70 2.63632
MT1G metallothionein 1G 2.54917
PECAM1 platelet/endothelial cell adhesion molecule 1 2.50776
CSNK2B casein kinase 2, beta polypeptide 2.45129
WDR93 WD repeat domain 93 2.42294
SLCO1C1 solute carrier organic anion transporter family, member 1C1 2.42294
SMYD2 SET and MYND domain containing 2 2.42294
KLHL1 kelch-like family member 1 2.42294
LRRC56 leucine rich repeat containing 56 2.42294
FXR1 fragile X mental retardation, autosomal homolog 1 2.38793
ELMOD2 ELMO/CED-12 domain containing 2 2.3776
IRS4 insulin receptor substrate 4 2.36066
CELSR3 cadherin, EGF LAG seven-pass G-type receptor 3 2.35732
ETFA electron-transfer-flavoprotein, alpha polypeptide 2.34469
OLFM3 olfactomedin 3 2.34244
RENBP renin binding protein 2.34244
CIMAP2 ciliary microtubule associated protein 2 2.32715
ZNF534 zinc finger protein 534 2.32715
OPRK1 opioid receptor, kappa 1 2.28544
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 2.28544
CIITA class II, major histocompatibility complex, transactivator 2.28544
SAMD5 sterile alpha motif domain containing 5 2.28544
CRYBG3 beta-gamma crystallin domain containing 3 2.28488
GOLPH3 golgi phosphoprotein 3 (coat-protein) 2.23806
PHGDH phosphoglycerate dehydrogenase 2.22604
EML5 echinoderm microtubule associated protein like 5 2.20824
SH2D3C SH2 domain containing 3C 2.18499
THOC6 THO complex 6 2.17988
ETFB electron-transfer-flavoprotein, beta polypeptide 2.1696
TRIM23 tripartite motif containing 23 2.16497
FBXO2 F-box protein 2 2.16497
FBP2 fructose-1,6-bisphosphatase 2 2.16089
DES desmin 2.16089
RIMS2 regulating synaptic membrane exocytosis 2 2.16089
CD101 CD101 molecule 2.16089
FAM229A family with sequence similarity 229, member A 2.16089
ENTPD2 ectonucleoside triphosphate diphosphohydrolase 2 2.16089
S100Z S100 calcium binding protein Z 2.16089
PRSS50 protease, serine, 50 2.16089
C19ORF53 chromosome 19 open reading frame 53 2.12441
CHID1 chitinase domain containing 1 2.12441
ATG16L1 autophagy related 16-like 1 (S. cerevisiae) 2.10334
NME9 NME/NM23 family member 9 2.10334
ZNF10 zinc finger protein 10 2.08665
POLR2K polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa 2.06696
ALDH5A1 aldehyde dehydrogenase 5 family, member A1 2.06478
GLRX5 glutaredoxin 5 2.06478
AVEN apoptosis, caspase activation inhibitor 2.04889
SMAD7 SMAD family member 7 2.04454
PADI4 peptidyl arginine deiminase, type IV 2.04034
GRHL2 grainyhead-like 2 (Drosophila) 2.02961
MTG1 mitochondrial ribosome-associated GTPase 1 2.02678
PRH1 proline-rich protein HaeIII subfamily 1 2.01702
MTRF1 mitochondrial translational release factor 1 2.01128
PUS7L pseudouridylate synthase 7 homolog (S. cerevisiae)-like 2.0083
NEK8 NIMA-related kinase 8 2.0083

decreased expression

Symbol Name Standardized Value
SLC5A5 solute carrier family 5 (sodium/iodide cotransporter), member 5 -3.08422
CCDC158 coiled-coil domain containing 158 -3.08422
MRRF mitochondrial ribosome recycling factor -3.08422
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7 -3.08422
GPR171 G protein-coupled receptor 171 -3.08422
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b -3.08422
PPP1R3D protein phosphatase 1, regulatory subunit 3D -3.08422
PARP8 poly (ADP-ribose) polymerase family, member 8 -3.0212
SHISA3 shisa family member 3 -2.98198
ZNF396 zinc finger protein 396 -2.98198
ICAM4 intercellular adhesion molecule 4 (Landsteiner-Wiener blood group) -2.98198
GLT6D1 glycosyltransferase 6 domain containing 1 -2.98198
R3HDML R3H domain containing-like -2.98198
MEIG1 meiosis/spermiogenesis associated 1 -2.98198
ATOH7 atonal homolog 7 (Drosophila) -2.98198
GMFG glia maturation factor, gamma -2.98198
RBIS ribosomal biogenesis factor -2.98198
HAO2 hydroxyacid oxidase 2 (long chain) -2.98198
FAM107A family with sequence similarity 107, member A -2.98198
CD48 CD48 molecule -2.98198
ZC3H11C zinc finger CCCH-type containing 11C -2.98198
ASB15 ankyrin repeat and SOCS box containing 15 -2.98198
SLC6A7 solute carrier family 6 (neurotransmitter transporter), member 7 -2.98198
IZUMO3 IZUMO family member 3 -2.98198
MUC1 mucin 1, cell surface associated -2.98198
CD160 CD160 molecule -2.98198
CPNE8-AS1 CPNE8 antisense RNA 1 -2.98198
PSORS1C1 psoriasis susceptibility 1 candidate 1 -2.98198
HLA-G major histocompatibility complex, class I, G -2.98198
C14ORF119 chromosome 14 open reading frame 119 -2.98198
BAIAP3 BAI1-associated protein 3 -2.98198
IGIP IgA-inducing protein -2.98198
SLC25A31 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 31 -2.98198
KPNA7 karyopherin alpha 7 (importin alpha 8) -2.98198
TEKT5 tektin 5 -2.98198
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) -2.98198
RSPH4A radial spoke head 4 homolog A (Chlamydomonas) -2.98198
PGR progesterone receptor -2.98198
POU3F2 POU class 3 homeobox 2 -2.98198
HSD17B13 hydroxysteroid (17-beta) dehydrogenase 13 -2.98198
MCF2L MCF.2 cell line derived transforming sequence-like -2.96827
COL10A1 collagen, type X, alpha 1 -2.90871
MAGEL2 melanoma antigen family L2 -2.8537
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A -2.80678
LMTK2 lemur tyrosine kinase 2 -2.66344
FGD6 FYVE, RhoGEF and PH domain containing 6 -2.63978
DNAJC17 DnaJ (Hsp40) homolog, subfamily C, member 17 -2.61812
ZNF14 zinc finger protein 14 -2.61696
PATL2 protein associated with topoisomerase II homolog 2 (yeast) -2.55779
PRXL2C peroxiredoxin like 2C -2.54917
SEPTIN4 septin 4 -2.53069
TRIP12 thyroid hormone receptor interactor 12 -2.50776
PCDHAC1 protocadherin alpha subfamily C, 1 -2.37805
EVL Enah/Vasp-like -2.3776
WSCD1 WSC domain containing 1 -2.36066
C15ORF40 chromosome 15 open reading frame 40 -2.32783
DCBLD2 discoidin, CUB and LCCL domain containing 2 -2.32336
AHCY adenosylhomocysteinase -2.28544
EXTL1 exostosin-like glycosyltransferase 1 -2.28077
PEX1 peroxisomal biogenesis factor 1 -2.2448
ADGRB2 adhesion G protein-coupled receptor B2 -2.20367
SUCLG1 succinate-CoA ligase, alpha subunit -2.19726
CCDC138 coiled-coil domain containing 138 -2.19155
TTF2 transcription termination factor, RNA polymerase II -2.17988
BCS1L BC1 (ubiquinol-cytochrome c reductase) synthesis-like -2.1696
EIF3B eukaryotic translation initiation factor 3, subunit B -2.16016
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -2.15393
COPZ1 coatomer protein complex, subunit zeta 1 -2.15393
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) -2.13488
CYCS cytochrome c, somatic -2.12715
SH3D19 SH3 domain containing 19 -2.12715
ZNF92 zinc finger protein 92 -2.11063
ISM1 isthmin 1, angiogenesis inhibitor -2.10356
DNAJB5 DnaJ (Hsp40) homolog, subfamily B, member 5 -2.10334
UCP2 uncoupling protein 2 (mitochondrial, proton carrier) -2.10334
BORCS6 BLOC-1 related complex subunit 6 -2.09683
ZC3H14 zinc finger CCCH-type containing 14 -2.08879
VIM vimentin -2.08665
SRP14 signal recognition particle 14kDa (homologous Alu RNA binding protein) -2.08638
NUP107 nucleoporin 107kDa -2.08079
PLPP6 phospholipid phosphatase 6 -2.06916
PRDX6 peroxiredoxin 6 -2.06916
TLR3 toll-like receptor 3 -2.06696
TRIL TLR4 interactor with leucine-rich repeats -2.06478
SACM1L SAC1 suppressor of actin mutations 1-like (yeast) -2.06478
PHF8 PHD finger protein 8 -2.04889
CELF1 CUGBP, Elav-like family member 1 -2.04778
MSRA methionine sulfoxide reductase A -2.04454
PKD1L3 polycystic kidney disease 1-like 3 -2.03344
RELL2 RELT-like 2 -2.03168
KLF12 Kruppel-like factor 12 -2.02961
APOM apolipoprotein M -2.02961
SNRPA small nuclear ribonucleoprotein polypeptide A -2.0275
SETD3 SET domain containing 3 -2.00264