SIX4 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description SIX homeobox 4|This gene encodes a member of the homeobox family, subfamily SIX. The drosophila homolog is a nuclear homeoprotein required for eye development. Studies in mouse show that this gene product functions as a transcription factor, and may have a role in the differentiation or maturation of neuronal cells. [provided by RefSeq, May 2010] (NCBI Entrez Gene Database, 51804)
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Genes

359 genes differentially expressed following the SIX4 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
FAM180A family with sequence similarity 180, member A 2.73998
CASP4 caspase 4, apoptosis-related cysteine peptidase 2.73998
MYBPC3 myosin binding protein C, cardiac 2.73998
OR10A4 olfactory receptor, family 10, subfamily A, member 4 2.73998
APLN apelin 2.73998
SKOR2 SKI family transcriptional corepressor 2 2.73998
PERM1 PPARGC1 and ESRR induced regulator, muscle 1 2.73998
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides 2.73998
DSG3 desmoglein 3 2.73998
PAX5 paired box 5 2.73998
RSPO1 R-spondin 1 2.73998
NUGGC nuclear GTPase, germinal center associated 2.73998
OSGIN1 oxidative stress induced growth inhibitor 1 2.73998
DPEP2 dipeptidase 2 2.73998
DUXA double homeobox A 2.73998
HEATR9 HEAT repeat containing 9 2.73998
PRICKLE4 prickle homolog 4 (Drosophila) 2.73998
BTC betacellulin 2.73998
DNASE1L2 deoxyribonuclease I-like 2 2.73998
CD163 CD163 molecule 2.73998
TNNI1 troponin I type 1 (skeletal, slow) 2.73998
PKP1 plakophilin 1 2.73998
HGF hepatocyte growth factor (hepapoietin A; scatter factor) 2.73998
TM4SF4 transmembrane 4 L six family member 4 2.73998
HORMAD1 HORMA domain containing 1 2.73998
KDM6A lysine (K)-specific demethylase 6A 2.73998
SHCBP1L SHC SH2-domain binding protein 1-like 2.73998
TRPC5OS TRPC5 opposite strand 2.73998
SLC39A12 solute carrier family 39 (zinc transporter), member 12 2.73998
GALR3 galanin receptor 3 2.73998
SP6 Sp6 transcription factor 2.73998
NMUR1 neuromedin U receptor 1 2.73998
PNLDC1 poly(A)-specific ribonuclease (PARN)-like domain containing 1 2.73998
GRM2 glutamate receptor, metabotropic 2 2.73998
FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b) 2.73998
CD3E CD3e molecule, epsilon (CD3-TCR complex) 2.73998
CD34 CD34 molecule 2.73998
GPD1 glycerol-3-phosphate dehydrogenase 1 (soluble) 2.73998
SPINK14 serine peptidase inhibitor, Kazal type 14 (putative) 2.73998
SPINK13 serine peptidase inhibitor, Kazal type 13 (putative) 2.73998
SLC23A3 solute carrier family 23, member 3 2.73998
C11ORF87 chromosome 11 open reading frame 87 2.73998
PTGFR prostaglandin F receptor (FP) 2.73998
TRPV5 transient receptor potential cation channel, subfamily V, member 5 2.73998
SFTPD surfactant protein D 2.73998
NOTUM notum pectinacetylesterase homolog (Drosophila) 2.73998
PTGER1 prostaglandin E receptor 1 (subtype EP1), 42kDa 2.73998
TDRD6 tudor domain containing 6 2.73998
MGARP mitochondria-localized glutamic acid-rich protein 2.73998
SLC28A2 solute carrier family 28 (concentrative nucleoside transporter), member 2 2.73998
UMODL1 uromodulin-like 1 2.73998
C5ORF46 chromosome 5 open reading frame 46 2.73998
ZNF503 zinc finger protein 503 2.73998
C1ORF232 chromosome 1 open reading frame 230 2.73998
MYH8 myosin, heavy chain 8, skeletal muscle, perinatal 2.73998
CXCL13 chemokine (C-X-C motif) ligand 13 2.73998
DUSP9 dual specificity phosphatase 9 2.73998
KRT80 keratin 80, type II 2.73998
SRGN serglycin 2.73998
PROX2 prospero homeobox 2 2.73998
BDKRB2 bradykinin receptor B2 2.73998
C10ORF53 chromosome 10 open reading frame 53 2.73998
SPATA25 spermatogenesis associated 25 2.73998
ARMCX5-GPRASP2 ARMCX5-GPRASP2 readthrough 2.73998
OSTN osteocrin 2.73998
ST6GALNAC1 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 2.73998
OR10H5 olfactory receptor, family 10, subfamily H, member 5 2.73998
SPAAR small regulatory polypeptide of amino acid response 2.73998
SMIM35 small integral membrane protein 35 2.73998
LY6L lymphocyte antigen 6 family member L 2.73998
TUBB8B tubulin beta 8B 2.73998
UBE2L5 ubiquitin conjugating enzyme E2 L5 2.73998
PPDPFL pancreatic progenitor cell differentiation and proliferation factor like 2.73998
CGB3 chorionic gonadotropin subunit beta 3 2.73998
CCDC187 coiled-coil domain containing 187 2.73998
SMIM36 small integral membrane protein 36 2.73998
H3-5 H3.5 histone 2.73998
SEPTIN14 septin 14 2.73998
BEST3 bestrophin 3 2.73998
ASIC3 acid sensing (proton gated) ion channel 3 2.73998
LIPK lipase, family member K 2.73998
RAET1E retinoic acid early transcript 1E 2.73998
PLVAP plasmalemma vesicle associated protein 2.73998
SRL sarcalumenin 2.73998
HLF hepatic leukemia factor 2.73998
ABCC9 ATP-binding cassette, sub-family C (CFTR/MRP), member 9 2.73998
CD6 CD6 molecule 2.73998
LRRD1 leucine-rich repeats and death domain containing 1 2.73998
CHADL chondroadherin-like 2.73998
DNAJC5B DnaJ (Hsp40) homolog, subfamily C, member 5 beta 2.73998
ASB15 ankyrin repeat and SOCS box containing 15 2.73998
HDC histidine decarboxylase 2.73998
PCDHA2 protocadherin alpha 2 2.73998
WNT9B wingless-type MMTV integration site family, member 9B 2.73998
GPR88 G protein-coupled receptor 88 2.73998
FGFBP1 fibroblast growth factor binding protein 1 2.73998
RGS21 regulator of G-protein signaling 21 2.73998
NR0B1 nuclear receptor subfamily 0, group B, member 1 2.73998
PIWIL1 piwi-like RNA-mediated gene silencing 1 2.73998
GDF10 growth differentiation factor 10 2.73998
TLR5 toll-like receptor 5 2.73998
OR2AT4 olfactory receptor, family 2, subfamily AT, member 4 2.73998
C4ORF17 chromosome 4 open reading frame 17 2.73998
CFAP99 cilia and flagella associated protein 99 2.73998
RACGAP1 Rac GTPase activating protein 1 2.73998
MYOZ2 myozenin 2 2.73998
THTPA thiamine triphosphatase 2.73998
DRD2 dopamine receptor D2 2.73998
PCDHGA3 protocadherin gamma subfamily A, 3 2.73998
NUPR1 nuclear protein, transcriptional regulator, 1 2.73998
COX7B2 cytochrome c oxidase subunit VIIb2 2.73998
MUC13 mucin 13, cell surface associated 2.73998
IL19 interleukin 19 2.73998
SEC14L3 SEC14-like 3 (S. cerevisiae) 2.73998
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39) 2.73998
EGR3 early growth response 3 2.73998
EPGN epithelial mitogen 2.73998
ALDH3B2 aldehyde dehydrogenase 3 family, member B2 2.73998
APOC4 apolipoprotein C-IV 2.73998
PAGE2 P antigen family, member 2 (prostate associated) 2.73998
CDHR5 cadherin-related family member 5 2.73998
CDHR4 cadherin-related family member 4 2.73998
HGH1 HGH1 homolog (S. cerevisiae) 2.73998
SCML4 sex comb on midleg-like 4 (Drosophila) 2.73998
KAZALD1 Kazal-type serine peptidase inhibitor domain 1 2.73998
GML glycosylphosphatidylinositol anchored molecule like 2.73998
ADAM2 ADAM metallopeptidase domain 2 2.73998
SLC52A1 solute carrier family 52 (riboflavin transporter), member 1 2.73998
SULT2A1 sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 2.73998
CLMB calcimembrin 2.73998
FAM135B family with sequence similarity 135, member B 2.73998
SAMD5 sterile alpha motif domain containing 5 2.73998
HLA-DQA2 major histocompatibility complex, class II, DQ alpha 2 2.73998
GOLGA8M golgin A8 family, member M 2.73998
MYADML2 myeloid-associated differentiation marker-like 2 2.73998
CAPSL calcyphosine-like 2.73998
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 2.73998
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3 2.73998
KCNA2 potassium channel, voltage gated shaker related subfamily A, member 2 2.73998
CNR2 cannabinoid receptor 2 (macrophage) 2.73998
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal 2.73998
ZNF835 zinc finger protein 835 2.73998
SRD5A2 steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) 2.73998
NYX nyctalopin 2.73998
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 2.73998
HMGB4 high mobility group box 4 2.73998
VSTM1 V-set and transmembrane domain containing 1 2.73998
SLC4A1 solute carrier family 4 (anion exchanger), member 1 (Diego blood group) 2.73998
SIGLEC16 sialic acid binding Ig-like lectin 16 (gene/pseudogene) 2.73998
SPHKAP SPHK1 interactor, AKAP domain containing 2.73998
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1 2.73998
NR5A1 nuclear receptor subfamily 5, group A, member 1 2.73998
INSM1 insulinoma-associated 1 2.73998
UBXN10 UBX domain protein 10 2.73998
RGS4 regulator of G-protein signaling 4 2.73998
GCGR glucagon receptor 2.73998
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide 2.73998
CST1 cystatin SN 2.73998
FNDC9 fibronectin type III domain containing 9 2.73998
GNG8 guanine nucleotide binding protein (G protein), gamma 8 2.73998
MTO1 mitochondrial tRNA translation optimization 1 2.73998
TEX38 testis expressed 38 2.73998
MAGEA10 melanoma antigen family A10 2.73998
SPRN shadow of prion protein homolog (zebrafish) 2.73998
NAT16 N-acetyltransferase 16 (GCN5-related, putative) 2.73998
ZMYND10 zinc finger, MYND-type containing 10 2.73998
DEFB134 defensin, beta 134 2.73998
CHRM1 cholinergic receptor, muscarinic 1 2.73998
CYBB cytochrome b-245, beta polypeptide 2.73998
TOPAZ1 testis and ovary specific PAZ domain containing 1 2.73998
CHRM4 cholinergic receptor, muscarinic 4 2.73998
SLC7A4 solute carrier family 7, member 4 2.73998
PAGE2B P antigen family, member 2B 2.73998
C9ORF57 chromosome 9 open reading frame 57 2.73998
CMTM5 CKLF-like MARVEL transmembrane domain containing 5 2.73998
PLA2G4D phospholipase A2, group IVD (cytosolic) 2.73998
STOML3 stomatin (EPB72)-like 3 2.73998
KCNA6 potassium channel, voltage gated shaker related subfamily A, member 6 2.73998
SLC13A2 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2 2.73998
CCL27 chemokine (C-C motif) ligand 27 2.73998
OXER1 oxoeicosanoid (OXE) receptor 1 2.73998
LRRC46 leucine rich repeat containing 46 2.73998
GPR179 G protein-coupled receptor 179 2.73998
GH1 growth hormone 1 2.73998
MMP10 matrix metallopeptidase 10 2.73998
TEX35 testis expressed 35 2.73998
NGB neuroglobin 2.73998
ENDOU endonuclease, polyU-specific 2.73998
PRRX1 paired related homeobox 1 2.73998
TAS2R41 taste receptor, type 2, member 41 2.73998
HSD11B2 hydroxysteroid (11-beta) dehydrogenase 2 2.7298
RPIA ribose 5-phosphate isomerase A 2.67669
GIPR gastric inhibitory polypeptide receptor 2.63561
PCDHB3 protocadherin beta 3 2.62024
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 2.61202
RGS19 regulator of G-protein signaling 19 2.53488
RBM12 RNA binding motif protein 12 2.51482
NIPSNAP2 nipsnap homolog 2 2.49521
OBSL1 obscurin-like 1 2.46342
NBPF9 neuroblastoma breakpoint family, member 9 2.43444
PHF5A PHD finger protein 5A 2.40385
ZPR1 ZPR1 zinc finger 2.40356
STK36 serine/threonine kinase 36 2.3532
MAP9 microtubule-associated protein 9 2.33887
CCND1 cyclin D1 2.32093
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 2.3184
SEPSECS Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase 2.31157
ASTE1 asteroid homolog 1 (Drosophila) 2.29687
PSMC6 proteasome (prosome, macropain) 26S subunit, ATPase, 6 2.28096
SPSB2 splA/ryanodine receptor domain and SOCS box containing 2 2.28096
PLEKHM2 pleckstrin homology domain containing, family M (with RUN domain) member 2 2.27738
TRIM21 tripartite motif containing 21 2.26162
NUMBL numb homolog (Drosophila)-like 2.24135
CLRN1 clarin 1 2.23698
CSNK2A3 casein kinase 2, alpha 3 polypeptide 2.23698
ZNF124 zinc finger protein 124 2.22407
FAM124B family with sequence similarity 124B 2.22407
VSNL1 visinin-like 1 2.19453
RPL3 ribosomal protein L3 2.18771
TUBGCP2 tubulin, gamma complex associated protein 2 2.18358
RBMS3 RNA binding motif, single stranded interacting protein 3 2.18247
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 2.17515
DDX19A DEAD (Asp-Glu-Ala-Asp) box polypeptide 19A 2.16863
SRPK2 SRSF protein kinase 2 2.14882
RIMKLB ribosomal modification protein rimK-like family member B 2.14882
MMAA methylmalonic aciduria (cobalamin deficiency) cblA type 2.14744
ISCA1 iron-sulfur cluster assembly 1 2.13595
FOXN3 forkhead box N3 2.11376
NME4 NME/NM23 nucleoside diphosphate kinase 4 2.1039
MGMT O-6-methylguanine-DNA methyltransferase 2.09911
SYT1 synaptotagmin I 2.09241
WDR74 WD repeat domain 74 2.0801
AHDC1 AT hook, DNA binding motif, containing 1 2.06157
ZNF611 zinc finger protein 611 2.06157
HAUS3 HAUS augmin-like complex, subunit 3 2.0493
SNCB synuclein, beta 2.03665
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 2.03583
DEAF1 DEAF1 transcription factor 2.03117
AACS acetoacetyl-CoA synthetase 2.01399
RBM45 RNA binding motif protein 45 2.00962
SLC7A6 solute carrier family 7 (amino acid transporter light chain, y+L system), member 6 2.00866
OTUD5 OTU deubiquitinase 5 2.00346
PKM pyruvate kinase, muscle 2.00321

decreased expression

Symbol Name Standardized Value
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase -2.73998
LDHAL6A lactate dehydrogenase A-like 6A -2.73998
ATG4A autophagy related 4A, cysteine peptidase -2.73998
C10ORF67 chromosome 10 open reading frame 67 -2.73998
EMCN endomucin -2.73998
TMEM52B transmembrane protein 52B -2.73998
KIF19 kinesin family member 19 -2.73998
NUDT21 nudix (nucleoside diphosphate linked moiety X)-type motif 21 -2.73998
RIC1 RAB6A GEF complex partner 1 -2.73998
TRIM17 tripartite motif containing 17 -2.73998
MGAM maltase-glucoamylase -2.73998
CYP4Z1 cytochrome P450, family 4, subfamily Z, polypeptide 1 -2.73998
AP1S2 adaptor-related protein complex 1, sigma 2 subunit -2.73998
IDO2 indoleamine 2,3-dioxygenase 2 -2.73998
TTLL2 tubulin tyrosine ligase-like family member 2 -2.73998
KLHL32 kelch-like family member 32 -2.73998
ACHE acetylcholinesterase (Yt blood group) -2.73998
PTPRQ protein tyrosine phosphatase, receptor type, Q -2.73998
GRXCR2 glutaredoxin, cysteine rich 2 -2.73998
PCDHB11 protocadherin beta 11 -2.73998
CLDN5 claudin 5 -2.73998
CC2D2B coiled-coil and C2 domain containing 2B -2.73998
REN renin -2.73998
NLRP10 NLR family, pyrin domain containing 10 -2.73998
TNS4 tensin 4 -2.73998
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 -2.73998
OR6A2 olfactory receptor, family 6, subfamily A, member 2 -2.73998
RBP4 retinol binding protein 4, plasma -2.73998
TSPYL5 TSPY-like 5 -2.73998
TMEM238L transmembrane protein 238 like -2.73998
S100Z S100 calcium binding protein Z -2.73998
PCP4 Purkinje cell protein 4 -2.73998
PCDHAC1 protocadherin alpha subfamily C, 1 -2.73998
ADIRF adipogenesis regulatory factor -2.73998
KLF1 Kruppel-like factor 1 (erythroid) -2.73998
SPMIP8 sperm microtubule inner protein 8 -2.73998
TMEFF2 transmembrane protein with EGF-like and two follistatin-like domains 2 -2.73998
LINC02983 long intergenic non-protein coding RNA 2983 -2.73998
KDM2A lysine (K)-specific demethylase 2A -2.73998
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal) -2.73998
SLC17A8 solute carrier family 17 (vesicular glutamate transporter), member 8 -2.73998
CLIC2 chloride intracellular channel 2 -2.73998
IQCN IQ motif containing N -2.73998
ECM1 extracellular matrix protein 1 -2.73998
GFI1B growth factor independent 1B transcription repressor -2.73998
GABRD gamma-aminobutyric acid (GABA) A receptor, delta -2.73998
JPH3 junctophilin 3 -2.68317
ZNF782 zinc finger protein 782 -2.67669
RAB22A RAB22A, member RAS oncogene family -2.6619
STARD5 StAR-related lipid transfer (START) domain containing 5 -2.65883
C2CD4C C2 calcium-dependent domain containing 4C -2.65873
C3ORF62 chromosome 3 open reading frame 62 -2.62477
TIGD4 tigger transposable element derived 4 -2.61554
ADGRD1 adhesion G protein-coupled receptor D1 -2.57851
BTN1A1 butyrophilin, subfamily 1, member A1 -2.57851
ABRAXAS1 abraxas 1, BRCA1 A complex subunit -2.48967
HOMER1 homer scaffolding protein 1 -2.47433
NEIL3 nei endonuclease VIII-like 3 (E. coli) -2.46026
RPS10 ribosomal protein S10 -2.46026
SYN2 synapsin II -2.44115
SAXO1 stabilizer of axonemal microtubules 1 -2.43996
ATP5MK ATP synthase membrane subunit k -2.41038
SAP25 Sin3A-associated protein, 25kDa -2.4064
KLHDC8A kelch domain containing 8A -2.4064
CYCS cytochrome c, somatic -2.4064
PSPN persephin -2.4064
SLC75A1 solute carrier family 75 member 1 -2.4064
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 -2.40105
ZNF69 zinc finger protein 69 -2.39935
ZNF480 zinc finger protein 480 -2.39175
FOXO1 forkhead box O1 -2.37896
RADX RPA1 related single stranded DNA binding protein, X-linked -2.37039
YEATS4 YEATS domain containing 4 -2.36919
ZNF582 zinc finger protein 582 -2.35837
GAS6 growth arrest-specific 6 -2.33318
KIAA1614 KIAA1614 -2.33296
LONP2 lon peptidase 2, peroxisomal -2.31588
CDK6 cyclin-dependent kinase 6 -2.31446
TPST1 tyrosylprotein sulfotransferase 1 -2.2961
ERMARD ER membrane-associated RNA degradation -2.27339
H4C3 H4 clustered histone 3 -2.26446
FASTKD2 FAST kinase domains 2 -2.26317
TLL1 tolloid-like 1 -2.24307
MAPK9 mitogen-activated protein kinase 9 -2.24236
COX8A cytochrome c oxidase subunit VIIIA (ubiquitous) -2.24236
TLR2 toll-like receptor 2 -2.23859
C5AR1 complement component 5a receptor 1 -2.23859
MFF mitochondrial fission factor -2.22982
NFASC neurofascin -2.19992
OST4 oligosaccharyltransferase 4 homolog (S. cerevisiae) -2.19453
PBX1 pre-B-cell leukemia homeobox 1 -2.18358
VIPAS39 VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog -2.17716
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -2.16651
RAB40A RAB40A, member RAS oncogene family -2.15265
RAB7A RAB7A, member RAS oncogene family -2.1502
CAMSAP2 calmodulin regulated spectrin-associated protein family, member 2 -2.14882
FLT3 fms-related tyrosine kinase 3 -2.14564
CFAP77 cilia and flagella associated protein 77 -2.14564
ZNF654 zinc finger protein 654 -2.13368
SPMIP2 sperm microtubule inner protein 2 -2.12904
ALDH4A1 aldehyde dehydrogenase 4 family, member A1 -2.1168
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2) -2.10911
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta -2.10911
C19ORF81 chromosome 19 open reading frame 81 -2.1054
ATP13A2 ATPase type 13A2 -2.07691
FRMD8 FERM domain containing 8 -2.0552
PDE8B phosphodiesterase 8B -2.04208
ZZEF1 zinc finger, ZZ-type with EF-hand domain 1 -2.03737
ABHD18 abhydrolase domain containing 18 -2.03418
MINAR1 membrane integral NOTCH2 associated receptor 1 -2.03367
MED23 mediator complex subunit 23 -2.02804
DHX35 DEAH (Asp-Glu-Ala-His) box polypeptide 35 -2.02804
ZNF440 zinc finger protein 440 -2.00962
CPT2 carnitine palmitoyltransferase 2 -2.0092
TRHDE thyrotropin-releasing hormone degrading enzyme -2.0092
IRX2 iroquois homeobox 2 -2.00346