| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/92409 |
| Similar Terms | |
| Downloads & Tools |
197 proteins with high or low expression in SKF 89976A relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ADCY10 | adenylate cyclase 10 (soluble) | 1.36 |
| BCL2L12 | BCL2-like 12 (proline rich) | 1.29 |
| ZC3H12C | zinc finger CCCH-type containing 12C | 1.14 |
| RETREG1 | reticulophagy regulator 1 | 0.95 |
| BMT2 | base methyltransferase of 25S rRNA 2 homolog | 0.93 |
| WWC3 | WWC family member 3 | 0.9 |
| MYO7B | myosin VIIB | 0.73 |
| ABCA13 | ATP-binding cassette, sub-family A (ABC1), member 13 | 0.6 |
| CCDC150 | coiled-coil domain containing 150 | 0.59 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.57 |
| KMT2B | lysine (K)-specific methyltransferase 2B | 0.53 |
| TTLL4 | tubulin tyrosine ligase-like family member 4 | 0.51 |
| ERI3 | ERI1 exoribonuclease family member 3 | 0.46 |
| AURKAIP1 | aurora kinase A interacting protein 1 | 0.43 |
| PISD | phosphatidylserine decarboxylase | 0.41 |
| ARAP2 | ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 | 0.41 |
| ARL16 | ADP-ribosylation factor-like 16 | 0.4 |
| ANKRD22 | ankyrin repeat domain 22 | 0.39 |
| TRMT13 | tRNA methyltransferase 13 homolog (S. cerevisiae) | 0.39 |
| STX1A | syntaxin 1A (brain) | 0.39 |
| EMC10 | ER membrane protein complex subunit 10 | 0.39 |
| IL10RB | interleukin 10 receptor, beta | 0.39 |
| BCORL1 | BCL6 corepressor-like 1 | 0.38 |
| PCLO | piccolo presynaptic cytomatrix protein | 0.38 |
| HAUS7 | HAUS augmin-like complex, subunit 7 | 0.37 |
| PTPN18 | protein tyrosine phosphatase, non-receptor type 18 (brain-derived) | 0.36 |
| GABPB1 | GA binding protein transcription factor, beta subunit 1 | 0.36 |
| CEP63 | centrosomal protein 63kDa | 0.36 |
| CMTM4 | CKLF-like MARVEL transmembrane domain containing 4 | 0.36 |
| DCLK2 | doublecortin-like kinase 2 | 0.36 |
| TMEM222 | transmembrane protein 222 | 0.36 |
| ZSCAN26 | zinc finger and SCAN domain containing 26 | 0.36 |
| ETV5 | ets variant 5 | 0.36 |
| GATD1 | glutamine amidotransferase class 1 domain containing 1 | 0.35 |
| SGTB | small glutamine-rich tetratricopeptide repeat (TPR)-containing, beta | 0.34 |
| AKAP6 | A kinase (PRKA) anchor protein 6 | 0.34 |
| ZNF524 | zinc finger protein 524 | 0.34 |
| SLC41A3 | solute carrier family 41, member 3 | 0.34 |
| ANP32A | acidic (leucine-rich) nuclear phosphoprotein 32 family, member A | 0.33 |
| WTAP | Wilms tumor 1 associated protein | 0.33 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.33 |
| KIAA1324L | KIAA1324-like | 0.33 |
| IL13RA1 | interleukin 13 receptor, alpha 1 | 0.33 |
| TMEM183B | transmembrane protein 183B | 0.33 |
| AGRN | agrin | 0.33 |
| MBLAC2 | metallo-beta-lactamase domain containing 2 | 0.32 |
| NSUN3 | NOP2/Sun domain family, member 3 | 0.32 |
| YAE1 | YAE1 maturation factor of ABCE1 | 0.31 |
| CPLANE1 | ciliogenesis and planar polarity effector complex subunit 1 | 0.31 |
| TRMO | tRNA methyltransferase O | 0.31 |
| ERAP1 | endoplasmic reticulum aminopeptidase 1 | 0.31 |
| LRP4 | low density lipoprotein receptor-related protein 4 | 0.31 |
| CALU | calumenin | 0.31 |
| FUT11 | fucosyltransferase 11 (alpha (1,3) fucosyltransferase) | 0.31 |
| HS6ST1 | heparan sulfate 6-O-sulfotransferase 1 | 0.3 |
| SNAPIN | SNAP-associated protein | 0.3 |
| ACVR1B | activin A receptor, type IB | 0.29 |
| MAN2A2 | mannosidase, alpha, class 2A, member 2 | 0.29 |
| FMNL1 | formin-like 1 | 0.29 |
| TSR2 | TSR2, 20S rRNA accumulation, homolog (S. cerevisiae) | 0.29 |
| NPHP4 | nephronophthisis 4 | 0.28 |
| NIN | ninein (GSK3B interacting protein) | 0.28 |
| TMPPE | transmembrane protein with metallophosphoesterase domain | 0.28 |
| MED28 | mediator complex subunit 28 | 0.28 |
| C5ORF30 | chromosome 5 open reading frame 30 | 0.28 |
| VPS41 | vacuolar protein sorting 41 homolog (S. cerevisiae) | 0.27 |
| TFAP4 | transcription factor AP-4 (activating enhancer binding protein 4) | 0.27 |
| TBC1D31 | TBC1 domain family, member 31 | 0.27 |
| CDS1 | CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1 | 0.27 |
| STARD3 | StAR-related lipid transfer (START) domain containing 3 | 0.27 |
| PPHLN1 | periphilin 1 | 0.27 |
| CES2 | carboxylesterase 2 | 0.27 |
| PMS2 | PMS2 postmeiotic segregation increased 2 (S. cerevisiae) | 0.27 |
| ZNF57 | zinc finger protein 57 | 0.27 |
| FAM89A | family with sequence similarity 89, member A | 0.27 |
| SET | SET nuclear proto-oncogene | 0.26 |
| SARDH | sarcosine dehydrogenase | 0.26 |
| RGN | regucalcin | 0.26 |
| ADM | adrenomedullin | 0.26 |
| IGF1R | insulin-like growth factor 1 receptor | 0.26 |
| HPCAL4 | hippocalcin like 4 | 0.26 |
| ACD | adrenocortical dysplasia homolog (mouse) | 0.26 |
| FUBP1 | far upstream element (FUSE) binding protein 1 | 0.26 |
| PTPRU | protein tyrosine phosphatase, receptor type, U | 0.26 |
| PEX5 | peroxisomal biogenesis factor 5 | 0.26 |
| KDM8 | lysine (K)-specific demethylase 8 | 0.26 |
| MROH6 | maestro heat-like repeat family member 6 | 0.26 |
| CDC34 | cell division cycle 34 | 0.25 |
| LARP6 | La ribonucleoprotein domain family, member 6 | 0.25 |
| AGFG2 | ArfGAP with FG repeats 2 | 0.25 |
| XTBD1 | XRN2 binding domain containing 1 | 0.25 |
| PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 | 0.25 |
| RAB30 | RAB30, member RAS oncogene family | 0.25 |
| TNIP2 | TNFAIP3 interacting protein 2 | 0.25 |
| SLC35A4 | solute carrier family 35, member A4 | 0.25 |
| MUC16 | mucin 16, cell surface associated | 0.25 |
| C16ORF72 | chromosome 16 open reading frame 72 | 0.25 |
| PRKCSH | protein kinase C substrate 80K-H | 0.25 |
| Symbol | Name | Standardized Value |
|---|---|---|
| KLHL23 | kelch-like family member 23 | -1.94 |
| RAB36 | RAB36, member RAS oncogene family | -1.02 |
| CNTRL | centriolin | -0.83 |
| FHOD3 | formin homology 2 domain containing 3 | -0.7 |
| RASSF3 | Ras association (RalGDS/AF-6) domain family member 3 | -0.64 |
| SNX33 | sorting nexin 33 | -0.62 |
| LSM5 | LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) | -0.57 |
| ASAP3 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 3 | -0.57 |
| ZCCHC24 | zinc finger, CCHC domain containing 24 | -0.55 |
| ALG12 | ALG12, alpha-1,6-mannosyltransferase | -0.53 |
| ZNF567 | zinc finger protein 567 | -0.5 |
| IGFBP2 | insulin-like growth factor binding protein 2, 36kDa | -0.49 |
| DNAH1 | dynein, axonemal, heavy chain 1 | -0.47 |
| SHC4 | SHC (Src homology 2 domain containing) family, member 4 | -0.46 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.43 |
| C4ORF33 | chromosome 4 open reading frame 33 | -0.41 |
| GPR180 | G protein-coupled receptor 180 | -0.38 |
| FN1 | fibronectin 1 | -0.38 |
| NDFIP1 | Nedd4 family interacting protein 1 | -0.37 |
| KIAA1210 | KIAA1210 | -0.37 |
| PTPN21 | protein tyrosine phosphatase, non-receptor type 21 | -0.37 |
| TMEM38B | transmembrane protein 38B | -0.37 |
| HRH1 | histamine receptor H1 | -0.36 |
| LCMT2 | leucine carboxyl methyltransferase 2 | -0.35 |
| PDGFRL | platelet-derived growth factor receptor-like | -0.35 |
| EPB41L4B | erythrocyte membrane protein band 4.1 like 4B | -0.34 |
| CCDC73 | coiled-coil domain containing 73 | -0.34 |
| FGGY | FGGY carbohydrate kinase domain containing | -0.34 |
| PALB2 | partner and localizer of BRCA2 | -0.34 |
| BBS4 | Bardet-Biedl syndrome 4 | -0.33 |
| PJA1 | praja ring finger 1, E3 ubiquitin protein ligase | -0.33 |
| TMSB10 | thymosin beta 10 | -0.33 |
| NAGA | N-acetylgalactosaminidase, alpha- | -0.32 |
| ACTB | actin, beta | -0.32 |
| NPHP3 | nephronophthisis 3 (adolescent) | -0.32 |
| MEX3C | mex-3 RNA binding family member C | -0.32 |
| TPM1 | tropomyosin 1 (alpha) | -0.32 |
| GALNT14 | polypeptide N-acetylgalactosaminyltransferase 14 | -0.31 |
| MTFMT | mitochondrial methionyl-tRNA formyltransferase | -0.31 |
| ADIRF | adipogenesis regulatory factor | -0.31 |
| NOL3 | nucleolar protein 3 (apoptosis repressor with CARD domain) | -0.31 |
| WDR25 | WD repeat domain 25 | -0.3 |
| RAD52 | RAD52 homolog (S. cerevisiae) | -0.3 |
| TK2 | thymidine kinase 2, mitochondrial | -0.3 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | -0.3 |
| FGFBP1 | fibroblast growth factor binding protein 1 | -0.29 |
| ACTR3B | ARP3 actin-related protein 3 homolog B (yeast) | -0.29 |
| MYZAP | myocardial zonula adherens protein | -0.29 |
| DNAJC6 | DnaJ (Hsp40) homolog, subfamily C, member 6 | -0.29 |
| TIMM8A | translocase of inner mitochondrial membrane 8 homolog A (yeast) | -0.29 |
| TSPYL2 | TSPY-like 2 | -0.29 |
| MISP3 | MISP family member 3 | -0.29 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.29 |
| MOSPD1 | motile sperm domain containing 1 | -0.29 |
| PRR36 | proline rich 36 | -0.29 |
| MRPS21 | mitochondrial ribosomal protein S21 | -0.29 |
| FAM210B | family with sequence similarity 210, member B | -0.28 |
| TMEM104 | transmembrane protein 104 | -0.28 |
| HIST3H2BB | histone cluster 3, H2bb | -0.28 |
| PPP2R5C | protein phosphatase 2, regulatory subunit B', gamma | -0.28 |
| MFGE8 | milk fat globule-EGF factor 8 protein | -0.28 |
| ATG4D | autophagy related 4D, cysteine peptidase | -0.28 |
| CINP | cyclin-dependent kinase 2 interacting protein | -0.28 |
| ARID5B | AT rich interactive domain 5B (MRF1-like) | -0.28 |
| B3GNT3 | UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3 | -0.27 |
| SLC38A9 | solute carrier family 38, member 9 | -0.27 |
| EEPD1 | endonuclease/exonuclease/phosphatase family domain containing 1 | -0.27 |
| ZNF823 | zinc finger protein 823 | -0.27 |
| C6ORF141 | chromosome 6 open reading frame 141 | -0.27 |
| SLC26A6 | solute carrier family 26 (anion exchanger), member 6 | -0.27 |
| EEF1AKMT2 | EEF1A lysine methyltransferase 2 | -0.27 |
| CLN8 | ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation) | -0.27 |
| EPB41L5 | erythrocyte membrane protein band 4.1 like 5 | -0.27 |
| APOE | apolipoprotein E | -0.26 |
| HEXIM2 | hexamethylene bis-acetamide inducible 2 | -0.26 |
| DPYSL2 | dihydropyrimidinase-like 2 | -0.26 |
| SS18 | synovial sarcoma translocation, chromosome 18 | -0.26 |
| ZNF394 | zinc finger protein 394 | -0.26 |
| ALK | anaplastic lymphoma receptor tyrosine kinase | -0.26 |
| COMTD1 | catechol-O-methyltransferase domain containing 1 | -0.26 |
| MRPL12 | mitochondrial ribosomal protein L12 | -0.25 |
| KLK6 | kallikrein-related peptidase 6 | -0.25 |
| YPEL5 | yippee-like 5 (Drosophila) | -0.25 |
| SLC39A7 | solute carrier family 39 (zinc transporter), member 7 | -0.25 |
| USP18 | ubiquitin specific peptidase 18 | -0.25 |
| TIMM13 | translocase of inner mitochondrial membrane 13 homolog (yeast) | -0.25 |
| HBA1 | hemoglobin, alpha 1 | -0.25 |
| TNK2 | tyrosine kinase, non-receptor, 2 | -0.25 |
| POLR2M | polymerase (RNA) II (DNA directed) polypeptide M | -0.25 |
| SOX6 | SRY (sex determining region Y)-box 6 | -0.24 |
| EIF3C | eukaryotic translation initiation factor 3, subunit C | -0.24 |
| PIK3C2B | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta | -0.24 |
| TGFB1I1 | transforming growth factor beta 1 induced transcript 1 | -0.24 |
| TMEM260 | transmembrane protein 260 | -0.24 |
| ATE1 | arginyltransferase 1 | -0.24 |
| MSMO1 | methylsterol monooxygenase 1 | -0.24 |
| C15ORF61 | chromosome 15 open reading frame 61 | -0.23 |
| ADPRHL1 | ADP-ribosylhydrolase like 1 | -0.23 |
| CXCL16 | chemokine (C-X-C motif) ligand 16 | -0.23 |
