SIX5 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description SIX homeobox 5|The protein encoded by this gene is a homeodomain-containing transcription factor that appears to function in the regulation of organogenesis. This gene is located downstream of the dystrophia myotonica-protein kinase gene. Mutations in this gene are a cause of branchiootorenal syndrome type 2. [provided by RefSeq, Jul 2009] (NCBI Entrez Gene Database, 147912)
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Genes

295 genes differentially expressed following the SIX5 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
CMTM5 CKLF-like MARVEL transmembrane domain containing 5 3.56837
TLR7 toll-like receptor 7 3.56837
THBD thrombomodulin 3.56837
MYOC myocilin, trabecular meshwork inducible glucocorticoid response 3.56837
C1ORF146 chromosome 1 open reading frame 146 3.56837
LRRC10B leucine rich repeat containing 10B 3.56837
SLC28A3 solute carrier family 28 (concentrative nucleoside transporter), member 3 3.56837
MLANA melan-A 3.56837
PRDM12 PR domain containing 12 3.56837
SIM2 single-minded family bHLH transcription factor 2 3.56837
OR2AT4 olfactory receptor, family 2, subfamily AT, member 4 3.56837
LRRC36 leucine rich repeat containing 36 3.56837
FPR1 formyl peptide receptor 1 3.56837
ALOX15B arachidonate 15-lipoxygenase, type B 3.56837
DNMT3L DNA (cytosine-5-)-methyltransferase 3-like 3.56837
KLF5 Kruppel-like factor 5 (intestinal) 3.56837
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13 3.56837
CKM creatine kinase, muscle 3.56837
VTCN1 V-set domain containing T cell activation inhibitor 1 3.56837
RBM20 RNA binding motif protein 20 3.56837
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 3.56837
SPINT4 serine peptidase inhibitor, Kunitz type 4 3.56837
FAM151A family with sequence similarity 151, member A 3.56837
CCER2 coiled-coil glutamate-rich protein 2 3.56837
ALX4 ALX homeobox 4 3.56837
ADRA2A adrenoceptor alpha 2A 3.56837
DUSP9 dual specificity phosphatase 9 3.56837
ZPBP zona pellucida binding protein 3.56837
AMDHD1 amidohydrolase domain containing 1 3.56837
TAS2R46 taste receptor, type 2, member 46 3.56837
CYLC1 cylicin, basic protein of sperm head cytoskeleton 1 3.56837
FAM9B family with sequence similarity 9, member B 3.35075
FBXL8 F-box and leucine-rich repeat protein 8 3.35075
DDX53 DEAD (Asp-Glu-Ala-Asp) box polypeptide 53 3.35075
SIGLEC7 sialic acid binding Ig-like lectin 7 3.35075
KLRK1 killer cell lectin-like receptor subfamily K, member 1 3.35075
ARHGAP36 Rho GTPase activating protein 36 3.35075
HES3 hes family bHLH transcription factor 3 3.35075
SCGB3A1 secretoglobin, family 3A, member 1 3.35075
HEATR9 HEAT repeat containing 9 3.35075
CRH corticotropin releasing hormone 3.35075
SPACA5 sperm acrosome associated 5 3.35075
LDHC lactate dehydrogenase C 3.35075
KCNE4 potassium channel, voltage gated subfamily E regulatory beta subunit 4 3.35075
MAGED4 melanoma antigen family D4 3.35075
CX3CR1 chemokine (C-X3-C motif) receptor 1 3.35075
GCKR glucokinase (hexokinase 4) regulator 3.35075
GNRHR gonadotropin-releasing hormone receptor 3.35075
OTUD6A OTU deubiquitinase 6A 3.35075
OR52E8 olfactory receptor, family 52, subfamily E, member 8 3.35075
MYCT1 myc target 1 3.35075
ASB5 ankyrin repeat and SOCS box containing 5 3.35075
SHCBP1L SHC SH2-domain binding protein 1-like 3.35075
GYS2 glycogen synthase 2 (liver) 3.35075
CD160 CD160 molecule 3.35075
CPXCR1 CPX chromosome region, candidate 1 3.35075
CSAG1 chondrosarcoma associated gene 1 3.35075
F5 coagulation factor V (proaccelerin, labile factor) 3.35075
ZNF705A zinc finger protein 705A 3.35075
IMPG2 interphotoreceptor matrix proteoglycan 2 3.35075
IMPG1 interphotoreceptor matrix proteoglycan 1 3.35075
TREX2 three prime repair exonuclease 2 3.35075
SRGN serglycin 3.35075
DNAAF1 dynein, axonemal, assembly factor 1 3.35075
CXCL13 chemokine (C-X-C motif) ligand 13 3.35075
CLDN16 claudin 16 3.35075
RTL5 retrotransposon Gag like 5 3.35075
RNF227 ring finger protein 227 3.35075
NFILZ NFIL3 like basic leucine zipper 3.35075
DEFB131A defensin beta 131A 3.35075
CIMAP1D CIMAP1 family member D 3.35075
LINC02268 long intergenic non-protein coding RNA 2268 3.35075
TAS1R1 taste receptor, type 1, member 1 3.35075
ATP2B3 ATPase, Ca++ transporting, plasma membrane 3 3.35075
SLC5A7 solute carrier family 5 (sodium/choline cotransporter), member 7 3.35075
CARD18 caspase recruitment domain family, member 18 3.35075
SLC6A1 solute carrier family 6 (neurotransmitter transporter), member 1 3.35075
NR1H4 nuclear receptor subfamily 1, group H, member 4 3.35075
INHBB inhibin, beta B 3.35075
FAM90A26 family with sequence similarity 90, member A26, pseudogene 3.35075
TMPRSS11A transmembrane protease, serine 11A 3.35075
TPBGL trophoblast glycoprotein-like 3.35075
SPDYE6 speedy/RINGO cell cycle regulator family member E6 3.35075
WNT11 wingless-type MMTV integration site family, member 11 3.35075
CBLN2 cerebellin 2 precursor 3.35075
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 3.35075
GZMM granzyme M (lymphocyte met-ase 1) 3.35075
MIP major intrinsic protein of lens fiber 3.35075
SLAMF7 SLAM family member 7 3.35075
TMEM179 transmembrane protein 179 3.35075
LOC124905976 uncharacterized LOC124905976 3.35075
HELT helt bHLH transcription factor 3.35075
ACOX2 acyl-CoA oxidase 2, branched chain 3.35075
PCDHGB1 protocadherin gamma subfamily B, 1 3.35075
ASTL astacin-like metallo-endopeptidase (M12 family) 3.35075
FSHR follicle stimulating hormone receptor 3.35075
MORC1 MORC family CW-type zinc finger 1 3.35075
PMP2 peripheral myelin protein 2 3.35075
SLCO2B1 solute carrier organic anion transporter family, member 2B1 3.35075
OR8H1 olfactory receptor, family 8, subfamily H, member 1 3.35075
CIDEC cell death-inducing DFFA-like effector c 3.35075
HSF4 heat shock transcription factor 4 3.35075
ZMYND15 zinc finger, MYND-type containing 15 3.35075
FGR FGR proto-oncogene, Src family tyrosine kinase 3.35075
PRSS51 protease, serine, 51 3.35075
AMN amnion associated transmembrane protein 3.35075
LRRC43 leucine rich repeat containing 43 3.35075
EDN1 endothelin 1 3.35075
C18ORF63 chromosome 18 open reading frame 63 3.35075
PRR23A proline rich 23A 3.35075
C2CD4B C2 calcium-dependent domain containing 4B 3.35075
PPP1R14D protein phosphatase 1, regulatory (inhibitor) subunit 14D 3.35075
P2RX2 purinergic receptor P2X, ligand gated ion channel, 2 3.35075
CPA3 carboxypeptidase A3 (mast cell) 3.35075
FBXO47 F-box protein 47 3.35075
GLT1D1 glycosyltransferase 1 domain containing 1 3.35075
DCLK3 doublecortin-like kinase 3 3.35075
CTAGE4 CTAGE family, member 4 3.35075
CRYBB2 crystallin, beta B2 3.35075
BTNL3 butyrophilin-like 3 3.35075
EGR4 early growth response 4 3.35075
KLK7 kallikrein-related peptidase 7 3.35075
GP5 glycoprotein V (platelet) 3.35075
MAPK11 mitogen-activated protein kinase 11 3.35075
TEX26 testis expressed 26 3.35075
TSPAN19 tetraspanin 19 3.35075
TMEM45B transmembrane protein 45B 3.35075
LMAN1L lectin, mannose-binding, 1 like 3.35075
SPNS3 spinster homolog 3 (Drosophila) 3.35075
BANF2 barrier to autointegration factor 2 3.35075
IL37 interleukin 37 3.35075
C17ORF78 chromosome 17 open reading frame 78 3.35075
RIPK3 receptor-interacting serine-threonine kinase 3 3.35075
CEACAM21 carcinoembryonic antigen-related cell adhesion molecule 21 3.35075
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase) 3.35075
NRSN1 neurensin 1 3.35075
SERPINB7 serpin peptidase inhibitor, clade B (ovalbumin), member 7 3.35075
SMCO1 single-pass membrane protein with coiled-coil domains 1 3.35075
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3 3.35075
MSMP microseminoprotein, prostate associated 3.35075
SLC38A3 solute carrier family 38, member 3 3.35075
TBC1D21 TBC1 domain family, member 21 3.35075
PRH2 proline-rich protein HaeIII subfamily 2 3.35075
NUTM2A NUT family member 2A 3.35075
HHIPL2 HHIP-like 2 3.35075
PNLIP pancreatic lipase 3.35075
TMEM31 transmembrane protein 31 3.35075
DEFB134 defensin, beta 134 3.35075
HIGD2B HIG1 hypoxia inducible domain family, member 2B 3.35075
AQP1 aquaporin 1 (Colton blood group) 3.35075
CLCA2 chloride channel accessory 2 3.35075
OR5B2 olfactory receptor, family 5, subfamily B, member 2 3.35075
RNF224 ring finger protein 224 3.35075
GDPD4 glycerophosphodiester phosphodiesterase domain containing 4 3.2185
NPIPA5 nuclear pore complex interacting protein family, member A5 3.2185
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 3.14514
FRMD8 FERM domain containing 8 2.98052
ZNF778 zinc finger protein 778 2.95404
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 2.9499
FAM161B family with sequence similarity 161, member B 2.88615
ATP6V1C1 ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1 2.83224
C14ORF39 chromosome 14 open reading frame 39 2.79883
CKS2 CDC28 protein kinase regulatory subunit 2 2.75694
TFB2M transcription factor B2, mitochondrial 2.75076
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 2.69119
TGFBR1 transforming growth factor, beta receptor 1 2.61791
RFESD Rieske (Fe-S) domain containing 2.61791
GDF15 growth differentiation factor 15 2.61791
MTERF1 mitochondrial transcription termination factor 1 2.57381
PIKFYVE phosphoinositide kinase, FYVE finger containing 2.51995
CHCHD7 coiled-coil-helix-coiled-coil-helix domain containing 7 2.50416
RPS6 ribosomal protein S6 2.44269
CPS1 carbamoyl-phosphate synthase 1, mitochondrial 2.42939
NIT2 nitrilase family, member 2 2.37287
LRRC58 leucine rich repeat containing 58 2.3404
CD80 CD80 molecule 2.32498
NETO1 neuropilin (NRP) and tolloid (TLL)-like 1 2.30761
GPX8 glutathione peroxidase 8 (putative) 2.30257
CIMAP2 ciliary microtubule associated protein 2 2.28913
CCN5 cellular communication network factor 5 2.27605
CFAP299 cilia and flagella associated protein 299 2.27605
BCORL1 BCL6 corepressor-like 1 2.27447
HLA-DPB1 major histocompatibility complex, class II, DP beta 1 2.2544
ZNF160 zinc finger protein 160 2.25211
GOLM2 golgi membrane protein 2 2.22727
PKM pyruvate kinase, muscle 2.20906
LYSMD1 LysM, putative peptidoglycan-binding, domain containing 1 2.16528
KLK5 kallikrein-related peptidase 5 2.15709
MBLAC1 metallo-beta-lactamase domain containing 1 2.15709
KIAA0825 KIAA0825 2.15709
GPRASP3 G protein-coupled receptor associated sorting protein family member 3 2.15709
DRD4 dopamine receptor D4 2.15709
FGF16 fibroblast growth factor 16 2.15709
ARHGAP31 Rho GTPase activating protein 31 2.15279
ANO5 anoctamin 5 2.12535
PASK PAS domain containing serine/threonine kinase 2.05058
NBEAL2 neurobeachin-like 2 2.04847
TMEM14C transmembrane protein 14C 2.04847
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 2.02786
CDC42 cell division cycle 42 2.00201
ZSCAN26 zinc finger and SCAN domain containing 26 2.00089

decreased expression

Symbol Name Standardized Value
DCLK2 doublecortin-like kinase 2 -3.56837
KCNRG potassium channel regulator -3.56837
TRPV4 transient receptor potential cation channel, subfamily V, member 4 -3.56837
MMAA methylmalonic aciduria (cobalamin deficiency) cblA type -3.56837
ADGRE3 adhesion G protein-coupled receptor E3 -3.56837
ZBTB8B zinc finger and BTB domain containing 8B -3.35075
EIF4E1B eukaryotic translation initiation factor 4E family member 1B -3.35075
SH2D6 SH2 domain containing 6 -3.35075
SYTL4 synaptotagmin-like 4 -3.35075
SLC9C2 solute carrier family 9, member C2 (putative) -3.35075
DLL1 delta-like 1 (Drosophila) -3.35075
MKX mohawk homeobox -3.35075
TRAM1L1 translocation associated membrane protein 1-like 1 -3.35075
F7 coagulation factor VII (serum prothrombin conversion accelerator) -3.35075
RSPH1 radial spoke head 1 homolog (Chlamydomonas) -3.35075
DNAJC22 DnaJ (Hsp40) homolog, subfamily C, member 22 -3.35075
GPRC5A G protein-coupled receptor, class C, group 5, member A -3.35075
PPARGC1B peroxisome proliferator-activated receptor gamma, coactivator 1 beta -3.35075
AKAP14 A kinase (PRKA) anchor protein 14 -3.35075
GBX2 gastrulation brain homeobox 2 -3.35075
SPMIP8 sperm microtubule inner protein 8 -3.35075
VEGFD vascular endothelial growth factor D -3.35075
YPEL4 yippee-like 4 (Drosophila) -3.35075
CDH22 cadherin 22, type 2 -3.35075
MRPS17 mitochondrial ribosomal protein S17 -3.35075
CTSO cathepsin O -3.35075
TMPRSS15 transmembrane protease, serine 15 -3.35075
UTS2B urotensin 2B -3.35075
CCDC17 coiled-coil domain containing 17 -3.35075
SYT15B synaptotagmin 15B -3.35075
TSLP thymic stromal lymphopoietin -3.35075
PRRT1 proline-rich transmembrane protein 1 -3.35075
SMNDC1 survival motor neuron domain containing 1 -3.26367
DGCR2 DiGeorge syndrome critical region gene 2 -3.12333
CCL28 chemokine (C-C motif) ligand 28 -2.98052
PPP6R3 protein phosphatase 6, regulatory subunit 3 -2.9499
PSMA3 proteasome (prosome, macropain) subunit, alpha type, 3 -2.85989
HIST1H2BI histone cluster 1, H2bi -2.84793
WIPF1 WAS/WASL interacting protein family, member 1 -2.73239
TRIM62 tripartite motif containing 62 -2.61317
SMYD5 SMYD family member 5 -2.6126
SH2D4A SH2 domain containing 4A -2.54663
LHFPL4 lipoma HMGIC fusion partner-like 4 -2.53999
CCN2 cellular communication network factor 2 -2.50537
TLN2 talin 2 -2.50416
ALPK1 alpha-kinase 1 -2.49212
PCDH19 protocadherin 19 -2.49185
RB1 retinoblastoma 1 -2.49185
TRAK1 trafficking protein, kinesin binding 1 -2.48235
RNF167 ring finger protein 167 -2.47989
ZNF19 zinc finger protein 19 -2.45611
MAPKAP1 mitogen-activated protein kinase associated protein 1 -2.45073
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 -2.38855
CDK8 cyclin-dependent kinase 8 -2.32136
FAT2 FAT atypical cadherin 2 -2.30761
DNAJC25 DnaJ (Hsp40) homolog, subfamily C , member 25 -2.28913
RHOBTB3 Rho-related BTB domain containing 3 -2.28412
CDK9 cyclin-dependent kinase 9 -2.28412
CTNND1 catenin (cadherin-associated protein), delta 1 -2.27447
VAMP5 vesicle-associated membrane protein 5 -2.27447
GASK1A golgi associated kinase 1A -2.25661
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -2.25211
DYDC1 DPY30 domain containing 1 -2.23179
RBX1 ring-box 1, E3 ubiquitin protein ligase -2.21262
USP39 ubiquitin specific peptidase 39 -2.20426
HLA-A major histocompatibility complex, class I, A -2.18117
DMAC1 distal membrane arm assembly component 1 -2.18079
ATP1A3 ATPase, Na+/K+ transporting, alpha 3 polypeptide -2.17787
AOC2 amine oxidase, copper containing 2 (retina-specific) -2.16469
MAP1LC3B2 microtubule-associated protein 1 light chain 3 beta 2 -2.15709
DNMBP dynamin binding protein -2.15709
CHCHD6 coiled-coil-helix-coiled-coil-helix domain containing 6 -2.15709
TAX1BP3 Tax1 (human T-cell leukemia virus type I) binding protein 3 -2.15709
OPN3 opsin 3 -2.15709
ZNF624 zinc finger protein 624 -2.15709
ACOT2 acyl-CoA thioesterase 2 -2.13365
RPL14 ribosomal protein L14 -2.13365
LRPPRC leucine-rich pentatricopeptide repeat containing -2.09549
MFGE8 milk fat globule-EGF factor 8 protein -2.08664
TBC1D19 TBC1 domain family, member 19 -2.0782
QRICH2 glutamine rich 2 -2.05058
PNCK pregnancy up-regulated nonubiquitous CaM kinase -2.02343
TMEM171 transmembrane protein 171 -2.02343
ZNG1F Zn regulated GTPase metalloprotein activator 1F -2.02343
RORB RAR-related orphan receptor B -2.02343
CCDC196 coiled-coil domain containing 196 -2.02343
ZNF555 zinc finger protein 555 -2.02208
PILRA paired immunoglobin-like type 2 receptor alpha -2.0214
METTL13 methyltransferase like 13 -2.02127
A2ML1 alpha-2-macroglobulin-like 1 -2.00805
RIC1 RAB6A GEF complex partner 1 -2.00671
EIF3H eukaryotic translation initiation factor 3, subunit H -2.00578
OTOG otogelin -2.00201
FOXO6 forkhead box O6 -2.00201