SIX6 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description SIX homeobox 6|The protein encoded by this gene is a homeobox protein that is similar to the Drosophila 'sine oculis' gene product. This gene is found in a cluster of related genes on chromosome 14 and is thought to be involved in eye development. Defects in this gene are a cause of isolated microphthalmia with cataract type 2 (MCOPCT2). [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 4990)
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Genes

298 genes differentially expressed following the SIX6 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
OR52H1 olfactory receptor, family 52, subfamily H, member 1 2.92357
GSTM5 glutathione S-transferase mu 5 2.92357
EDEM3 ER degradation enhancer, mannosidase alpha-like 3 2.92357
LRRC55 leucine rich repeat containing 55 2.92357
DSG3 desmoglein 3 2.92357
TYRP1 tyrosinase-related protein 1 2.92357
GFAP glial fibrillary acidic protein 2.92357
FOLR3 folate receptor 3 (gamma) 2.92357
ADH1A alcohol dehydrogenase 1A (class I), alpha polypeptide 2.92357
C19ORF67 chromosome 19 open reading frame 67 2.92357
OR10A5 olfactory receptor, family 10, subfamily A, member 5 2.92357
GRXCR2 glutaredoxin, cysteine rich 2 2.92357
RXFP2 relaxin/insulin-like family peptide receptor 2 2.92357
IZUMO3 IZUMO family member 3 2.92357
ALOX15 arachidonate 15-lipoxygenase 2.92357
SPINK6 serine peptidase inhibitor, Kazal type 6 2.92357
TSGA13 testis specific, 13 2.92357
PON1 paraoxonase 1 2.92357
GPR151 G protein-coupled receptor 151 2.92357
ADGRG4 adhesion G protein-coupled receptor G4 2.92357
NCF1 neutrophil cytosolic factor 1 2.92357
MYOM2 myomesin 2 2.92357
FSCN2 fascin actin-bundling protein 2, retinal 2.92357
ITIH3 inter-alpha-trypsin inhibitor heavy chain 3 2.92357
PRR22 proline rich 22 2.92357
TDO2 tryptophan 2,3-dioxygenase 2.92357
NWD2 NACHT and WD repeat domain containing 2 2.92357
KIAA1755 KIAA1755 2.92357
ALDH8A1 aldehyde dehydrogenase 8 family, member A1 2.92357
PRSS21 protease, serine, 21 (testisin) 2.92357
EBI3 Epstein-Barr virus induced 3 2.92357
R3HDML R3H domain containing-like 2.92357
CDRT15 CMT1A duplicated region transcript 15 2.92357
RPEL1 ribulose-5-phosphate-3-epimerase-like 1 2.92357
GPHB5 glycoprotein hormone beta 5 2.92357
OR51L1 olfactory receptor, family 51, subfamily L, member 1 2.92357
CRX cone-rod homeobox 2.92357
CLEC5A C-type lectin domain family 5, member A 2.92357
BFSP2 beaded filament structural protein 2, phakinin 2.92357
TAS2R13 taste receptor, type 2, member 13 2.92357
BMP5 bone morphogenetic protein 5 2.92357
MYO1G myosin IG 2.92357
SPHK1 sphingosine kinase 1 2.92357
TSSK1B testis-specific serine kinase 1B 2.92357
ZC3H11C zinc finger CCCH-type containing 11C 2.92357
CAPN3 calpain 3, (p94) 2.92357
KRT81 keratin 81, type II 2.92357
KRT80 keratin 80, type II 2.92357
FMOD fibromodulin 2.92357
TMEM40 transmembrane protein 40 2.92357
ASB4 ankyrin repeat and SOCS box containing 4 2.92357
MIOX myo-inositol oxygenase 2.92357
GCSAM germinal center-associated, signaling and motility 2.92357
ATP4B ATPase, H+/K+ exchanging, beta polypeptide 2.92357
ZNF726 zinc finger protein 726 2.92357
GBP6 guanylate binding protein family, member 6 2.92357
CPNE8-AS1 CPNE8 antisense RNA 1 2.92357
C20ORF204 chromosome 20 open reading frame 204 2.92357
RHEX regulator of hemoglobinization and erythroid cell expansion 2.92357
H3C3 H3 clustered histone 3 2.92357
TEX13D TEX13 family member D 2.92357
GSTT4 glutathione S-transferase theta 4 2.92357
CCDC9B coiled-coil domain containing 9B 2.92357
H1-6 H1.6 linker histone, cluster member 2.92357
ALDOB aldolase B, fructose-bisphosphate 2.92357
PARVG parvin, gamma 2.92357
BEST3 bestrophin 3 2.92357
FAM3D family with sequence similarity 3, member D 2.92357
ACR acrosin 2.92357
NRN1 neuritin 1 2.92357
CFHR5 complement factor H-related 5 2.92357
TMPRSS11F transmembrane protease, serine 11F 2.92357
RHOXF2B Rhox homeobox family, member 2B 2.92357
GOT1L1 glutamic-oxaloacetic transaminase 1-like 1 2.92357
LRRD1 leucine-rich repeats and death domain containing 1 2.92357
UCN urocortin 2.92357
RLBP1 retinaldehyde binding protein 1 2.92357
IZUMO4 IZUMO family member 4 2.92357
PGLYRP1 peptidoglycan recognition protein 1 2.92357
CELA2A chymotrypsin-like elastase family, member 2A 2.92357
FOXI2 forkhead box I2 2.92357
ARHGEF38 Rho guanine nucleotide exchange factor (GEF) 38 2.92357
ITK IL2-inducible T-cell kinase 2.92357
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 2.92357
PCDHA8 protocadherin alpha 8 2.92357
RAB44 RAB44, member RAS oncogene family 2.92357
ACTL10 actin-like 10 2.92357
CHRND cholinergic receptor, nicotinic, delta (muscle) 2.92357
ABRA actin binding Rho activating protein 2.92357
MYF6 myogenic factor 6 (herculin) 2.92357
CRTAM cytotoxic and regulatory T cell molecule 2.92357
WFDC9 WAP four-disulfide core domain 9 2.92357
CALHM1 calcium homeostasis modulator 1 2.92357
SPINK9 serine peptidase inhibitor, Kazal type 9 2.92357
SLC6A12 solute carrier family 6 (neurotransmitter transporter), member 12 2.92357
CPA3 carboxypeptidase A3 (mast cell) 2.92357
TRIM55 tripartite motif containing 55 2.92357
EMP2 epithelial membrane protein 2 2.92357
BPIFB1 BPI fold containing family B, member 1 2.92357
LCN9 lipocalin 9 2.92357
GLYATL3 glycine-N-acyltransferase-like 3 2.92357
KCNK9 potassium channel, two pore domain subfamily K, member 9 2.92357
AKR1B15 aldo-keto reductase family 1, member B15 2.92357
FOXE3 forkhead box E3 2.92357
ERICH4 glutamate-rich 4 2.92357
OTC ornithine carbamoyltransferase 2.92357
BTNL3 butyrophilin-like 3 2.92357
OR10R2 olfactory receptor, family 10, subfamily R, member 2 2.92357
MCCD1 mitochondrial coiled-coil domain 1 2.92357
LMOD3 leiomodin 3 (fetal) 2.92357
CCL19 chemokine (C-C motif) ligand 19 2.92357
RBBP8NL RBBP8 N-terminal like 2.92357
CAPSL calcyphosine-like 2.92357
SPTA1 spectrin, alpha, erythrocytic 1 2.92357
POU4F1 POU class 4 homeobox 1 2.92357
OR8J1 olfactory receptor, family 8, subfamily J, member 1 2.92357
KCNA1 potassium channel, voltage gated shaker related subfamily A, member 1 2.92357
GAS2L2 growth arrest-specific 2 like 2 2.92357
WNT2 wingless-type MMTV integration site family member 2 2.92357
TRIM7 tripartite motif containing 7 2.92357
CSF1R colony stimulating factor 1 receptor 2.92357
PPP1R14C protein phosphatase 1, regulatory (inhibitor) subunit 14C 2.92357
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1 2.92357
HOPX HOP homeobox 2.92357
SIRPG signal-regulatory protein gamma 2.92357
SLCO2B1 solute carrier organic anion transporter family, member 2B1 2.92357
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) 2.92357
GSTA1 glutathione S-transferase alpha 1 2.92357
LHX5 LIM homeobox 5 2.92357
GOLGA8S golgin A8 family, member S 2.92357
ANKRD30B ankyrin repeat domain 30B 2.92357
ITLN1 intelectin 1 (galactofuranose binding) 2.92357
PSORS1C1 psoriasis susceptibility 1 candidate 1 2.92357
MT1A metallothionein 1A 2.92357
HHIPL2 HHIP-like 2 2.92357
COL22A1 collagen, type XXII, alpha 1 2.92357
TRPM5 transient receptor potential cation channel, subfamily M, member 5 2.92357
CALML5 calmodulin-like 5 2.92357
LONP2 lon peptidase 2, peroxisomal 2.92357
LRRC38 leucine rich repeat containing 38 2.92357
MAGEA10 melanoma antigen family A10 2.92357
TTC34 tetratricopeptide repeat domain 34 2.92357
ANXA8 annexin A8 2.92357
PGPEP1L pyroglutamyl-peptidase I-like 2.92357
ANGPTL6 angiopoietin-like 6 2.92357
KCNK15 potassium channel, two pore domain subfamily K, member 15 2.92357
FOXG1 forkhead box G1 2.92357
ASCL5 achaete-scute family bHLH transcription factor 5 2.92357
TBC1D26 TBC1 domain family, member 26 2.92357
KRT15 keratin 15, type I 2.92357
FBXO39 F-box protein 39 2.92357
CIDEA cell death-inducing DFFA-like effector a 2.92357
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) 2.92357
DMBT1 deleted in malignant brain tumors 1 2.92357
MSX1 msh homeobox 1 2.91169
PRMT6 protein arginine methyltransferase 6 2.88809
C8ORF48 chromosome 8 open reading frame 48 2.87136
ANKRD61 ankyrin repeat domain 61 2.87136
FLACC1 flagellum associated containing coiled-coil domains 1 2.87136
IQCN IQ motif containing N 2.8408
ARL6IP4 ADP-ribosylation factor-like 6 interacting protein 4 2.7093
HPSE heparanase 2.68191
HES1 hes family bHLH transcription factor 1 2.60016
GCNT7 glucosaminyl (N-acetyl) transferase family member 7 2.60016
SP3 Sp3 transcription factor 2.55844
CDCA7L cell division cycle associated 7-like 2.55844
PRRC1 proline-rich coiled-coil 1 2.54606
ATAD5 ATPase family, AAA domain containing 5 2.54606
S1PR2 sphingosine-1-phosphate receptor 2 2.44659
LGR6 leucine-rich repeat containing G protein-coupled receptor 6 2.42718
KPNA7 karyopherin alpha 7 (importin alpha 8) 2.42581
FBXL17 F-box and leucine-rich repeat protein 17 2.42306
BIRC2 baculoviral IAP repeat containing 2 2.41624
AKAP14 A kinase (PRKA) anchor protein 14 2.40028
DCST2 DC-STAMP domain containing 2 2.3978
BTBD2 BTB (POZ) domain containing 2 2.38956
MCRIP1 MAPK regulated corepressor interacting protein 1 2.38059
CCDC175 coiled-coil domain containing 175 2.34113
TMEM123 transmembrane protein 123 2.3213
RAB38 RAB38, member RAS oncogene family 2.31837
FAM32A family with sequence similarity 32, member A 2.31837
FSIP1 fibrous sheath interacting protein 1 2.30555
PRAF2 PRA1 domain family, member 2 2.28929
SLC38A6 solute carrier family 38, member 6 2.28414
FHIP2B FHF complex subunit HOOK interacting protein 2B 2.27929
APOL1 apolipoprotein L, 1 2.26997
LAMP3 lysosomal-associated membrane protein 3 2.26997
SLC47A2 solute carrier family 47 (multidrug and toxin extrusion), member 2 2.26997
PTPRJ protein tyrosine phosphatase, receptor type, J 2.26997
SLC35D2 solute carrier family 35 (UDP-GlcNAc/UDP-glucose transporter), member D2 2.26997
ZFYVE26 zinc finger, FYVE domain containing 26 2.23691
PI4K2B phosphatidylinositol 4-kinase type 2 beta 2.21142
KLF8 Kruppel-like factor 8 2.20359
DHRS4 dehydrogenase/reductase (SDR family) member 4 2.20216
DEDD death effector domain containing 2.18094
BBC3 BCL2 binding component 3 2.16984
EIF4E2 eukaryotic translation initiation factor 4E family member 2 2.16233
SCMH1 sex comb on midleg homolog 1 (Drosophila) 2.15543
PLAC8L1 PLAC8-like 1 2.14004
FBXO48 F-box protein 48 2.128
IFITM1 interferon induced transmembrane protein 1 2.12525
ARMCX4 armadillo repeat containing, X-linked 4 2.11966
PSMG4 proteasome (prosome, macropain) assembly chaperone 4 2.10839
COX6C cytochrome c oxidase subunit VIc 2.08305
RAB12 RAB12, member RAS oncogene family 2.07522
PLA2G4C phospholipase A2, group IVC (cytosolic, calcium-independent) 2.06119
YARS1 tyrosyl-tRNA synthetase 1 2.05566
MAPRE3 microtubule-associated protein, RP/EB family, member 3 2.05315
ZRANB2 zinc finger, RAN-binding domain containing 2 2.04951
PLSCR1 phospholipid scramblase 1 2.02128
IMPA1 inositol(myo)-1(or 4)-monophosphatase 1 2.01848
TUT1 terminal uridylyl transferase 1, U6 snRNA-specific 2.01807
PGF placental growth factor 2.00064

decreased expression

Symbol Name Standardized Value
SPINT3 serine peptidase inhibitor, Kunitz type, 3 -2.92357
CLDN5 claudin 5 -2.92357
IL12A interleukin 12A -2.92357
CATSPERT catsper channel auxiliary subunit tau -2.92357
CPED1 cadherin-like and PC-esterase domain containing 1 -2.92357
TECRL trans-2,3-enoyl-CoA reductase-like -2.92357
TMEM229A transmembrane protein 229A -2.92357
VTCN1 V-set domain containing T cell activation inhibitor 1 -2.92357
NOS3 nitric oxide synthase 3 (endothelial cell) -2.92357
AVP arginine vasopressin -2.92357
AKR7L aldo-keto reductase family 7-like (gene/pseudogene) -2.92357
FGF9 fibroblast growth factor 9 -2.92357
SPAG6 sperm associated antigen 6 -2.92357
CD160 CD160 molecule -2.92357
UCP3 uncoupling protein 3 (mitochondrial, proton carrier) -2.92357
AP2S1 adaptor-related protein complex 2, sigma 1 subunit -2.92357
UTS2 urotensin 2 -2.92357
PCDHGB4 protocadherin gamma subfamily B, 4 -2.92357
SPATA9 spermatogenesis associated 9 -2.92357
SPATA18 spermatogenesis associated 18 -2.92357
TTC9B tetratricopeptide repeat domain 9B -2.92357
PLET1 placenta expressed transcript 1 -2.92357
RTL9 retrotransposon Gag like 9 -2.92357
AANAT aralkylamine N-acetyltransferase -2.92357
NHLH1 nescient helix loop helix 1 -2.92357
UNC13C unc-13 homolog C (C. elegans) -2.92357
MAGIX MAGI family member, X-linked -2.92357
TMEM275 transmembrane protein 275 -2.92357
FN3KRP fructosamine 3 kinase related protein -2.90253
ZNF774 zinc finger protein 774 -2.87136
MTARC1 mitochondrial amidoxime reducing component 1 -2.85473
SIGLEC10 sialic acid binding Ig-like lectin 10 -2.64395
CDH26 cadherin 26 -2.64395
SH2B2 SH2B adaptor protein 2 -2.60869
MYL12B myosin, light chain 12B, regulatory -2.60016
HDHD5 haloacid dehalogenase like hydrolase domain containing 5 -2.54337
CHD1L chromodomain helicase DNA binding protein 1-like -2.48246
MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2 -2.42939
BHLHA15 basic helix-loop-helix family, member a15 -2.42306
ETV7 ets variant 7 -2.42306
TRIM17 tripartite motif containing 17 -2.42306
RNASE1 ribonuclease, RNase A family, 1 (pancreatic) -2.42306
IRX3 iroquois homeobox 3 -2.42306
TENT5B terminal nucleotidyltransferase 5B -2.41573
CSNK1G3 casein kinase 1, gamma 3 -2.41573
LCP1 lymphocyte cytosolic protein 1 (L-plastin) -2.4107
ZNF816 zinc finger protein 816 -2.3978
MROH6 maestro heat-like repeat family member 6 -2.36774
ALDH1L2 aldehyde dehydrogenase 1 family, member L2 -2.33414
RPS2 ribosomal protein S2 -2.3213
PTAFR platelet-activating factor receptor -2.31946
TRIM61 tripartite motif containing 61 -2.31837
TRIM41 tripartite motif containing 41 -2.31837
HS3ST4 heparan sulfate (glucosamine) 3-O-sulfotransferase 4 -2.30727
CHMP7 charged multivesicular body protein 7 -2.28929
ASIC2 acid sensing (proton gated) ion channel 2 -2.26997
TM4SF18 transmembrane 4 L six family member 18 -2.26997
ZFAND5 zinc finger, AN1-type domain 5 -2.26997
MGME1 mitochondrial genome maintenance exonuclease 1 -2.25552
C11ORF58 chromosome 11 open reading frame 58 -2.2513
TNNI3K TNNI3 interacting kinase -2.23959
EDN1 endothelin 1 -2.23959
PCYOX1L prenylcysteine oxidase 1 like -2.23691
WDR74 WD repeat domain 74 -2.22513
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor -2.18922
MORC3 MORC family CW-type zinc finger 3 -2.16233
CAPN11 calpain 11 -2.16171
FAM181B family with sequence similarity 181, member B -2.16171
AFF4 AF4/FMR2 family, member 4 -2.16171
CENPX centromere protein X -2.16171
CARF calcium responsive transcription factor -2.15865
CCDC86 coiled-coil domain containing 86 -2.15511
SPTLC3 serine palmitoyltransferase, long chain base subunit 3 -2.13397
PIK3C2G phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma -2.10936
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein -2.10129
MARCKSL1 MARCKS-like 1 -2.09193
MTSS2 MTSS I-BAR domain containing 2 -2.08305
BRINP1 bone morphogenetic protein/retinoic acid inducible neural-specific 1 -2.05566
PCDH7 protocadherin 7 -2.05566
TXLNG taxilin gamma -2.05315
MRPS2 mitochondrial ribosomal protein S2 -2.04581
ACBD5 acyl-CoA binding domain containing 5 -2.03991
RNPS1 RNA binding protein S1, serine-rich domain -2.03038
SLC52A3 solute carrier family 52 (riboflavin transporter), member 3 -2.01512
ZSCAN21 zinc finger and SCAN domain containing 21 -2.0057